{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:21:57Z","timestamp":1789089717494,"version":"build-2803163510"},"reference-count":412,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FWF","award":["KLI-1036B"],"award-info":[{"award-number":["KLI-1036B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>In cardiology, acetylsalicylic acid (ASA) and warfarin are among the most commonly used prophylactic therapies against thromboembolic events. Drug\u2013drug interactions are generally well-known. Less known are the drug\u2013nutrient interactions (DNIs), impeding drug absorption and altering micronutritional status. ASA and warfarin might influence the micronutritional status of patients through different mechanisms such as binding or modification of binding properties of ligands, absorption, transport, cellular use or concentration, or excretion. Our article reviews the drug\u2013nutrient interactions that alter micronutritional status. Some of these mechanisms could be investigated with the aim to potentiate the drug effects. DNIs are seen occasionally in ASA and warfarin and could be managed through simple strategies such as risk stratification of DNIs on an individual patient basis; micronutritional status assessment as part of the medical history; extensive use of the drug\u2013interaction probability scale to reference little-known interactions, and application of a personal, predictive, and preventive medical model using omics.<\/jats:p>","DOI":"10.3390\/nu16070950","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T13:16:41Z","timestamp":1711459001000},"page":"950","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Potential Drug\u2013Nutrient Interactions of 45 Vitamins, Minerals, Trace Elements, and Associated Dietary Compounds with Acetylsalicylic Acid and Warfarin\u2014A Review of the Literature"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8746-5758","authenticated-orcid":false,"given":"David","family":"Renaud","sequence":"first","affiliation":[{"name":"DIU MAPS, Fundamental and Biomedical Sciences, Paris-Cit\u00e9 University, 75006 Paris, France"},{"name":"DIU MAPS, Health Sciences Faculty, Universidad Europea Miguel de Cervantes, 47012 Valladolid, Spain"},{"name":"Fundacja Recover, 05-124 Skrzeszew, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"H\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, University Hospital Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3626-3270","authenticated-orcid":false,"given":"Miriam","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health, Division of Pediatrics III\u2014Cardiology, Pulmonology, Allergology and Cystic Fibrosis, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5001\/omj.2011.21","article-title":"Food Drug Interactions","volume":"26","author":"Bushra","year":"2011","journal-title":"Oman Med. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1542\/pir.2022-005641","article-title":"Common Food and Drug Interactions","volume":"44","author":"Vuong","year":"2023","journal-title":"Pediatr. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1007\/s40265-017-0832-z","article-title":"A Review of Food\u2013Drug Interactions on Oral Drug Absorption","volume":"77","author":"Deng","year":"2017","journal-title":"Drugs"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Roe, D.A. (1989). Diet and Drug Interactions, Springer.","DOI":"10.1007\/978-94-011-6047-6"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0140-6736(99)06457-0","article-title":"Herb-Drug Interactions","volume":"355","year":"2000","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.2165\/00003495-200565090-00005","article-title":"Herb-Drug Interactions: A Literature Review","volume":"65","author":"Hu","year":"2005","journal-title":"Drugs"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.2165\/00003495-200161150-00002","article-title":"Interactions Between Herbal Medicines and Prescribed Drugs: A Systematic Review","volume":"61","author":"Izzo","year":"2001","journal-title":"Drugs"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2003.06.039","article-title":"Cardiovascular Pharmacotherapy and Herbal Medicines: The Risk of Drug Interaction","volume":"98","author":"Izzo","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13167-016-0059-1","article-title":"Drug-Micronutrient Interactions: Food for Thought and Thought for Action","volume":"7","author":"Karadima","year":"2016","journal-title":"EPMA J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.nut.2012.11.011","article-title":"Effects of Widely Used Drugs on Micronutrients: A Story Rarely Told","volume":"29","author":"Samaras","year":"2013","journal-title":"Nutrition"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1177\/0148607113488799","article-title":"Drug-Nutrient Interactions","volume":"37","author":"Chan","year":"2013","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1592\/phco.2005.25.12.1789","article-title":"An Approach to Evaluating Drug-Nutrient Interactions","volume":"25","author":"Santos","year":"2005","journal-title":"Pharmacotherapy"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mohn, E., Kern, H., Saltzman, E., Mitmesser, S., and McKay, D. (2018). Evidence of Drug\u2013Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10010036"},{"key":"ref_14","first-page":"51","article-title":"Drug and Food Interactions as They Affect the Nutrition of Older Individuals","volume":"5","author":"Roe","year":"1993","journal-title":"Aging Milan Italy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00075197-200205000-00014","article-title":"Drug-Nutrient Interaction in Clinical Nutrition","volume":"5","author":"Chan","year":"2002","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_16","first-page":"26","article-title":"Interactions between drugs and micronutrients","volume":"29","year":"2006","journal-title":"Med. Monatsschr. Pharm."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Pitchumoni, C.S., and Dharmarajan, T.S. (2012). Geriatric Gastroenterology, Springer.","DOI":"10.1007\/978-1-4419-1623-5"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Bendich, A., and Deckelbaum, R.J. (2005). Preventive Nutrition, Humana Press.","DOI":"10.1007\/1592598803"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/ajcn\/49.1.127","article-title":"Biotin Transport in the Human Intestine: Inhibition by Anticonvulsant Drugs","volume":"49","author":"Said","year":"1989","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.49.5.1444","article-title":"Biotin Catabolism Is Accelerated in Adults Receiving Long-Term Therapy with Anticonvulsants","volume":"49","author":"Mock","year":"1997","journal-title":"Neurology"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Bendich, A., and Deckelbaum, R.J. (2010). Preventive Nutrition, Humana Press.","DOI":"10.1007\/978-1-60327-542-2"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1177\/8755122518780742","article-title":"Medications and Micronutrients: Identifying Clinically Relevant Interactions and Addressing Nutritional Needs","volume":"34","author":"Prescott","year":"2018","journal-title":"J. Pharm. Technol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/jcpt.12075","article-title":"Drug and Nutrition Interactions: Not Just Food for Thought","volume":"38","author":"Boullata","year":"2013","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000115345","article-title":"Food and Drug Interaction: Consequences for the Nutrition\/Health Status","volume":"52","author":"Genser","year":"2008","journal-title":"Ann. Nutr. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1017\/S0029665110001989","article-title":"Drugs and Nutrition: How Side Effects Can Influence Nutritional Intake","volume":"69","author":"White","year":"2010","journal-title":"Proc. Nutr. Soc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1177\/0883073814538510","article-title":"Drug-Induced Mitochondrial Neuropathy in Children: A Conceptual Framework for Critical Windows of Development","volume":"29","author":"Wallace","year":"2014","journal-title":"J. Child Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1017\/S0029665110001576","article-title":"Important Drug\u2013Nutrient Interactions","volume":"69","author":"Mason","year":"2010","journal-title":"Proc. Nutr. Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1079\/NRR200486","article-title":"An Overview of Interactions between Micronutrients and of Micronutrients with Drugs, Genes and Immune Mechanisms","volume":"17","author":"Thurnham","year":"2004","journal-title":"Nutr. Res. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1128\/AAC.33.11.1841","article-title":"Effect of Ferrous Sulfate and Multivitamins with Zinc on Absorption of Ciprofloxacin in Normal Volunteers","volume":"33","author":"Polk","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2125.1992.tb04010.x","article-title":"Norfloxacin Interaction with Antacids and Minerals","volume":"33","author":"Campbell","year":"1992","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Boullata, J.I., and Armenti, V.T. (2009). Handbook of Drug-Nutrient Interactions, Humana Press.","DOI":"10.1007\/978-1-60327-362-6"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00508-009-1232-5","article-title":"Synergism between Pyronaridine and Retinol in Plasmodium Falciparum in Vitro","volume":"121","author":"Proell","year":"2009","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_33","first-page":"93","article-title":"[Influence of vitamins-antioxidants on antiaggregative effect of acetylsalicylic acid]","volume":"69","author":"Galiyan","year":"1997","journal-title":"Ukr. Biokhimicheskii Zhurnal 1978"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/ajcn\/85.2.333","article-title":"Micronutrients in HIV-Positive Persons Receiving Highly Active Antiretroviral Therapy","volume":"85","author":"Drain","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1177\/0148607110362694","article-title":"Cisplatin Upregulates Glutamine Transport in Human Intestinal Epithelial Cells: The Protective Mechanism of Glutamine on Intestinal Mucosa After Chemotherapy","volume":"34","author":"Nose","year":"2010","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000371618","article-title":"The Epidemiology of Global Micronutrient Deficiencies","volume":"66","author":"Bailey","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1365-2796.2007.01901.x","article-title":"Understanding Ageing from an Evolutionary Perspective: 4th Key Symposium: Understanding Ageing","volume":"263","author":"Kirkwood","year":"2008","journal-title":"J. Intern. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35041682","article-title":"Why Do We Age?","volume":"408","author":"Kirkwood","year":"2000","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"17589","DOI":"10.1073\/pnas.0608757103","article-title":"Low Micronutrient Intake May Accelerate the Degenerative Diseases of Aging through Allocation of Scarce Micronutrients by Triage","volume":"103","author":"Ames","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3945\/ajcn.2009.27930","article-title":"Vitamin K, an Example of Triage Theory: Is Micronutrient Inadequacy Linked to Diseases of Aging?","volume":"90","author":"McCann","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ka\u017amierczak-Bara\u0144ska, J., and Karwowski, B.T. (2022). Vitamin K Contribution to DNA Damage\u2014Advantage or Disadvantage? A Human Health Response. Nutrients, 14.","DOI":"10.3390\/nu14204219"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1096\/fj.11-180885","article-title":"Adaptive Dysfunction of Selenoproteins from the Perspective of the Triage Theory: Why Modest Selenium Deficiency May Increase Risk of Diseases of Aging","volume":"25","author":"McCann","year":"2011","journal-title":"FASEB J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00394-017-1510-3","article-title":"Public Health Relevance of Drug\u2013Nutrition Interactions","volume":"56","author":"Navis","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jada.2011.09.002","article-title":"Drug\u2013Nutrient Interactions: A Broad View with Implications for Practice","volume":"112","author":"Boullata","year":"2012","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Boullata, J.I., and Armenti, V.T. (2010). Handbook of Drug-Nutrient Interactions, Humana Press.","DOI":"10.1007\/978-1-60327-362-6"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1365-2796.2010.02300.x","article-title":"Historical Perspectives: Drug Interactions\u2014It All Began with Cheese","volume":"268","year":"2010","journal-title":"J. Intern. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cptl.2020.11.007","article-title":"Impact of Interdisciplinary Education on Pharmacy Student Knowledge and Comfort with Counseling on Drug-Nutrient Interactions","volume":"13","author":"Drummond","year":"2021","journal-title":"Curr. Pharm. Teach. Learn."