{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:29:56Z","timestamp":1790368196978,"version":"4.1.0"},"reference-count":100,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT\u2014The Foundation for Science and Technology","doi-asserted-by":"publisher","award":["UIDB\/05021\/2020"],"award-info":[{"award-number":["UIDB\/05021\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>In this review, we explored the therapeutic potential of oleuropein (OLE) and hydroxytyrosol (HT) in the treatment of neuroblastoma (NB). NB is an extracranial tumour that predominantly affects children aged between 17 and 18 months. Recurrence and drug resistance have emerged as the biggest challenges when treating NB, leading to a crucial need for new therapeutic approaches. Food of the Mediterranean Diet (MD) presents several health benefits, including that of cancer treatment. In this review, we emphasised olive oil since it is one of the main liquid ingredients of the MD. OLE is the principal phenolic compound that constitutes olive oil and is hydrolysed to produce HT. Considering that tumour cells produce increased amounts of reactive oxygen species, this review highlights the antioxidant properties of OLE and HT and how they could result in increased cellular antioxidant defences and reduced oxidative damage in NB cells. Moreover, we highlight that these phenolic compounds lead to apoptosis and cell cycle arrest, reduce the side effects caused by conventional treatments, and activate tumours that become dormant as a resistance mechanism. Future research should explore the effects of these compounds and other antioxidants on the treatment of NB in vivo.<\/jats:p>","DOI":"10.3390\/nu16060818","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T13:23:11Z","timestamp":1710336191000},"page":"818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Olive Oil Components as Novel Antioxidants in Neuroblastoma Treatment: Exploring the Therapeutic Potential of Oleuropein and Hydroxytyrosol"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6353-5184","authenticated-orcid":false,"given":"Marta","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Laboratory of Histology and Embryology, Department of Microscopy, School of Medicine and Biomedical Sciences (ICBAS), University of Porto (U.Porto), 4050-313 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-3221","authenticated-orcid":false,"given":"Anna","family":"Aiello","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, 90133 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9949-5861","authenticated-orcid":false,"given":"Mar\u00eda","family":"Rodr\u00edguez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Biochemistry Area, Faculty of Environmental Sciences and Biochemistry, University of Castilla-La Mancha, Avenue Carlos III s\/n, 45071 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3565-9529","authenticated-orcid":false,"given":"Giulia","family":"Accardi","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, 90133 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6942-3023","authenticated-orcid":false,"given":"Emma","family":"Burgos-Ramos","sequence":"additional","affiliation":[{"name":"Biochemistry Area, Faculty of Environmental Sciences and Biochemistry, University of Castilla-La Mancha, Avenue Carlos III s\/n, 45071 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-6006","authenticated-orcid":false,"given":"Paula","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Histology and Embryology, Department of Microscopy, School of Medicine and Biomedical Sciences (ICBAS), University of Porto (U.Porto), 4050-313 Porto, Portugal"},{"name":"iNOVA Media Lab, ICNOVA-NOVA Institute of Communication, NOVA School of Social Sciences and Humanities, Universidade NOVA de Lisboa, 1069-061 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/S0140-6736(07)60983-0","article-title":"Neuroblastoma","volume":"369","author":"Maris","year":"2007","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1056\/NEJMra0804577","article-title":"Recent advances in neuroblastoma","volume":"362","author":"Maris","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrc1014","article-title":"Neuroblastoma: Biological insights into a clinical enigma","volume":"3","author":"Brodeur","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jpedsurg.2018.09.004","article-title":"Update on neuroblastoma","volume":"54","author":"Newman","year":"2019","journal-title":"J. Pediatr. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chicco, D., Sanavia, T., and Jurman, G. (2023). Signature literature review reveals AHCY, DPYSL3, and NME1 as the most recurrent prognostic genes for neuroblastoma. BioData Min., 16.","DOI":"10.1186\/s13040-023-00325-1"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-3016.2008.00983.x","article-title":"The epidemiology of neuroblastoma: A review","volume":"23","author":"Heck","year":"2009","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1470-2045(17)30186-9","article-title":"International incidence of childhood cancer, 2001\u201310: A population-based registry study","volume":"18","author":"Colombet","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_8","unstructured":"Gini, A., Colombet, M., Ries, L.A.G., Moreno, F., Dolya, A., Hesseling, P., Young Shin, H., Stiller, C.A., and Steliarova-Foucher, E. (2022). ECSA Scientific Day 2022, World Health Organization. Abs. No. 9."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Missailidis, S. (2008). Anticancer Therapeutics, Wiley.","DOI":"10.1002\/9780470697047"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hashem, S., Ali, T.A., Akhtar, S., Nisar, S., Sageena, G., Ali, S., Al-Mannai, S., Therachiyil, L., Mir, R., and Elfaki, I. (2022). Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents. Biomed. Pharmacother., 150.","DOI":"10.1016\/j.biopha.2022.113054"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.phrs.2009.01.017","article-title":"Natural compounds for cancer treatment and prevention","volume":"59","author":"Nobili","year":"2009","journal-title":"Pharmacol. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00210-015-1191-5","article-title":"Natural compounds for pediatric cancer treatment","volume":"389","author":"Ferrucci","year":"2016","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_13","first-page":"267","article-title":"Promising natural products as anti-cancer agents against neuroblastoma","volume":"8","author":"Yasukawa","year":"2015","journal-title":"Int. J. Cancer Res. Prev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.2174\/156652412803833508","article-title":"Honokiol: A novel natural agent for cancer prevention and therapy","volume":"12","author":"Arora","year":"2012","journal-title":"Curr. Mol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1142\/S0192415X19500472","article-title":"Honokiol Induces Autophagic Apoptosis in Neuroblastoma Cells through a P53-Dependent Pathway","volume":"47","author":"Lin","year":"2019","journal-title":"Am. J. Chin. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Pati\u00f1o-Morales, C.C., Jaime-Cruz, R., S\u00e1nchez-G\u00f3mez, C., Corona, J.C., Hern\u00e1ndez-Cruz, E.Y., Kalinova-Jelezova, I., Pedraza-Chaverri, J., Maldonado, P.D., Silva-Islas, C.A., and Salazar-Garc\u00eda, M. (2022). Antitumor Effects of Natural Compounds Derived from Allium sativum on Neuroblastoma: An Overview. Antioxidants, 11.","DOI":"10.3390\/antiox11010048"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.surg.2004.01.017","article-title":"Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice","volume":"136","author":"Chen","year":"2004","journal-title":"Surgery"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1089\/ars.2016.6860","article-title":"Reactive oxygen species-mediated loss of synaptic Akt1 signaling leads to deficient activity-dependent protein translation early in Alzheimer\u2019s disease","volume":"27","author":"Ahmad","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wu, J., Li, Y., He, Q., and Yang, X. (2023). Exploration of the Use of Natural Compounds in Combination with Chemotherapy Drugs for Tumor Treatment. Molecules, 28.","DOI":"10.3390\/molecules28031022"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1017\/S1368980011002515","article-title":"Mediterranean diet pyramid today. Science and cultural updates","volume":"14","author":"Battino","year":"2011","journal-title":"Public Health Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Silva, P., Rodr\u00edguez-P\u00e9rez, M., and Burgos-Ramos, E. (2023). Zebrafish Model Insights into Mediterranean Diet Liquids: Olive Oil and Wine. Antioxidants, 12.","DOI":"10.3390\/antiox12101843"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mentella, M.C., Scaldaferri, F., Ricci, C., Gasbarrini, A., and Miggiano, G.A.D. (2019). Cancer and Mediterranean Diet: A Review. Nutrients, 11.","DOI":"10.3390\/nu11092059"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3390\/encyclopedia1020031","article-title":"Mediterranean Diet","volume":"1","author":"Sikalidis","year":"2021","journal-title":"Encyclopedia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9139","DOI":"10.3390\/nu7115459","article-title":"Definition