{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:20:06Z","timestamp":1790774406142,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"grants from SANTELYS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Although their efficacy has been well-established in Oncology, the use of platinum salts remains limited due to the occurrence of acute kidney injury (AKI). Caffeine has been suggested as a potential pathophysiological actor of platinum-salt-induced AKI, through its hemodynamic effects. This work aims to study the association between caffeine consumption and the risk of platinum-salt-induced AKI, based on both clinical and experimental data. The clinical study involved a single-center prospective cohort study including all consecutive thoracic cancer patients receiving a first-line platinum-salt (cisplatin or carboplatin) chemotherapy between January 2017 and December 2018. The association between daily caffeine consumption (assessed by a validated auto-questionnaire) and the risk of platinum-salt induced AKI or death was estimated by cause-specific Cox proportional hazards models adjusted for several known confounders. Cellular viability, relative renal NGAL expression and\/or BUN levels were assessed in models of renal tubular cells and mice co-exposed to cisplatin and increasing doses of caffeine. Overall, 108 patients were included (mean age 61.7 years, 65% men, 80% tobacco users), among whom 34 (31.5%) experienced a platinum-salt-induced AKI (67% Grade 1) over a 6-month median follow-up. The group of high-caffeine consumption (\u2265386 mg\/day) had a two-fold higher hazard of AKI (adjusted HR [95% CI], 2.19 [1.05; 4.57]), without any significant association with mortality. These results are consistent with experimental data confirming enhanced cisplatin-related nephrotoxicity in the presence of increasing doses of caffeine, in both in vitro and in vivo models. Overall, this study suggests a potentially deleterious effect of high doses of daily caffeine consumption on the risk of platinum-salt-related AKI, in both clinical and experimental settings.<\/jats:p>","DOI":"10.3390\/nu16060889","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T05:56:07Z","timestamp":1710914167000},"page":"889","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Daily Caffeine Consumption May Increase the Risk of Acute Kidney Injury Related to Platinum-Salt Chemotherapy in Thoracic Cancer Patients: A Translational Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4988-206X","authenticated-orcid":false,"given":"Aghiles","family":"Hamroun","sequence":"first","affiliation":[{"name":"Public Health-Epidemiology Department, Nephrology Department, Lille University Hospital Center, 59000 Lille, France"},{"name":"Lille 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Lille University Hospital Center, Institut Pasteur de Lille, UMR9020-U1277\u2014CANTHER\u2014Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Blum","sequence":"additional","affiliation":[{"name":"Lille University, Inserm, Lille University Hospital Center, UMR-S1172 LilNCog, Lille Neuroscience and Cognition, 59000 Lille, France"},{"name":"Alzheimer and Tauopathies, LabEx DISTALZ, 59045 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9549-3722","authenticated-orcid":false,"given":"Cynthia","family":"Van der Hauwaert","sequence":"additional","affiliation":[{"name":"Lille University, CNRS, Inserm, Lille University Hospital Center, Institut Pasteur de Lille, UMR9020-U1277\u2014CANTHER\u2014Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Scherpereel","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Department, Lille University Hospital Center, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Cortot","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Department, Lille University Hospital Center, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Lenain","sequence":"additional","affiliation":[{"name":"Nephrology Department, Lille University Hospital Center, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Maanaoui","sequence":"additional","affiliation":[{"name":"Nephrology Department, Lille University Hospital Center, 59000 Lille, France"},{"name":"Lille University, U1190 Translational Research for Diabetes, Inserm, Institut Pasteur de Lille, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Pottier","sequence":"additional","affiliation":[{"name":"Lille University, CNRS, Inserm, Lille University Hospital Center, Institut Pasteur de Lille, UMR9020-U1277\u2014CANTHER\u2014Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000 Lille, France"},{"name":"Toxicology and Genetic Diseases Department, Lille University Hospital Center, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-7973","authenticated-orcid":false,"given":"Christelle","family":"Cauffiez","sequence":"additional","affiliation":[{"name":"Lille University, CNRS, Inserm, Lille University Hospital Center, Institut Pasteur de Lille, UMR9020-U1277\u2014CANTHER\u2014Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Glowacki","sequence":"additional","affiliation":[{"name":"Lille University, CNRS, Inserm, Lille University Hospital Center, Institut Pasteur de Lille, UMR9020-U1277\u2014CANTHER\u2014Cancer Heterogeneity, Plasticity and Resistance to Therapies, 59000 Lille, France"},{"name":"Nephrology Department, Lille University Hospital Center, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8113","DOI":"10.1039\/c0dt00292e","article-title":"The status of platinum anticancer drugs in the clinic and in clinical trials","volume":"39","author":"Wheate","year":"2010","journal-title":"Dalton Trans."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: 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