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Given the considerable health potential of milk-derived peptides, the aim of this study was to investigate the protective effects of glycomacropeptide (GMP) on metabolic syndrome. Particular emphasis was placed on the potential mechanisms mitigating cardiometabolic disorders in high-fat, high-fructose diet-fed mice in the presence of GMP or Bipro, an isocaloric control. The administration of GMP for 12 weeks reduced obesity, hyperglycemia and hyperinsulinemia caused by a high-fat, high-fructose diet, resulting in a decline in insulin resistance. GMP also lessened systemic inflammation, as indicated by decreased circulating inflammatory cytokines. In the intestinal and hepatic tissues, GMP improved homeostasis by increasing insulin sensitivity and attenuating high-fat, high-fructose-induced inflammation, oxidative stress and endoplasmic reticulum stress. Biochemical and histological analyses revealed improved hepatic steatosis and fatty acid composition in the livers of high-fat, high-fructose diet-fed mice treated with GMP compared to Bipro. A trend toward a decrease in bile acids without any marked changes in intestinal microbiota composition characterized GMP-treated animals compared to those administered Bipro. GMP offers considerable potential for fighting metabolic syndrome-related components and complications given its beneficial effects on risk factors such as inflammation, oxidative stress and endoplasmic reticulum stress without involving the intestinal microbiota.<\/jats:p>","DOI":"10.3390\/nu16060871","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T08:17:29Z","timestamp":1710749849000},"page":"871","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glycomacropeptide as an Efficient Agent to Fight Pathophysiological Mechanisms of Metabolic Syndrome"],"prefix":"10.3390","volume":"16","author":[{"given":"Mathilde Foisy","family":"Sauv\u00e9","sequence":"first","affiliation":[{"name":"Research Centre, Sainte-Justine University Health Center, Montreal, QC H3T 1C5, Canada"},{"name":"Department of Nutrition, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1A8, 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Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1111\/jam.15078","article-title":"Bio-therapeutics from human milk: Prospects and perspectives","volume":"131","author":"Singh","year":"2021","journal-title":"J. Appl. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Nielsen, S.D.-H., Liang, N., Rathish, H., Kim, B.J., Lueangsakulthai, J., Koh, J., Qu, Y., Schulz, H.-J., and Dallas, D.C. (2023). Bioactive milk peptides: An updated comprehensive overview and database. Crit. Rev. Food Sci. Nutr., 1\u201320.","DOI":"10.1080\/10408398.2023.2240396"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Foisy-Sauv\u00e9, M., Ahmarani, L., Delvin, E., San\u00e9, A.T., Spahis, S., and Levy, E. (2020). Glycomacropeptide Prevents Iron\/Ascorbate-Induced Oxidative Stress, Inflammation and Insulin Sensitivity with an Impact on Lipoprotein Production in Intestinal Caco-2\/15 Cells. Nutrients, 12.","DOI":"10.3390\/nu12041175"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Sauv\u00e9, M.F., Feldman, F., Koudoufio, M., Ould-Chikh, N.-E.-H., Ahmarani, L., Sane, A., N\u2019timbane, T., El-Jalbout, R., Patey, N., and Spahis, S. (2021). Glycomacropeptide for Management of Insulin Resistance and Liver Metabolic Perturbations. Biomedicines, 9.","DOI":"10.3390\/biomedicines9091140"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/joim.12584","article-title":"Roles of the gut in the metabolic syndrome: An overview","volume":"281","year":"2017","journal-title":"J. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1038\/s41598-020-58863-1","article-title":"Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice","volume":"10","author":"Daoust","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"Ding","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet\u2013induced obesity and diabetes in mice","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41367-020-0017-1","article-title":"From obesity through gut microbiota to cardiovascular diseases: A dangerous journey","volume":"10","author":"Marzullo","year":"2020","journal-title":"Int. J. Obes. Suppl."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1097\/CM9.0000000000000696","article-title":"Gut microbiota and metabolic syndrome","volume":"133","author":"Wang","year":"2020","journal-title":"Chin. Med. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2337\/db08-1637","article-title":"Butyrate improves insulin sensitivity and increases energy expenditure in mice","volume":"58","author":"Gao","year":"2009","journal-title":"Diabetes"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"Groen","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/21623945.2016.1252011","article-title":"Branched short-chain fatty acids modulate glucose and lipid metabolism in primary adipocytes","volume":"5","author":"Heimann","year":"2016","journal-title":"Adipocyte"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/01.mpg.0000232019.79025.8f","article-title":"Effects of bovine \u03b1-lactalbumin and casein glycomacropeptide\u2013enriched infant formulae on faecal microbiota in healthy term infants","volume":"43","author":"Redgrave","year":"2006","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0300-9084(98)80022-9","article-title":"Casein peptide release and passage to the blood in humans during digestion of milk or yogurt","volume":"80","author":"Chabance","year":"1998","journal-title":"Biochimie"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/glycob\/cwt162","article-title":"Structural and functional characteristics of bovine milk protein glycosylation","volume":"24","author":"Kane","year":"2014","journal-title":"Glycobiology"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Yuan, Q., Zhan, B., Chang, R., Du, M., and