{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:03:36Z","timestamp":1790298216406,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The changes in body composition during androgen deprivation therapy (ADT) in patients suffering from prostate cancer (PCa) are recognized by professionals more often as biomarker for effective treatment. The aim of this study was to investigate the impact of ADT on the sarcopenia development in PCa. The following databases were used: PubMed, Embase, Web of Science and Scopus databases. Out of 2183 studies, 7 were included in this review. The fixed-effect model was used in the meta-analysis. A significant increase in SATI (Subcutaneous Adipose Tissue Index) of 0.32 (95% CI: 0.13\u20130.51) p = 0.001, decrease in SMI (Skeletal Muscle Index) of \u22120.38 (95% CI: \u22120.57 to \u22120.19) p &lt; 0.0001, and SMD (Skeletal Muscle Density) of \u22120.46 (95% CI: \u22120.69 to \u22120.24) p &lt; 0.0001 were observed. No statistical association was visible between ADT and changes in BMI (Body Mass Index), 0.05 (95% CI: \u22120.18\u20130.28), p = 0.686, and VATI (Visceral Adipose Tissue Index): 0.17 (95% CI: \u22120.02 to 0.37), p = 0.074. In conclusion, the ADT significantly contributes to the body composition changes and sarcopenia development.<\/jats:p>","DOI":"10.3390\/nu16050656","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T10:40:17Z","timestamp":1708944017000},"page":"656","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Influence of Androgen Deprivation Therapy on the Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5944-1642","authenticated-orcid":false,"given":"Marta","family":"Stelmach-Mardas","sequence":"first","affiliation":[{"name":"Department of Obesity Treatment, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, 60-569 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Warcho\u0142","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry, Poznan University of Medical Sciences, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Garczyk","sequence":"additional","affiliation":[{"name":"Department of Obesity Treatment, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, 60-569 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Warcho\u0142","sequence":"additional","affiliation":[{"name":"Department of Obesity Treatment, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, 60-569 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Korczak","sequence":"additional","affiliation":[{"name":"Department of Chemotherapy, The Greater Poland Cancer Center, 61-866 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Litwiniuk","sequence":"additional","affiliation":[{"name":"Department of Cancer Pathology and Prevention, Poznan University of Medical Sciences, 61-866 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Brajer-Luftmann","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, 60-569 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Mardas","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology, Institute of Oncology, Poznan University of Medical Sciences, 60-569 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"ref_1","first-page":"CD013245","article-title":"Abiraterone acetate in combination with androgen deprivation therapy compared to androgen deprivation therapy only for metastatic hormone-sensitive prostate cancer","volume":"12","author":"Sathianathen","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41391-021-00442-0","article-title":"Associations of Fat and Muscle Mass with Overall Survival in Men with Prostate Cancer: A Systematic Review with Meta-Analysis","volume":"25","author":"Lopez","year":"2022","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41391-021-00450-0","article-title":"Supervised Exercise Therapy Compared with No Exercise Therapy to Reverse Debilitating Effects of Androgen Deprivation Therapy in Patients with Prostate Cancer: A Systematic Review and Meta-Analysis","volume":"25","author":"Ussing","year":"2022","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Shao, W., Zhang, H., Qi, H., and Zhang, Y. (2022). The Effects of Exercise on Body Composition of Prostate Cancer Patients Receiving Androgen Deprivation Therapy: An Update Systematic Review and Meta-Analysis. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0263918"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European Consensus on Definition and Diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_7","unstructured":"(2023, May 18). ICD-10 Version: 2019. Available online: https:\/\/icd.who.int\/browse10\/2019\/en#\/M62.5."