{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:39:20Z","timestamp":1790959160490,"version":"4.1.0"},"reference-count":70,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(1) Background: Gastric cancer is a significant cause of cancer-related mortality worldwide. Weight loss and malnutrition associated with cancer are linked with increased mortality rates and reduced quality of life. Cancer cachexia, characterised by the loss of skeletal muscle, is associated with approximately 20% of cancer-related deaths and differs from malnutrition in that it cannot be fully reversed by nutritional support alone. It is now recognised that the primary pathophysiological process underlying cancer cachexia is chronic inflammation leading to increased calorie consumption. Current treatments that focus on nutritional supplementation, psychological counselling, appetite stimulation and reducing inflammation are lacking in efficacy. This review focuses on the evidence supporting the potential roles of natural anti-inflammatory products and their derivatives including fatty acids, probiotics, amino acids, curcumin, fucoidan, epigallocatechin-3-gallate, ginger, resveratrol and Boswellia serrata in the management of gastric cancer cachexia. (2) Results: While natural anti-inflammatory products show promise in a number of in vitro and in vivo studies, there are only a small number of human studies available. Where present, the evidence base is heterogeneous, with varying study methodologies and outcomes. (3) Conclusions: Natural anti-inflammatory products represent a potential adjunctive therapy for gastric cancer cachexia. Further research, particularly well-designed clinical trials, is needed to elucidate their optimal role, dosing and safety profiles in the management of gastric cancer cachexia.<\/jats:p>","DOI":"10.3390\/nu16081246","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T06:10:18Z","timestamp":1713766218000},"page":"1246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Treatment of Cachexia in Gastric Cancer: Exploring the Use of Anti-Inflammatory Natural Products and Their Derivatives"],"prefix":"10.3390","volume":"16","author":[{"given":"Jerocin Vishani","family":"Loyala","sequence":"first","affiliation":[{"name":"Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2GW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billy","family":"Down","sequence":"additional","affiliation":[{"name":"High Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe HP11 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-4768","authenticated-orcid":false,"given":"Enoch","family":"Wong","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2GW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13045-023-01451-3","article-title":"Gastric Cancer Treatment: Recent Progress and Future Perspectives","volume":"16","author":"Guan","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Conti, C.B., Agnesi, S., Scaravaglio, M., Masseria, P., Dinelli, M.E., Oldani, M., and Uggeri, F. (2023). Early Gastric Cancer: Update on Prevention, Diagnosis and Treatment. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20032149"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mocan, L. (2021). Surgical Management of Gastric Cancer: A Systematic Review. J. Clin. Med., 10.","DOI":"10.3390\/jcm10122557"},{"key":"ref_4","unstructured":"(2024, February 11). Stomach Cancer Survival Rates and Statistics\u2014NCI, Available online: https:\/\/www.cancer.gov\/types\/stomach\/survival."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.2217\/fon-2021-0186","article-title":"Role of Nutritional Care and General Guidance for Patients with Advanced or Metastatic Gastric Cancer","volume":"17","author":"Mizukami","year":"2021","journal-title":"Future Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-Associated Cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1007\/s11864-022-01028-1","article-title":"Understanding Cancer Cachexia and Its Implications in Upper Gastrointestinal Cancers","volume":"23","author":"Brown","year":"2022","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.2147\/CMAR.S261585","article-title":"Cancer Cachexia: Definition, Staging, and Emerging Treatments","volume":"12","author":"Ni","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_9","unstructured":"(2024, March 03). Definition and Classification of Cancer Cachexia: An International Consensus\u2014The Lancet Oncology. Available online: https:\/\/www.thelancet.com\/journals\/lanonc\/article\/PIIS1470-2045(10)70218-7\/abstract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and Classification of Cancer Cachexia: An International Consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Braha, A., Albai, A., Timar, B., Negru, \u0218., Sorin, S., Roman, D., and Popovici, D. (2022). Nutritional Interventions to Improve Cachexia Outcomes in Cancer-A Systematic Review. Medicina, 58.","DOI":"10.3390\/medicina58070966"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/SPC.0000000000000016","article-title":"Nutritional Counseling and Nutritional Supplements: A Cornerstone of Multidisciplinary Cancer Care for Cachectic Patients","volume":"7","author":"Isenring","year":"2013","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Panebianco, C., Villani, A., Potenza, A., Favaro, E., Finocchiaro, C., Perri, F., and Pazienza, V. (2023). Targeting Gut Microbiota in Cancer Cachexia: Towards New Treatment Options. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24031849"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.33590\/emjgastroenterol\/20-00181","article-title":"Editor\u2019s Pick: Cachexia in Patients with Gastrointestinal Cancers: Contributing Factors, Prevention, and Current Management Approaches","volume":"9","author":"Grundmann","year":"2020","journal-title":"EMJ Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.6004\/jnccn.2020.7615","article-title":"Cachexia and Dietetic Interventions in Patients With Esophagogastric Cancer: A Multicenter Cohort Study","volume":"19","author":"Dijksterhuis","year":"2021","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1200\/JCO.20.00611","article-title":"Management of Cancer Cachexia: ASCO Guideline","volume":"38","author":"Roeland","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Herremans, K.M., Riner, A.N., Cameron, M.E., and Trevino, J.G. (2019). The Microbiota and Cancer Cachexia. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246267"},{"key":"ref_18","first-page":"7","article-title":"Nutritional and Botanical Modulation of the Inflammatory Cascade\u2014Eicosanoids, Cyclooxygenases, and Lipoxygenases\u2014As an Adjunct in Cancer Therapy","volume":"1","author":"Wallace","year":"2002","journal-title":"Integr. Cancer Ther."},{"key":"ref_19","unstructured":"(2024, February 13). Office of Dietary Supplements\u2014Dietary Supplements: What You Need to Know, Available online: https:\/\/ods.od.nih.gov\/factsheets\/WYNTK-Consumer\/."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Han, Y., Kim, H.I., and Park, J. (2023). The Role of Natural Products in the Improvement of Cancer-Associated Cachexia. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108772"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/07315724.2002.10719248","article-title":"Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases","volume":"21","author":"Simopoulos","year":"2002","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.2174\/138161209788168155","article-title":"Probiotics, Immune Function, Infection and Inflammation: A Review of the Evidence from Studies Conducted in Humans","volume":"15","author":"Lomax","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert Consensus Document. The International Scientific Association for Probiotics and Prebiotics Consensus Statement on the Scope and Appropriate Use of the Term Probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Carbone, J.W., and Pasiakos, S.M. (2019). Dietary Protein and Muscle Mass: Translating Science to Application and Health Benefit. Nutrients, 11.","DOI":"10.3390\/nu11051136"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1017\/S0029665111000024","article-title":"Efficacy and Consequences of Very-High-Protein Diets for Athletes and Exercisers","volume":"70","author":"Tipton","year":"2011","journal-title":"Proc. Nutr. Soc."},{"key":"ref_26","first-page":"4781","article-title":"Analysis of the Tumoricidal and Anti-Cachectic Potential of Curcumin","volume":"34","author":"Oelkrug","year":"2014","journal-title":"Anticancer Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Wu, C.-J., Yeh, T.-P., Wang, Y.-J., Hu, H.-F., Tsay, S.-L., and Liu, L.-C. (2022). Effectiveness of Fucoidan on Supplemental Therapy in Cancer Patients: A Systematic Review. Healthcare, 10.","DOI":"10.3390\/healthcare10050923"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1038\/s41598-017-05278-0","article-title":"Fish Oil-Enriched Nutrition Combined with Systemic Chemotherapy for Gastrointestinal Cancer Patients with Cancer Cachexia","volume":"7","author":"Shirai","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.canlet.2011.02.023","article-title":"Epigallocatechin-3-Gallate Effectively Attenuates Skeletal Muscle Atrophy Caused by Cancer Cachexia","volume":"305","author":"Wang","year":"2011","journal-title":"Cancer Lett."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1007\/s00520-019-05129-w","article-title":"The Effect of Ginger (Zingiber Officinale Roscoe) in Patients with Advanced Cancer","volume":"28","author":"Bhargava","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jcsm.13120","article-title":"Capsaicin Alleviates Cisplatin-induced Muscle Loss and Atrophy in Vitro and in Vivo","volume":"14","author":"Huang","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Yoon, S.L., and Grundmann, O. (2023). Relevance of Dietary Supplement Use in Gastrointestinal-Cancer-Associated Cachexia. Nutrients, 15.","DOI":"10.3390\/nu15153391"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Coniglio, S., Shumskaya, M., and Vassiliou, E. (2023). Unsaturated Fatty Acids and Their Immunomodulatory Properties. Biology, 12.","DOI":"10.3390\/biology12020279"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1042\/BST20160474","article-title":"Omega-3 Fatty Acids and Inflammatory Processes: From Molecules to Man","volume":"45","author":"Calder","year":"2017","journal-title":"Biochem. Soc. Trans."