{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:13:23Z","timestamp":1779358403046,"version":"3.51.4"},"reference-count":115,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Ministry of Research and Education","award":["01EA1808A"],"award-info":[{"award-number":["01EA1808A"]}]},{"name":"German Federal Ministry of Research and Education","award":["01EA1708"],"award-info":[{"award-number":["01EA1708"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Hypertriglyceridemia and diabetes mellitus type 2 are among the most important metabolic diseases globally. Diet plays a vital role in the development and progression of both clinical pictures. For the 10-week randomized, controlled, intervention study, 67 subjects with elevated plasma triglyceride (TG) concentrations (\u22651.7 mmol\/L) and 69 subjects with elevated fasting glucose concentrations (\u22655.6 &lt; 7.0 mmol\/L) were recruited. The intervention groups received specially developed, individualized menu plans and regular counseling sessions to lower (A) TG or (B) fasting glucose and glycated hemoglobin A1c as well as other cardiovascular and diabetic risk factors. The hypertriglyceridemia intervention group was further supplemented with fish oil (3.5 g\/d eicosapentaenoic acid + docosahexaenoic acid). The two control groups maintained a typical Western diet. Blood samples were taken every 2 weeks, and anthropometric data were collected. A follow-up examination was conducted after another 10 weeks. In both intervention groups, there were comparable significant reductions in blood lipids, glucose metabolism, and anthropometric parameters. These results were, with a few exceptions, significantly more pronounced in the intervention groups than in the corresponding control groups (comparison of percentage change from baseline). In particular, body weight was reduced by 7.4% (6.4 kg) and 7.5% (5.9 kg), low-density lipoprotein cholesterol concentrations by 19.8% (0.8 mmol\/L) and 13.0% (0.5 mmol\/L), TG concentrations by 18.2% (0.3 mmol\/L) and 13.0% (0.2 mmol\/L), and homeostatic model assessment for insulin resistance by 31.8% (1.1) and 26.4% (0.9) (p &lt; 0.05) in the hypertriglyceridemia and prediabetes intervention groups, respectively. Some of these changes were maintained until follow-up. In patients with elevated TG or fasting glucose, implementing individualized menu plans in combination with regular counseling sessions over 10 weeks led to a significant improvement in cardiovascular and diabetic risk factors.<\/jats:p>","DOI":"10.3390\/nu16091261","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T07:38:51Z","timestamp":1713944331000},"page":"1261","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Validation of Nutritional Approaches to Modulate Cardiovascular and Diabetic Risk Factors in Patients with Hypertriglyceridemia or Prediabetes\u2014The MoKaRi II Randomized Controlled Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Theresa S.","family":"Braun","sequence":"first","affiliation":[{"name":"Junior Research Group Nutritional Concepts, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Stra\u00dfe 25-29, 07743 Jena, Germany"},{"name":"Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Dornburger Stra\u00dfe 25-29, 07743 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Drobner","sequence":"additional","affiliation":[{"name":"Junior Research Group Nutritional Concepts, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Stra\u00dfe 25-29, 07743 Jena, Germany"},{"name":"Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Dornburger Stra\u00dfe 25-29, 07743 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Kipp","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Sophien- and Hufeland Hospital, Henry-van-de-Velde-Str. 1, 99425 Weimar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kiehntopf","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Diagnostics, University Hospital Jena, Am Klinikum 1, 07747 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schlattmann","sequence":"additional","affiliation":[{"name":"Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Dornburger Stra\u00dfe 25-29, 07743 Jena, Germany"},{"name":"Department of Medical Statistics and Epidemiology, Institute of Medical Statistics, Computer and Data Sciences, University Hospital Jena, Bachstra\u00dfe 18, 07743 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-840X","authenticated-orcid":false,"given":"Stefan","family":"Lorkowski","sequence":"additional","affiliation":[{"name":"Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Dornburger Stra\u00dfe 25-29, 07743 Jena, Germany"},{"name":"Department of Nutritional Biochemistry and Physiology, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Stra\u00dfe 