{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:31:15Z","timestamp":1790616675276,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondecyt","award":["1200839"],"award-info":[{"award-number":["1200839"]}]},{"name":"Fondecyt","award":["11190856"],"award-info":[{"award-number":["11190856"]}]},{"name":"Fondecyt","award":["LASPGHAN 2020"],"award-info":[{"award-number":["LASPGHAN 2020"]}]},{"name":"Fondecyt","award":["79190112"],"award-info":[{"award-number":["79190112"]}]},{"name":"Research Project Contest in Pediatric Nutrition for Young Researchers of Latin America","award":["1200839"],"award-info":[{"award-number":["1200839"]}]},{"name":"Research Project Contest in Pediatric Nutrition for Young Researchers of Latin America","award":["11190856"],"award-info":[{"award-number":["11190856"]}]},{"name":"Research Project Contest in Pediatric Nutrition for Young Researchers of Latin America","award":["LASPGHAN 2020"],"award-info":[{"award-number":["LASPGHAN 2020"]}]},{"name":"Research Project Contest in Pediatric Nutrition for Young Researchers of Latin America","award":["79190112"],"award-info":[{"award-number":["79190112"]}]},{"name":"CONICYT-PFCHA\/Magister Nacional\/year 2019-file","award":["1200839"],"award-info":[{"award-number":["1200839"]}]},{"name":"CONICYT-PFCHA\/Magister Nacional\/year 2019-file","award":["11190856"],"award-info":[{"award-number":["11190856"]}]},{"name":"CONICYT-PFCHA\/Magister Nacional\/year 2019-file","award":["LASPGHAN 2020"],"award-info":[{"award-number":["LASPGHAN 2020"]}]},{"name":"CONICYT-PFCHA\/Magister Nacional\/year 2019-file","award":["79190112"],"award-info":[{"award-number":["79190112"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>NAFLD has become the leading cause of chronic liver disease in children, as a direct consequence of the high prevalence of childhood obesity. This study aimed to characterize body composition trajectories from childhood to adolescence and their association with the risk of developing nonalcoholic fatty liver disease (NAFLD) during adolescence. The participants were part of the \u2018Chilean Growth and Obesity Cohort Study\u2019, comprising 784 children who were followed prospectively from age 3 years. Annual assessments of nutritional status and body composition were conducted, with ultrasound screening for NAFLD during adolescence revealing a 9.8% prevalence. Higher waist circumference measures were associated with NAFLD from age 3 years (p = 0.03), all skin folds from age 4 years (p &lt; 0.01), and DXA body fat measurements from age 12 years (p = 0.01). The fat-free mass index was higher in females (p = 0.006) but not in males (p = 0.211). The second and third tertiles of the fat mass index (FMI) had odds ratios for NAFLD during adolescence of 2.19 (1.48\u20133.25, 95% CI) and 6.94 (4.79\u201310.04, 95% CI), respectively. Elevated waist circumference, skin folds, and total body fat were identified as risk factors for future NAFLD development. A higher FMI during childhood was associated with an increased risk of NAFLD during adolescence.<\/jats:p>","DOI":"10.3390\/nu16060785","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T07:25:32Z","timestamp":1710141932000},"page":"785","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relation between Body Composition Trajectories from Childhood to Adolescence and Nonalcoholic Fatty Liver Disease Risk"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8540-1326","authenticated-orcid":false,"given":"Gigliola","family":"Alberti","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Division of Pediatrics, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330077, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Faune","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330077, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2895-0369","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330077, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9894-2615","authenticated-orcid":false,"given":"Florencia","family":"De Barbieri","sequence":"additional","affiliation":[{"name":"Radiology Department, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330077, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristi\u00e1n","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Radiology Department, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330077, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Instituto de Nutrici\u00f3n y Tecnolog\u00eda de los Alimentos, INTA, Universidad de Chile, Santiago 7830490, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8282-4024","authenticated-orcid":false,"given":"Fernando","family":"Becerra","sequence":"additional","affiliation":[{"name":"Independent Researcher, Santiago 8330077, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0400-2164","authenticated-orcid":false,"given":"Juan Crist\u00f3bal","family":"Gana","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Division of Pediatrics, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330077, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,9]]},"reference":[{"key":"ref_1","unstructured":"Organizaci\u00f3n Mundial de la Salud (OMS) (2021, May 14). 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