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Five experimental assessments were performed by 37 adolescent swimmers. During the first session, the athletes went to the laboratory facility for venous blood sampling. The critical velocity protocol was conducted over the 4 subsequent days to measure aerobic performance (CV), comprising maximal efforts over distances of 100, 200, 400, and 800 m in a swimming pool. RBCs were obtained and extracted for analysis using the liquid chromatography\u2014high resolution mass spectrometry untargeted approach. A total of 2146 ions were detected in the RBCs, of which 119 were identified. The enrichment pathway analysis indicated intermediary lipids in the glycerophospholipid, glycerolipid, sphingolipid, linoleic acid, and alpha-linolenic metabolisms, as well as pentose and glucuronate interconversions. A significant impact of the intermediary lipids was observed for the glycerophospholipid metabolism, including phosphatidylethanolamine (PE), phosphatidylcholine (PC), 1-acyl-sn-glycero-3-phosphocholine, sn-glycerol 3-phosphate, and phosphatidic acid. Inverse and significant associations were observed for PE 18:2\/18:3 (r = \u22120.39; p = 0.015), PC 18:3\/20:0 (r = \u22120.33; p = 0.041), and phosphatidic acid 18:0\/0:0 (r = \u22120.47; p = 0.003) with aerobic performance. Swimmers who exhibited higher levels of aerobic performance also had the lowest abundance of PE, PC, and phosphatidic acid.<\/jats:p>","DOI":"10.3390\/nu16060765","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T11:33:06Z","timestamp":1709811186000},"page":"765","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glycerophospholipids in Red Blood Cells Are Associated with Aerobic Performance in Young Swimmers"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6400-5201","authenticated-orcid":false,"given":"\u00c1lex Aparecido Rosini","family":"Silva","sequence":"first","affiliation":[{"name":"MS<sup>4<\/sup>Life Laboratory of Mass Spectrometry, Health Sciences Postgraduate Program, S\u00e3o Francisco University, Bragan\u00e7a Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Bertolucci","sequence":"additional","affiliation":[{"name":"Research Group on Technology Applied to Exercise Physiology\u2014GTAFE, Health Sciences Postgraduate Program, S\u00e3o Francisco University, Bragan\u00e7a Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2976-8999","authenticated-orcid":false,"given":"Pedro Paulo Menezes","family":"Scariot","sequence":"additional","affiliation":[{"name":"Research Group on Technology Applied to Exercise Physiology\u2014GTAFE, Health Sciences Postgraduate Program, S\u00e3o Francisco University, Bragan\u00e7a Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5320-1066","authenticated-orcid":false,"given":"Jo\u00e3o Pedro","family":"da Cruz","sequence":"additional","affiliation":[{"name":"Research Group on Technology Applied to Exercise Physiology\u2014GTAFE, Health Sciences Postgraduate Program, S\u00e3o Francisco University, Bragan\u00e7a Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio Marcio Macedo","family":"Mendes","sequence":"additional","affiliation":[{"name":"MS<sup>4<\/sup>Life Laboratory of Mass Spectrometry, Health Sciences Postgraduate Program, S\u00e3o Francisco University, Bragan\u00e7a Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo Cardoso","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"MS<sup>4<\/sup>Life Laboratory of Mass Spectrometry, Health Sciences Postgraduate Program, S\u00e3o Francisco University, Bragan\u00e7a Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1165-163X","authenticated-orcid":false,"given":"Catharina Delry","family":"Plumari","sequence":"additional","affiliation":[{"name":"MS<sup>4<\/sup>Life Laboratory of Mass Spectrometry, Health Sciences Postgraduate Program, S\u00e3o Francisco University, Bragan\u00e7a Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8025-1357","authenticated-orcid":false,"given":"Ivan Gustavo Masseli","family":"Dos Reis","sequence":"additional","affiliation":[{"name":"Research Group on Technology Applied to Exercise Physiology\u2014GTAFE, Health Sciences Postgraduate Program, S\u00e3o Francisco University, Bragan\u00e7a Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-8594","authenticated-orcid":false,"given":"Andreia Melo","family":"Porcari","sequence":"additional","affiliation":[{"name":"MS<sup>4<\/sup>Life Laboratory of Mass Spectrometry, Health Sciences Postgraduate Program, S\u00e3o Francisco University, Bragan\u00e7a Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8324-8866","authenticated-orcid":false,"given":"Leonardo Henrique Dalcheco","family":"Messias","sequence":"additional","affiliation":[{"name":"Research Group on Technology Applied to Exercise Physiology\u2014GTAFE, Health Sciences Postgraduate Program, S\u00e3o Francisco University, Bragan\u00e7a Paulista 12916-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"ref_1","first-page":"332","article-title":"Red blood cells in sports: Effects of exercise and training on oxygen supply by red blood cells","volume":"4","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1365-201X.2004.01361.x","article-title":"Red blood cell pH, the Bohr effect, and other oxygenation-linked phenomena in blood O2 and CO2 transport","volume":"182","author":"Jensen","year":"2004","journal-title":"Acta Physiol. Scand."