25, 07743 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4063-6199","authenticated-orcid":false,"given":"Christine","family":"Dawczynski","sequence":"additional","affiliation":[{"name":"Junior Research Group Nutritional Concepts, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Stra\u00dfe 25-29, 07743 Jena, Germany"},{"name":"Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Dornburger Stra\u00dfe 25-29, 07743 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"m3109","DOI":"10.1136\/bmj.m3109","article-title":"Management of hypertriglyceridemia","volume":"371","author":"Simha","year":"2020","journal-title":"BMJ"},{"key":"ref_2","first-page":"825","article-title":"The Diagnosis and Treatment of Hypertriglyceridemia","volume":"116","author":"Parhofer","year":"2019","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_3","first-page":"242","article-title":"Prevalencia de hipertrigliceridemia en adultos y factores cardiometab\u00f3licos asociados. Estudio SIMETAP-HTG","volume":"32","year":"2020","journal-title":"Clin. Investig. Arterioscler."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s40119-020-00170-x","article-title":"Prevalence of US Adults with Triglycerides \u2265150 mg\/dL: NHANES 2007\u20132014","volume":"9","author":"Fan","year":"2020","journal-title":"Cardiol. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12933-015-0268-2","article-title":"PROMETHEUS: An observational, cross-sectional, retrospective study of hypertriglyceridemia in Russia","volume":"14","author":"Karpov","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sakboonyarat, B., Poovieng, J., Jongcherdchootrakul, K., Srisawat, P., Hatthachote, P., Mungthin, M., and Rangsin, R. (2022). Prevalence of hypertriglyceridemia among Royal Thai Army personnel and its related cardiometabolic risk factors, from 2017 to 2021. BMC Public Health, 22.","DOI":"10.1186\/s12889-022-13992-2"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1210\/jc.2011-3213","article-title":"Evaluation and treatment of hypertriglyceridemia: An Endocrine Society clinical practice guideline","volume":"97","author":"Berglund","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1161\/CIR.0b013e3182160726","article-title":"Triglycerides and cardiovascular disease: A scientific statement from the American Heart Association","volume":"123","author":"Miller","year":"2011","journal-title":"Circulation"},{"key":"ref_9","first-page":"21","article-title":"Overweight and obesity among adults in Germany\u2014Results from GEDA 2019\/2020-EHIS","volume":"7","author":"Schienkiewitz","year":"2022","journal-title":"J. Health Monit."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s11906-018-0812-z","article-title":"The Global Epidemic of the Metabolic Syndrome","volume":"20","author":"Saklayen","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_11","unstructured":"Deutsche Diabetes Gesellschaft, and Diabetesde\u2014Deutsche Diabetes-Hilfe (2024, February 05). Deutscher Gesundheitsbericht Diabetes 2023. Available online: https:\/\/www.ddg.info\/fileadmin\/user_upload\/Gesundheitsbericht_2023_gesamt_offene_Datei.pdf."},{"key":"ref_12","unstructured":"Karanchi, H., Muppidi, V., and Wyne, K. (2024, February 05). Hypertriglyceridemia, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459368\/."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacl.2015.09.002","article-title":"National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2","volume":"9","author":"Jacobson","year":"2015","journal-title":"J. Clin. Lipidol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1055\/s-0031-1281550","article-title":"Hypertriglycerid\u00e4mie: Prognostische Bedeutung und Therapiem\u00f6glichkeiten","volume":"136","author":"Custodis","year":"2011","journal-title":"Dtsch. Med. Wochenschr."},{"key":"ref_15","unstructured":"Deutsche Diabetes Gesellschaft, and diabetesDE\u2014Deutsche Diabetes-Hilfe (2024, February 05). Deutscher Gesundheitsbericht Diabetes 2022. Available online: https:\/\/www.ddg.info\/fileadmin\/user_upload\/Gesundheitsbericht_2022_final.pdf."},{"key":"ref_16","unstructured":"International Diabetes Federation (2024, February 05). IDF Diabetes Atlas, 10th ed. Available online: https:\/\/diabetesatlas.org\/atlas\/tenth-edition\/."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11886-019-1107-y","article-title":"Epidemiology of Diabetes Mellitus and Cardiovascular Disease","volume":"21","author":"Glovaci","year":"2019","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_18","unstructured":"World Health Organization (2024, February 05). Diabetes. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diabetes."