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/bjh.14520","article-title":"The Aspirin Story\u2014From Willow to Wonder Drug","volume":"177","author":"Desborough","year":"2017","journal-title":"Br. J. Haematol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/S0248-8663(00)88721-4","article-title":"Pharmacologie de l\u2019aspirine","volume":"21","author":"Tanasescu","year":"2000","journal-title":"Rev. M\u00e9decine Interne"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.1016\/S0002-9343(98)00069-2","article-title":"The Effect of Aspirin and Nonsteroidal Anti-Inflammatory Drugs on Prostaglandins","volume":"105","author":"Bjorkman","year":"1998","journal-title":"Am. J. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"12387","DOI":"10.1016\/S0021-9258(19)49852-9","article-title":"Prostaglandin Endoperoxide Synthase. The Aspirin Acetylation Region","volume":"267","author":"Shimokawa","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Tacconelli, S., Contursi, A., Falcone, L., Mucci, M., D\u2019Agostino, I., Fullone, R., Sacco, A., Zucchelli, M., Bruno, A., and Ballerini, P. (2020). Characterization of Cyclooxygenase-2 Acetylation and Prostanoid Inhibition by Aspirin in Cellular Systems. Biochem. Pharmacol., 178.","DOI":"10.1016\/j.bcp.2020.114094"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1055\/s-2007-996108","article-title":"Aspirin and Platelets: The Antiplatelet Action of Aspirin and Its Role in Thrombosis Treatment and Prophylaxis","volume":"23","year":"1997","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs","volume":"231","author":"Vane","year":"1971","journal-title":"Nat. New Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6514","DOI":"10.1021\/ja0003932","article-title":"Tyrosine-385 Is Critical for Acetylation of Cyclooxygenase-2 by Aspirin","volume":"122","author":"Hochgesang","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1161\/ATVBAHA.109.183707","article-title":"Effects of Aspirin on Clot Structure and Fibrinolysis Using a Novel In Vitro Cellular System","volume":"29","author":"Ajjan","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1182\/blood-2006-01-010645","article-title":"Antithrombotic Properties of Aspirin and Resistance to Aspirin: Beyond Strictly Antiplatelet Actions","volume":"109","author":"Undas","year":"2007","journal-title":"Blood"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1161\/01.RES.82.9.1016","article-title":"Aspirin Increases Ferritin Synthesis in Endothelial Cells: A Novel Antioxidant Pathway","volume":"82","author":"Oberle","year":"1998","journal-title":"Circ. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s13760-021-01714-1","article-title":"Combined Influence of ABCB1 Genetic Polymorphism and DNA Methylation on Aspirin Resistance in Chinese Ischemic Stroke Patients","volume":"122","author":"Xu","year":"2022","journal-title":"Acta Neurol. Belg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.amjcard.2020.12.022","article-title":"Aspirin for Primary Prevention of Cardiovascular Disease in the 21st Century: A Review of the Evidence","volume":"144","author":"Angiolillo","year":"2021","journal-title":"Am. J. Cardiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1161\/01.CIR.0000047062.03282.A3","article-title":"Aspirin Alters the Cardioprotective Effects of the Factor XIII Val34Leu Polymorphism","volume":"107","author":"Undas","year":"2003","journal-title":"Circulation"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/01.rhu.0000128851.12010.46","article-title":"Risk of Upper Gastrointestinal Injury and Events in Patients Treated with Cyclooxygenase (COX)-1\/COX-2 Nonsteroidal Antiinflammatory Drugs (NSAIDs), COX-2 Selective NSAIDs, and Gastroprotective Cotherapy: An Appraisal of the Literature","volume":"10","author":"Dubois","year":"2004","journal-title":"JCR J. Clin. Rheumatol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Fuentes, A., Pineda, M., and Venkata, K. (2018). Comprehension of Top 200 Prescribed Drugs in the US as a Resource for Pharmacy Teaching, Training and Practice. Pharmacy, 6.","DOI":"10.3390\/pharmacy6020043"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"160S","DOI":"10.1378\/chest.08-0670","article-title":"Pharmacology and Management of the Vitamin K Antagonists","volume":"133","author":"Ansell","year":"2008","journal-title":"Chest"},{"key":"ref_65","first-page":"47","article-title":"Anticoagulation Proteins C and S","volume":"214","author":"Esmon","year":"1987","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Lim, G.B. (2017). Warfarin: From Rat Poison to Clinical Use. Nat. Rev. Cardiol.","DOI":"10.1038\/nrcardio.2017.172"},{"key":"ref_67","unstructured":"Jaffer, I.H., and Weitz, J.I. (2018). Hematology, Elsevier."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0163-7258(96)00140-4","article-title":"Human P450 Metabolism of Warfarin","volume":"73","author":"Kaminsky","year":"1997","journal-title":"Pharmacol. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2165\/00003088-200140080-00003","article-title":"Pharmacogenetics of Warfarin Elimination and Its Clinical Implications","volume":"40","author":"Takahashi","year":"2001","journal-title":"Clin. Pharmacokinet."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0009-9236(98)90103-5","article-title":"Metabolism of Warfarin Enantiomers in Japanese Patients with Heart Disease Having Different CYP2C9 and CYP2C19 Genotypes*","volume":"63","author":"Takahashi","year":"1998","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1096\/fasebj.6.2.1537465","article-title":"Characterization of Human Cytochrome P450 Enzymes","volume":"6","author":"Guengerich","year":"1992","journal-title":"FASEB J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1177\/0897190014544823","article-title":"A Comprehensive Review of Potential Warfarin-Fruit Interactions","volume":"28","author":"Norwood","year":"2015","journal-title":"J. Pharm. Pract."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0163-7258(90)90030-6","article-title":"Enzyme Induction in the Cytochrome P-450 System","volume":"45","author":"Okey","year":"1990","journal-title":"Pharmacol. Ther."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1021\/tx00025a009","article-title":"Hydroxylation of Warfarin by Human cDNA-Expressed Cytochrome P-450: A Role for P-4502C9 in the Etiology of (S)-Warfarin-Drug Interactions","volume":"5","author":"Rettie","year":"1992","journal-title":"Chem. Res. Toxicol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0006-2952(66)90182-1","article-title":"A Comparison of the Isomers of Warfarin","volume":"15","author":"Eble","year":"1966","journal-title":"Biochem. Pharmacol."},{"key":"ref_76","first-page":"447","article-title":"Polymorphism of Cytochrome P450 and Xenobiotic Toxicity","volume":"181\u2013182","year":"2002","journal-title":"Toxicology"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Preissner, S.C., Hoffmann, M.F., Preissner, R., Dunkel, M., Gewiess, A., and Preissner, S. (2013). Polymorphic Cytochrome P450 Enzymes (CYPs) and Their Role in Personalized Therapy. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0082562"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2174\/138920009789895480","article-title":"Genetic Polymorphism of the Human Cytochrome P450 2C9 Gene and Its Clinical Significance","volume":"10","author":"Wang","year":"2009","journal-title":"Curr. Drug Metab."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/sj.tpj.6500308","article-title":"Influence of CYP2C9 Polymorphisms, Demographic Factors and Concomitant Drug Therapy on Warfarin Metabolism and Maintenance Dose","volume":"5","author":"Herman","year":"2005","journal-title":"Pharmacogenomics J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.clpt.2005.08.006","article-title":"Several-Fold Increase in Risk of Overanticoagulation by CYP2C9 Mutations","volume":"78","author":"Lindh","year":"2005","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2710.2008.00887.x","article-title":"The Effect of CYP2C19 Genotypes on the Pharmacokinetics of Warfarin Enantiomers","volume":"33","author":"Uno","year":"2008","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.3945\/ajcn.117.155424","article-title":"Fecal Concentrations of Bacterially Derived Vitamin K Forms Are Associated with Gut Microbiota Composition but Not Plasma or Fecal Cytokine Concentrations in Healthy Adults","volume":"106","author":"Karl","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"73","DOI":"10.12938\/bmfh.17-007","article-title":"Can Vitamin K Synthesis Altered by Dysbiosis of Microbiota Be Blamed in the Etiopathogenesis of Venous Thrombosis?","volume":"36","author":"Aydin","year":"2017","journal-title":"Biosci. Microbiota Food Health"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1182\/blood-2007-11-122010","article-title":"CYP4F2 Genetic Variant Alters Required Warfarin Dose","volume":"111","author":"Caldwell","year":"2008","journal-title":"Blood"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/sj.tpj.6500220","article-title":"Warfarin Sensitivity Related to CYP2C9, CYP3A5, ABCB1 (MDR1) and Other Factors","volume":"4","author":"Wadelius","year":"2004","journal-title":"Pharmacogenomics J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/08998280.2001.11927781","article-title":"A Review of Warfarin Dosing and Monitoring","volume":"14","author":"Kuruvilla","year":"2001","journal-title":"Bayl. Univ. Med. Cent. Proc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11883-000-0090-4","article-title":"Does Differing Metabolism by Cytochrome P450 Have Clinical Importance?","volume":"2","author":"Davidson","year":"2000","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/clpt.2008.10","article-title":"Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin","volume":"84","author":"Gage","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.blre.2017.02.001","article-title":"Old and New Oral Anticoagulants: Food, Herbal Medicines and Drug Interactions","volume":"31","author":"Frigerio","year":"2017","journal-title":"Blood Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1001\/archinte.165.10.1095","article-title":"Systematic Overview of Warfarin and Its Drug and Food Interactions","volume":"165","author":"Holbrook","year":"2005","journal-title":"Arch. Intern. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.2146\/ajhp090489","article-title":"Probable Interaction between Warfarin and Bee Pollen","volume":"67","author":"Hurren","year":"2010","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.tjnut.2023.02.016","article-title":"A Practical Guide to Adjust Micronutrient Biomarkers for Inflammation Using the BRINDA Method","volume":"153","author":"Luo","year":"2023","journal-title":"J. Nutr."},{"key":"ref_93","unstructured":"Morris, A.L., and Mohiuddin, S.S. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1079\/NRR200241","article-title":"Micronutrient Cofactor Research with Extensions to Applications","volume":"15","author":"McCormick","year":"2002","journal-title":"Nutr. Res. Rev."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nfs.2018.03.001","article-title":"Micronutrients in the Life Cycle: Requirements and Sufficient Supply","volume":"11","author":"Jana","year":"2018","journal-title":"NFS J."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Hrub\u0161a, M., Siatka, T., Nejmanov\u00e1, I., Vopr\u0161alov\u00e1, M., Kujovsk\u00e1 Kr\u010dmov\u00e1, L., Matou\u0161ov\u00e1, K., Javorsk\u00e1, L., Mac\u00e1kov\u00e1, K., Mercolini, L., and Remi\u00e3o, F. (2022). Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5. Nutrients, 14.","DOI":"10.3390\/nu14030484"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-94-007-2199-9_11","article-title":"Thiamin(e): The Spark of Life","volume":"Volume 56","author":"Stanger","year":"2012","journal-title":"Water Soluble Vitamins"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Marrs, C., and Lonsdale, D. (2021). Hiding in Plain Sight: Modern Thiamine Deficiency. Cells, 10.","DOI":"10.3390\/cells10102595"},{"key":"ref_99","unstructured":"(2023, October 04). Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition. ScienceDirect. Available online: http:\/\/www.sciencedirect.com:5070\/book\/9780128103876\/thiamine-deficiency-disease-dysautonomia-and-high-calorie-malnutrition."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.abb.2013.02.015","article-title":"The Human Flavoproteome","volume":"535","author":"Lienhart","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/jimd.12058","article-title":"Disorders of Riboflavin Metabolism","volume":"42","author":"Balasubramaniam","year":"2019","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3390\/molecules15010442","article-title":"Vitamin B6: A Molecule for Human Health?","volume":"15","author":"Hellmann","year":"2010","journal-title":"Molecules"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/biof.8","article-title":"Biotin","volume":"35","author":"Zempleni","year":"2009","journal-title":"BioFactors"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/cga.12233","article-title":"Nutritional Role of Folate","volume":"57","author":"Ebara","year":"2017","journal-title":"Congenit. Anom."