of the Mediterranean Diet; A Literature Review","volume":"7","author":"Davis","year":"2015","journal-title":"Nutrients"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/1438-9312(200210)104:9\/10<698::AID-EJLT698>3.0.CO;2-A","article-title":"Mediterranean diet, olive oil and health","volume":"104","author":"Wahrburg","year":"2002","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41430-018-0304-x","article-title":"Extra virgin olive oil: More than a healthy fat","volume":"72","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/med.1028","article-title":"Antioxidant and other biological activities of phenols from olives and olive oil","volume":"22","author":"Visioli","year":"2002","journal-title":"Med. Res. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Serreli, G., and Deiana, M. (2018). Biological Relevance of Extra Virgin Olive Oil Polyphenols Metabolites. Antioxidants, 7.","DOI":"10.3390\/antiox7120170"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez del R\u00edo, L., Guti\u00e9rrez-Casado, E., Varela-L\u00f3pez, A., and Villalba, J.M. (2016). Olive Oil and the Hallmarks of Aging. Molecules, 21.","DOI":"10.3390\/molecules21020163"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"933","DOI":"10.2174\/1381612013397654","article-title":"Mediterranean diet and health: Biological importance of olive oil","volume":"7","author":"Barranco","year":"2001","journal-title":"Curr. Pharm. Des."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/mnfr.200800269","article-title":"Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1\/2 and cyclin D1","volume":"53","author":"Corona","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1001\/jamainternmed.2015.4838","article-title":"Mediterranean Diet and Invasive Breast Cancer Risk among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial","volume":"175","author":"Toledo","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/01635581.2014.922204","article-title":"Extra virgin olive oil phenols suppress migration and invasion of T24 human bladder cancer cells through modulation of matrix metalloproteinase-2","volume":"66","author":"Coccia","year":"2014","journal-title":"Nutr. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.yexcr.2013.11.022","article-title":"Olive oil compounds inhibit vascular endothelial growth factor receptor-2 phosphorylation","volume":"322","author":"Lamy","year":"2014","journal-title":"Exp. Cell Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.3892\/or.2016.5150","article-title":"Extra-virgin olive oil phenols block cell cycle progression and modulate chemotherapeutic toxicity in bladder cancer cells","volume":"36","author":"Coccia","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"De Santis, S., Cariello, M., Piccinin, E., Sabb\u00e0, C., and Moschetta, A. (2019). Extra Virgin Olive Oil: Lesson from Nutrigenomics. Nutrients, 11.","DOI":"10.3390\/nu11092085"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"17409","DOI":"10.18632\/oncotarget.15538","article-title":"Oleuropein, unexpected benefits!","volume":"8","author":"Sun","year":"2017","journal-title":"Oncotarget"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1111\/1750-3841.14198","article-title":"Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates","volume":"83","author":"Imran","year":"2018","journal-title":"J. Food Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tifs.2013.03.003","article-title":"Protective role of oleuropein and its metabolite hydroxytyrosol on cancer","volume":"31","author":"Mayas","year":"2013","journal-title":"Trends Food Sci."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Butt, M.S., Tariq, U., Naz, A., and Rizwan, M. (2021). Neuroprotective effects of oleuropein: Recent developments and contemporary research. J. Food Biochem., 45.","DOI":"10.1111\/jfbc.13967"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1200\/JCO.2008.16.0630","article-title":"Overall genomic pattern is a predictor of outcome in neuroblastoma","volume":"27","author":"Schleiermacher","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1200\/JCO.1999.17.7.2264","article-title":"Molecular biology of neuroblastoma","volume":"17","author":"Maris","year":"1999","journal-title":"J. Clin. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"a014415","DOI":"10.1101\/cshperspect.a014415","article-title":"Neuroblastoma and MYCN","volume":"3","author":"Huang","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2184130","DOI":"10.1080\/2162402X.2023.2184130","article-title":"Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy","volume":"12","author":"Valind","year":"2023","journal-title":"Oncoimmunology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1038\/onc.2010.22","article-title":"Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma","volume":"29","author":"Ochiai","year":"2010","journal-title":"Oncogene"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"101771","DOI":"10.1016\/j.molmet.2023.101771","article-title":"Metabolic protein kinase signalling in neuroblastoma","volume":"75","author":"Smiles","year":"2023","journal-title":"Mol. Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1573396314666180129101627","article-title":"Biological and Genetic Features of Neuroblastoma and Their Clinical Importance","volume":"14","author":"Aygun","year":"2018","journal-title":"Curr. Pediatr. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3835(01)00530-4","article-title":"Trk receptor tyrosine kinases: A bridge between cancer and neural development","volume":"169","author":"Nakagawara","year":"2001","journal-title":"Cancer Lett."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.canlet.2005.02.051","article-title":"Biological effects of TrkA and TrkB receptor signaling in neuroblastoma","volume":"228","author":"Schramm","year":"2005","journal-title":"Cancer Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1158\/0008-5472.CAN-10-2627","article-title":"A SP1\/MIZ1\/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF","volume":"71","author":"Iraci","year":"2011","journal-title":"Cancer Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/A:1005729329526","article-title":"Expression of TrkA, TrkB and TrkC in human neuroblastomas","volume":"31","author":"Brodeur","year":"1997","journal-title":"J. Neurooncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"353403","DOI":"10.3389\/fendo.2018.00129","article-title":"The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues","volume":"9","author":"Goetzman","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1111\/cas.12278","article-title":"Dihydropyrimidinase-like protein 3 expression is negatively regulated by MYCN and associated with clinical outcome in neuroblastoma","volume":"104","author":"Tan","year":"2013","journal-title":"Cancer Sci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Bownes, L.V., Williams, A.P., Marayati, R., Stafman, L.L., Markert, H., Quinn, C.H., Wadhwani, N., Aye, J.M., Stewart, J.E., and Yoon, K.J. (2021). EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0246244"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/MPH.0000000000000329","article-title":"PI3King the lock: Targeting the PI3K\/Akt\/mTOR pathway as a novel therapeutic strategy in neuroblastoma","volume":"37","author":"King","year":"2015","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2174\/156800909789271521","article-title":"The PI3K\/Akt\/mTOR pathway as therapeutic target in neuroblastoma","volume":"9","author":"Fulda","year":"2009","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","article-title":"Oxidative stress in cancer","volume":"38","author":"Hayes","year":"2020","journal-title":"Cancer Cell"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.canlet.2005.01.046","article-title":"Reactive oxygen species: Biological stimuli of neuroblastoma cell response","volume":"228","author":"Marengo","year":"2005","journal-title":"Cancer Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jpedsurg.2007.10.040","article-title":"Oxidative status in neuroblastoma: A source of stress?","volume":"43","author":"Novotny","year":"2008","journal-title":"J. Pediatr. Surg."},{"key":"ref_60","unstructured":"Martin, C.R., and Preedy, V.R. (2020). Oxidative Stress and Dietary Antioxidants in Neurological Diseases, Academic Press."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.nut.2012.02.014","article-title":"Role of antioxidants in cancer therapy","volume":"29","year":"2013","journal-title":"Nutrition"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Zeb, A. (2020). Concept, mechanism, and applications of phenolic antioxidants in foods. J. Food Biochem., 44.","DOI":"10.1111\/jfbc.13394"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Kulikova, O.I., Fedorova, T.N., Lopachev, A.V., Orlova, V.S., and Grachev, V.A. (2016). Effects of antioxidants on the viability of the human neuroblastoma SH-SY5Y cell culture under the conditions of heavy-metal toxicity. Biol. Med., 8.","DOI":"10.4172\/0974-8369.1000305"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.surg.2015.03.062","article-title":"Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma","volume":"158","author":"Zhu","year":"2015","journal-title":"Surgery"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.taap.2005.04.009","article-title":"Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine","volume":"209","author":"Cascales","year":"2005","journal-title":"Toxicol. Appl. Pharm."