},{"key":"ref_19","unstructured":"Robert Koch-Institut (2024, February 05). Diabetes in Deutschland: Bericht der Nationalen Diabetes-Surveillance 2019. Available online: https:\/\/edoc.rki.de\/handle\/176904\/6299."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.2337\/dc17-0954","article-title":"Burden of Mortality Attributable to Diagnosed Diabetes: A Nationwide Analysis Based on Claims Data from 65 Million People in Germany","volume":"40","author":"Jacobs","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e041508","DOI":"10.1136\/bmjopen-2020-041508","article-title":"Excess mortality in adults with documented diabetes in Germany: Routine data analysis of all insurance claims in Germany 2013\u20132014","volume":"11","author":"Schmidt","year":"2021","journal-title":"BMJ Open"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10654-017-0352-x","article-title":"A network meta-analysis on the comparative efficacy of different dietary approaches on glycaemic control in patients with type 2 diabetes mellitus","volume":"33","author":"Schwingshackl","year":"2018","journal-title":"Eur. J. Epidemiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10654-017-0246-y","article-title":"Food groups and risk of type 2 diabetes mellitus: A systematic review and meta-analysis of prospective studies","volume":"32","author":"Schwingshackl","year":"2017","journal-title":"Eur. J. Epidemiol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Uusitupa, M., Khan, T.A., Viguiliouk, E., Kahleova, H., Rivellese, A.A., Hermansen, K., Pfeiffer, A., Thanopoulou, A., Salas-Salvad\u00f3, J., and Schwab, U. (2019). Prevention of Type 2 Diabetes by Lifestyle Changes: A Systematic Review and Meta-Analysis. Nutrients, 11.","DOI":"10.3390\/nu11112611"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/dom.13499","article-title":"Carbohydrate quantity in the dietary management of type 2 diabetes: A systematic review and meta-analysis","volume":"21","author":"Brurberg","year":"2019","journal-title":"Diabetes Obes. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.diabres.2018.02.026","article-title":"Effect of dietary carbohydrate restriction on glycemic control in adults with diabetes: A systematic review and meta-analysis","volume":"139","author":"Sainsbury","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.numecd.2015.05.005","article-title":"Glycemic index, glycemic load and glycemic response: An International Scientific Consensus Summit from the International Carbohydrate Quality Consortium (ICQC)","volume":"25","author":"Augustin","year":"2015","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.2337\/diacare.26.12.3230","article-title":"The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity","volume":"26","author":"Louheranta","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.3945\/jn.116.242552","article-title":"Dietary Patterns and Type 2 Diabetes: A Systematic Literature Review and Meta-Analysis of Prospective Studies","volume":"147","author":"Jannasch","year":"2017","journal-title":"J. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1093\/eurheartj\/ehw272","article-title":"2016 ESC\/EAS Guidelines for the Management of Dyslipidaemias","volume":"37","author":"Catapano","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1055\/a-1515-8638","article-title":"Definition, Klassifikation und Diagnostik des Diabetes mellitus: Update 2021","volume":"16","author":"Schleicher","year":"2021","journal-title":"Diabetologie und Stoffwechsel"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.bbalip.2011.08.005","article-title":"Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA","volume":"1811","author":"Degen","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Lee, Y.-M., Kim, S.-A., Lee, I.-K., Kim, J.-G., Park, K.-G., Jeong, J.-Y., Jeon, J.-H., Shin, J.-Y., and Lee, D.-H. (2016). Effect of a Brown Rice Based Vegan Diet and Conventional Diabetic Diet on Glycemic Control of Patients with Type 2 Diabetes: A 12-Week Randomized Clinical Trial. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155918"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.amjcard.2011.04.015","article-title":"Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension MARINE trial)","volume":"108","author":"Bays","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B (Methodol.)"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fendo.2020.00252","article-title":"Causes and Consequences of Hypertriglyceridemia","volume":"11","author":"Packard","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_39","unstructured":"Biesalski, H.K., Bischoff, S.C., Pirlich, M., and Weimann, A. (2018). Ern\u00e4hrungsmedizin, 5. vollst\u00e4ndig \u00fcberarbeitete und erweiterte Auflage, Georg Thieme Verlag."