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"i26","DOI":"10.1136\/bjsports-2013-092841","article-title":"Relationship between changes in haemoglobin mass and maximal oxygen uptake after hypoxic exposure","volume":"47","author":"Saunders","year":"2013","journal-title":"Br. J. Sports Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/JES.0b013e3181d4957a","article-title":"Impact of Alterations in Total Hemoglobin Mass on VO2max","volume":"38","author":"Schmidt","year":"2010","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Wang, H., Wei, H.W., Shen, H.C., Li, Z.Z., Cheng, Y., Duan, L.S., Yin, L., Yu, J., and Guo, J.R. (2020). To study the effect of oxygen carrying capacity on expressed changes of erythrocyte membrane protein in different storage times. Biosci. Rep., 40.","DOI":"10.1042\/BSR20200799"},{"key":"ref_6","first-page":"65","article-title":"Decreased red blood cell deformability and impaired oxygen utilization during human sepsis","volume":"59","author":"Powell","year":"1993","journal-title":"Am. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"H898","DOI":"10.1152\/ajpheart.1987.253.4.H898","article-title":"Influence of reduced red cell deformability on regional blood flow","volume":"253","author":"Simchon","year":"1987","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"H2188","DOI":"10.1152\/ajpheart.1999.276.6.H2188","article-title":"Greater erythrocyte deformability in world-class endurance athletes","volume":"276","author":"Smith","year":"1999","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev.ph.49.030187.001141","article-title":"Red cell deformability and its relevance to blood flow","volume":"49","author":"Chien","year":"1987","journal-title":"Annu. Rev. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3233\/JCB-15007","article-title":"Advances in the measurement of red blood cell deformability: A brief review","volume":"1","author":"Kim","year":"2015","journal-title":"J. Cell. Biotechnol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"a011601","DOI":"10.1101\/cshperspect.a011601","article-title":"Erythropoiesis: Development and differentiation","volume":"3","author":"Dzierzak","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3389\/fphys.2019.00945","article-title":"Red Blood Cells: Chasing Interactions","volume":"10","author":"Pretini","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3389\/fphys.2017.01076","article-title":"From Erythroblasts to Mature Red Blood Cells: Organelle Clearance in Mammals","volume":"8","author":"Moras","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"15111","DOI":"10.1038\/s41598-020-72176-3","article-title":"Quantitative analysis of red blood cell membrane phospholipids and modulation of cell-macrophage interactions using cyclodextrins","volume":"10","author":"Vahedi","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e14275","DOI":"10.14814\/phy2.14275","article-title":"Maximal exercise and erythrocyte epoxy fatty acids: A lipidomics study","volume":"7","author":"Gollasch","year":"2019","journal-title":"Physiol. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e14040","DOI":"10.14814\/phy2.14040","article-title":"Maximal exercise and erythrocyte fatty-acid status: A lipidomics study","volume":"7","author":"Gollasch","year":"2019","journal-title":"Physiol. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e14165","DOI":"10.14814\/phy2.14165","article-title":"Maximal exercise and plasma cytochrome P450 and lipoxygenase mediators: A lipidomics study","volume":"7","author":"Gollasch","year":"2019","journal-title":"Physiol. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-59127-8","article-title":"Lipidomic profiles, lipid trajectories and clinical biomarkers in female elite endurance athletes","volume":"10","author":"Varga","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wang, A., Zhang, H., Liu, J., Yan, Z., Sun, Y., Su, W., Yu, J., Mi, J., and Zhao, L. (2023). Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20043329"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.chroma.2012.12.048","article-title":"Ultrahigh pressure liquid chromatography\u2013(tandem) mass spectrometry in human sports drug testing: Possibilities and limitations","volume":"1292","author":"Thevis","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1123\/ijsnem.2014-0047","article-title":"Physical and Energy Requirements of Competitive Swimming Events","volume":"24","author":"Pyne","year":"2014","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1249\/00003677-199600240-00004","article-title":"The slow component of oxygen uptake kinetics in humans","volume":"24","author":"Gaesser","year":"1996","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00717953","article-title":"Determination and validity of critical velocity as an index of swimming performance in the competitive swimmer","volume":"64","author":"Wakayoshi","year":"1992","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"948422","DOI":"10.3389\/fphys.2022.948422","article-title":"Associations among sleep, hematologic profile, and aerobic and anerobic capacity of young swimmers: A