{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:59:08Z","timestamp":1789750748217,"version":"4.0.1"},"reference-count":35,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: In recent years, whole blood parameters and derivatives have been used as prognostic criteria in the course of various diseases. The aim of this study was to evaluate the relationship between parameters such as the neutrophil\u2013lymphocyte ratio (NLR), the systemic immune-inflammation index (SII), the prognostic nutritional index (PNI), controlling nutritional status (CONUT) score, nutritional risk index (NRI) and immunonutrition status and disease activity in patients with ischemic stroke of the small-vessel, large-vessel and other etiologies. Methods: We retrospectively evaluated the records of 1454 consecutive ischemic stroke patients hospitalized in the emergency department of Gaziosmanpasa Education and Research Hospital from 2019 to 2023. Results: Of the 1350 patients with ischemic stroke included in the study, 58.8% had small-vessel disease, 29.3% had large-vessel disease and 11.9% had other etiologies. There was a significant difference between the three etiology groups for PNI and CONUT. The mean of PNI was 47.30 \u00b1 8.06 in the other etiology group, 37.25 \u00b1 7.23 in the small-vessel group, and 34.78 \u00b1 8.16 in the large-vessel disease group. The mean of CONUT was 5.49 \u00b1 1.20 in the small-vessel group, 5.12 \u00b1 1.46 in the large-vessel group and 4.22 \u00b1 1.11 in the other etiology group. In addition, CONUT and PNI were also found to be independent risk factors for mortality. A negative significant correlation was observed between PNI and NLR (r: \u22120.692), SII (r: \u22120.591), and CONUT (r: \u22120.511). Significant correlations were observed between CONUT and NLR (r: 0.402), SII (r: 0.312). Conclusions: PNI, CONUT and NRI were found as more accurate prognostic indicators of nutritional status in patients with ischemic stroke. NLR and SII may be important predictive markers in the course and prognosis of stroke.<\/jats:p>","DOI":"10.3390\/nu16081225","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T03:57:07Z","timestamp":1713758227000},"page":"1225","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Relationship between Neutrophil\u2013Lymphocyte Ratios with Nutritional Status, Risk of Nutritional Indices, Prognostic Nutritional Indices and Morbidity in Patients with Ischemic Stroke"],"prefix":"10.3390","volume":"16","author":[{"given":"Naile Fevziye","family":"Misirlioglu","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Gaziosmanpa\u015fa Training and Research Hospital, University of Health Sciences, Istanbul 34098, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9593-5869","authenticated-orcid":false,"given":"Nedim","family":"Uzun","sequence":"additional","affiliation":[{"name":"Department of Emergency, Gaziosmanpa\u015fa Training and Research Hospital, University of Health Sciences, Istanbul 34098, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulenay Defne","family":"Ozen","sequence":"additional","affiliation":[{"name":"Department of Psychology, McGill University, Montreal, QC H3A 1G1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"\u00c7alik","sequence":"additional","affiliation":[{"name":"Department of Emergency, Gaziosmanpa\u015fa Training and Research Hospital, University of Health Sciences, Istanbul 34098, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ertugrul","family":"Altinbilek","sequence":"additional","affiliation":[{"name":"Department of Emergency, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Sciences, Istanbul 34098, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necmettin","family":"Sutasir","sequence":"additional","affiliation":[{"name":"Department of Emergency, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Sciences, Istanbul 34098, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-5501","authenticated-orcid":false,"given":"Sena","family":"Baykara Sayili","sequence":"additional","affiliation":[{"name":"Emergency Department, Istanbul Training and Research Hospital, Istanbul 34075, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-8498","authenticated-orcid":false,"given":"Hafize","family":"Uzun","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Istanbul Atlas University, Istanbul 34403, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,20]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021). Cardiovascular Diseases (CVDs) Fact Sheets, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0140-6736(16)30506-2","article-title":"Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): A case-control study","volume":"388","author":"Chin","year":"2016","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/0141076816680121","article-title":"The definition of stroke","volume":"110","author":"Coupland","year":"2017","journal-title":"J. R. Soc. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart disease and stroke statistics\u20142018 update: A report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.clnu.2016.06.028","article-title":"Malnutrition risk predicts recovery of full oral intake among older adult stroke undergoing enteral nutrition: Secondary analysis of a multicentre survey (the APPLE patients study)","volume":"36","author":"Nishioka","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0002-9610(80)90246-9","article-title":"Prognostic nutritional index in gastrointestinal surgery","volume":"139","author":"Buzby","year":"1980","journal-title":"Am. J. Surg."},{"key":"ref_7","first-page":"38","article-title":"CONUT: A tool for controlling nutritional status. First validation in a hospital population","volume":"20","author":"Mancha","year":"2005","journal-title":"Nutr. Hosp."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1232557","DOI":"10.3389\/fneur.2023.1232557","article-title":"Elevated white blood cell counts in ischemic stroke patients are associated with increased mortality and new vascular events","volume":"14","author":"Vo","year":"2023","journal-title":"Front. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e17986","DOI":"10.1016\/j.heliyon.2023.e17986","article-title":"Neuroinflammation and anti-inflammatory therapy for ischemic stroke","volume":"9","author":"Cao","year":"2023","journal-title":"Heliyon"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.2147\/JIR.S399021","article-title":"Circulating Leukocyte as an Inflammatory Biomarker: Association with Fibrinogen and Neuronal Damage in Acute Ischemic Stroke","volume":"16","author":"Han","year":"2023","journal-title":"J. Inflamm. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.amjcard.2009.09.007","article-title":"Usefulness of neutrophil\/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting","volume":"105","author":"Gibson","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_12","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec","year":"2001","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jcla.21639","article-title":"Neutrophil to lymphocyte ratio predicts poor prognosis in ischemic cerebrovascular disease","volume":"28","author":"Celikbilek","year":"2014","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_14","first-page":"653","article-title":"Neutrophil lymphocyte ratios in stroke subtypes and transient ischemic attack","volume":"17","author":"Gokhan","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.04.007","article-title":"Is neutrophil\/lymphocyte ratio predict to short-term mortality in acute cerebral infarct independently from infarct volume?","volume":"23","author":"Tokgoz","year":"2014","journal-title":"J. Stroke Cerebrovasc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1161\/STROKEAHA.113.004099","article-title":"Homocysteine as a predictor of early neurological deterioration in acute ischemic stroke","volume":"45","author":"Kwon","year":"2014","journal-title":"Stroke"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.1158\/1078-0432.CCR-14-0442","article-title":"Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma","volume":"20","author":"Hu","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_19","first-page":"1001","article-title":"Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients","volume":"85","author":"Onodera","year":"1984","journal-title":"Nihon Geka Gakkai Zasshi"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Nishikawa, H., Yoh, K., Enomoto, H., Ishii, N., Iwata, Y., Takata, R., Nishimura, T., Aizawa, N., Sakai, Y., and Ikeda, N. (2018). The Relationship between Controlling Nutritional (CONUT) Score and Clinical Markers among Adults with Hepatitis C Virus Related Liver Cirrhosis. Nutrients, 10.","DOI":"10.3390\/nu10091185"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Iseki, Y., Shibutani, M., Maeda, K., Nagahara, H., Ohtani, H., Sugano, K., Ikeya, T., Muguruma, K., Tanaka, H., and Toyokawa, T. (2015). Impact of the Preoperative Controlling Nutritional Status (CONUT) Score on the Survival after Curative Surgery for Colorectal Cancer. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0132488"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Bo, Y., Wang, K., Liu, Y., You, J., Cui, H., Zhu, Y., Lu, Q., and Yuan, L. (2016). The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155903"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.amjcard.2011.12.026","article-title":"Predicting Outcome in Patients With Left Ventricular Systolic Chronic Heart Failure Using a Nutritional Risk Index","volume":"109","author":"Clark","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2374289520901817","DOI":"10.1177\/2374289520901817","article-title":"Educational Case: Etiologies, Mechanisms, and Treatment of Stroke","volume":"7","author":"Velez","year":"2020","journal-title":"Acad. Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e2250233","DOI":"10.1002\/eji.202250233","article-title":"Macrophage and monocyte subsets in response to ischemic stroke","volume":"53","author":"Mass","year":"2023","journal-title":"Eur. J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1212\/WNL.0000000000009179","article-title":"Analysis of the association of MPO and MMP-9 with stroke severity and outcome: Cohort study","volume":"95","author":"Maestrini","year":"2020","journal-title":"Neurology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Agard, T.A., Hass, R., Cavrak, M.E., Foual, N.S., Byrum, C., Adcock, A.K., Gehan, D., and Petrone, A.B. (2023). Neutrophil lymphocyte ratio (NLR) and systemic immune inflammatory index (SII) for the differential diagnosis of CT-negative mild acute ischemic stroke and transient ischemic attack. Int. J. Neurosci., 1\u20138.","DOI":"10.1080\/00207454.2023.2171877"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pneurobio.2017.10.001","article-title":"Blood-brain barrier dysfunction and recovery after ischemic stroke","volume":"163\u2013164","author":"Jiang","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12974-019-1516-2","article-title":"Neuroinflammation: Friend and foe for ischemic stroke","volume":"16","author":"Jayaraj","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1016\/j.clnu.2021.04.018","article-title":"Association between malnutrition and long-term mortality in older adults with ischemic stroke","volume":"40","author":"Yuan","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.jacc.2020.06.058","article-title":"Prevalence and Prognostic Significance of Malnutrition in Patients With Acute Coronary Syndrome","volume":"76","author":"Pardal","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/00033197211040365","article-title":"Prognostic Value of 3 Nutritional Screening Tools to Predict 30-Day Outcome in Patients Undergoing Carotid Artery Stenting","volume":"73","author":"Efe","year":"2022","journal-title":"Angiology"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Han, X., Cai, J., Li, Y., Rong, X., Li, Y., He, L., Li, H., Liang, Y., Huang, H., and Xu, Y. (2022). Baseline Objective Malnutritional Indices as Immune-Nutritional Predictors of Long-Term Recurrence in Patients with Acute Ischemic Stroke. Nutrients, 14.","DOI":"10.3390\/nu14071337"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Di Vincenzo, O., Pagano, E., Cervone, M., Natale, R., Morena, A., Esposito, A., Pasanisi, F., and Scalfi, L. (2023). High Nutritional Risk Is Associated with Poor Functional Status and Prognostic Biomarkers in Stroke Patients at Admission to a Rehabilitation Unit. Nutrients, 15.","DOI":"10.3390\/nu15194144"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Gheri, C.F., Scalfi, L., Biffi, B., Pancani, S., Madiai, S., Di Vincenzo, O., Ghaderi, M., Celoni, R., Dalladonna, M., and Draghi, F. (2023). Relationship between Nutritional Risk, Clinical and Demographic Characteristics, and Pressure Ulcers in Patients with Severe Acquired Brain Injuries Attending a Rehabilitative Program. Nutrients, 15.","DOI":"10.3390\/nu15153336"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/8\/1225\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:31:25Z","timestamp":1760106685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/8\/1225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,20]]},"references-count":35,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["nu16081225"],"URL":"https:\/\/doi.org\/10.3390\/nu16081225","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,20]]}}}