Mao, X. (2020). Antidiabetic effect of casein glycomacropeptide hydrolysates on high-fat diet and STZ-induced diabetic mice via regulating insulin signaling in skeletal muscle and modulating gut microbiota. Nutrients, 12.","DOI":"10.3390\/nu12010220"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"20559","DOI":"10.1038\/srep20559","article-title":"Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0021-9258(18)70226-3","article-title":"Phosphorus assay in column chromatography","volume":"234","author":"Bartlett","year":"1959","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"100423","DOI":"10.1016\/j.jlr.2023.100423","article-title":"High-fat diet reveals the impact of Sar1b defects on lipid and lipoprotein profile and cholesterol metabolism","volume":"64","author":"Auclair","year":"2023","journal-title":"J. Lipid Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1194\/jlr.D023788","article-title":"Adiposoft: Automated software for the analysis of white adipose tissue cellularity in histological sections","volume":"53","author":"Galarraga","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"12001","DOI":"10.1038\/s41598-020-68971-7","article-title":"Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning","volume":"10","author":"Choi","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/B978-0-12-411619-1.00006-9","article-title":"Quantifying size and number of adipocytes in adipose tissue","volume":"537","author":"Parlee","year":"2014","journal-title":"Methods Enzymol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.plefa.2008.07.005","article-title":"Lipid profile, fatty acid composition and pro- and anti-oxidant status in pediatric patients with attention-deficit\/hyperactivity disorder","volume":"79","author":"Spahis","year":"2008","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bbi.2023.03.009","article-title":"Effects of pair-housing pubertal and adult male and female mice on LPS-induced age-dependent immune responses: A potential role for the gut microbiota","volume":"110","author":"Murray","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample in-ference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"McMurdie, P.J., and Holmes, S. (2013). phyloseq: An R package for reproducible interactive analysis and graphics of microbiome census data. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061217"},{"key":"ref_38","unstructured":"Mirarab, S., Nguyen, N., and Warnow, T. (2012). Biocomputing 2012, World Scientific."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2 for prediction of metagenome functions","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.aca.2014.11.015","article-title":"An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography\u2013tandem mass spectrometry","volume":"854","author":"Han","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Davis, N.M., Proctor, D.M., Holmes, S.P., Relman, D.A., and Callahan, B.J. (2018). Simple statistical identification and removal of con-taminant sequences in marker-gene and metagenomics data. Microbiome, 6.","DOI":"10.1186\/s40168-018-0605-2"},{"key":"ref_42","unstructured":"Oksanen, J. (2023, September 18). Vegan: Community Ecology Package. Available online: http:\/\/vegan.r-forge.r-project.org\/."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Love, M.I., Huber, W., and Anders, S. (2014). Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol., 15.","DOI":"10.1186\/s13059-014-0550-8"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/nmeth.2658","article-title":"Differential abundance analysis for microbial marker-gene surveys","volume":"10","author":"Paulson","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1074\/jbc.R113.534743","article-title":"Unfolded protein response signaling and metabolic diseases","volume":"289","author":"Lee","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2013.01.027","article-title":"Ameliorating effects of casein glycomacropeptide on obesity induced by high-fat diet in male Sprague-Dawley rats","volume":"56","author":"Xu","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/09540105.2013.823912","article-title":"Anti-apoptotic effects of milk-derived casein glycomacropeptide on mice with ulcerative colitis","volume":"25","author":"Chen","year":"2014","journal-title":"Food Agric. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Cui, Y., Zhu, C., Ming, Z., Cao, J., Yan, Y., Zhao, P., Pang, G., Deng, Z., Yao, Y., and Chen, Q. (2017). Molecular mechanisms by which casein glycomacropeptide maintains internal homeostasis in mice with experimental ulcerative colitis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0181075"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05488","article-title":"Abdominal obesity and metabolic syndrome","volume":"444","author":"Lemieux","year":"2006","journal-title":"Nature"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2048004016633371","DOI":"10.1177\/2048004016633371","article-title":"A clinical perspective of obesity, metabolic syndrome and cardiovascular disease","volume":"5","author":"Han","year":"2016","journal-title":"JRSM Cardiovasc. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3168\/jds.2010-3827","article-title":"Attenuating effect of casein glycomacropeptide on proliferation, differentiation, and lipid accumulation of in vitro Sprague-Dawley rat preadipocytes","volume":"94","author":"Xu","year":"2011","journal-title":"J. Dairy Sci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G.A., Beguinot, F., and Miele, C. (2019). Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092358"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of insulin action and insulin resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"101169","DOI":"10.1016\/j.molmet.2021.101169","article-title":"A guide to understanding endoplasmic reticulum stress in metabolic disorders","volume":"47","author":"Lemmer","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","article-title":"Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease","volume":"69","author":"Lebeaupin","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ghezzal, S., Postal, B.G., Quevrain, E., Brot, L., Seksik, P., Leturque, A., Thenet, S., and Carri\u00e8re, V. (2020). Palmitic acid damages gut epithelium integrity and initiates inflammatory cytokine production. Biochim. Biophys. Acta (BBA)\u2014Mol. Cell Biol. Lipids, 1865.","DOI":"10.1016\/j.bbalip.2019.158530"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"28990","DOI":"10.1038\/srep28990","article-title":"High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22","volume":"6","author":"Gulhane","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/febs.14389","article-title":"Liver function and dysfunction\u2014A unique window into the physiological reach of ER stress and the unfolded protein response","volume":"286","author":"Rutkowski","year":"2019","journal-title":"FEBS J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.tibs.2007.09.003","article-title":"That which does not kill me makes me stronger: Adapting to chronic ER stress","volume":"32","author":"Rutkowski","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: Controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s12276-021-00560-8","article-title":"The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling","volume":"53","author":"Bhattarai","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s41467-019-08591-6","article-title":"Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism","volume":"10","author":"Sasako","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.plipres.2009.12.002","article-title":"The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice","volume":"49","author":"Guillou","year":"2010","journal-title":"Prog. Lipid Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.tjnut.2023.03.014","article-title":"Glycomacropeptide Impacts Amylin-Mediated Satiety, Postprandial Markers of Glucose Homeostasis, and the Fecal Microbiome in Obese Postmenopausal Women","volume":"153","author":"Hansen","year":"2023","journal-title":"J. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Montanari, C., Ceccarani, C., Corsello, A., Zuvadelli, J., Ottaviano, E., Cas, M.D., Banderali, G., Zuccotti, G., Borghi, E., and Verduci, E. (2022). Glycomacropeptide Safety and Its Effect on Gut Microbiota in Patients with Phenylketonuria: A Pilot Study. Nutrients, 14.","DOI":"10.3390\/nu14091883"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1017\/S0007114520003736","article-title":"Casein glycomacropeptide is well tolerated in healthy adults and changes neither high-sensitive C-reactive protein, gut microbiota nor faecal butyrate: A restricted randomised trial","volume":"125","author":"Wernlund","year":"2021","journal-title":"Br. J. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1021\/acs.jafc.8b06414","article-title":"Retention of microbiota diversity by lactose-free milk in a mouse model of elderly gut microbiota","volume":"67","author":"Ntemiri","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Deng, K., Shuai, M., Zhang, Z., Jiang, Z., Fu, Y., Shen, L., Zheng, J.-S., and Chen, Y.-M. (2022). Temporal relationship among adiposity, gut microbiota, and insulin resistance in a longitudinal human cohort. BMC Med., 20.","DOI":"10.1186\/s12916-022-02376-3"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Vacca, M., Celano, G., Calabrese, F.M., Portincasa, P., Gobbetti, M., and De Angelis, M. (2020). The controversial role of human gut lachnospiraceae. Microorganisms, 8.","DOI":"10.3390\/microorganisms8040573"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/gbe\/evu050","article-title":"A phylogenomic view of ecological specialization in the Lachnospiraceae, a family of digestive tract-associated bacteria","volume":"6","author":"Meehan","year":"2014","journal-title":"Genome Biol. Evol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/ajcn\/nqab402","article-title":"Tolerability and SCFA production after resistant starch supplementation in humans: A systematic review of randomized controlled studies","volume":"115","author":"Sobh","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1926842","DOI":"10.1080\/19490976.2021.1926842","article-title":"Resistant starch, microbiome, and precision modulation","volume":"13","author":"Dobranowski","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"107795","DOI":"10.1016\/j.jdiacomp.2020.107795","article-title":"Phenotypic sexual dimorphism in response to dietary fat manipulation in C57BL\/6J mice","volume":"35","author":"Casimiro","year":"2021","journal-title":"J. Diabetes Its Complicat."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Pettersson, U.S., Walden, T.B., Carlsson, P.-O., Jansson, L., and Phillipson, M. (2012). Female mice are protected against high-fat diet in-duced metabolic syndrome and increase the regulatory T cell population in adipose tissue. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046057"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/jn\/nxab400","article-title":"Top-Down Glycopeptidomics Reveals Intact Glycomacropeptide Is Digested to a Wide Array of Peptides in Human Jejunum","volume":"152","author":"Koh","year":"2022","journal-title":"J. Nutr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/6\/871\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:15:04Z","timestamp":1760105704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/6\/871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,17]]},"references-count":76,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["nu16060871"],"URL":"https:\/\/doi.org\/10.3390\/nu16060871","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,17]]}}}