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.nut.2004.05.026","article-title":"Impact of Fish Oil and Melatonin on Cachexia in Patients with Advanced Gastrointestinal Cancer: A Randomized Pilot Study","volume":"21","author":"Persson","year":"2005","journal-title":"Nutrition"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Aquila, G., Re Cecconi, A.D., Brault, J.J., Corli, O., and Piccirillo, R. (2020). Nutraceuticals and Exercise against Muscle Wasting during Cancer Cachexia. Cells, 9.","DOI":"10.3390\/cells9122536"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/cncr.20362","article-title":"Phase II Study of High-Dose Fish Oil Capsules for Patients with Cancer-Related Cachexia","volume":"101","author":"Burns","year":"2004","journal-title":"Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/sj.embor.7400731","article-title":"The Gut Flora as a Forgotten Organ","volume":"7","author":"Shanahan","year":"2006","journal-title":"EMBO Rep."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"R\u00edos-Covi\u00e1n, D., Ruas-Madiedo, P., Margolles, A., Gueimonde, M., De Los Reyes-Gavil\u00e1n, C.G., and Salazar, N. (2016). Intestinal Short Chain Fatty Acids and Their Link with Diet and Human Health. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00185"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1089\/jir.2013.0020","article-title":"The Altered Tight Junctions: An Important Gateway of Bacterial Translocation in Cachexia Patients with Advanced Gastric Cancer","volume":"34","author":"Jiang","year":"2014","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Huang, F., Li, S., Chen, W., Han, Y., Yao, Y., Yang, L., Li, Q., Xiao, Q., Wei, J., and Liu, Z. (2023). Postoperative Probiotics Administration Attenuates Gastrointestinal Complications and Gut Microbiota Dysbiosis Caused by Chemotherapy in Colorectal Cancer Patients. Nutrients, 15.","DOI":"10.3390\/nu15020356"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zaharuddin, L., Mokhtar, N.M., Muhammad Nawawi, K.N., and Raja Ali, R.A. (2019). A Randomized Double-Blind Placebo-Controlled Trial of Probiotics in Post-Surgical Colorectal Cancer. BMC Gastroenterol., 19.","DOI":"10.1186\/s12876-019-1047-4"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11803","DOI":"10.18632\/oncotarget.7730","article-title":"Beneficial Bacteria Inhibit Cachexia","volume":"7","author":"Varian","year":"2016","journal-title":"Oncotarget"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1038\/ismej.2015.209","article-title":"Synbiotic Approach Restores Intestinal Homeostasis and Prolongs Survival in Leukaemic Mice with Cachexia","volume":"10","author":"Bindels","year":"2016","journal-title":"ISME J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1093\/annonc\/mdu106","article-title":"The Efficacy and Safety of Probiotics in People with Cancer: A Systematic Review","volume":"25","author":"Redman","year":"2014","journal-title":"Ann. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.clnu.2011.05.008","article-title":"Muscle Protein Synthesis in Cancer Patients Can Be Stimulated with a Specially Formulated Medical Food","volume":"30","author":"Deutz","year":"2011","journal-title":"Clin. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Johal, J., Han, C.Y., Joseph, R., Munn, Z., Agbejule, O.A., Crawford-Williams, F., Wallen, M.P., Chan, R.J., and Hart, N.H. (2022). Dietary Supplements in People with Metastatic Cancer Who Are Experiencing Malnutrition, Cachexia, Sarcopenia, and Frailty: A Scoping Review. Nutrients, 14.","DOI":"10.3390\/nu14132642"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Cencioni, C., Trestini, I., Piro, G., Bria, E., Tortora, G., Carbone, C., and Spallotta, F. (2022). Gastrointestinal Cancer Patient Nutritional Management: From Specific Needs to Novel Epigenetic Dietary Approaches. Nutrients, 14.","DOI":"10.3390\/nu14081542"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/jnci\/88.8.550","article-title":"Effects of Administration of Oral Branched-Chain Amino Acids on Anorexia and Caloric Intake in Cancer Patients","volume":"88","author":"Cangiano","year":"1996","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"(2024, February 11). Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action. Available online: https:\/\/www.hindawi.com\/journals\/jnme\/2012\/136937\/.","DOI":"10.1155\/2012\/136937"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/1097-0142(19860701)58:1<147::AID-CNCR2820580126>3.0.CO;2-I","article-title":"Improved Protein Kinetics and Albumin Synthesis by Branched Chain Amino Acid-Enriched Total Parenteral Nutrition in Cancer Cachexia. A Prospective Randomized Crossover Trial","volume":"58","author":"Tayek","year":"1986","journal-title":"Cancer"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ragni, M., Fornelli, C., Nisoli, E., and Penna, F. (2022). Amino Acids in Cancer and Cachexia: An Integrated View. Cancers, 14.","DOI":"10.3390\/cancers14225691"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.31557\/APJCP.2022.23.7.2333","article-title":"A Double-Blind, Placebo-Controlled Randomized Phase IIa Study: Evaluating the Effect of Curcumin for Treatment of Cancer Anorexia\u2013Cachexia Syndrome in Solid Cancer Patients","volume":"23","author":"Chaiworramukkul","year":"2022","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Stohs, S.J., Chen, O., Ray, S.D., Ji, J., Bucci, L.R., and Preuss, H.G. (2020). Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review. Molecules, 25.","DOI":"10.3390\/molecules25061397"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s00280-013-2151-8","article-title":"A Phase I Study Investigating the Safety and Pharmacokinetics of Highly Bioavailable Curcumin (Theracurmin) in Cancer Patients","volume":"71","author":"Kanai","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_56","first-page":"2895","article-title":"Phase I Clinical Trial of Curcumin, a Chemopreventive Agent, in Patients with High-Risk or Pre-Malignant Lesions","volume":"21","author":"Cheng","year":"2001","journal-title":"Anticancer Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Li, W., Swiderski, K., Murphy, K.T., and Lynch, G.S. (2022). Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia. Antioxidants, 11.","DOI":"10.3390\/antiox11020183"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Anisha, G.S., Padmakumari, S., Patel, A.K., Pandey, A., and Singhania, R.R. (2022). Fucoidan from Marine Macroalgae: Biological Actions and Applications in Regenerative Medicine, Drug Delivery Systems and Food Industry. Bioengineering, 9.","DOI":"10.3390\/bioengineering9090472"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Wang, Y., Xing, M., Cao, Q., Ji, A., Liang, H., and Song, S. (2019). Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies. Mar. Drugs, 17.","DOI":"10.3390\/md17030183"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.4236\/jct.2015.611111","article-title":"Effect of Fucoidan Dietary Supplement on the Chemotherapy Treatment of Patients with Unresectable Advanced Gastric Cancer","volume":"06","author":"Ikeguchi","year":"2015","journal-title":"J. Cancer Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"100037","DOI":"10.1016\/j.focha.2022.100037","article-title":"Approaches to Overcome Bioavailability Inconsistencies of Epigallocatechin Gallate, a Powerful Anti-Oxidant in Green Tea","volume":"1","author":"Furniturewalla","year":"2022","journal-title":"Food Chem. Adv."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4137\/IMI.S36273","article-title":"The Effectiveness of Ginger in the Prevention of Nausea and Vomiting during Pregnancy and Chemotherapy","volume":"11","author":"Lete","year":"2016","journal-title":"Integr. Med. Insights"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3945\/jn.113.188367","article-title":"Quercetin Supplementation Attenuates the Progression of Cancer Cachexia in Apc Mice","volume":"144","author":"Enos","year":"2014","journal-title":"J. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/nure.12152","article-title":"Molecular and Physiological Actions of Quercetin: Need for Clinical Trials to Assess Its Benefits in Human Disease","volume":"72","author":"Miles","year":"2014","journal-title":"Nutr. Rev."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Meng, X., Zhou, J., Zhao, C.-N., Gan, R.-Y., and Li, H.-B. (2020). Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review. Foods, 9.","DOI":"10.3390\/foods9030340"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Penedo-V\u00e1zquez, A., Duran, X., Mateu, J., L\u00f3pez-Postigo, A., and Barreiro, E. (2021). Curcumin and Resveratrol Improve Muscle Function and Structure through Attenuation of Proteolytic Markers in Experimental Cancer-Induced Cachexia. Molecules, 26.","DOI":"10.3390\/molecules26164904"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"13278","DOI":"10.1038\/s41598-023-39279-z","article-title":"The Effect of Resveratrol, Curcumin and Quercetin Combination on Immuno-Suppression of Tumor Microenvironment for Breast Tumor-Bearing Mice","volume":"13","author":"Li","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Al-Bahlani, S., Burney, I.A., Al-Dhahli, B., Al-Kharusi, S., Al-Kharousi, F., Al-Kalbani, A., and Ahmed, I. (2020). Boswellic Acid Sensitizes Gastric Cancer Cells to Cisplatin-Induced Apoptosis via P53-Mediated Pathway. BMC Pharmacol. Toxicol., 21.","DOI":"10.1186\/s40360-020-00442-1"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/10408398.2012.691916","article-title":"Plant Food Supplements with Anti-Inflammatory Properties: A Systematic Review (II)","volume":"53","author":"Badea","year":"2013","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5822","DOI":"10.3748\/wjg.v26.i38.5822","article-title":"Acetyl-11-Keto-\u03b2-Boswellic Acid Inhibits Proliferation and Induces Apoptosis of Gastric Cancer Cells through the Phosphatase and Tensin Homolog \/Akt\/ Cyclooxygenase-2 Signaling Pathway","volume":"26","author":"Sun","year":"2020","journal-title":"World J. Gastroenterol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/8\/1246\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:32:10Z","timestamp":1760106730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/8\/1246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":70,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["nu16081246"],"URL":"https:\/\/doi.org\/10.3390\/nu16081246","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]}}}