},{"key":"ref_8","unstructured":"(2023, May 18). ICD-11 Coding Tool Mortality and Morbidity Statistics (MMS). Available online: https:\/\/icd.who.int\/ct11\/icd11_mms\/en\/release."},{"key":"ref_9","unstructured":"(2020). Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J. Am. Med. Dir. Assoc., 21, 300\u2013307."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.2522\/ptj.20060302","article-title":"Physical Function in Men with Prostate Cancer on Androgen Deprivation Therapy","volume":"87","author":"Clay","year":"2007","journal-title":"Phys. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/pcan.2008.51","article-title":"Reduced Muscle Strength and Functional Performance in Men with Prostate Cancer Undergoing Androgen Suppression: A Comprehensive Cross-Sectional Investigation","volume":"12","author":"Taaffe","year":"2009","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1200\/JCO.2010.29.8091","article-title":"Impact of Androgen-Deprivation Therapy on Physical Function and Quality of Life in Men with Nonmetastatic Prostate Cancer","volume":"28","author":"Alibhai","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1002\/cncr.29355","article-title":"Long-Term Impact of Androgen-Deprivation Therapy on Physical Function and Quality of Life","volume":"121","author":"Alibhai","year":"2015","journal-title":"Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1046\/j.1365-2265.2002.01551.x","article-title":"Long-Term Effects of Androgen Deprivation Therapy in Prostate Cancer Patients","volume":"56","author":"Basaria","year":"2002","journal-title":"Clin. Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/21681805.2023.2168050","article-title":"Onset of Androgen Deprivation Therapy Leads to Rapid Deterioration of Body Composition, Physical Performance, Cardiometabolic Health and Quality-of-Life in Prostate Cancer Patients","volume":"57","author":"Overkamp","year":"2023","journal-title":"Scand J. Urol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/1754-9485.12124","article-title":"Effect of Androgen Deprivation Therapy on Muscle Attenuation in Men with Prostate Cancer","volume":"58","author":"Chang","year":"2014","journal-title":"J. Med. Imaging Radiat. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1200\/JCO.2011.38.8850","article-title":"Sarcopenia during Androgen-Deprivation Therapy for Prostate Cancer","volume":"30","author":"Smith","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.annonc.2020.06.011","article-title":"Prostate Cancer: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up\u2020","volume":"31","author":"Parker","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_19","unstructured":"(2023, July 20). R: The R Project for Statistical Computing. Available online: https:\/\/www.r-project.org\/."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1177\/0962280219889080","article-title":"Estmeansd: Estimating the Sample Mean and Standard Deviation from Commonly Reported Quantiles in Meta-Analysis 2022","volume":"9","author":"McGrath","year":"2020","journal-title":"Stat. Methods Med. Res."},{"key":"ref_21","unstructured":"(2023, July 20). Companion R Package for the Guide Doing Meta-Analysis in R. Available online: https:\/\/dmetar.protectlab.org\/."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Korczak, J., Mardas, M., Litwiniuk, M., Bogda\u0144ski, P., and Stelmach-Mardas, M. (2023). Androgen Deprivation Therapy for Prostate Cancer Influences Body Composition Increasing Risk of Sarcopenia. Nutrients, 15.","DOI":"10.3390\/nu15071631"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9242243","DOI":"10.1155\/2022\/9242243","article-title":"Clinical Features and Body Composition in Men with Hormone-Sensitive Metastatic Prostate Cancer: A Pilot Study Examining Differences by Race","volume":"2022","author":"Sheean","year":"2022","journal-title":"Prostate Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying Heterogeneity in a Meta-Analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"722652","DOI":"10.3389\/fonc.2021.722652","article-title":"Muscle Loss During Androgen Deprivation Therapy Is Associated With Higher Risk of Non-Cancer Mortality in High-Risk Prostate Cancer","volume":"11","author":"Chiang","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12603-019-1294-7","article-title":"HoSAGE: Sarcopenia in Older Patients before and after Treatment with Androgen Deprivation Therapy and Radiotherapy for Prostate Cancer","volume":"24","author":"Couderc","year":"2020","journal-title":"J. Nutr. Health