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ajcn\/71.2.412","article-title":"Carbohydrate-induced hypertriacylglycerolemia: Historical perspective and review of biological mechanisms","volume":"71","author":"Parks","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/ajcn\/nqz298","article-title":"Carbohydrate quality changes and concurrent changes in cardiovascular risk factors: A longitudinal analysis in the PREDIMED-Plus randomized trial","volume":"111","author":"Toledo","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.metabol.2007.11.002","article-title":"Dietary glycemic index, dietary glycemic load, blood lipids, and C-reactive protein","volume":"57","author":"Levitan","year":"2008","journal-title":"Metabolism"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"nzy094","DOI":"10.1093\/cdn\/nzy094","article-title":"Dietary Fiber Is Independently Related to Blood Triglycerides Among Adults with Overweight and Obesity","volume":"3","author":"Hannon","year":"2019","journal-title":"Curr. Dev. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/oby.2003.135","article-title":"Variations in body composition and plasma lipids in response to a high-carbohydrate diet","volume":"11","author":"Archer","year":"2003","journal-title":"Obes. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.nut.2013.06.011","article-title":"Moderate replacement of carbohydrates by dietary fats affects features of metabolic syndrome: A randomized crossover clinical trial","volume":"30","author":"Rajaie","year":"2014","journal-title":"Nutrition"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Volk, B.M., Kunces, L.J., Freidenreich, D.J., Kupchak, B.R., Saenz, C., Artistizabal, J.C., Fernandez, M.L., Bruno, R.S., Maresh, C.M., and Kraemer, W.J. (2014). Effects of step-wise increases in dietary carbohydrate on circulating saturated Fatty acids and palmitoleic Acid in adults with metabolic syndrome. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113605"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1093\/ajcn\/85.6.1527","article-title":"Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins","volume":"85","author":"Shin","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1001\/jama.294.19.2455","article-title":"Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: Results of the OmniHeart randomized trial","volume":"294","author":"Appel","year":"2005","journal-title":"JAMA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3945\/ajcn.115.123281","article-title":"Comparison of the DASH (Dietary Approaches to Stop Hypertension) diet and a higher-fat DASH diet on blood pressure and lipids and lipoproteins: A randomized controlled trial","volume":"103","author":"Chiu","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.jand.2013.07.010","article-title":"Comparison of effects of long-term low-fat vs high-fat diets on blood lipid levels in overweight or obese patients: A systematic review and meta-analysis","volume":"113","author":"Schwingshackl","year":"2013","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jacl.2008.12.008","article-title":"Effects of moderate (MF) versus lower fat (LF) diets on lipids and lipoproteins: A meta-analysis of clinical trials in subjects with and without diabetes","volume":"3","author":"Cao","year":"2009","journal-title":"J. Clin. Lipidol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3945\/ajcn.115.109116","article-title":"Diets with high-fat cheese, high-fat meat, or carbohydrate on cardiovascular risk markers in overweight postmenopausal women: A randomized crossover trial","volume":"102","author":"Thorning","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/ajcn\/88.2.272","article-title":"Dietary monounsaturated fat activates metabolic pathways for triglyceride-rich lipoproteins that involve apolipoproteins E and C-III","volume":"88","author":"Zheng","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1463-1326.2009.01151.x","article-title":"A low carbohydrate Mediterranean diet improves cardiovascular risk factors and diabetes control among overweight patients with type 2 diabetes mellitus: A 1-year prospective randomized intervention study","volume":"12","author":"Elhayany","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1007\/s00125-019-4956-4","article-title":"A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: A randomised controlled trial","volume":"62","author":"Skytte","year":"2019","journal-title":"Diabetologia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1464-5491.2007.02104.x","article-title":"A comparison of the influence of a high-fat diet enriched in monounsaturated fatty acids and conventional diet on weight loss and metabolic parameters in obese non-diabetic and Type 2 diabetic patients","volume":"24","author":"Brunerova","year":"2007","journal-title":"Diabet. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/gerona\/gls236","article-title":"Cardiometabolic risk after weight loss and subsequent weight regain in overweight and obese postmenopausal women","volume":"68","author":"Beavers","year":"2013","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/ajcn\/66.3.649","article-title":"Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids","volume":"66","author":"Grimsgaard","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/ajcn\/71.5.1085","article-title":"Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men","volume":"71","author":"Mori","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/ajcn\/76.2.326","article-title":"The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans","volume":"76","author":"Nestel","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e1801157","DOI":"10.1002\/mnfr.201801157","article-title":"EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"63","author":"Zhou","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1093\/ajcn\/76.5.1007","article-title":"Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension","volume":"76","author":"Woodman","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1586\/14779072.6.3.391","article-title":"Prescription omega-3 fatty acids and their lipid effects: Physiologic mechanisms of action and clinical implications","volume":"6","author":"Bays","year":"2008","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11883-010-0131-6","article-title":"Saturated fatty acids and risk of coronary heart disease: Modulation by replacement nutrients","volume":"12","author":"Sun","year":"2010","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"18S","DOI":"10.1177\/0148607115595980","article-title":"Functional Roles of Fatty Acids and Their Effects on Human Health","volume":"39","author":"Calder","year":"2015","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.pathol.2018.10.013","article-title":"Diet, exercise and weight loss and dyslipidaemia","volume":"51","author":"Clifton","year":"2019","journal-title":"Pathology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000437243","article-title":"Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases","volume":"67","author":"Wolfram","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev-physiol-012110-142233","article-title":"Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport","volume":"73","author":"Jia","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3945\/ajcn.115.109165","article-title":"Whole-grain and blood lipid changes in apparently healthy adults: A systematic review and meta-analysis of randomized controlled studies","volume":"102","author":"Ross","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/ajcn\/69.1.30","article-title":"Cholesterol-lowering effects of dietary fiber: A meta-analysis","volume":"69","author":"Brown","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/07315724.2000.10718967","article-title":"Mechanisms of the effects of grains on insulin and glucose responses","volume":"19","author":"Hallfrisch","year":"2000","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11130-016-0529-6","article-title":"New Horizons for the Study of Dietary Fiber and Health: A Review","volume":"71","author":"Fuller","year":"2016","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3945\/jn.115.210575","article-title":"van. Palm Oil Consumption Increases LDL Cholesterol Compared with Vegetable Oils Low in Saturated Fat in a Meta-Analysis of Clinical Trials","volume":"145","author":"Sun","year":"2015","journal-title":"J. Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.numecd.2020.12.032","article-title":"The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials","volume":"31","author":"Schoeneck","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.clnu.2020.10.032","article-title":"Effects of soluble fiber supplementation on glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials","volume":"40","author":"Xie","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Reynolds, A.N., Akerman, A.P., and Mann, J. (2020). Dietary fibre and whole grains in diabetes management: Systematic review and meta-analyses. PLoS Med., 17.","DOI":"10.1371\/journal.pmed.1003053"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/ajcn\/56.2.320","article-title":"Effects of weight reduction on blood lipids and lipoproteins: A meta-analysis","volume":"56","author":"Dattilo","year":"1992","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.2174\/1871530320666200429235830","article-title":"Higher Body Mass Index, Uric Acid Levels, and Lower Cholesterol Levels are Associated with Greater Weight