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1177\/15648265080292S103","article-title":"Folate and Vitamin B12 Metabolism: Overview and Interaction with Riboflavin, Vitamin B6, and Polymorphisms","volume":"29","author":"Shane","year":"2008","journal-title":"Food Nutr. Bull."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3390\/nu2030299","article-title":"Vitamin B12 in Health and Disease","volume":"2","author":"Samman","year":"2010","journal-title":"Nutrients"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12291-013-0375-3","article-title":"Vitamin C in Disease Prevention and Cure: An Overview","volume":"28","author":"Chambial","year":"2013","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Carr, A., and Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9.","DOI":"10.3390\/nu9111211"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1475-2891-2-7","article-title":"Vitamin C in Human Health and Disease Is Still a Mystery? An Overview","volume":"2","author":"Naidu","year":"2003","journal-title":"Nutr. J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.pharmthera.2015.12.003","article-title":"Vitamin E Therapy beyond Cancer: Tocopherol versus Tocotrienol","volume":"162","author":"Peh","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/j.lfs.2005.12.001","article-title":"Tocotrienols: Vitamin E beyond Tocopherols","volume":"78","author":"Sen","year":"2006","journal-title":"Life Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0083-6729(07)76008-9","article-title":"Tocotrienols: The Emerging Face of Natural Vitamin E","volume":"Volume 76","author":"Sen","year":"2007","journal-title":"Vitamins & Hormones"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1258\/0007142991902510","article-title":"Diagnosis and Detection of Deficiencies of Micronutrients: Minerals","volume":"55","author":"Jackson","year":"1999","journal-title":"Br. Med. Bull."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.2215\/CJN.05910809","article-title":"Calcium Metabolism in Health and Disease","volume":"5","author":"Peacock","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00223-020-00686-3","article-title":"Phosphate Metabolism in Health and Disease","volume":"108","author":"Peacock","year":"2021","journal-title":"Calcif. Tissue Int."},{"key":"ref_116","first-page":"47","article-title":"Magnesium Metabolism and Its Disorders","volume":"24","author":"Swaminathan","year":"2003","journal-title":"Clin. Biochem. Rev."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3945\/an.113.005215","article-title":"Sodium","volume":"5","author":"Strazzullo","year":"2014","journal-title":"Adv. Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"368S","DOI":"10.3945\/an.112.003533","article-title":"Potassium and Health","volume":"4","author":"Weaver","year":"2013","journal-title":"Adv. Nutr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejim.2011.11.013","article-title":"Chloride: The Queen of Electrolytes?","volume":"23","author":"Berend","year":"2012","journal-title":"Eur. J. Intern. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1111\/hdi.12542","article-title":"Overview of Iron Metabolism in Health and Disease","volume":"21","author":"Dev","year":"2017","journal-title":"Hemodial. Int."},{"key":"ref_121","first-page":"164","article-title":"Review on Iron and Its Importance for Human Health","volume":"19","author":"Abbaspour","year":"2014","journal-title":"J. Res. Med. Sci. Off. J. Isfahan Univ. Med. Sci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.mam.2005.07.015","article-title":"Copper, Oxidative Stress, and Human Health","volume":"26","author":"Keen","year":"2005","journal-title":"Mol. Aspects Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e000784","DOI":"10.1136\/openhrt-2018-000784","article-title":"Copper Deficiency May Be a Leading Cause of Ischaemic Heart Disease","volume":"5","author":"DiNicolantonio","year":"2018","journal-title":"Open Heart"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1054S","DOI":"10.1093\/ajcn\/67.5.1054S","article-title":"Copper Absorption and Bioavailability","volume":"67","author":"Wapnir","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.pharmthera.2014.11.014","article-title":"Role of Copper in Regression of Cardiac Hypertrophy","volume":"148","author":"Zheng","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00204-011-0775-1","article-title":"Zinc and Human Health: An Update","volume":"86","author":"Chasapis","year":"2012","journal-title":"Arch. Toxicol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jtemb.2006.01.006","article-title":"Zinc Requirements and the Risks and Benefits of Zinc Supplementation","volume":"20","author":"Maret","year":"2006","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1079\/PHN2001143","article-title":"Selenium, Selenoproteins and Human Health: A Review","volume":"4","author":"Brown","year":"2001","journal-title":"Public Health Nutr."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(00)02490-9","article-title":"The Importance of Selenium to Human Health","volume":"356","author":"Rayman","year":"2000","journal-title":"Lancet"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Hatch-McChesney, A., and Lieberman, H.R. (2022). Iodine and Iodine Deficiency: A Comprehensive Review of a Re-Emerging Issue. Nutrients, 14.","DOI":"10.3390\/nu14173474"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S1474-4422(17)30180-1","article-title":"Vitamins in Stroke Prevention: Time to Reconsider","volume":"16","author":"Spence","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_132","unstructured":"Institute of Medicine, Food and Nutrition Board, Subcommittee on Upper Reference Levels of Nutrients, and Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline (1998). Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline, National Academies Press."},{"key":"ref_133","unstructured":"Panel on Micronutrients, Food and Nutrition Board (2001). Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, National Academies Press."},{"key":"ref_134","unstructured":"Panel on Dietary Antioxidants and Related Compounds, Subcommittee on Upper Reference Levels of Nutrients, Subcommittee on Interpretation and Uses of Dietary Reference Intakes, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, and Institute of Medicine (2000). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids, National Academies Press."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"10836","DOI":"10.1073\/pnas.1809045115","article-title":"Prolonging Healthy Aging: Longevity Vitamins and Proteins","volume":"115","author":"Ames","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/physrev.1992.72.1.101","article-title":"Physiological Actions of Taurine","volume":"72","author":"Huxtable","year":"1992","journal-title":"Physiol. Rev."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1007\/s00726-011-0962-7","article-title":"Mechanism Underlying the Antioxidant Activity of Taurine: Prevention of Mitochondrial Oxidant Production","volume":"42","author":"Jong","year":"2012","journal-title":"Amino Acids"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1186\/1423-0127-17-S1-S23","article-title":"A Role for Taurine in Mitochondrial Function","volume":"17","author":"Hansen","year":"2010","journal-title":"J. Biomed. Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0083-6729(08)60271-X","article-title":"Ergothioneine","volume":"Volume 17","author":"Melville","year":"1959","journal-title":"Vitamins & Hormones"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1089\/ars.2016.6778","article-title":"Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation","volume":"26","author":"Cheah","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Cheah, I.K., and Halliwell, B. (2021). Ergothioneine, Recent Developments. Redox Biol., 42.","DOI":"10.1016\/j.redox.2021.101868"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Jonscher, K.R., Chowanadisai, W., and Rucker, R.B. (2021). Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention. Biomolecules, 11.","DOI":"10.3390\/biom11101441"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.jnutbio.2013.07.008","article-title":"Dietary Pyrroloquinoline Quinone (PQQ) Alters Indicators of Inflammation and Mitochondrial-Related Metabolism in Human Subjects","volume":"24","author":"Harris","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.3390\/nu7042897","article-title":"The Queuine Micronutrient: Charting a Course from Microbe to Man","volume":"7","author":"Fergus","year":"2015","journal-title":"Nutrients"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.plipres.2018.04.004","article-title":"A Global Perspective on Carotenoids: Metabolism, Biotechnology, and Benefits for Nutrition and Health","volume":"70","author":"Avalos","year":"2018","journal-title":"Prog. Lipid Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/ijfs.14260","article-title":"Lycopene\u2014A Bioactive Carotenoid Offering Multiple Health Benefits: A Review","volume":"55","author":"Przybylska","year":"2020","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/nutrit\/nuv064","article-title":"Absorption, Metabolism, and Functions of \u03b2-Cryptoxanthin","volume":"74","author":"Burri","year":"2016","journal-title":"Nutr. Rev."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1002\/jsfa.6942","article-title":"Beta-Cryptoxanthin as a Source of Vitamin A: Beta-Cryptoxanthin as a Source of Vitamin A","volume":"95","author":"Burri","year":"2015","journal-title":"J. Sci. Food Agric."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/10408690590957188","article-title":"Astaxanthin: A Review of Its Chemistry and Applications","volume":"46","author":"Goycoolea","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"105479","DOI":"10.1016\/j.phrs.2021.105479","article-title":"Therapeutic Uses of Natural Astaxanthin: An Evidence-Based Review Focused on Human Clinical Trials","volume":"166","author":"Donoso","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1753-4887.2009.00246.x","article-title":"Choline: An Essential Nutrient for Public Health","volume":"67","author":"Zeisel","year":"2009","journal-title":"Nutr. Rev."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/NT.0000000000000302","article-title":"Choline: The Underconsumed and Underappreciated Essential Nutrient","volume":"53","author":"Wallace","year":"2018","journal-title":"Nutr. Today"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Kumar, N., and Goel, N. (2019). Phenolic Acids: Natural Versatile Molecules with Promising Therapeutic Applications. Biotechnol. Rep., 24.","DOI":"10.1016\/j.btre.2019.e00370"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2174\/138920106779116856","article-title":"Essential Fatty Acids\u2014A Review","volume":"7","author":"Das","year":"2006","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/biot.200600012","article-title":"Essential Fatty Acids: Biochemistry, Physiology and Pathology","volume":"1","author":"Das","year":"2006","journal-title":"Biotechnol. J."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Cholewski, M., Tomczykowa, M., and Tomczyk, M. (2018). A Comprehensive Review of Chemistry, Sources and Bioavailability of Omega-3 Fatty Acids. Nutrients, 10.","DOI":"10.3390\/nu10111662"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00726-009-0269-0","article-title":"Amino Acids: Metabolism, Functions, and Nutrition","volume":"37","author":"Wu","year":"2009","journal-title":"Amino Acids"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tma.2021.05.001","article-title":"The Regulation of Healthspan and Lifespan by Dietary Amino Acids","volume":"5","author":"Babygirija","year":"2021","journal-title":"Transl. Med. Aging"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3945\/an.116.012971","article-title":"Nutritionally Nonessential Amino Acids: A Misnomer in Nutritional Sciences","volume":"8","author":"Hou","year":"2017","journal-title":"Adv. Nutr."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1161\/CIRCULATIONAHA.116.025338","article-title":"Gut Microbe-Generated Trimethylamine N-Oxide from Dietary Choline Is Prothrombotic in Subjects","volume":"135","author":"Zhu","year":"2017","journal-title":"Circulation"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2478\/v10102-011-0027-5","article-title":"Toxicological Aspects of the Use of Phenolic Compounds in Disease Prevention","volume":"4","author":"Kyselova","year":"2011","journal-title":"Interdiscip. Toxicol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/icb.1943.20","article-title":"The Effect of Salicylates (A) on the estimation of thiamine by the thiochrome method, (B) on the excretion of thiamine","volume":"21","author":"Cleland","year":"1943","journal-title":"Aust. J. Exp. Biol. Med. Sci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/icb.1946.34","article-title":"The effect of salicylates and thiamine deficiency on the thiamine content of rat tissue","volume":"24","author":"Cleland","year":"1946","journal-title":"Aust. J. Exp. Biol. Med. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S0021-9258(18)62357-9","article-title":"Mode of Action of Aspirin","volume":"246","author":"Mehlman","year":"1971","journal-title":"J. Biol. Chem."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/adc.23.113.40","article-title":"Salicylate Therapy in Children","volume":"23","author":"Maggioni","year":"1948","journal-title":"Arch. Dis. Child."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0140-6736(81)92627-1","article-title":"Is cutaneous flushing prostaglandin mediated?","volume":"317","author":"Phillips","year":"1981","journal-title":"Lancet"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1753-0407.2012.00216.x","article-title":"Role of Prostaglandin D2 and the Autonomic Nervous System in Niacin-Induced Flushing: PGD2 and ANS in Niacin-Induced Flushing","volume":"5","author":"Parson","year":"2013","journal-title":"J. Diabetes"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"6682","DOI":"10.1073\/pnas.0601574103","article-title":"Antagonism of the Prostaglandin D2 Receptor 1 Suppresses Nicotinic Acid-Induced Vasodilation in Mice and Humans","volume":"103","author":"Cheng","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"AP59","DOI":"10.1161\/circoutcomes.4.suppl_1.AP59","article-title":"Abstract P59: Aspirin Improves the Impact of Niacin-Associated Flushing on Quality of Life Measures","volume":"4","author":"Jiang","year":"2011","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/ATVBAHA.114.303742","article-title":"Heating Up the Cutaneous Flushing Response","volume":"34","author":"Offermanns","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/j.1742-1241.2009.02099.x","article-title":"The Mechanism and Mitigation of Niacin-Induced Flushing","volume":"63","author":"Kamanna","year":"2009","journal-title":"Int. J. Clin. Pract."},{"key":"ref_172","first-page":"165","article-title":"The Effect of Aspirin on Niacin-Induced Cutaneous Reactions","volume":"34","author":"Whelan","year":"1992","journal-title":"J. Fam. Pract."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1525-1497.1997.07118.x","article-title":"Effect of Two Aspirin Pretreatment Regimens on Niacin-Induced Cutaneous Reactions","volume":"12","author":"Jungnickel","year":"1997","journal-title":"J. Gen. Intern. Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/ard.27.5.414","article-title":"Nature of Anaemia in Rheumatoid Arthritis. IX. Folate Metabolism in Patients with Rheumatoid Arthritis","volume":"27","author":"Omer","year":"1968","journal-title":"Ann. Rheum. Dis."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/bmj.1.5490.765","article-title":"Folic-Acid Deficiency in Rheumatoid Arthritis: Relation of Levels of Serum Folic-Acid Activity of Treatment with Phenylbutazone","volume":"1","author":"Deller","year":"1966","journal-title":"BMJ"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/bmj.1.5377.212","article-title":"Folic-Acid Deficiency in Rheumatoid Arthritis","volume":"1","author":"Gough","year":"1964","journal-title":"BMJ"},{"key":"ref_177","first-page":"944","article-title":"Aspirin and Folate Binding: In Vivo and in Vitro Studies of Serum Binding and Urinary Excretion of Endogenous Folate","volume":"103","author":"Lawrence","year":"1984","journal-title":"J. Lab. Clin. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1038\/sj.ejcn.1600989","article-title":"Drugs-Nutrient Interactions: A Potential Problem during Adolescence","volume":"54","year":"2000","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1182\/blood.V38.4.405.405","article-title":"Interrelationship of Rheumatoid Arthritis, Folic Acid, and Aspirin","volume":"38","author":"Alter","year":"1971","journal-title":"Blood"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1042\/bj2820197","article-title":"Inhibition of Folate-Dependent Enzymes by Non-Steroidal Anti-Inflammatory Drugs","volume":"282","author":"Baggott","year":"1992","journal-title":"Biochem. J."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1042\/bj2720339","article-title":"Detection of Inhibition of 5-Aminoimidazole-4-Carboxamide Ribotide Transformylase by Thioinosinic Acid and Azathioprine by a New Colorimetric Assay","volume":"272","author":"Ha","year":"1990","journal-title":"Biochem. J."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1093\/jnci\/djp346","article-title":"Antagonistic Effects of Aspirin and Folic Acid on Inflammation Markers and Subsequent Risk of Recurrent Colorectal Adenomas","volume":"101","author":"Ho","year":"2009","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mehy.2004.08.035","article-title":"High-Dose Folate May Improve Platelet Function in Acute Coronary Syndrome and Other Pathologies Associated with Increased Platelet Oxidative Stress","volume":"69","author":"McCarty","year":"2007","journal-title":"Med. Hypotheses"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.amjcard.2004.06.047","article-title":"Association of Aspirin Use with Vitamin B12 Deficiency (Results of the BACH Study)","volume":"94","author":"Laheij","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"g5226","DOI":"10.1136\/bmj.g5226","article-title":"Vitamin B12 Deficiency","volume":"349","author":"Hunt","year":"2014","journal-title":"BMJ"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Carabotti, M., Annibale, B., and Lahner, E. (2021). Common Pitfalls in the Management of Patients with Micronutrient Deficiency: Keep in Mind the Stomach. Nutrients, 13.","DOI":"10.3390\/nu13010208"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0950-3536(05)80224-0","article-title":"Malabsorption of Food Cobalamin","volume":"8","author":"Carmel","year":"1995","journal-title":"Baillieres Clin. Haematol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1503\/cmaj.1031155","article-title":"Vitamin B12 (Cobalamin) Deficiency in Elderly Patients","volume":"171","author":"Andres","year":"2004","journal-title":"Can. Med. Assoc. J."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1016\/S1590-8658(02)80170-0","article-title":"Consequences of Helicobacter Pylori Infection on the Absorption of Micronutrients","volume":"34","author":"Annibale","year":"2002","journal-title":"Dig. Liver Dis."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1007\/s12603-021-1708-1","article-title":"Effectiveness of B Vitamins and Their Interactions with Aspirin in Improving Cognitive Functioning in Older People with Mild Cognitive Impairment: Pooled Post-Hoc Analyses of Two Randomized Trials","volume":"25","author":"Wu","year":"2021","journal-title":"J. Nutr. Health Aging"},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Zhu, Z., and Ni, Y. (2020). Interaction between Aspirin and Vitamin C with Human Serum Albumin as Binary and Ternary Systems. Spectrochim. Acta. A Mol. Biomol. Spectrosc., 236.","DOI":"10.1016\/j.saa.2020.118356"},{"key":"ref_192","first-page":"83","article-title":"Vitamin C-Aspirin Interactions","volume":"23","author":"Basu","year":"1982","journal-title":"Int. J. Vitam. Nutr. Res. Suppl. Int. Z. Vitam.-Ernahrungsforschung Suppl."},{"key":"ref_193","first-page":"591","article-title":"Intestinal Absorption of Aspirin. Influence of pH, Taurocholate, Ascorbate, and Ethanol","volume":"98","author":"Hollander","year":"1981","journal-title":"J. Lab. Clin. Med."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/j.1552-4604.1978.tb01601.x","article-title":"Demonstration of Saturation Kinetics in the Intestinal Absorption of Vitamin C in Man and the Guinea Pig","volume":"18","author":"Nelson","year":"1978","journal-title":"J. Clin. Pharmacol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(71)91441-3","article-title":"Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis","volume":"297","author":"Sahud","year":"1971","journal-title":"Lancet"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"481","DOI":"10.5414\/CPP42481","article-title":"Effects of Acetylsalicylic Acid on Ascorbic Acid Concentrations in Plasma, Gastric Mucosa, Gastric Juice and Urine a Double-Blind Study in Healthy Subjects","volume":"42","author":"Schulz","year":"2004","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"ref_197","first-page":"125","article-title":"Ascorbic Acid Attenuates Aspirin-Induced Gastric Damage: Role of Inducible Nitric Oxide Synthase","volume":"57","author":"Konturek","year":"2006","journal-title":"J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1046\/j.1365-2036.2001.00975.x","article-title":"Role of Reactive Oxygen Metabolites in Aspirin-Induced Gastric Damage in Humans: Gastroprotection by Vitamin C","volume":"15","author":"Pohle","year":"2001","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1365-2710.1992.tb01315.x","article-title":"Vitamin C Aspirin Interactions in Laboratory Animals","volume":"17","year":"1992","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/BF03001121","article-title":"The Effect of Salicylate Medication upon the Urinary Excretion of Vitamin C","volume":"15","author":"Spitzer","year":"1948","journal-title":"Am. J. Dig. Dis."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3181\/00379727-35-8838C","article-title":"Influence of Acetylsalicylic Acid (Aspirin) on Urinary Excretion of Ascorbic Acid","volume":"35","author":"Daniels","year":"1936","journal-title":"Exp. Biol. Med."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/j.1552-4604.1973.tb00203.x","article-title":"The Effects of Aspirin on the Metabolic Availability of Ascorbic Acid in Human Beings","volume":"13","author":"Loh","year":"1973","journal-title":"J. Clin. Pharmacol. New Drugs"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/000992288502400801","article-title":"Nutritional Consequences of Drugs Used in Pediatrics","volume":"24","author":"Oiness","year":"1985","journal-title":"Clin. Pediatr."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jneuroim.2006.01.003","article-title":"Ascorbic Acid Enhances the Inhibitory Effect of Aspirin on Neuronal Cyclooxygenase-2-Mediated Prostaglandin E2 Production","volume":"174","author":"Akundi","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/jcb.20116","article-title":"L-Ascorbic Acid Represses Constitutive Activation of NF-kappaB and COX-2 Expression in Human Acute Myeloid Leukemia, HL-60","volume":"93","author":"Han","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jnutbio.2003.07.003","article-title":"Protective Effect of Vitamin C against the Ethanol Mediated Toxic Effects on Human Brain Glial Cells","volume":"14","author":"Paniagua","year":"2003","journal-title":"J. Nutr. Biochem."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1161\/01.CIR.94.10.2434","article-title":"\u03b1-Tocopherol Inhibits Aggregation of Human Platelets by a Protein Kinase C\u2013Dependent Mechanism","volume":"94","author":"Freedman","year":"1996","journal-title":"Circulation"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1172\/JCI108331","article-title":"Vitamin E. An Inhibitor of the Platelet Release Reaction","volume":"57","author":"Steiner","year":"1976","journal-title":"J. Clin. Investig."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0090-6980(81)90040-X","article-title":"In Vitro Effects of Synthetic Antioxidants and Vitamin E on Arachidonic Acid Metabolism and Thromboxane Formation in Human Platelets and on Platelet Aggregation","volume":"22","author":"Agradi","year":"1981","journal-title":"Prostaglandins"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.lfs.2006.04.025","article-title":"Antioxidant and Antiplatelet Effects of the Alpha-Tocopherol\u2013Aspirin Combination in Type 1-like Diabetic Rats","volume":"79","author":"Arrebola","year":"2006","journal-title":"Life Sci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/ajcn\/37.4.641","article-title":"Vitamin E in Plasma and Platelets of Human Diabetic Patients and Control Subjects","volume":"37","author":"Vatassery","year":"1983","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3109\/07853899709002602","article-title":"Increased Tendency towards Gingival Bleeding Caused by Joint Effect of \u03b1-Tocopherol Supplementation and Acetylsalicylic Acid","volume":"30","author":"Liede","year":"1998","journal-title":"Ann. Med."