complex network approach","volume":"13","author":"Kraemer","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0141-9854.2003.00577.x","article-title":"Evaluation of the coulter LH 750 haematology analyzer compared with flow cytometry as the reference method for WBC, platelet and nucleated RBC count","volume":"26","author":"Igout","year":"2004","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1007\/s00216-018-1200-x","article-title":"One- vs two-phase extraction: Re-evaluation of sample preparation procedures for untargeted lipidomics in plasma samples","volume":"410","author":"Gil","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Silva, A.A.R., Cardoso, M.R., Rezende, L.M., Lin, J.Q., Guimaraes, F., Silva, G.R.P., Murgu, M., Priolli, D.G., Eberlin, M.N., and Tata, A. (2020). Multiplatform Investigation of Plasma and Tissue Lipid Signatures of Breast Cancer Using Mass Spectrometry Tools. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103611"},{"key":"ref_28","first-page":"1013","article-title":"Fitting Structure-Data Files (.SDF) Libraries to Progenesis QI Identification Searches","volume":"34","author":"Sanches","year":"2023","journal-title":"J. Braz. Chem. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8620","DOI":"10.1038\/s41598-020-65420-3","article-title":"Corresponding Assessment Scenarios in Laboratory and on-Court Tests: Centrality Measurements by Complex Networks Analysis in Young Basketball Players","volume":"10","author":"Gobatto","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Hagberg, A., Schult, D., and Swart, P. (2008, January 21). Exploring Network Structure, Dynamics, and Function using NetworkX. Proceedings of the 7th Python in Science Conference, Pasadena, CA, USA.","DOI":"10.25080\/TCWV9851"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1194\/jlr.R046094","article-title":"Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells","volume":"55","author":"Hishikawa","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Klem, S., Klingler, M., Demmelmair, H., and Koletzko, B. (2012). Efficient and Specific Analysis of Red Blood Cell Glycerophospholipid Fatty Acid Composition. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033874"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Tanczos, B., Somogyi, V., Bombicz, M., Juhasz, B., Nemeth, N., and Deak, A. (2021). Changes of Hematological and Hemorheological Parameters in Rabbits with Hypercholesterolemia. Metabolites, 11.","DOI":"10.3390\/metabo11040249"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1357-2725(03)00195-X","article-title":"Damage to the structure of erythrocyte plasma membranes in patients with type-2 hypercholesterolemia","volume":"36","author":"Koter","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2147\/VHRM.S2656","article-title":"Determination of RBC membrane and serum lipid composition in trinidadian type II diabetics with and without nephropathy","volume":"4","author":"Nayak","year":"2008","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1373\/clinchem.2005.058644","article-title":"Increased lipid concentration is associated with increased hemolysis","volume":"51","author":"Dimeski","year":"2005","journal-title":"Clin. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Shama, S., Jang, H., Wang, X., Zhang, Y., Shahin, N.N., Motawi, T.K., Kim, S., Gawrieh, S., and Liu, W. (2023). Phosphatidylethanolamines Are Associated with Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Adults and Induce Liver Cell Metabolic Perturbations and Hepatic Stellate Cell Activation. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021034"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/BF00281545","article-title":"Changes of platelet phospholipids in diabetes mellitus","volume":"21","author":"Kalofoutis","year":"1981","journal-title":"Diabetologia"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3233\/CBM-160602","article-title":"Serum phosphatidylethanolamine levels distinguish benign from malignant solitary pulmonary nodules and represent a potential diagnostic biomarker for lung cancer","volume":"16","author":"Fahrmann","year":"2016","journal-title":"Cancer Biomark."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Vieyra, I., Rodr\u00edguez-Varela, M., Garc\u00eda-Rubio, D., De la Mora-Mojica, B., M\u00e9ndez-M\u00e9ndez, J., Dur\u00e1n-\u00c1lvarez, C., and Cerecedo, D. (2019). Alterations to plasma membrane lipid contents affect the biophysical properties of erythrocytes from individuals with hypertension. Biochim. Biophys. Acta (BBA)\u2014Biomembr., 1861.","DOI":"10.1016\/j.bbamem.2019.05.018"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ab.2010.06.027","article-title":"A liquid chromatography\u2013tandem mass spectrometry method for measurement of N-modified phosphatidylethanolamines","volume":"405","author":"Guo","year":"2010","journal-title":"Anal. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/bmc.1157","article-title":"Identification of 1-palmitoyl-2-linoleoyl-phosphatidylethanolamine modifications under oxidative stress conditions by LC-MS\/MS","volume":"23","author":"Domingues","year":"2009","journal-title":"Biomed. Chromatogr."