{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:19Z","timestamp":1787029219124,"version":"build-2736575974"},"reference-count":58,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bionap S.r.l."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Gut dysbiosis refers to an imbalance in gut microbiota composition and function. Opuntia ficus-indica extract has been shown to modulate gut microbiota by improving SCFA production in vivo and gastrointestinal discomfort (GD) in humans. The aim of this study was to demonstrate the efficacy of OdiliaTM on gastrointestinal health by changing the microbial diversity of species involved in inflammation, immunity, oxidation, and the brain\u2013gut\u2013muscle axis. A randomized, double-blind clinical trial was conducted in 80 adults with gut dysbiosis. The intervention consisted of a 300 mg daily intake of OdiliaTM (n = 40) or maltodextrin as a placebo (n = 40), administered for 8 weeks. Intervention effect was evaluated using 16S metagenomics and GIQLI\/GSAS scores at baseline, at 4 and 8 weeks. Eight weeks of OdiliaTM supplementation positively modulates gut microbiota composition with a significant reduction in the Firmicutes to Bacteroidetes ratio (p = 0.0012). Relative abundances of beneficial bacteria (Bacteroides and Clostridium_XIVa) were significantly increased (p &lt; 0.001), in contrast to a significant reduction in pro-inflammatory bacteria (p &lt; 0.001). Accordingly, GIQLI and GSAS scores revealed successful improvement in GD. OdiliaTM may represent an effective and well-tolerated treatment in subjects with gut dysbiosis.<\/jats:p>","DOI":"10.3390\/nu16050586","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T05:42:46Z","timestamp":1708494166000},"page":"586","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Randomized, Double-Blind, Placebo-Controlled Trial: Efficacy of Opuntia ficus-indica Prebiotic Supplementation in Subjects with Gut Dysbiosis"],"prefix":"10.3390","volume":"16","author":[{"given":"Marta","family":"Mellai","sequence":"first","affiliation":[{"name":"Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy"},{"name":"Genomics & Transcriptomics Unit, Center for Translational Research on Autoimmune and Allergic Disease, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Allesina","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetto","family":"Edoardo","sequence":"additional","affiliation":[{"name":"GIGA-CP Italian Association for Primary Care Gastroenterology, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Cascella","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9147-302X","authenticated-orcid":false,"given":"Vincenzo","family":"Nobile","sequence":"additional","affiliation":[{"name":"R&D Department, Complife Italia S.r.l., 27028 San Martino Siccomario, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Spina","sequence":"additional","affiliation":[{"name":"Nutratech S.r.l., Spin-Off of University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Amone","sequence":"additional","affiliation":[{"name":"Nutratech S.r.l., Spin-Off of University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-2838","authenticated-orcid":false,"given":"Vincenzo","family":"Zaccaria","sequence":"additional","affiliation":[{"name":"R&D Department, Bionap S.r.l., 95032 Belpasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violetta","family":"Insolia","sequence":"additional","affiliation":[{"name":"Alma Mater Europea, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2852-0919","authenticated-orcid":false,"given":"Anna","family":"Perri","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Magna Grecia University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2081-463X","authenticated-orcid":false,"given":"Danilo","family":"Lofaro","sequence":"additional","affiliation":[{"name":"Department of Mechanical, Energy, Management Engineering, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5963-6762","authenticated-orcid":false,"given":"Francesco","family":"Puoci","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87100 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. 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