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1381S","DOI":"10.1093\/ajcn\/62.6.1381S","article-title":"Vitamin E plus Aspirin Compared with Aspirin Alone in Patients with Transient Ischemic Attacks","volume":"62","author":"Steiner","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/ajcn\/77.3.700","article-title":"Mixed Tocopherols Inhibit Platelet Aggregation in Humans: Potential Mechanisms123","volume":"77","author":"Liu","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1017\/S0954422414000146","article-title":"Vitamin E\u2014Drug Interactions: Molecular Basis and Clinical Relevance","volume":"27","author":"Podszun","year":"2014","journal-title":"Nutr. Res. Rev."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1023\/A:1005417929009","article-title":"Effect of Vitamin E on Aspirin-Induced Gastric Mucosal Injury in Rats","volume":"45","author":"Sugimoto","year":"2000","journal-title":"Dig. Dis. Sci."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1046\/j.1440-6047.2002.00298.x","article-title":"Comparative Effects of a Tocotrienol-Rich Fraction and Tocopherol in Aspirin-Induced Gastric Lesions in Rats","volume":"11","author":"Nafeeza","year":"2002","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.jnutbio.2008.08.004","article-title":"A Combination of Aspirin and \u03b3-Tocopherol Is Superior to That of Aspirin and \u03b1-Tocopherol in Anti-Inflammatory Action and Attenuation of Aspirin-Induced Adverse Effects","volume":"20","author":"Jiang","year":"2009","journal-title":"J. Nutr. Biochem."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0090-6980(75)90011-8","article-title":"Effects of Aspirin on Renal Sodium Excretion, Blood Pressure, and Plasma and Extracellular Fluid Volume in Salt-Loaded Rats","volume":"10","author":"Susic","year":"1975","journal-title":"Prostaglandins"},{"key":"ref_220","first-page":"219","article-title":"Effects of Nonsteroidal Anti-Inflammatory Drugs (NSAID) on Renal Excretion of Sodium and Water, and on Body Fluid Volume in Rats","volume":"209","author":"Kadokawa","year":"1979","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.repc.2017.05.008","article-title":"Aspirin and Blood Pressure: Effects When Used Alone or in Combination with Antihypertensive Drugs","volume":"36","author":"Costa","year":"2017","journal-title":"Rev. Port. Cardiol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.ejheart.2008.06.014","article-title":"Renal Effects of Aspirin Are Clearly Dose-Dependent and Are of Clinical Importance from a Dose of 160 Mg","volume":"10","author":"Juhlin","year":"2008","journal-title":"Eur. J. Heart Fail."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(13)61752-3","article-title":"The Framingham Heart Study and the Epidemiology of Cardiovascular Disease: A Historical Perspective","volume":"383","author":"Mahmood","year":"2014","journal-title":"Lancet"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/ajcn\/74.2.219","article-title":"Aspirin Intake and the Use of Serum Ferritin as a Measure of Iron Status","volume":"74","author":"Fleming","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s002770050537","article-title":"Iron Status in Danes Updated 1994. I: Prevalence of Iron Deficiency and Iron Overload in 1332 Men Aged 40\u201370 Years. Influence of Blood Donation, Alcohol Intake, and Iron Supplementation","volume":"78","author":"Milman","year":"1999","journal-title":"Ann. Hematol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"913","DOI":"10.7326\/M23-0675","article-title":"Effect of Low-Dose Aspirin Versus Placebo on Incidence of Anemia in the Elderly: A Secondary Analysis of the Aspirin in Reducing Events in the Elderly Trial","volume":"176","author":"McQuilten","year":"2023","journal-title":"Ann. Intern. Med."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Gaskell, H., Derry, S., and Moore, R.A. (2010). Is There an Association between Low Dose Aspirin and Anemia (without Overt Bleeding)?: Narrative Review. BMC Geriatr., 10.","DOI":"10.1186\/1471-2318-10-71"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.amjmed.2012.06.036","article-title":"Aspirin-Associated Iron Loss: An Anticancer Mechanism Even in the Short Term?","volume":"126","author":"Mascitelli","year":"2013","journal-title":"Am. J. Med."},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Martell, A.E., and Smith, R.M. (1977). Other Organic Ligands, Springer.","DOI":"10.1007\/978-1-4757-1568-2"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0271-5317(95)92586-9","article-title":"Effects of Over-the-Counter Drugs on 51chromium Retention and Urinary Excretion in Rats","volume":"15","author":"Davis","year":"1995","journal-title":"Nutr. Res."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-1-4615-3436-5_20","article-title":"Taurine Potentiates the Antiaggregatory Action of Aspirin and Indomethacin","volume":"Volume 315","author":"Lombardini","year":"1992","journal-title":"Taurine"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-1-4899-0405-8_20","article-title":"Suppression of Bronchial Response to Platelet Activating Factor Following Taurine Administration","volume":"Volume 217","author":"Huxtable","year":"1987","journal-title":"The Biology of Taurine"},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Ro\u015fca, A.E., Vl\u0103d\u0103reanu, A.-M., Mirica, R., Anghel-Timaru, C.-M., Mititelu, A., Popescu, B.O., C\u0103runtu, C., Voiculescu, S.E., Gologan, \u015e., and Onis\u00e2i, M. (2022). Taurine and Its Derivatives: Analysis of the Inhibitory Effect on Platelet Function and Their Antithrombotic Potential. J. Clin. Med., 11.","DOI":"10.3390\/jcm11030666"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1248\/bpb1978.5.495","article-title":"Electrophysiological Approach to the Action of Taurine on Rat Gastric Mucosa","volume":"5","author":"Kimura","year":"1982","journal-title":"J. Pharmacobiodyn."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0009-8981(71)90307-X","article-title":"Taurine Excretion and the Influence of Drugs","volume":"35","author":"Rylance","year":"1971","journal-title":"Clin. Chim. Acta"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10812-007-0033-8","article-title":"Association of Riboflavin, Caffeine, and Sodium Salicylate in Aqueous Solution","volume":"74","author":"Baranovskii","year":"2007","journal-title":"J. Appl. Spectrosc."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jphotobiol.2016.08.042","article-title":"Caffeine Metabolites Not Caffeine Protect against Riboflavin Photosensitized Oxidative Damage Related to Skin and Eye Health","volume":"163","author":"Scurachio","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1046\/j.1468-2982.1994.1405328.x","article-title":"High-Dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study","volume":"14","author":"Schoenen","year":"1994","journal-title":"Cephalalgia"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/1574884711666151214104315","article-title":"Oral Administration of Sustained Release Niacin Inhibits Platelet Aggregation","volume":"11","author":"Norgard","year":"2016","journal-title":"Curr. Clin. Pharmacol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1067\/mhj.2000.109648","article-title":"Effect of Niacin, Warfarin, and Antioxidant Therapy on Coagulation Parameters in Patients with Peripheral Arterial Disease in the Arterial Disease Multiple Intervention Trial (ADMIT)","volume":"140","author":"Chesney","year":"2000","journal-title":"Am. Heart J."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0002-9149(98)00393-2","article-title":"Effect of Niacin Supplementation on Fibrinogen Levels in Patients with Peripheral Vascular Disease","volume":"82","author":"Philipp","year":"1998","journal-title":"Am. J. Cardiol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.nutres.2011.08.001","article-title":"Pantethine, a Derivative of Vitamin B5 Used as a Nutritional Supplement, Favorably Alters Low-Density Lipoprotein Cholesterol Metabolism in Low\u2013 to Moderate\u2013Cardiovascular Risk North American Subjects: A Triple-Blinded Placebo and Diet-Controlled Investigation","volume":"31","author":"Rumberger","year":"2011","journal-title":"Nutr. Res."},{"key":"ref_243","first-page":"49","article-title":"Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia","volume":"6","author":"Hiramatsu","year":"1981","journal-title":"Tokai J. Exp. Clin. Med."},{"key":"ref_244","first-page":"89","article-title":"Effect of Chronic Administration of Aspirin, Phenobarbitone and Oxytetracycline on the Plasma Levels of Vitamin A in Albino Rats (Partially Retrieved on a Server of the World Health Organization)","volume":"40","author":"Maqbool","year":"1990","journal-title":"JPMA J. Pak. Med. Assoc."},{"key":"ref_245","first-page":"289","article-title":"Gastric Cytoprotective Effects of Vitamin A and Other Carotenoids","volume":"5","author":"Bata","year":"1983","journal-title":"Int. J. Tissue React."},{"key":"ref_246","first-page":"315","article-title":"Interrelationships between the Gastric Cytoprotective Effects of Vitamin A and Beta-Carotene and the Gastric Mucosal Superoxide Dismutase Activity in Rats","volume":"64","author":"Zsoldos","year":"1984","journal-title":"Acta Physiol. Hung."},{"key":"ref_247","first-page":"35","article-title":"Cytoprotective Effect of Free Radical Scavengers against Mucosal Damage Produced by Different Antirheumatic Drugs","volume":"8","author":"Past","year":"1986","journal-title":"Int. J. Tissue React."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/00004836-199006000-00006","article-title":"Chronic \u03b2-Carotene Supplementation Does Not Alter the Gastric Mucosal Response to Acute Aspirin Ingestion","volume":"12","author":"Moses","year":"1990","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/jn\/119.1.105","article-title":"Provitamin A Function of Carotenoids: The Conversion of \u03b2-Carotene into Vitamin A","volume":"119","author":"Olson","year":"1989","journal-title":"J. Nutr."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/1043-6618(90)90744-X","article-title":"Effect of Aspirin and Indomethacin on the Serum and Urinary Calcium, Magnesium and Phosphate","volume":"22","author":"Gomaa","year":"1990","journal-title":"Pharmacol. Res."},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Bennati, G., Cirino, M., Benericetti, G., Maximova, N., Zanier, M., Pigato, F., Parzianello, A., Maestro, A., Barbi, E., and Zanon, D. (2023). Compounded Effervescent Magnesium for Familial Hypomagnesemia: A Case Report. Pharmaceuticals, 16.","DOI":"10.3390\/ph16060785"},{"key":"ref_252","unstructured":"Think Healthy Group, Inc. (2022, July 11). Bioavailability of Single-Dose Magnesium Salts, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04139928."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0162-0134(94)00024-5","article-title":"Copper(II) Interactions with Nonsteroidal Antiinflammatory Agents. I. Salicylic Acid and Acetylsalicylic Acid","volume":"57","author":"Brumas","year":"1995","journal-title":"J. Inorg. Biochem."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/14756360290030734","article-title":"Transition Metal Acetylsalicylates and Their Anti-Inflammatory Activity","volume":"17","author":"Chohan","year":"2002","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2222.1991.tb00831.x","article-title":"Selenium Status in Relation to Reduced Glutathione Peroxidase Activity in Aspirin-Sensitive Asthma","volume":"21","author":"Pearson","year":"1991","journal-title":"Clin. Exp. Allergy"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1017\/jns.2013.17","article-title":"Regulation of Inflammation by Selenium and Selenoproteins: Impact on Eicosanoid Biosynthesis","volume":"2","author":"Mattmiller","year":"2013","journal-title":"J. Nutr. Sci."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/01635588609513884","article-title":"Dietary Fat and Selenium Effects on Ex Vivo Prostaglandin Production in Rat Colon, Kidney, and Blood","volume":"8","author":"Birt","year":"1986","journal-title":"Nutr. Cancer"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/taap.1995.1204","article-title":"The Effect of Selenium Compounds (Selenite, Selenate, Ebselen) on the Production of Thromboxane and Prostacyclin by the Human Term Placenta in Vitro","volume":"135","author":"Eisenmann","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1055\/s-0038-1647308","article-title":"Selenium Dependent Glutathione Peroxidase: A Physiological Regulatory System for Platelet Function","volume":"64","author":"Perona","year":"1990","journal-title":"Thromb. Haemost."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF02784589","article-title":"Chromium Metabolism: A Literature Review","volume":"32","author":"Ducros","year":"1992","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0304-4165(64)90228-4","article-title":"Chromium (III) Binding to Serum Proteins, Specifically Siderophilin","volume":"90","author":"Hopkins","year":"1964","journal-title":"Biochim. Biophys. Acta BBA-Gen. Subj."