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Carballeda Sangiao, N., Chamorro, S., de Pascual-Teresa, S., and Goya, L. (2021). Aqueous Extract of Cocoa Phenolic Compounds Protects Differentiated Neuroblastoma SH-SY5Y Cells from Oxidative Stress. Biomolecules, 11.","DOI":"10.3390\/biom11091266"},{"key":"ref_67","first-page":"2016","article-title":"The health effects of oleuropein, one of the major phenolic compounds of olives, Olea europaea L","volume":"28","author":"Gamli","year":"2016","journal-title":"Ital. J. Food Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/ajcn\/62.6.1276","article-title":"Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers","volume":"62","author":"Hollman","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1093\/jn\/130.12.2996","article-title":"Oleuropein, an antioxidant polyphenol from olive oil, is poorly absorbed from isolated perfused rat intestine","volume":"130","author":"Edgecombe","year":"2000","journal-title":"J. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jff.2014.09.001","article-title":"Biological activities of the natural antioxidant oleuropein: Exceeding the expectation\u2014A mini-review","volume":"18","author":"Hassen","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ptr.7325","article-title":"An updated review on the potential antineoplastic actions of oleuropein","volume":"36","author":"Zheng","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jbiotec.2019.12.016","article-title":"Hydroxytyrosol: A natural compound with promising pharmacological activities","volume":"309","author":"Bertelli","year":"2020","journal-title":"J. Biotechnol."},{"key":"ref_73","first-page":"18","article-title":"Hydroxytyrosol and Potential Uses in Cardiovascular Diseases, Cancer, and AIDS","volume":"1","year":"2014","journal-title":"Front. Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Nikou, T., Sakavitsi, M.E., Kalampokis, E., and Halabalaki, M. (2022). Metabolism and Bioavailability of Olive Bioactive Constituents Based on In Vitro, In Vivo and Human Studies. Nutrients, 14.","DOI":"10.3390\/nu14183773"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Nediani, C., Ruzzolini, J., Romani, A., and Calorini, L. (2019). Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases. Antioxidants, 8.","DOI":"10.3390\/antiox8120578"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Gallardo-Fern\u00e1ndez, M., Gonzalez-Ramirez, M., Cerezo, A.B., Troncoso, A.M., and Garcia-Parrilla, M.C. (2022). Hydroxytyrosol in Foods: Analysis, Food Sources, EU Dietary Intake, and Potential Uses. Foods, 11.","DOI":"10.3390\/foods11152355"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Bucciantini, M., Leri, M., Nardiello, P., Casamenti, F., and Stefani, M. (2021). Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties. Antioxidants, 10.","DOI":"10.3390\/antiox10071044"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12967-014-0219-9","article-title":"Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: Focus on protection against cardiovascular and metabolic diseases","volume":"12","author":"Bulotta","year":"2014","journal-title":"J. Transl. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3892\/ijmm.2017.3078","article-title":"Assessment of the antioxidant activity of an olive oil total polyphenolic fraction and hydroxytyrosol from a Greek Olea europea variety in endothelial cells and myoblasts","volume":"40","author":"Kouka","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s12035-011-8181-5","article-title":"Modulation of Nrf2\/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders","volume":"44","author":"Scapagnini","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.gene.2016.03.038","article-title":"Investigation of anticancer mechanism of oleuropein via cell cycle and apoptotic pathways in SH-SY5Y neuroblastoma cells","volume":"585","author":"Dodurga","year":"2016","journal-title":"Gene"},{"key":"ref_82","first-page":"1591","article-title":"The Effects of Oleuropein on Different Clinically Types of Human Neuroblastoma Cells","volume":"2","author":"Altun","year":"2018","journal-title":"Proceedings"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Laghezza Masci, V., Bernini, R., Villanova, N., Clemente, M., Cicaloni, V., Tinti, L., Salvini, L., Taddei, A.R., Tiezzi, A., and Ovidi, E. (2022). In Vitro Anti-Proliferative and Apoptotic Effects of Hydroxytyrosyl Oleate on SH-SY5Y Human Neuroblastoma Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232012348"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Goldsmith, C.D., Bond, D.R., Jankowski, H., Weidenhofer, J., Stathopoulos, C.E., Roach, P.D., and Scarlett, C.J. (2018). The Olive Biophenols Oleuropein and Hydroxytyrosol Selectively Reduce Proliferation, Influence the Cell Cycle, and Induce Apoptosis in Pancreatic Cancer Cells. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19071937"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1039\/D0FO00089B","article-title":"Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells","volume":"11","author":"Cirmi","year":"2020","journal-title":"Food Funct."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"101750","DOI":"10.1016\/j.genrep.2023.101750","article-title":"Hydroxytyrosol\u2019s effect on the expression of apoptosis and oxidative stress related genes in BE (2)-C neuroblastoma cell line","volume":"31","author":"Pakravan","year":"2023","journal-title":"Gene Rep."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Rishmawi, S., Haddad, F., Dokmak, G., and Karaman, R. (2022). A Comprehensive Review on the Anti-Cancer Effects of Oleuropein. Life, 12.","DOI":"10.3390\/life12081140"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jtemb.2017.08.002","article-title":"Oleuropein shows copper complexing properties and noxious effect on cultured SH-SY5Y neuroblastoma cells depending on cell copper content","volume":"44","author":"Capo","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"9236","DOI":"10.3390\/ijms16059236","article-title":"In vitro and in vivo antitumoral effects of combinations of polyphenols, or polyphenols and anticancer drugs: Perspectives on cancer treatment","volume":"16","author":"Fantini","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jff.2014.03.027","article-title":"Oleuropein inhibits tumour growth and metastases dissemination in ovariectomised nude mice with MCF-7 human breast tumour xenografts","volume":"8","author":"Sepporta","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_91","first-page":"17","article-title":"Synergistic anti-breast-cancer effects of combined treatment with oleuropein and doxorubicin in vivo","volume":"25","author":"Elamin","year":"2019","journal-title":"Altern. Ther. Health Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/mnfr.201500605","article-title":"Chemopreventive effect of oleuropein in colitis-associated colorectal cancer in c57bl\/6 mice","volume":"60","author":"Giner","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.3945\/jn.109.104992","article-title":"Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice","volume":"139","author":"Kimura","year":"2009","journal-title":"J. Nutr."},{"key":"ref_94","first-page":"43","article-title":"Pre-Initiation Effect of Oleuropein towards Apoptotic and Oxidative Stress Levels on the Early Development of Two-Stage Skin Carcinogenesis","volume":"8","author":"John","year":"2019","journal-title":"J. Krishna Inst. Med. Sci. Univ."},{"key":"ref_95","first-page":"S117","article-title":"Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours","volume":"55","author":"Quiles","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"759172","DOI":"10.3389\/fphar.2021.759172","article-title":"Hydroxytyrosol Inhibits MDSCs and Promotes M1 Macrophages in Mice with Orthotopic Pancreatic Tumor","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Karkovi\u0107 Markovi\u0107, A., Tori\u0107, J., Barbari\u0107, M., and Jakobu\u0161i\u0107 Brala, C. (2019). Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health. Molecules, 24.","DOI":"10.3390\/molecules24102001"},{"key":"ref_98","first-page":"304","article-title":"Antioxidants in cancer therapy; their actions and interactions with oncologic therapies","volume":"4","author":"Lamson","year":"1999","journal-title":"Altern. Med. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.drudis.2018.01.021","article-title":"Administration of antioxidants in cancer: Debate of the decade","volume":"23","author":"Khurana","year":"2018","journal-title":"Drug Discov. Today"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/nutrit\/nuz027","article-title":"The conundrum of dietary antioxidants in cancer chemotherapy","volume":"78","author":"Ilghami","year":"2020","journal-title":"Nutr. 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