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Pohl, E.E., and Jovanovic, O. (2019). The Role of Phosphatidylethanolamine Adducts in Modification of the Activity of Membrane Proteins under Oxidative Stress. Molecules, 24.","DOI":"10.3390\/molecules24244545"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"18170","DOI":"10.1074\/jbc.M110.213470","article-title":"Phosphatidylethanolamines modified by \u03b3-ketoaldehyde (\u03b3KA) induce endoplasmic reticulum stress and endothelial activation","volume":"286","author":"Guo","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/jms.3373","article-title":"New covalent modifications of phosphatidylethanolamine by alkanals: Mass spectrometry based structural characterization and biological effects","volume":"49","author":"Annibal","year":"2014","journal-title":"J. Mass Spectrom."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1074\/jbc.M115.706523","article-title":"Phosphatidylethanolamine Is a Key Regulator of Membrane Fluidity in Eukaryotic Cells","volume":"291","author":"Dawaliby","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/bs.ircmb.2015.10.001","article-title":"Phosphatidylethanolamine Metabolism in Health and Disease","volume":"321","author":"Calzada","year":"2016","journal-title":"Int. Rev. Cell. Mol. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Nemkov, T., Skinner, S.C., Nader, E., Stefanoni, D., Robert, M., Cendali, F., Stauffer, E., Cibiel, A., Boisson, C., and Connes, P. (2021). Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020896"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1152\/jappl.2000.88.6.2074","article-title":"Effects of swimming exercise on red blood cell rheology in trained and untrained rats","volume":"88","author":"Ozlem","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1152\/japplphysiol.00368.2002","article-title":"Time course of hemorheological alterations after heavy anaerobic exercise in untrained human subjects","volume":"94","author":"Yalcin","year":"2003","journal-title":"J. Appl. Physiol. (1985)"},{"key":"ref_51","first-page":"89","article-title":"The triphasic effects of exercise on blood rheology: Which relevance to physiology and pathophysiology?","volume":"19","author":"Brun","year":"1998","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/pai.12729","article-title":"Oxidative stress in asthmatic and non-asthmatic adolescent swimmers-A breathomics approach","volume":"28","author":"Couto","year":"2017","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40798-017-0114-z","article-title":"A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines","volume":"4","author":"Diboun","year":"2018","journal-title":"Sports Med. Open"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1080\/02640414.2020.1851933","article-title":"Non-targeted metabolomics analyses by mass spectrometry to explore metabolic stress after six training weeks in high level swimmers","volume":"39","author":"Pla","year":"2021","journal-title":"J. Sports Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"858869","DOI":"10.3389\/fphys.2022.858869","article-title":"Blood Metabolomics Analysis Identifies Differential Serum Metabolites in Elite and Sub-elite Swimmers","volume":"13","author":"Cai","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Mendes, F.M.M., Sanches, P.H.G., Silva, \u00c1.A.R., Reis, I., Carvalho, P.O., Porcari, A.M., and Messias, L.H.D. (2022). Plasma Amino Acids and Acylcarnitines Are Associated with the Female but Not Male Adolescent Swimmer\u2019s Performance: An Integration between Mass Spectrometry and Complex Network Approaches. Biology, 11.","DOI":"10.3390\/biology11121734"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/0026-0495(89)90068-1","article-title":"Dietary fat and hormonal effects on erythrocyte membrane fluidity and lipid composition in adult women","volume":"38","author":"Berlin","year":"1989","journal-title":"Metabolism"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0005-2736(86)90061-1","article-title":"Changes in membrane lipid composition of human erythrocytes after dietary supplementation of (n-3) polyunsaturated fatty acids. Maintenance of membrane fluidity","volume":"854","author":"Schouten","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"604","DOI":"10.2337\/diab.35.5.604","article-title":"Dietary sardine oil increases erythrocyte membrane fluidity in diabetic patients","volume":"35","author":"Kamada","year":"1986","journal-title":"Diabetes"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/00365519309090699","article-title":"The effect of dietary N-3 fatty acids on osmotic fragility and membrane fluidity of human erythrocytes","volume":"215","author":"Hagve","year":"1993","journal-title":"Scand. J. Clin. Lab. Investig. Suppl."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jnutbio.2010.03.007","article-title":"Effects of weight loss on erythrocyte membrane composition and fluidity in overweight and moderately obese women","volume":"22","author":"Cazzola","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1080\/10715762.2016.1231403","article-title":"Fatty acid-related modulations of membrane fluidity in cells: Detection and implications","volume":"50","author":"Maulucci","year":"2016","journal-title":"Free Radic. 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