{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:22:15Z","timestamp":1788988935029,"version":"build-2803163510"},"reference-count":46,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Key Research and Development Plan","award":["2022YFC2703503"],"award-info":[{"award-number":["2022YFC2703503"]}]},{"name":"the National Key Research and Development Plan","award":["82271706"],"award-info":[{"award-number":["82271706"]}]},{"name":"the National Key Research and Development Plan","award":["82261128001"],"award-info":[{"award-number":["82261128001"]}]},{"name":"the National Key Research and Development Plan","award":["SHDC2022CRS046"],"award-info":[{"award-number":["SHDC2022CRS046"]}]},{"name":"the National Natural Sciences Foundation of China","award":["2022YFC2703503"],"award-info":[{"award-number":["2022YFC2703503"]}]},{"name":"the National Natural Sciences Foundation of China","award":["82271706"],"award-info":[{"award-number":["82271706"]}]},{"name":"the National Natural Sciences Foundation of China","award":["82261128001"],"award-info":[{"award-number":["82261128001"]}]},{"name":"the National Natural Sciences Foundation of China","award":["SHDC2022CRS046"],"award-info":[{"award-number":["SHDC2022CRS046"]}]},{"name":"the Clinical Research Plan of Shanghai Shenkang Hospital Development Center","award":["2022YFC2703503"],"award-info":[{"award-number":["2022YFC2703503"]}]},{"name":"the Clinical Research Plan of Shanghai Shenkang Hospital Development Center","award":["82271706"],"award-info":[{"award-number":["82271706"]}]},{"name":"the Clinical Research Plan of Shanghai Shenkang Hospital Development Center","award":["82261128001"],"award-info":[{"award-number":["82261128001"]}]},{"name":"the Clinical Research Plan of Shanghai Shenkang Hospital Development Center","award":["SHDC2022CRS046"],"award-info":[{"award-number":["SHDC2022CRS046"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Preeclampsia is a primary placental disorder, with impaired placental vascularization leading to uteroplacental hypoperfusion. We aimed to investigate differences in metal and metalloid content between the placentas of women with preeclampsia and healthy controls. This was a case\u2013control study in 63 women with preeclampsia and 113 healthy women. Clinical data were obtained from medical records. Inductively coupled plasma mass spectrometry (ICP-MS) was used to measure the placental metals and metalloids content. Compared with healthy control subjects, preeclampsia was associated with a significantly lower concentration of essential elements (magnesium, calcium, iron, copper, zinc, and selenium) in the placental tissue. After multivariable adjustment, an interquartile range (IQR) increase in selenium concentration was associated with a reduced risk of preeclampsia with an OR of 0.50 (95% CI: 0.33\u20130.77). The joint effects of multiple selected metals and metalloids were associated with a reduced risk of preeclampsia. The lower placental magnesium, chromium, iron, zinc, and selenium concentrations of preeclampsia cases indicate a potential link to its pathogenesis. It also provides an intriguing avenue for future research in revealing the underlying mechanisms and potential intervention strategies for preeclampsia.<\/jats:p>","DOI":"10.3390\/nu16060769","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T11:33:06Z","timestamp":1709811186000},"page":"769","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reduction in Placental Metal and Metalloid in Preeclampsia: A Case\u2013Control Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Yanhui","family":"Hao","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Wu","sequence":"additional","affiliation":[{"name":"The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Yue","sequence":"additional","affiliation":[{"name":"Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-1792","authenticated-orcid":false,"given":"Yanting","family":"Wu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hefeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3637-754X","authenticated-orcid":false,"given":"Weibin","family":"Wu","sequence":"additional","affiliation":[{"name":"The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S1237","DOI":"10.1016\/j.ajog.2020.09.037","article-title":"Eclampsia in the 21st century","volume":"226","author":"Bartal","year":"2022","journal-title":"Am. 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