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Beckman Postdoctoral Fellowship","doi-asserted-by":"publisher","award":["UL1TR002003"],"award-info":[{"award-number":["UL1TR002003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center for Clinical and Translational Science","award":["R03HD095056"],"award-info":[{"award-number":["R03HD095056"]}]},{"name":"Center for Clinical and Translational Science","award":["1U24DK131617-01"],"award-info":[{"award-number":["1U24DK131617-01"]}]},{"name":"Center for Clinical and Translational Science","award":["K12HD101373"],"award-info":[{"award-number":["K12HD101373"]}]},{"name":"Center for Clinical and Translational Science","award":["UL1TR002003"],"award-info":[{"award-number":["UL1TR002003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Pregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter the host immune system to promote inflammation. Multiple perinatal disorders have been associated with inflammation, maternal metabolic alterations, and gut microbial dysbiosis, including gestational diabetes mellitus, pre-eclampsia, preterm birth, and mood disorders. However, the effects of high-inflammatory diets on the gut microbiota during pregnancy have yet to be fully explored. We aimed to address this gap using a system-based approach to characterize associations among dietary inflammatory potential, a measure of diet quality, and the gut microbiome during pregnancy. Forty-seven pregnant persons were recruited prior to 16 weeks of gestation. Participants completed a food frequency questionnaire (FFQ) and provided fecal samples. Dietary inflammatory potential was assessed using the Dietary Inflammatory Index (DII) from the FFQ data. Fecal samples were analyzed using 16S rRNA amplicon sequencing. Differential taxon abundances with respect to the DII score were identified, and the microbial metabolic potential was predicted using PICRUSt2. Inflammatory diets were associated with decreased vitamin and mineral intake and a dysbiotic gut microbiota structure and predicted metabolism. Gut microbial compositional differences revealed a decrease in short-chain fatty acid producers such as Faecalibacterium, and an increase in predicted vitamin B12 synthesis, methylglyoxal detoxification, galactose metabolism, and multidrug efflux systems in pregnant individuals with increased DII scores. Dietary inflammatory potential was associated with a reduction in the consumption of vitamins and minerals and predicted gut microbiota metabolic dysregulation.<\/jats:p>","DOI":"10.3390\/nu16070935","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T14:00:23Z","timestamp":1711375223000},"page":"935","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8370-5537","authenticated-orcid":false,"given":"Suzanne A.","family":"Alvernaz","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Illinois, Chicago, IL 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Illinois, Chicago, IL 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unnathi","family":"Nagelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Illinois, Chicago, IL 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3385-8460","authenticated-orcid":false,"given":"Lacey B.","family":"Pezley","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition, University of Illinois, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bazil","family":"LaBomascus","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition, University of Illinois, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7920-7001","authenticated-orcid":false,"given":"Jack A.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, San Diego, CA 92093, USA"},{"name":"Scripps Oceanographic Institute, University of California, San Diego, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline M.","family":"Maki","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Illinois, Chicago, IL 60607, USA"},{"name":"Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA"},{"name":"Department of Obstetrics and Gynecology, University of Illinois, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Tussing-Humphreys","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition, University of Illinois, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Pe\u00f1alver Bernab\u00e9","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Illinois, Chicago, IL 60607, USA"},{"name":"Center for Bioinformatics and Quantitative Biology, University of Illinois, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1295S","DOI":"10.1093\/ajcn\/71.5.1295s","article-title":"Folic acid: Influence on the outcome of pregnancy","volume":"71","author":"Scholl","year":"2000","journal-title":"Am. 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