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"A18","DOI":"10.1016\/S0002-8223(95)00411-4","article-title":"Aspirin and Buffering Compounds Affect the Absorption and Retention of 51chromium","volume":"95","author":"Sparks","year":"1995","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1079\/BJN2003994","article-title":"Tomatoes Have Natural Anti-Thrombotic Effects","volume":"90","author":"Yamamoto","year":"2003","journal-title":"Br. J. Nutr."},{"key":"ref_264","doi-asserted-by":"crossref","unstructured":"Das, R.K., Datta, T., Biswas, D., Duss, R., O\u2019Kennedy, N., and Duttaroy, A.K. (2021). Evaluation of the Equivalence of Different Intakes of Fruitflow in Affecting Platelet Aggregation and Thrombin Generation Capacity in a Randomized, Double-Blinded Pilot Study in Male Subjects. BMC Nutr., 7.","DOI":"10.1186\/s40795-021-00485-5"},{"key":"ref_265","doi-asserted-by":"crossref","unstructured":"Chen, H., Zhang, S., Wang, H., Bao, L., Wu, W., and Qi, R. (2022). Fruitflow Inhibits Platelet Function by Suppressing Akt\/GSK3\u03b2, Syk\/PLC\u03b32 and P38 MAPK Phosphorylation in Collagen-Stimulated Platelets. BMC Complement. Med. Ther., 22.","DOI":"10.1186\/s12906-022-03558-5"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4103\/0253-7613.174428","article-title":"Comparative Evaluation of Antiplatelet Effect of Lycopene with Aspirin and the Effect of Their Combination on Platelet Aggregation: An in Vitro Study","volume":"48","author":"Sawardekar","year":"2016","journal-title":"Indian J. Pharmacol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/jn\/129.4.849","article-title":"Plasma Lycopene Concentrations in Humans Are Determined by Lycopene Intake, Plasma Cholesterol Concentrations and Selected Demographic Factors","volume":"129","author":"Mayne","year":"1999","journal-title":"J. Nutr."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3945\/ajcn.116.150821","article-title":"Relative Contribution of \u03b1-Carotene to Postprandial Vitamin A Concentrations in Healthy Humans after Carrot Consumption","volume":"106","author":"Cooperstone","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/MJT.0b013e31819cdbbd","article-title":"The In Vitro Effects of Xancor, a Synthetic Astaxanthine Derivative, on Hemostatic Biomarkers in Aspirin-Na\u00efve and Aspirin-Treated Subjects with Multiple Risk Factors for Vascular Disease","volume":"17","author":"Serebruany","year":"2010","journal-title":"Am. J. Ther."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/bmc-2019-0001","article-title":"ATP Synthase: Structure, Function and Inhibition","volume":"10","author":"Neupane","year":"2019","journal-title":"Biomol. Concepts"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"45184","DOI":"10.1038\/srep45184","article-title":"Aspirin Induces Cell Death by Directly Modulating Mitochondrial Voltage-Dependent Anion Channel (VDAC)","volume":"7","author":"Tewari","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2013.03.002","article-title":"Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure","volume":"17","author":"Liesa","year":"2013","journal-title":"Cell Metab."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.clnu.2018.08.032","article-title":"Feeding Mitochondria: Potential Role of Nutritional Components to Improve Critical Illness Convalescence","volume":"38","author":"Wesselink","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1196\/annals.1297.073","article-title":"Delaying the Mitochondrial Decay of Aging","volume":"1019","author":"Ames","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0006-2944(73)90008-2","article-title":"Effects of Chronic Acetylsalicylate Administration on Several Nutritional and Biochemical Parameters in Rats Fed Diets of Varied Thiamin Content","volume":"8","author":"Mackerer","year":"1973","journal-title":"Biochem. Med."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.mam.2005.07.007","article-title":"Mineral and Vitamin Deficiencies Can Accelerate the Mitochondrial Decay of Aging","volume":"26","author":"Ames","year":"2005","journal-title":"Mol. Aspects Med."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1161\/01.CIR.92.4.767","article-title":"Attenuation of the Synthesis of Plasminogen Activator Inhibitor Type 1 by Niacin: A Potential Link Between Lipid Lowering and Fibrinolysis","volume":"92","author":"Brown","year":"1995","journal-title":"Circulation"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00043798-199706000-00002","article-title":"Nicotinic Acid Treatment Shifts the Fibrinolytic Balance Favourably and Decreases Plasma Fibrinogen in Hypertriglyceridaemic Men","volume":"4","author":"Johansson","year":"1997","journal-title":"J. Cardiovasc. Risk"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1345\/aph.1Q242","article-title":"Critically Elevated INR in a Patient on Warfarin After Increase in Extended-Release Niacin Dose","volume":"45","author":"Christopher","year":"2011","journal-title":"Ann. Pharmacother."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"H239","DOI":"10.1111\/j.1750-3841.2012.02939.x","article-title":"Folate Content and Composition of Vegetables Commonly Consumed in China","volume":"77","author":"Shohag","year":"2012","journal-title":"J. Food Sci."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/biof.5520340106","article-title":"Folate Content in Different Strawberry Genotypes and Folate Status in Healthy Subjects after Strawberry Consumption","volume":"34","author":"Tulipani","year":"2008","journal-title":"BioFactors"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"36","DOI":"10.21101\/cejph.a3785","article-title":"Seasonal Folate Serum Concentrations at Different Nutrition","volume":"21","year":"2013","journal-title":"Cent. Eur. J. Public Health"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.thromres.2014.04.024","article-title":"Higher Vitamin K Intake Is Associated with Better INR Control and a Decreased Need for INR Tests in Long-Term Warfarin Therapy","volume":"134","author":"Leblanc","year":"2014","journal-title":"Thromb. Res."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"nzz035.OR36-04-19","DOI":"10.1093\/cdn\/nzz035.OR36-04-19","article-title":"Increasing Dietary Vitamin K Intake Stabilizes Anticoagulation Therapy in Warfarin-Treated Patients with a History of Instability: A 24-Week Randomized Controlled Trial (OR36-04-19)","volume":"3","author":"Ferland","year":"2019","journal-title":"Curr. Dev. Nutr."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jand.2015.12.023","article-title":"Avoidance of Vitamin K-Rich Foods Is Common among Warfarin Users and Translates into Lower Usual Vitamin K Intakes","volume":"116","author":"Leblanc","year":"2016","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_286","first-page":"1493","article-title":"Hyperhomocysteinemia and B-Vitamin Status after Discontinuation of Oral Anticoagulation Therapy in Patients with a History of Venous Thromboembolism","volume":"41","author":"Harrington","year":"2003","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/MBC.0b013e32832aa6a1","article-title":"Erythrocyte Folate and 5-Methyltetrahydrofolate Levels Decline during 6 Months of Oral Anticoagulation with Warfarin","volume":"20","author":"Harrington","year":"2009","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1515\/cclm-2016-0092","article-title":"High Homocysteine and Low Folate Plasma Concentrations Are Associated with Cardiovascular Events but Not Bleeding during Warfarin Treatment","volume":"54","author":"Lind","year":"2016","journal-title":"Clin. Chem. Lab. Med. CCLM"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.clinthera.2010.02.008","article-title":"Effects of Folic Acid Supplementation on the Pharmacokinetics and Anticoagulant Effect of Warfarin: An Open-Label, Prospective Study of Long-Term Administration in Adults","volume":"32","author":"Muszkat","year":"2010","journal-title":"Clin. Ther."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0002-8223(95)00158-1","article-title":"Interaction of Dietary Factors with Oral Anticoagulants: Review and Applications","volume":"95","author":"Harris","year":"1995","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1001\/jama.1973.03220040054020","article-title":"Ascorbic Acid and Warfarin","volume":"223","author":"Deckert","year":"1973","journal-title":"JAMA"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1001\/jama.1971.03180230079026","article-title":"Interaction of Ascorbic Acid and Warfarin","volume":"215","author":"Rosenthal","year":"1971","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1001\/jama.1972.03200230052025","article-title":"Interaction of Ascorbic Acid and Warfarin","volume":"221","author":"Smith","year":"1972","journal-title":"JAMA"},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1001\/jama.1972.03190370069026","article-title":"Interaction of Ascorbic Acid and Warfarin","volume":"219","author":"Hume","year":"1972","journal-title":"JAMA"},{"key":"ref_295","first-page":"690","article-title":"The Effect of Ascorbic Acid given to Patients on Chronic Anticoagulant Therapy","volume":"18","author":"Dedichen","year":"1973","journal-title":"Boll. Soc. Ital. Cardiol."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0041-008X(74)90130-6","article-title":"Warfarin and Ascorbic Acid: Lack of Evidence for a Drug Interaction","volume":"28","author":"Weintraub","year":"1974","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/0041-008X(75)90278-1","article-title":"Lack of a Clinically Important Interaction between Warfarin and Ascorbic Acid","volume":"31","author":"Feetam","year":"1975","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.thromres.2005.07.017","article-title":"Dietary Related Plasma Vitamin C Concentration Has No Effect on Anticoagulation Response to Warfarin","volume":"118","author":"Wynne","year":"2006","journal-title":"Thromb. Res."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2146\/ajhp110704","article-title":"Possible Warfarin Resistance Due to Interaction with Ascorbic Acid: Case Report and Literature Review","volume":"70","author":"Sattar","year":"2013","journal-title":"Am. J. Health-Syst. Pharm. AJHP Off. J. Am. Soc. Health-Syst. Pharm."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1177\/106002800203600504","article-title":"Interaction between Warfarin and Mango Fruit","volume":"36","year":"2002","journal-title":"Ann. Pharmacother."},{"key":"ref_301","unstructured":"(1985). Vitamin Supplements. Med. Lett. Drugs Ther., 27, 66\u201368."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/004982599238632","article-title":"Effects of Arachidonic Acid, Prostaglandins, Retinol, Retinoic Acid and Cholecalciferol on Xenobiotic Oxidations Catalysed by Human Cytochrome P450 Enzymes","volume":"29","author":"Yamazaki","year":"1999","journal-title":"Xenobiotica"},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2165\/00002018-199513010-00002","article-title":"How ???Safe??? Are Antioxidant Vitamins?","volume":"13","author":"Garewal","year":"1995","journal-title":"Drug Saf."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0002-9149(97)89357-5","article-title":"Effect of Vitamin E on the Anticoagulant Response to Warfarin","volume":"77","author":"Kim","year":"1996","journal-title":"Am. J. Cardiol."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"e000364","DOI":"10.1161\/JAHA.113.000364","article-title":"Vitamin E Serum Levels and Bleeding Risk in Patients Receiving Oral Anticoagulant Therapy: A Retrospective Cohort Study","volume":"2","author":"Pastori","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1749-6632.1982.tb31275.x","article-title":"The effect of vitamin e on warfarin-induced vitamin k deficiency*","volume":"393","author":"Corrigan","year":"1982","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1753-4887.2008.00123.x","article-title":"Vitamin E and K Interactions--a 50-Year-Old Problem","volume":"66","author":"Traber","year":"2008","journal-title":"Nutr. Rev."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/jcph.774","article-title":"The Effect of Treatment of Vitamin D Deficiency on the Level of P-Selectin and Hs-CRP in Patients with Thromboembolism: A Pilot Randomized Clinical Trial","volume":"57","author":"Hejazi","year":"2017","journal-title":"J. Clin. Pharmacol."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s40119-022-00268-4","article-title":"Influence of Vitamin D Status on the Maintenance Dose of Warfarin in Patients Receiving Chronic Warfarin Therapy","volume":"11","author":"Khansari","year":"2022","journal-title":"Cardiol. Ther."},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"Mohammad, S., Mishra, A., and Ashraf, M.Z. (2019). Emerging Role of Vitamin D and Its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis. Biomolecules, 9.","DOI":"10.3390\/biom9110649"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1096\/fj.201800956R","article-title":"ABCB1 (P-Glycoprotein) Regulates Vitamin D Absorption and Contributes to Its Transintestinal Efflux","volume":"33","author":"Margier","year":"2019","journal-title":"FASEB J."