{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:04:18Z","timestamp":1791551058621,"version":"4.3.4"},"reference-count":121,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Aging is the result of several complex and multifactorial processes, where several agents contribute to an increased intrinsic vulnerability and susceptibility to age-related diseases. The hallmarks of aging are a set of biological mechanisms that are finely regulated and strictly interconnected, initiating or contributing to biological changes and anticipating several age-related diseases. The complex network of cellular and intercellular connections between the hallmarks might represent a possible target for the research of agents with pleiotropic effects. Vitamin D (VitD) is known to have a positive impact not only on muscle and bone health but also on several extra-skeletal districts, due to the widespread presence of Vitamin D Receptors (VDRs). VitD and VDR could be molecules potentially targeting the hallmarks of the aging network. To date, evidence about the potential effects of VitD on the hallmarks of aging is scarce in humans and mainly based on preclinical models. Although underpowered and heterogeneous, in-human studies seem to confirm the modulatory effect of VitD on some hallmarks of aging and diseases. However, more investigations are needed to clarify the pleiotropic effects of VitD and its impact on the hallmark of aging, hopefully highlighting the courses for translational applications and potential clinical conclusions.<\/jats:p>","DOI":"10.3390\/nu16060906","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T06:35:30Z","timestamp":1711002930000},"page":"906","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1245-1963","authenticated-orcid":false,"given":"Carmelinda","family":"Ruggiero","sequence":"first","affiliation":[{"name":"Geriatric and Orthogeriatric Units, Division Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, 06156 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-8420","authenticated-orcid":false,"given":"Laura","family":"Tafaro","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7424-6212","authenticated-orcid":false,"given":"Luisella","family":"Cianferotti","sequence":"additional","affiliation":[{"name":"Bone Metabolic Diseases Unit, Department of Experimental, Clinical and Biomedical Sciences \u201cMario Serio\u201d, University of Florence, University Hospital Careggi, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-7146","authenticated-orcid":false,"given":"Flavia","family":"Tramontana","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria Giovanna","family":"Macchione","sequence":"additional","affiliation":[{"name":"Geriatric and Orthogeriatric Units, Division Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, 06156 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Caffarelli","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Virdis","sequence":"additional","affiliation":[{"name":"Geriatrics Unit, Department of Clinical & Experimental Medicine, University Hospital of Pisa, 56124 Pisa, 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Italy"},{"name":"Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Napoli","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes, Department of Medicine, Fundation Campus Bio-Medico University, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Calsolaro","sequence":"additional","affiliation":[{"name":"Geriatrics Unit, Department of Clinical & Experimental Medicine, University Hospital of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of 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