{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:03:26Z","timestamp":1791396206101,"version":"4.3.3"},"reference-count":53,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Research Projects in Health","award":["PI18\/00834"],"award-info":[{"award-number":["PI18\/00834"]}]},{"name":"Spanish Research Projects in Health","award":["RD21\/0012\/0009"],"award-info":[{"award-number":["RD21\/0012\/0009"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III (ISCIII)\u2014the State Plan for Scientific and Technical Research and Innovation-","doi-asserted-by":"publisher","award":["PI18\/00834"],"award-info":[{"award-number":["PI18\/00834"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III (ISCIII)\u2014the State Plan for Scientific and Technical Research and Innovation-","doi-asserted-by":"publisher","award":["RD21\/0012\/0009"],"award-info":[{"award-number":["RD21\/0012\/0009"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"RICORS SAMID \u201cMaternal and Child Health and Development Network\u201d","award":["PI18\/00834"],"award-info":[{"award-number":["PI18\/00834"]}]},{"name":"RICORS SAMID \u201cMaternal and Child Health and Development Network\u201d","award":["RD21\/0012\/0009"],"award-info":[{"award-number":["RD21\/0012\/0009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Nosocomial infections are a frequent and serious problem in extremely low birth weight (ELBW) infants. Donor human milk (DHM) is the best alternative for feeding these babies when mother\u2019s own milk (MOM) is not available. Recently, a patented prototype of a High-Temperature Short-Time (HTST) pasteurizer adapted to a human milk bank setting showed a lesser impact on immunologic components. We designed a multicentre randomized controlled trial that investigates whether, in ELBW infants with an insufficient MOM supply, the administration of HTST pasteurized DHM reduces the incidence of confirmed catheter-associated sepsis compared to DHM pasteurized with the Holder method. From birth until 34 weeks postmenstrual age, patients included in the study received DHM, as a supplement, pasteurized by the Holder or HTST method. A total of 213 patients were randomized; 79 (HTST group) and 81 (Holder group) were included in the analysis. We found no difference in the frequency of nosocomial sepsis between the patients of the two methods\u201441.8% (33\/79) of HTST group patients versus 45.7% (37\/81) of Holder group patients, relative risk 0.91 (0.64\u20131.3), p = 0.62. In conclusion, when MOM is not available, supplementing during admission with DHM pasteurized by the HTST versus Holder method might not have an impact on the incidence of catheter-associated sepsis.<\/jats:p>","DOI":"10.3390\/nu16071090","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T09:31:23Z","timestamp":1712568683000},"page":"1090","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Impact of Supplementation with Pasteurized Donor Human Milk by High-Temperature Short-Time Method versus Holder Method in Extremely Low Birth Weight Infants: A Multicentre Randomized Controlled Trial"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0541-3870","authenticated-orcid":false,"given":"Nadia Raquel","family":"Garc\u00eda-Lara","sequence":"first","affiliation":[{"name":"Department of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Aladina-MGU-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Escuder-Vieco","sequence":"additional","affiliation":[{"name":"Aladina-MGU-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cabrera-Lafuente","sequence":"additional","affiliation":[{"name":"Department of Neonatology, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Institute for Health Research\u2013IdiPaz, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Keller","sequence":"additional","affiliation":[{"name":"Aladina-MGU-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"De Diego-Poncela","sequence":"additional","affiliation":[{"name":"Department of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Aladina-MGU-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Jim\u00e9nez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Neonatology, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Institute for Health Research\u2013IdiPaz, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-0420","authenticated-orcid":false,"given":"Raquel","family":"N\u00fa\u00f1ez-Ramos","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nutrition, 12 de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Flores-Ant\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Aladina-MGU-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Escribano-Palomino","sequence":"additional","affiliation":[{"name":"Department of Neonatology, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Institute for Health Research\u2013IdiPaz, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Alonso-D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Aladina-MGU-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"V\u00e1zquez-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Aladina-MGU-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-1836","authenticated-orcid":false,"given":"Noelia","family":"Ureta-Velasco","sequence":"additional","affiliation":[{"name":"Department of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Aladina-MGU-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier De La","family":"Cruz-B\u00e9rtolo","sequence":"additional","affiliation":[{"name":"Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Clinical Research Platform IC+12, Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Rosa","family":"Pall\u00e1s-Alonso","sequence":"additional","affiliation":[{"name":"Department of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Aladina-MGU-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/S0378-3782(12)70019-1","article-title":"Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units","volume":"88","author":"Hornik","year":"2012","journal-title":"Early Hum. 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