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/01.ATV.20.2.317","article-title":"Warfarin-Induced Artery Calcification Is Accelerated by Growth and Vitamin D","volume":"20","author":"Price","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/jclinpath-2019-205997","article-title":"Laboratory Assessment of Vitamin K Status","volume":"73","author":"Card","year":"2020","journal-title":"J. Clin. Pathol."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/09674845.2017.1336854","article-title":"Therapeutic Warfarin Use and the Extrahepatic Functions of Vitamin K-Dependent Proteins","volume":"74","author":"Donaldson","year":"2017","journal-title":"Br. J. Biomed. Sci."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3945\/an.111.001628","article-title":"The Role of Vitamin K in Soft-Tissue Calcification","volume":"3","author":"Theuwissen","year":"2012","journal-title":"Adv. Nutr."},{"key":"ref_316","doi-asserted-by":"crossref","unstructured":"Roumeliotis, S., Dounousi, E., Eleftheriadis, T., and Liakopoulos, V. (2019). Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030628"},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/biof.1844","article-title":"Carboxylative Efficacy of Trans and Cis MK7 and Comparison with Other Vitamin K Isomers","volume":"48","author":"Cirilli","year":"2022","journal-title":"BioFactors Oxf. Engl."},{"key":"ref_318","doi-asserted-by":"crossref","unstructured":"Sato, T., Inaba, N., and Yamashita, T. (2020). MK-7 and Its Effects on Bone Quality and Strength. Nutrients, 12.","DOI":"10.3390\/nu12040965"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"128510","DOI":"10.1016\/j.foodchem.2020.128510","article-title":"P-Glycoprotein (ABCB1) Is Involved in Vitamin K Efflux","volume":"343","author":"Margier","year":"2021","journal-title":"Food Chem."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"afab263","DOI":"10.1093\/ageing\/afab263","article-title":"Warfarin and Increased Fracture Risk? Answering the Big Question","volume":"51","author":"Fawzy","year":"2022","journal-title":"Age Ageing"},{"key":"ref_321","first-page":"174550572311655","article-title":"The Interplay between Bone and Heart Health as Reflected in Medication Effects: A Narrative Review","volume":"19","author":"Trost","year":"2023","journal-title":"Womens Health"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1007\/s00198-015-3411-8","article-title":"Timing of Low Bone Mineral Density and Predictors of Bone Mineral Density Trajectory in Children on Long-Term Warfarin: A Longitudinal Study","volume":"27","author":"Avila","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1756-185X.2009.01395.x","article-title":"Reduced Bone Density in Patients on Long-Term Warfarin","volume":"12","author":"Rezaieyazdi","year":"2009","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"e019618","DOI":"10.1161\/JAHA.120.019618","article-title":"Fracture Risks in Patients Treated with Different Oral Anticoagulants: A Systematic Review and Meta-Analysis","volume":"10","author":"Huang","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s00198-014-2912-1","article-title":"Warfarin Use and Fracture Risk: An Evidence-Based Mechanistic Insight","volume":"26","author":"Sugiyama","year":"2015","journal-title":"Osteoporos. Int."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"635.e1","DOI":"10.1016\/j.amjmed.2015.11.032","article-title":"Warfarin and Vascular Calcification","volume":"129","author":"Poterucha","year":"2016","journal-title":"Am. J. Med."},{"key":"ref_327","doi-asserted-by":"crossref","unstructured":"Lee, S.J., Lee, I.-K., and Jeon, J.-H. (2020). Vascular Calcification\u2014New Insights into Its Mechanism. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082685"},{"key":"ref_328","doi-asserted-by":"crossref","unstructured":"Elango, K., Javaid, A., Khetarpal, B.K., Ramalingam, S., Kolandaivel, K.P., Gunasekaran, K., and Ahsan, C. (2021). The Effects of Warfarin and Direct Oral Anticoagulants on Systemic Vascular Calcification: A Review. Cells, 10.","DOI":"10.3390\/cells10040773"},{"key":"ref_329","unstructured":"(2023, October 10). Anticoagulation Algorithm for Fontan Patients. American College of Cardiology. Available online: https:\/\/www.acc.org\/Latest-in-Cardiology\/Articles\/2023\/04\/05\/14\/10\/Anticoagulation-Algorithm-For-Fontan-Patients."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/FJC.0000000000001082","article-title":"Ginkgo Biloba Extract EGB761 Alleviates Warfarin-Induced Aortic Valve Calcification Through the BMP2\/Smad1\/5\/Runx2 Signaling Pathway","volume":"78","author":"Liu","year":"2021","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_331","unstructured":"(2008). Haemorrhage Due to Ginkgo Biloba?. Prescrire Int., 17, 19."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/jth.12203","article-title":"Effect of Low-Dose Supplements of Menaquinone-7 (Vitamin K2) on the Stability of Oral Anticoagulant Treatment: Dose-Response Relationship in Healthy Volunteers","volume":"11","author":"Theuwissen","year":"2013","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_333","first-page":"186","article-title":"Interactions between Warfarin and Herbal Products, Minerals, and Vitamins: A Pharmacist\u2019s Guide","volume":"54","author":"Stenton","year":"2001","journal-title":"Can. J. Hosp. Pharm."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1007\/s12011-021-03036-y","article-title":"The Effect of Serum Magnesium Level on Stable Anticoagulation in Patients Using Warfarin for Various Cardiac Indications","volume":"200","author":"Ardahanli","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"8541","DOI":"10.1074\/jbc.271.15.8541","article-title":"Magnesium(II) Is a Crucial Constituent of the Blood Coagulation Cascade","volume":"271","author":"Sekiya","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1021\/acs.biochem.5b00608","article-title":"Tissue Factor Residues That Modulate Magnesium-Dependent Rate Enhancements of the Tissue Factor\/Factor VIIa Complex","volume":"54","author":"Gajsiewicz","year":"2015","journal-title":"Biochemistry"},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1053\/j.jrn.2014.10.002","article-title":"The Importance of Vitamin K Monitoring with Warfarin (Coumadin) Use in Chronic Kidney Disease Patients","volume":"25","author":"Han","year":"2015","journal-title":"J. Ren. Nutr."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1111\/imj.14970","article-title":"Serum Potassium Abnormalities in Chronic Kidney Disease: Prevalence, Patient Characteristics and Clinical Outcomes","volume":"51","author":"Brookes","year":"2021","journal-title":"Intern. Med. J."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jccase.2019.01.002","article-title":"Interaction between Warfarin and Astaxanthin: A Case Report","volume":"19","author":"Santiyanon","year":"2019","journal-title":"J. Cardiol. Cases"},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.fct.2013.04.053","article-title":"Inhibitory Effects of Astaxanthin, \u03b2-Cryptoxanthin, Canthaxanthin, Lutein, and Zeaxanthin on Cytochrome P450 Enzyme Activities","volume":"59","author":"Zheng","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1977.57.1.1","article-title":"Prothrombin Structure, Activation, and Biosynthesis","volume":"57","author":"Suttie","year":"1977","journal-title":"Physiol. Rev."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1093\/jn\/111.12.2087","article-title":"Vitamin K-Dependent Reactions in Rat Liver: Role of Flavoproteins","volume":"111","author":"Preusch","year":"1981","journal-title":"J. Nutr."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/BF01320909","article-title":"The Effect of Warfarin on Urine Calcium Oxalate Crystal Growth Inhibition and Urinary Excretion of Calcium and Nephrocalcin","volume":"53","author":"Worcester","year":"1993","journal-title":"Calcif. Tissue Int."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/BF01964007","article-title":"The Interaction of Warfarin with Antacid Constituents in the Gut","volume":"35","author":"McElnay","year":"1979","journal-title":"Experientia"},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/cpt1973142231","article-title":"Effect of Coadministration of Aluminum and Magnesium Hydroxides on Absorption of Anticoagulants in Man","volume":"14","author":"Ambre","year":"1973","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_346","doi-asserted-by":"crossref","unstructured":"Blancquaert, L., Vervaet, C., and Derave, W. (2019). Predicting and Testing Bioavailability of Magnesium Supplements. Nutrients, 11.","DOI":"10.3390\/nu11071663"},{"key":"ref_347","unstructured":"PubChem (2023, October 10). Warfarin Sodium, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/16204922."},{"key":"ref_348","unstructured":"(2023, October 10). DailyMed\u2014WARFARIN SODIUM Tablet, Available online: https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=36a919ce-7a21-40c0-9af5-2299bf2b1f97."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"c38","DOI":"10.1159\/000228074","article-title":"Increased Iron Requirement in Hemodialysis Patients on Antiplatelet Agents or Warfarin","volume":"113","author":"Flint","year":"2009","journal-title":"Nephron Clin. Pract."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0140-6736(78)91963-3","article-title":"Altered warfarin metabolism in iron-deficient patient","volume":"312","author":"Nicholls","year":"1978","journal-title":"Lancet"},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12210-016-0565-z","article-title":"Heme Iron Centers in Cytochrome P450: Structure and Catalytic Activity","volume":"28","author":"Gilardi","year":"2017","journal-title":"Rend. Lincei"},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fphys.2018.00044","article-title":"Coenzyme Q10 Supplementation in Aging and Disease","volume":"9","author":"Bernier","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.mito.2007.02.006","article-title":"The Antioxidant Role of Coenzyme Q","volume":"7","author":"Bentinger","year":"2007","journal-title":"Mitochondrion"},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1002\/fsn3.1492","article-title":"The Effect of Coenzyme Q10 Supplementation on Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials","volume":"8","author":"Sangsefidi","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_355","first-page":"109","article-title":"Anticoagulant Activity of a Naphthoquinone Analog of Vitamin K and an Inhibitor of Coenzyme Q10- Enzyme Systems","volume":"13","author":"Combs","year":"1976","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1469-185X.1971.tb01179.x","article-title":"Ubiquinones, plastoquinones and vitamins K","volume":"46","author":"Morton","year":"1971","journal-title":"Biol. Rev."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1515\/DMDI.2001.18.2.99","article-title":"Effect of Ubidecarenone on Warfarin Anticoagulation and Pharmacokinetics of Warfarin Enantiomers in Rats","volume":"18","author":"Zhou","year":"2001","journal-title":"Drug Metabol. Drug Interact."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/1389200053586091","article-title":"Effect of Coenzyme Q10 on Warfarin Hydroxylation in Rat and Human Liver Microsomes","volume":"6","author":"Zhou","year":"2005","journal-title":"Curr. Drug Metab."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1093\/ajhp\/57.13.1221","article-title":"Potential Interactions between Alternative Therapies and Warfarin","volume":"57","author":"Heck","year":"2000","journal-title":"Am. J. Health-Syst. Pharm. AJHP Off. J. Am. Soc. Health-Syst. Pharm."},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/S0140-6736(94)90736-6","article-title":"Reduced Effect of Warfarin Caused by Ubidecarenone","volume":"344","author":"Spigset","year":"1994","journal-title":"Lancet"},{"key":"ref_361","first-page":"3226","article-title":"[Interaction between warfarin and coenzyme Q10]","volume":"160","author":"Landbo","year":"1998","journal-title":"Ugeskr. Laeger"},{"key":"ref_362","first-page":"1868","article-title":"[Effect of Coenzyme Q10 and Ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment. A randomized, double-blind, placebo-controlled cross-over trial]","volume":"165","author":"Engelsen","year":"2003","journal-title":"Ugeskr. Laeger"},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1136\/bmj.325.7372.1073","article-title":"Oral Anticoagulation and Risk of Death: A Medical Record Linkage Study","volume":"325","year":"2002","journal-title":"BMJ"},{"key":"ref_364","unstructured":"Fiddian-Green, R.G. (2024, March 20). Did the Anticoagulants Cause Deaths by Inducing Mitochondrial Dysfuinction?. Available online: https:\/\/www.bmj.com\/rapid-response\/2011\/10\/29\/did-anticoagulants-cause-deaths-inducing-mitochondrial-dysfuinction."