{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:08:14Z","timestamp":1793192894905,"version":"4.5.0"},"reference-count":49,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","doi-asserted-by":"publisher","award":["7173\/2021"],"award-info":[{"award-number":["7173\/2021"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Bras\u00edlia DPI\/COPEI","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"University of Bras\u00edlia DPI\/COPEI","award":["7173\/2021"],"award-info":[{"award-number":["7173\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Populational aging is marked by chronic noncommunicable diseases, such as metabolic syndrome (MetS). IL-10 and IL-1\u03b2 are pleiotropic cytokines with multiple biological effects linked to metabolic disorders. This cross-sectional study assessed 193 participants\u2019 IL-10 and IL-1\u03b2 serum levels regarding their role in developing MetS, clinical characteristics, and their IL1B rs1143627 and IL10 rs1800890 variants\u2019 genotype frequencies in a population over 60. IL-10 levels correlated weakly with HDL levels and fat mass and inversely with triglycerides, glucose, glycated hemoglobin, and estimated average blood glucose levels. IL-10 levels were also indirectly influenced by the patient\u2019s T2DM duration, lean mass amount, and bone mineral content. Participants with altered HDL, elevated serum glucose, raised HbA1c levels, or those over 80 had reduced serum IL-10 levels compared to those with normal levels or other age groups, respectively. Women also had higher serum IL-10 levels than men. Dissimilarly, IL-1\u03b2 levels correlated directly only with the number of total leukocytes and segmented neutrophils, showing only significant variations with self-reported alcohol consumption. Our study also found that those with the IL10 AA genotype (lower IL-10 levels) had a significantly higher risk of developing MetS. These findings may help direct future research and more targeted therapeutic approaches in older adults.<\/jats:p>","DOI":"10.3390\/nu16081241","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T03:57:07Z","timestamp":1713758227000},"page":"1241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["IL-10 and IL-1\u03b2 Serum Levels, Genetic Variants, and Metabolic Syndrome: Insights into Older Adults\u2019 Clinical Characteristics"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3563-6415","authenticated-orcid":false,"given":"Renata de Souza","family":"Freitas","sequence":"first","affiliation":[{"name":"Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasilia, Federal District, Bras\u00edlia 72220-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-0735","authenticated-orcid":false,"given":"Calliandra Maria","family":"de Souza Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences and Technologies, Faculty of Ceil\u00e2ndia, University of Bras\u00edlia, Federal District, Bras\u00edlia 72220-900, Brazil"},{"name":"Faculty of Ceil\u00e2ndia, University of Brasilia, Federal District, Bras\u00edlia 72220-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-9452","authenticated-orcid":false,"given":"Caroline","family":"Ferreira Fratelli","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences and Technologies, Faculty of Ceil\u00e2ndia, University of Bras\u00edlia, Federal District, Bras\u00edlia 72220-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Ramos de Lima","sequence":"additional","affiliation":[{"name":"Faculty of Ceil\u00e2ndia, University of Brasilia, Federal District, Bras\u00edlia 72220-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Morato Stival","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences and Technologies, Faculty of Ceil\u00e2ndia, University of Bras\u00edlia, Federal District, Bras\u00edlia 72220-900, Brazil"},{"name":"Faculty of Ceil\u00e2ndia, University of Brasilia, Federal District, Bras\u00edlia 72220-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9332-9029","authenticated-orcid":false,"given":"Silvana","family":"Schwerz Funghetto","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences and Technologies, Faculty of Ceil\u00e2ndia, University of Bras\u00edlia, Federal District, Bras\u00edlia 72220-900, Brazil"},{"name":"Faculty of Ceil\u00e2ndia, University of Brasilia, Federal District, Bras\u00edlia 72220-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6836-3583","authenticated-orcid":false,"given":"Izabel Cristina","family":"Rodrigues da Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences and Technologies, Faculty of Ceil\u00e2ndia, University of Bras\u00edlia, Federal District, Bras\u00edlia 72220-900, Brazil"},{"name":"Faculty of Ceil\u00e2ndia, University of Brasilia, Federal District, Bras\u00edlia 72220-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ros\u00e2ngela","family":"Vieira de Andrade","sequence":"additional","affiliation":[{"name":"Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasilia, Federal District, Bras\u00edlia 72220-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"ref_1","unstructured":"(2023, April 01). 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