{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:55:58Z","timestamp":1789664158300,"version":"4.0.1"},"reference-count":58,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Miteinander gegen Krebs e.V.","award":["E204160128"],"award-info":[{"award-number":["E204160128"]}]},{"name":"Miteinander gegen Krebs e.V.","award":["W\/2\u2014LFFP 21\/13"],"award-info":[{"award-number":["W\/2\u2014LFFP 21\/13"]}]},{"name":"Miteinander gegen Krebs e.V.","award":["MU 4812\/2-1:2"],"award-info":[{"award-number":["MU 4812\/2-1:2"]}]},{"name":"a grant from the federal state of Saarland","award":["E204160128"],"award-info":[{"award-number":["E204160128"]}]},{"name":"a grant from the federal state of Saarland","award":["W\/2\u2014LFFP 21\/13"],"award-info":[{"award-number":["W\/2\u2014LFFP 21\/13"]}]},{"name":"a grant from the federal state of Saarland","award":["MU 4812\/2-1:2"],"award-info":[{"award-number":["MU 4812\/2-1:2"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["E204160128"],"award-info":[{"award-number":["E204160128"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["W\/2\u2014LFFP 21\/13"],"award-info":[{"award-number":["W\/2\u2014LFFP 21\/13"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["MU 4812\/2-1:2"],"award-info":[{"award-number":["MU 4812\/2-1:2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(1) Background: Vitamin D levels in patients remain inadequately understood, with research yielding inconsistent findings. Breast cancer patients, particularly due to oncological therapies, face an increased risk of osteopenia, which can be exacerbated by a vitamin D deficiency. (2) Methods: The prospective observational \u201cBEGYN-1\u201d study assessed serum 25(OH)D levels at baseline and quarterly thereafter. Clinical, pathological, nutritional, vitamin supplementation, and lifestyle data were recorded. (3) Results: Before treatment, 68.5% of patients were vitamin D deficient (&lt;30 ng\/mL), with 4.6% experiencing severe deficiency (&lt;10 ng\/mL). The median baseline 25(OH)D levels were 24 ng\/mL (range: 4.8 to 64.7 ng\/mL). Throughout the study, the median vitamin D levels increased to 48 ng\/mL (range: 22.0 to 76.7 ng\/mL). Before diagnosis, 16.7% received vitamin D substitution, and 97.8% received vitamin D substitution throughout the year with a median weekly dose of 20,000 IU. It took at least three quarterly assessments for 95% of patients to reach the normal range. A multiple GEE analysis identified associations between 25(OH)D levels and supplementation, season, age, VLDL, magnesium levels, and endocrine therapy. (4) Conclusions: Physicians should monitor 25(OH)D levels before, during, and after oncological therapy to prevent vitamin D deficiency and to adjust substitution individually. While variables such as seasons, age, VLDL, magnesium, diet, and oncological interventions affect 25(OH)D levels, supplementation has the greatest impact.<\/jats:p>","DOI":"10.3390\/nu16060854","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T14:05:25Z","timestamp":1710511525000},"page":"854","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Course of Vitamin D Levels in Newly Diagnosed Non-Metastatic Breast Cancer Patients over One Year with Quarterly Controls and Substitution"],"prefix":"10.3390","volume":"16","author":[{"given":"Cosima","family":"Zemlin","sequence":"first","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"},{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University, Campus Homburg, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Altmayer","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Theresa","family":"Schleicher","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Stuhlert","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"W\u00f6rmann","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura-Sophie","family":"Scherer","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Clara","family":"Thul","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisanne Sophie","family":"Spenner","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana Alisa","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Wind","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-8479","authenticated-orcid":false,"given":"Elisabeth","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Neonatology, Saarland University Medical Center, 66421 Homburg, Germany"},{"name":"Department of General Pediatrics and Neonatology, Saarland University, Campus Homburg, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7620-2432","authenticated-orcid":false,"given":"Regine","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Neonatology, Saarland University Medical Center, 66421 Homburg, Germany"},{"name":"Department of General Pediatrics and Neonatology, Saarland University, Campus Homburg, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-4873","authenticated-orcid":false,"given":"Sybelle","family":"Goedicke-Fritz","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Neonatology, Saarland University Medical Center, 66421 Homburg, Germany"},{"name":"Department of General Pediatrics and Neonatology, Saarland University, Campus Homburg, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Wagenpfeil","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Epidemiology and Medical Informatics (IMBEI), Saarland University, Campus Homburg, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-7419","authenticated-orcid":false,"given":"Michael","family":"Zemlin","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Neonatology, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich-Franz","family":"Solomayer","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9254-6953","authenticated-orcid":false,"given":"J\u00f6rg","family":"Reichrath","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Saarland University Medical Center, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3488-5073","authenticated-orcid":false,"given":"Carolin","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University Medical Center, 66421 Homburg, Germany"},{"name":"Department of Gynecology, Obstetrics & Reproductive Medicine, Saarland University, Campus Homburg, 66421 Homburg, Germany"},{"name":"Department of Anesthesiology, Outcomes Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2023, June 15). 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