},{"key":"ref_365","doi-asserted-by":"crossref","unstructured":"Be\u021biu, A.M., Noveanu, L., H\u00e2ncu, I.M., Lascu, A., Petrescu, L., Maack, C., Elm\u00e9r, E., and Muntean, D.M. (2022). Mitochondrial Effects of Common Cardiovascular Medications: The Good, the Bad and the Mixed. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113653"},{"key":"ref_366","doi-asserted-by":"crossref","unstructured":"Szabo, R., Bodolea, C., and Mocan, T. (2021). Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications. Nanomaterials, 11.","DOI":"10.3390\/nano11112958"},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.tips.2019.04.014","article-title":"Predicting and Understanding the Human Microbiome\u2019s Impact on Pharmacology","volume":"40","author":"Hitchings","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/cpt.1437","article-title":"Pharmacomicrobiomics: The Holy Grail to Variability in Drug Response?","volume":"106","author":"Sharma","year":"2019","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev-pharmtox-010919-023612","article-title":"The Role of the Microbiome in Drug Response","volume":"60","author":"Pryor","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_370","doi-asserted-by":"crossref","unstructured":"Masnoon, N., Shakib, S., Kalisch-Ellett, L., and Caughey, G.E. (2017). What Is Polypharmacy? A Systematic Review of Definitions. BMC Geriatr., 17.","DOI":"10.1186\/s12877-017-0621-2"},{"key":"ref_371","doi-asserted-by":"crossref","unstructured":"Bakaki, P.M., Horace, A., Dawson, N., Winterstein, A., Waldron, J., Staley, J., Pestana Knight, E.M., Meropol, S.B., Liu, R., and Johnson, H. (2018). Defining Pediatric Polypharmacy: A Scoping Review. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0208047"},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.clnesp.2022.03.007","article-title":"The Association between Polypharmacy and Malnutrition(Risk) in Older People: A Systematic Review","volume":"49","author":"Kok","year":"2022","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1345\/aph.1R621","article-title":"Prevalence and Risk of Potential Cytochrome P450-Mediated Drug-Drug Interactions in Older Hospitalized Patients with Polypharmacy","volume":"47","author":"Doan","year":"2013","journal-title":"Ann. Pharmacother."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.3390\/nu7053524","article-title":"Suboptimal Micronutrient Intake among Children in Europe","volume":"7","author":"Kaganov","year":"2015","journal-title":"Nutrients"},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1093\/jn\/137.12.2794","article-title":"Interactions between Nutrition and Environmental Exposures: Effects on Health Outcomes in Women and Children","volume":"137","author":"Kordas","year":"2007","journal-title":"J. Nutr."},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1136\/heartjnl-2014-305723","article-title":"Lean Mass Deficits, Vitamin D Status and Exercise Capacity in Children and Young Adults after Fontan Palliation","volume":"100","author":"Avitabile","year":"2014","journal-title":"Heart"},{"key":"ref_377","unstructured":"Bruun, D.E.R. (2021). Vitamin D and Calcium Intake in Children with Fontan Circulation\u2014In Relationship to Vitamin D Status and Bone Mineral Density. [Master\u2019s Thesis, University of Oslo]."},{"key":"ref_378","unstructured":"Charpie, J.R. (2022, May 08). Vitamin C May Improve Endothelial Function and Exercise Capacity in Functional Single Ventricle Patients after Fontan Palliation; Clinical Ttrial Registration NCT00974025, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00974025."},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/chd.12848","article-title":"Progressive Loss of Bone Mass in Children with Fontan Circulation","volume":"14","author":"Diab","year":"2019","journal-title":"Congenit. Heart Dis."},{"key":"ref_380","doi-asserted-by":"crossref","unstructured":"Renaud, D., Scholl-B\u00fcrgi, S., Karall, D., and Michel, M. (2023). Comparative Metabolomics in Single Ventricle Patients after Fontan Palliation: A Strong Case for a Targeted Metabolic Therapy. Metabolites, 13.","DOI":"10.3390\/metabo13080932"},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"8930","DOI":"10.1038\/s41598-020-65852-x","article-title":"Targeted Metabolomic Analysis of Serum Amino Acids in the Adult Fontan Patient with a Dominant Left Ventricle","volume":"10","author":"Michel","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"204062232091603","DOI":"10.1177\/2040622320916031","article-title":"Targeted Metabolomic Analysis of Serum Phospholipid and Acylcarnitine in the Adult Fontan Patient with a Dominant Left Ventricle","volume":"11","author":"Michel","year":"2020","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00431-016-2700-3","article-title":"\u201cNihilism\u201d of Chronic Heart Failure Therapy in Children and Why Effective Therapy Is Withheld","volume":"175","author":"Schranz","year":"2016","journal-title":"Eur. J. Pediatr."},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1517\/14740338.5.3.433","article-title":"Warfarin and Its Interactions with Foods, Herbs and Other Dietary Supplements","volume":"5","author":"Nutescu","year":"2006","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0140-6736(07)61092-7","article-title":"The Challenge of Managing Drug Interactions in Elderly People","volume":"370","author":"Mallet","year":"2007","journal-title":"Lancet"},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mehy.2014.12.004","article-title":"Thiamine and Magnesium Deficiencies: Keys to Disease","volume":"84","author":"Lonsdale","year":"2015","journal-title":"Med. Hypotheses"},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"e1590","DOI":"10.1016\/S2214-109X(22)00367-9","article-title":"Micronutrient Deficiencies among Preschool-Aged Children and Women of Reproductive Age Worldwide: A Pooled Analysis of Individual-Level Data from Population-Representative Surveys","volume":"10","author":"Stevens","year":"2022","journal-title":"Lancet Glob. Health"},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1098\/rstb.1991.0028","article-title":"Evolution of Senescence: Late Survival Sacrificed for Reproduction","volume":"332","author":"Kirkwood","year":"1991","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1017\/S0029665118002781","article-title":"Approaches to Improving Micronutrient Status Assessment at the Population Level","volume":"78","author":"Lamers","year":"2019","journal-title":"Proc. Nutr. Soc."},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1093\/jn\/132.11.3422","article-title":"Mineral Intakes of Elderly Adult Supplement and Non-Supplement Users in the Third National Health and Nutrition Examination Survey","volume":"132","author":"Ervin","year":"2002","journal-title":"J. Nutr."},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1055\/s-0041-106337","article-title":"Anamnese und k\u00f6rperliche Untersuchung","volume":"141","year":"2015","journal-title":"DMW-Dtsch. Med. Wochenschr."},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1345\/aph.1H423","article-title":"Proposal for a New Tool to Evaluate Drug Interaction Cases","volume":"41","author":"Horn","year":"2007","journal-title":"Ann. Pharmacother."},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1592\/phco.29.8.1002","article-title":"Potential Interaction Between Pomegranate Juice and Warfarin","volume":"29","author":"Komperda","year":"2009","journal-title":"Pharmacotherapy"},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1345\/aph.1M510","article-title":"INR Elevation with Maitake Extract in Combination with Warfarin","volume":"44","author":"Hanselin","year":"2010","journal-title":"Ann. Pharmacother."},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"855","DOI":"10.4236\/ijcm.2014.514115","article-title":"PPPM (Predictive, Preventive and Personalized Medicine) as a New Model of the National and International Healthcare Services and Thus a Promising Strategy to Prevent a Disease: From Basics to Practice","volume":"05","author":"Sadkovsky","year":"2014","journal-title":"Int. J. Clin. Med."},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/cpt.1532","article-title":"The Age of Omics-Driven Precision Medicine","volume":"106","author":"McColl","year":"2019","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"299","DOI":"10.31887\/DCNS.2016.18.3\/jkrier","article-title":"Genomic Sequencing in Clinical Practice: Applications, Challenges, and Opportunities","volume":"18","author":"Krier","year":"2016","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4331\/wjbc.v12.i5.57","article-title":"Proteomics: Concepts and Applications in Human Medicine","volume":"12","author":"Alshekaili","year":"2021","journal-title":"World J. Biol. Chem."},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s44222-023-00023-x","article-title":"Translating Metabolomics into Clinical Practice","volume":"1","author":"Kirwan","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"key":"ref_400","doi-asserted-by":"crossref","unstructured":"Archibald, J. (2018). Genomics: A Very Short Introduction, Oxford University Press.","DOI":"10.1093\/actrade\/9780198786207.001.0001"},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/sj.ejcn.1602590","article-title":"Pharmacogenomics and Nutrigenomics: Synergies and Differences","volume":"61","author":"Ghosh","year":"2007","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_402","first-page":"55","article-title":"Nutrigenetics and Nutraceuticals: The next Wave Riding on Personalized Medicine","volume":"149","author":"Subbiah","year":"2007","journal-title":"Transl. Res. J. Lab. Clin. Med."},{"key":"ref_403","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/02648725.1996.10647923","article-title":"Progress with Proteome Projects: Why All Proteins Expressed by a Genome Should Be Identified and How to Do It","volume":"13","author":"Wilkins","year":"1996","journal-title":"Biotechnol. Genet. Eng. Rev."},{"key":"ref_404","doi-asserted-by":"crossref","first-page":"a000588","DOI":"10.1101\/mcs.a000588","article-title":"Metabolomics: An Emerging but Powerful Tool for Precision Medicine","volume":"1","author":"Clish","year":"2015","journal-title":"Mol. Case Stud."},{"key":"ref_405","doi-asserted-by":"crossref","first-page":"994068","DOI":"10.3389\/fcvm.2022.994068","article-title":"Metabolomics and Random Forests in Patients with Complex Congenital Heart Disease","volume":"9","author":"Michel","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_406","doi-asserted-by":"crossref","unstructured":"(2011). Patient-Specific Modelling & Bioinformatics in PPPM. EPMA J., 2, 181\u2013187.","DOI":"10.1007\/s13167-011-0123-9"},{"key":"ref_407","doi-asserted-by":"crossref","unstructured":"Steg, A., Oczkowicz, M., and Smo\u0142ucha, G. (2022). Omics as a Tool to Help Determine the Effectiveness of Supplements. Nutrients, 14.","DOI":"10.3390\/nu14245305"},{"key":"ref_408","doi-asserted-by":"crossref","unstructured":"McClorry, S., Slupsky, C.M., Lind, T., Karlsland \u00c5keson, P., Hernell, O., and \u00d6hlund, I. (2020). Effectiveness of Vitamin D Supplementation in Swedish Children May Be Negatively Impacted by BMI and Serum Fructose. J. Nutr. Biochem., 75.","DOI":"10.1016\/j.jnutbio.2019.108251"},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1475-2891-12-148","article-title":"Micronutrients Supplementation and Nutritional Status in Cognitively Impaired Elderly Persons: A Two-Month Open Label Pilot Study","volume":"12","author":"Dismar","year":"2013","journal-title":"Nutr. J."},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"116589","DOI":"10.1016\/j.trac.2022.116589","article-title":"Foodomics in Health: Advanced Techniques for Studying the Bioactive Role of Foods","volume":"150","author":"Ortea","year":"2022","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_411","doi-asserted-by":"crossref","unstructured":"Stouras, I., Papaioannou, T.G., Tsioufis, K., Eliopoulos, A.G., and Sanoudou, D. (2022). The Challenge and Importance of Integrating Drug\u2013Nutrient\u2013Genome Interactions in Personalized Cardiovascular Healthcare. J. Pers. Med., 12.","DOI":"10.3390\/jpm12040513"},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11239-013-0978-9","article-title":"Nutri-Pharmacogenomics of Warfarin Anticoagulation Therapy: VKORC1 Genotype-Dependent Influence of Dietary Vitamin K Intake","volume":"38","author":"Saito","year":"2014","journal-title":"J. Thromb. Thrombolysis"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/7\/950\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:18:40Z","timestamp":1760105920000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/7\/950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,26]]},"references-count":412,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["nu16070950"],"URL":"https:\/\/doi.org\/10.3390\/nu16070950","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,26]]}}}