{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:40:41Z","timestamp":1790278841468,"version":"4.1.0"},"reference-count":92,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union (NextGeneration EU)","award":["PE_00000019"],"award-info":[{"award-number":["PE_00000019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Maternal\u2013child health suggests the critical impact of maternal nutrition during the pre-conception and gestational periods, with some genetic variants also playing a significant role. Our systematic review provides an overview of epidemiological studies exploring the interactions between genetic variants, maternal dietary habits, and neonatal and\/or maternal pregnancy outcomes. Methods: From its inception until June 2023, we conducted a comprehensive literature search on PubMed, Embase, and Web of Science databases. Results: On a total of 29 epidemiological studies, 11 studies were conducted to explore the interplay between genetic variants and dietary factors, focusing on the risks associated with gestational diabetes mellitus, hypertensive disorders of pregnancy, recurrent spontaneous abortion, recurrent pregnancy loss, iron deficiency anemia, and gestational weight gain. Concerning neonatal outcomes, six studies investigated the interplay between genetic variants, dietary factors, and anthropometric measures, while eight studies delved into abnormal embryonic development, two studies focused on preterm birth, and two studies explored other neonatal outcomes. Conclusions: Deeply understanding gene\u2013diet interactions could be useful in developing highly personalized approaches to maternal and child nutrition, as well as in exploring the potential implications in disease prevention and the promotion of the long-term well-being of both mothers and their offspring.<\/jats:p>","DOI":"10.3390\/nu16070994","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T13:20:53Z","timestamp":1711632053000},"page":"994","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exploring Gene\u2013Diet Interactions for Mother\u2013Child Health: A Systematic Review of Epidemiological Studies"],"prefix":"10.3390","volume":"16","author":[{"given":"Giuliana","family":"Favara","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2655-8574","authenticated-orcid":false,"given":"Andrea","family":"Maugeri","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2023-2135","authenticated-orcid":false,"given":"Roberta","family":"Magnano San Lio","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0905-5003","authenticated-orcid":false,"given":"Martina","family":"Barchitta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-8162","authenticated-orcid":false,"given":"Antonella","family":"Agodi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Barchitta, M., Magnano San Lio, R., La Rosa, M.C., La Mastra, C., Favara, G., Ferrante, G., Galvani, F., Pappalardo, E., Ettore, C., and Ettore, G. (2023). The Effect of Maternal Dietary Patterns on Birth Weight for Gestational Age: Findings from the MAMI-MED Cohort. Nutrients, 15.","DOI":"10.3390\/nu15081922"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8123","DOI":"10.1080\/14767058.2021.1962843","article-title":"Maternal periconceptional nutrition matters. A scoping review of the current literature","volume":"35","author":"Montagnoli","year":"2022","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.7762\/cnr.2019.8.1.64","article-title":"Maternal Dietary Patterns and Their Association with Pregnancy Outcomes","volume":"8","author":"Paknahad","year":"2019","journal-title":"Clin. Nutr. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-3016.2012.01281.x","article-title":"Effect of women\u2019s nutrition before and during early pregnancy on maternal and infant outcomes: A systematic review","volume":"26","author":"Ramakrishnan","year":"2012","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ajog.2021.12.035","article-title":"The importance of nutrition in pregnancy and lactation: Lifelong consequences","volume":"226","author":"Marshall","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mizuno, S., Nagaie, S., Tamiya, G., Kuriyama, S., Obara, T., Ishikuro, M., Tanaka, H., Kinoshita, K., Sugawara, J., and Yamamoto, M. (2023). Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: A prospective cohort study. BMC Pregnancy Childbirth, 23.","DOI":"10.1186\/s12884-023-05919-5"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3945\/jn.114.190686","article-title":"Preconception dietary patterns in human pregnancies are associated with preterm delivery","volume":"144","author":"Grieger","year":"2014","journal-title":"J. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/OGX.0000000000000329","article-title":"Current Concepts of Maternal Nutrition","volume":"71","author":"Lowensohn","year":"2016","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e12716","DOI":"10.1111\/aji.12716","article-title":"Immunological function of vitamin D during human pregnancy","volume":"78","author":"Ji","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/1759720X17706453","article-title":"Vitamin D in pregnancy: Current perspectives and future directions","volume":"9","author":"Kiely","year":"2017","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/OGX.0b013e318223614c","article-title":"Folic acid in obstetric practice: A review","volume":"66","author":"Talaulikar","year":"2011","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_12","first-page":"CD006896","article-title":"Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes","volume":"2013","author":"Lassi","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1265\/ehpm.21-00033","article-title":"Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: A review","volume":"27","author":"Kobayashi","year":"2022","journal-title":"Environ. Health Prev. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/s41430-018-0356-y","article-title":"Associations between maternal dietary patterns and infant birth weight, small and large for gestational age in the Norwegian Mother and Child Cohort Study","volume":"73","author":"Juodakis","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3945\/ajcn.115.107219","article-title":"Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population","volume":"101","author":"Zinck","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/AOG.0b013e3181e80979","article-title":"Maternal folate-related gene environment interactions and congenital heart defects","volume":"116","author":"Hobbs","year":"2010","journal-title":"Obstet. Gynecol."},{"key":"ref_17","first-page":"e38001","article-title":"Association of Methylenetetrahydrofolate Reductase Gene Polymorphism in Mothers With Adverse Clinical Outcomes in Neonates","volume":"15","author":"Panigrahi","year":"2023","journal-title":"Cureus"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.gene.2017.10.087","article-title":"Vitamin D receptor (VDR) polymorphisms are associated to spontaneous preterm birth and maternal aspects","volume":"642","author":"Javorski","year":"2018","journal-title":"Gene"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.placenta.2016.12.028","article-title":"Placental genetic variations in vitamin D metabolism and birthweight","volume":"50","author":"Workalemahu","year":"2017","journal-title":"Placenta"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1002\/fsn3.2948","article-title":"Impact of vitamin D on maternal and fetal health: A review","volume":"10","author":"Arshad","year":"2022","journal-title":"Food Sci. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Bulloch, R.E., Wall, C.R., McCowan, L.M.E., Taylor, R.S., Roberts, C.T., and Thompson, J.M.D. (2020). The Effect of Interactions between Folic Acid Supplementation and One Carbon Metabolism Gene Variants on Small-for-Gestational-Age Births in the Screening for Pregnancy Endpoints (SCOPE) Cohort Study. Nutrients, 12.","DOI":"10.3390\/nu12061677"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1231.e1","DOI":"10.1016\/j.ajog.2006.07.024","article-title":"Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth","volume":"195","author":"Engel","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wang, S., Duan, Y., Jiang, S., Bi, Y., Pang, X., Liu, C., Yang, Z., and Lai, J. (2022). Relationships between Maternal Gene Polymorphisms in One Carbon Metabolism and Adverse Pregnancy Outcomes: A Prospective Mother and Child Cohort Study in China. Nutrients, 14.","DOI":"10.3390\/nu14102108"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"112024","DOI":"10.18632\/oncotarget.22999","article-title":"Effect of gene-lifestyle interaction on gestational diabetes risk","volume":"8","author":"Popova","year":"2017","journal-title":"Oncotarget"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12263-022-00716-9","article-title":"Interactions of CDKAL1 rs7747752 polymorphism and serum levels of L-carnitine and choline are related to increased risk of gestational diabetes mellitus","volume":"17","author":"Wang","year":"2022","journal-title":"Genes Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1017\/S1368980020000609","article-title":"The association of the glucokinase rs4607517 polymorphism with gestational diabetes mellitus and its interaction with sweets consumption in Chinese women","volume":"24","author":"Ao","year":"2021","journal-title":"Public Health Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100069","DOI":"10.1016\/j.metop.2020.100069","article-title":"TCF7L2 rs7903146 polymorphism modulates the association between adherence to a Mediterranean diet and the risk of gestational diabetes mellitus","volume":"8","author":"Barabash","year":"2020","journal-title":"Metab. Open"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Mo, M., Shao, B., Xin, X., Luo, W., Si, S., Jiang, W., Wang, S., Shen, Y., Wu, J., and Yu, Y. (2021). The Association of Gene Variants in the Vitamin D Metabolic Pathway and Its Interaction with Vitamin D on Gestational Diabetes Mellitus: A Prospective Cohort Study. Nutrients, 13.","DOI":"10.3390\/nu13124220"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8313901","DOI":"10.1155\/2019\/8313901","article-title":"VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma\u2019anshan Birth Cohort (MABC) Study","volume":"2019","author":"Zhu","year":"2019","journal-title":"J. Diabetes Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00394-022-02987-9","article-title":"Polymorphisms of haptoglobin modify the relationship between dietary iron and the risk of gestational iron-deficiency anemia","volume":"62","author":"Hu","year":"2023","journal-title":"Eur. J. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5080492","DOI":"10.1155\/2018\/5080492","article-title":"The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women","volume":"2018","author":"Meng","year":"2018","journal-title":"J. Nutr. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Si, S., Mo, M., Cheng, H., Peng, Z., Alifu, X., Zhou, H., Chi, P., Zhuang, Y., and Yu, Y. (2022). The Association of Vitamin D and Its Pathway Genes\u2019 Polymorphisms with Hypertensive Disorders of Pregnancy: A Prospective Cohort Study. Nutrients, 14.","DOI":"10.3390\/nu14112355"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/humrep\/deaa095","article-title":"Effects of MTHFR C677T polymorphism on vitamin D, homocysteine and natural killer cell cytotoxicity in women with recurrent pregnancy losses","volume":"35","author":"Ota","year":"2020","journal-title":"Hum. Reprod."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1159\/000484297","article-title":"Interactive Effects of Snps Located within CD28\/B7Pathway and Environment on Susceptibility to Recurrent Spontaneous Abortion","volume":"43","author":"Wang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Lee, S.S., Ling, K.H., Tusimin, M., Subramaniam, R., Rahim, K.F., and Loh, S.P. (2022). Interplay between Maternal and Neonatal Vitamin D Deficiency and Vitamin-D-Related Gene Polymorphism with Neonatal Birth Anthropometry. Nutrients, 14.","DOI":"10.3390\/nu14030564"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.nut.2016.10.006","article-title":"Effects of maternal genetic polymorphisms in vitamin D-binding protein and serum 25-hydroxyvitamin D concentration on infant birth weight","volume":"35","author":"Chun","year":"2017","journal-title":"Nutrition"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Aji, A.S., Lipoeto, N.I., Yusrawati, Y., Malik, S.G., Kusmayanti, N.A., Susanto, I., Nurunniyah, S., Alfiana, R.D., Wahyuningsih, W., and Majidah, N.M. (2022). Impact of maternal dietary carbohydrate intake and vitamin D-related genetic risk score on birth length: The Vitamin D Pregnant Mother (VDPM) cohort study. BMC Pregnancy Childbirth, 22.","DOI":"10.1186\/s12884-022-05020-3"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12263-014-0429-z","article-title":"Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: Their impact on newborn\u2019s anthropometric parameters","volume":"9","author":"Chen","year":"2014","journal-title":"Genes Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s40200-019-00480-5","article-title":"A genetic approach to study the relationship between maternal Vitamin D status and newborn anthropometry measurements: The Vitamin D pregnant mother (VDPM) cohort study","volume":"19","author":"Aji","year":"2020","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"111349","DOI":"10.1016\/j.nut.2021.111349","article-title":"Association of vitamin D and gene variants in the vitamin D metabolic pathway with preterm birth","volume":"89","author":"Wang","year":"2021","journal-title":"Nutrition"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"114187","DOI":"10.1016\/j.envpol.2020.114187","article-title":"Maternal serum level of manganese, single nucleotide polymorphisms, and risk of spontaneous preterm birth: A nested case-control study in China","volume":"262","author":"Hao","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wu, W.C., Lin, H.C., Liao, W.L., Tsai, Y.Y., Chen, A.C., Chen, H.C., Lin, H.Y., Liao, L.N., and Chao, P.M. (2020). FADS Genetic Variants in Taiwanese Modify Association of DHA Intake and Its Proportions in Human Milk. Nutrients, 12.","DOI":"10.3390\/nu12020543"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/dna.2009.1009","article-title":"Transforming growth factor beta-3 and environmental factors and cleft lip with\/without cleft palate","volume":"29","author":"Guo","year":"2010","journal-title":"DNA Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijcard.2020.08.018","article-title":"Association of maternal dietary intakes and CBS gene polymorphisms with congenital heart disease in offspring","volume":"322","author":"Li","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"ref_46","first-page":"1317","article-title":"MTRR 66A>G polymorphism in relation to congenital heart defects","volume":"44","author":"Kouwenberg","year":"2006","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/oxfordjournals.aje.a009555","article-title":"Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida","volume":"148","author":"Shaw","year":"1998","journal-title":"Am. J. Epidemiol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Miettinen, M.E., Smart, M.C., Kinnunen, L., Harjutsalo, V., Reinert-Hartwall, L., Ylivinkka, I., Surcel, H.M., Lamberg-Allardt, C., Hitman, G.A., and Tuomilehto, J. (2017). Genetic determinants of serum 25-hydroxyvitamin D concentration during pregnancy and type 1 diabetes in the child. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184942"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"785440","DOI":"10.3389\/fped.2021.785440","article-title":"Association of Maternal Dietary Habits and","volume":"9","author":"Song","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Luo, M., Wang, T., Huang, P., Zhang, S., Song, X., Sun, M., Liu, Y., Wei, J., Shu, J., and Zhong, T. (2022). Association and Interaction Effect of. Nutrients, 14.","DOI":"10.3390\/nu14153094"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s10552-016-0799-1","article-title":"A family-based study of gene variants and maternal folate and choline in neuroblastoma: A report from the Children\u2019s Oncology Group","volume":"27","author":"Mazul","year":"2016","journal-title":"Cancer Causes Control"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s12519-016-0054-6","article-title":"Effect of prenatal antioxidant intake on infants\u2019 respiratory infection is modified by a CD14 polymorphism","volume":"13","author":"Hong","year":"2017","journal-title":"World J. Pediatr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/aje\/kwg273","article-title":"Association between gestational diabetes and pregnancy-induced hypertension","volume":"158","author":"Bryson","year":"2003","journal-title":"Am. J. Epidemiol."},{"key":"ref_54","first-page":"850","article-title":"Gestational diabetes mellitus and lesser degrees of pregnancy hyperglycemia: Association with increased risk of spontaneous preterm birth","volume":"102","author":"Hedderson","year":"2003","journal-title":"Obstet. Gynecol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"l6398","DOI":"10.1136\/bmj.l6398","article-title":"Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring: Population based cohort study with 40 years of follow-up","volume":"367","author":"Yu","year":"2019","journal-title":"BMJ"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.diabres.2018.05.010","article-title":"Prevalence of gestational diabetes and subsequent Type 2 diabetes among U.S. women","volume":"141","author":"Casagrande","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.amjmed.2008.09.034","article-title":"Risk factors for type 2 diabetes among women with gestational diabetes: A systematic review","volume":"122","author":"Barone","year":"2009","journal-title":"Am. J. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00404-018-4857-7","article-title":"FTO, GCKR, CDKAL1 and CDKN2A\/B gene polymorphisms and the risk of gestational diabetes mellitus: A meta-analysis","volume":"298","author":"Guo","year":"2018","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","article-title":"Global causes of maternal death: A WHO systematic analysis","volume":"2","author":"Say","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0140-6736(06)68397-9","article-title":"WHO analysis of causes of maternal death: A systematic review","volume":"367","author":"Khan","year":"2006","journal-title":"Lancet"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"107.e101","DOI":"10.1016\/j.ajog.2018.04.002","article-title":"Long-term mortality risk and life expectancy following recurrent hypertensive disease of pregnancy","volume":"219","author":"Theilen","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Yu, Y. (2023). Micronutrients in Maternal and Infant Health: Where We Are and Where We Should Go. Nutrients, 15.","DOI":"10.3390\/books978-3-0365-7273-4"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e15181","DOI":"10.7717\/peerj.15181","article-title":"Association between","volume":"11","author":"Guo","year":"2023","journal-title":"PeerJ"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4103\/0300-1652.86126","article-title":"Autoantibody profile and other immunological parameters in recurrent spontaneous abortion patients","volume":"52","author":"Shankarkumar","year":"2011","journal-title":"Niger. Med. J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1182\/bloodadvances.2021004352","article-title":"Suboptimal iron deficiency screening in pregnancy and the impact of socioeconomic status in a high-resource setting","volume":"5","author":"Teichman","year":"2021","journal-title":"Blood Adv."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.clnu.2019.01.019","article-title":"Haptoglobin phenotype influences the effectiveness of diet-induced weight loss in middle-age abdominally obese women with metabolic abnormalities","volume":"39","author":"Tang","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1089\/ars.2016.6793","article-title":"Haptoglobin","volume":"26","author":"Andersen","year":"2017","journal-title":"Antioxid. Redox Signal"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.nut.2016.04.009","article-title":"Association of the FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms with maternal body weight during pregnancy","volume":"32","author":"Martins","year":"2016","journal-title":"Nutrition"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2018-00083","article-title":"Children Born Small for Gestational Age: Differential Diagnosis, Molecular Genetic Evaluation, and Implications","volume":"39","author":"Finken","year":"2018","journal-title":"Endocr. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"McCowan, L.M., Thompson, J.M., Taylor, R.S., Baker, P.N., North, R.A., Poston, L., Roberts, C.T., Simpson, N.A., Walker, J.J., and Myers, J. (2017). Prediction of Small for Gestational Age Infants in Healthy Nulliparous Women Using Clinical and Ultrasound Risk Factors Combined with Early Pregnancy Biomarkers. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0169311"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"14035","DOI":"10.1073\/pnas.1210730109","article-title":"Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development","volume":"109","author":"Lage","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Kalisch-Smith, J.I., Ved, N., and Sparrow, D.B. (2020). Environmental Risk Factors for Congenital Heart Disease. Cold Spring Harb. Perspect. Biol., 12.","DOI":"10.1101\/cshperspect.a037234"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"109050","DOI":"10.1016\/j.diabres.2021.109050","article-title":"IDF Diabetes Atlas: Estimation of Global and Regional Gestational Diabetes Mellitus Prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group\u2019s Criteria","volume":"183","author":"Wang","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.abb.2012.04.001","article-title":"Where is the vitamin D receptor?","volume":"523","author":"Wang","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Voltan, G., Cannito, M., Ferrarese, M., Ceccato, F., and Camozzi, V. (2023). Vitamin D: An Overview of Gene Regulation, Ranging from Metabolism to Genomic Effects. Genes, 14.","DOI":"10.3390\/genes14091691"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1177\/15648265080292S112","article-title":"Gene-nutrient interactions: Importance of folic acid and vitamin B12 during early embryogenesis","volume":"29","author":"Finnell","year":"2008","journal-title":"Food Nutr. Bull."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/cga.12232","article-title":"Genetic polymorphisms and folate status","volume":"57","author":"Hiraoka","year":"2017","journal-title":"Congenit. Anom."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s10552-012-0004-0","article-title":"Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: The ESCALE study (SFCE)","volume":"23","author":"Amigou","year":"2012","journal-title":"Cancer Causes Control"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/sj.ejcn.1602810","article-title":"Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women","volume":"62","author":"Barbosa","year":"2008","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.gene.2013.09.063","article-title":"Folate: Metabolism, genes, polymorphisms and the associated diseases","volume":"533","author":"Nazki","year":"2014","journal-title":"Gene"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/1471-0528.13202","article-title":"Effectiveness of folic acid supplementation in pregnancy on reducing the risk of small-for-gestational age neonates: A population study, systematic review and meta-analysis","volume":"122","author":"Hodgetts","year":"2015","journal-title":"Int. J. Obstet. Gynaecol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/MBC.0b013e328344f80f","article-title":"Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies","volume":"22","author":"Klai","year":"2011","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3945\/ajcn.111.016212","article-title":"Maternal homocysteine and small-for-gestational-age offspring: Systematic review and meta-analysis","volume":"95","author":"Hogeveen","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1017\/S0007114515003980","article-title":"Early pregnancy vitamin D status and risk for adverse maternal and infant outcomes in a bi-ethnic cohort: The Behaviors Affecting Baby and You (B.A.B.Y.) Study","volume":"114","author":"Nobles","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1017\/S000711451000022X","article-title":"Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: Results of the multi-ethnic Amsterdam Born Children and their Development cohort","volume":"104","author":"Leffelaar","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1210\/jc.2014-4407","article-title":"Maternal vitamin D deficiency during pregnancy elevates the risks of small for gestational age and low birth weight infants in Chinese population","volume":"100","author":"Chen","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0361-9230(01)00456-7","article-title":"Manganese toxicity is associated with mitochondrial dysfunction and DNA fragmentation in rat primary striatal neurons","volume":"55","author":"Malecki","year":"2001","journal-title":"Brain Res. Bull."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"7580707","DOI":"10.1155\/2018\/7580707","article-title":"The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions","volume":"2018","author":"Li","year":"2018","journal-title":"Oxidative Med. Cell Longev."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.freeradbiomed.2013.01.032","article-title":"Manganese neurotoxicity and the role of reactive oxygen species","volume":"62","author":"Gavin","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jtemb.2009.02.005","article-title":"Antioxidants activities and concentration of selenium, zinc and copper in preterm and IUGR human placentas","volume":"23","author":"Zadrozna","year":"2009","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.siny.2010.04.001","article-title":"Maturation of the antioxidant system and the effects on preterm birth","volume":"15","author":"Davis","year":"2010","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e23376","DOI":"10.1002\/jcla.23376","article-title":"Association between variants in vitamin D-binding protein gene and vitamin D deficiency among pregnant women in china","volume":"34","author":"Dong","year":"2020","journal-title":"J. Clin. Lab. 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