Aging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/pros.24088","article-title":"CT-Based Assessment of Body Composition Following Neoadjuvant Chemohormonal Therapy in Patients with Castration-Na\u00efve Oligometastatic Prostate Cancer","volume":"81","author":"Sheikhbahaei","year":"2021","journal-title":"Prostate"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00223-019-00586-1","article-title":"Does Use of Androgen Deprivation Therapy (ADT) in Men with Prostate Cancer Increase the Risk of Sarcopenia?","volume":"105","author":"Owen","year":"2019","journal-title":"Calcif. Tissue Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jgo.2019.03.017","article-title":"Presence of Sarcopenic Obesity and Evaluation of the Associated Muscle Quality in Japanese Older Men with Prostate Cancer Undergoing Androgen Deprivation Therapy","volume":"10","author":"Kimura","year":"2019","journal-title":"J. Geriatr. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bmb\/ldq008","article-title":"Sarcopenia: Characteristics, mechanisms and functional significance","volume":"95","author":"Narici","year":"2010","journal-title":"Br. Med. Bull."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"110","DOI":"10.5534\/wjmh.182001","article-title":"Testosterone Replacement, Muscle Strength, and Physical Function","volume":"36","author":"Nam","year":"2018","journal-title":"World J. Mens Health"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1152\/jappl.1989.66.1.498","article-title":"Effect of testosterone on muscle mass and muscle protein synthesis","volume":"66","author":"Griggs","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kalu\u017aniak-Szymanowska, A., Krzymi\u0144ska-Siemaszko, R., Deskur-\u015amielecka, E., Lewandowicz, M., Kaczmarek, B., and Wieczorowska-Tobis, K. (2021). Malnutrition, Sarcopenia, and Malnutrition-Sarcopenia Syndrome in Older Adults with COPD. Nutrients, 14.","DOI":"10.3390\/nu14010044"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Son, S.W., Song, D.S., Chang, U.I., and Yang, J.M. (2021). Definition of Sarcopenia in Chronic Liver Disease. Life, 11.","DOI":"10.3390\/life11040349"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"de Pablos-Rodr\u00edguez, P., Del Pino-Sede\u00f1o, T., Infante-Ventura, D., de Armas-Castellano, A., Ram\u00edrez Backhaus, M., Ferrer, J.F.L., de Pablos-Velasco, P., Rueda-Dom\u00ednguez, A., and Trujillo-Mart\u00edn, M.M. (2022). Prognostic Impact of Sarcopenia in Patients with Advanced Prostate Carcinoma: A Systematic Review. J. Clin. Med., 12.","DOI":"10.3390\/jcm12010057"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.urology.2003.10.063","article-title":"Changes in fat and lean body mass during androgen-deprivation therapy for prostate cancer","volume":"63","author":"Smith","year":"2004","journal-title":"Urology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1056\/NEJMoa041943","article-title":"Risk of fracture after androgen deprivation for prostate cancer","volume":"352","author":"Shahinian","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/aja.2011.104","article-title":"Muscle function, physical performance and body composition changes in men with prostate cancer undergoing androgen deprivation therapy","volume":"2","author":"Storer","year":"2012","journal-title":"Asian J. Androl."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/jcsm.12831","article-title":"Computed tomography-defined low skeletal muscle index and density in cancer patients: Observations from a systematic review","volume":"12","author":"McGovern","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"920","DOI":"10.2337\/dc09-1825","article-title":"Visceral Adiposity Index: A reliable indicator of visceral fat function associated with cardiometabolic risk","volume":"33","author":"Amato","year":"2010","journal-title":"Diabetes Care."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/pros.24054","article-title":"Abdominal and pelvic adipose tissue distribution and risk of prostate cancer recurrence after radiation therapy","volume":"80","author":"Howard","year":"2020","journal-title":"Prostate"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/5\/656\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:05:03Z","timestamp":1760105103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/5\/656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["nu16050656"],"URL":"https:\/\/doi.org\/10.3390\/nu16050656","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,26]]}}}