Loss","volume":"20","author":"Zupo","year":"2020","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0026-0495(92)90134-V","article-title":"Benefit from hypocaloric diet in obese men depends on the extent of weight-loss regarding cholesterol, and on a simultaneous change in body fat distribution regarding insulin sensitivity and glucose tolerance","volume":"41","author":"Richter","year":"1992","journal-title":"Metabolism"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"628109","DOI":"10.3389\/fcvm.2020.628109","article-title":"The Triglyceride-Glucose Index, an Insulin Resistance Marker, Was Non-linear Associated with All-Cause and Cardiovascular Mortality in the General Population","volume":"7","author":"Liu","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12933-022-01511-x","article-title":"Triglyceride-glucose index as a marker in cardiovascular diseases: Landscape and limitations","volume":"21","author":"Tao","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"101941","DOI":"10.1016\/j.pmedr.2022.101941","article-title":"Triglyceride glucose index: A new biomarker in predicting cardiovascular risk","volume":"29","author":"Juvanhol","year":"2022","journal-title":"Prev. Med. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/S2666-7568(22)00247-1","article-title":"Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): A prospective cohort study","volume":"4","author":"Abat","year":"2023","journal-title":"Lancet Healthy Longev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"101365","DOI":"10.1016\/j.diabet.2022.101365","article-title":"Triglyceride-glucose index associates with incident heart failure: A cohort study","volume":"48","author":"Xu","year":"2022","journal-title":"Diabetes Metab."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12933-022-01606-5","article-title":"Association between the triglyceride-glucose index and severity of coronary artery disease","volume":"21","author":"Wang","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cgh.2012.12.031","article-title":"External validation of the fatty liver index for identifying nonalcoholic fatty liver disease in a population-based study","volume":"11","author":"Koehler","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Bedogni, G., Bellentani, S., Miglioli, L., Masutti, F., Passalacqua, M., Castiglione, A., and Tiribelli, C. (2006). The Fatty Liver Index: A simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol., 6.","DOI":"10.1186\/1471-230X-6-33"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12933-022-01642-1","article-title":"Fatty liver index as a predictor for incident type 2 diabetes in community-dwelling adults: Longitudinal findings over 12 years","volume":"21","author":"Seo","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Wargny, M., Smati, S., Pichelin, M., Bigot-Corbel, E., Authier, C., Dierry, V., Za\u00efr, Y., Jacquin, V., Hadjadj, S., and Boursier, J. (2019). Fatty liver index is a strong predictor of changes in glycemic status in people with prediabetes: The IT-DIAB study. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0221524"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"221","DOI":"10.15403\/jgld-3404","article-title":"Fatty Liver Index as a Simple and Useful Predictor for 10-year Cardiovascular Disease Risks Determined by Framingham Risk Score in the General Korean Population","volume":"30","author":"Chung","year":"2021","journal-title":"J. Gastrointest. Liver Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1056\/NEJMoa021778","article-title":"Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes","volume":"348","author":"Gaede","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/S0140-6736(00)02345-X","article-title":"Measurement of lipid-soluble vitamins-further adjustment needed?","volume":"355","author":"Traber","year":"2000","journal-title":"Lancet"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1017\/S000711451500272X","article-title":"Vitamin E function and requirements in relation to PUFA","volume":"114","author":"Raederstorff","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e000513","DOI":"10.1161\/JAHA.113.000513","article-title":"Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: A dose-response randomized controlled trial","volume":"2","author":"Flock","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1016\/S0022-2275(20)37132-7","article-title":"Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: An 18-month controlled study","volume":"38","author":"Katan","year":"1997","journal-title":"J. Lipid Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0021-9150(85)90106-6","article-title":"The effects of dietary omega-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers","volume":"55","author":"Cartwright","year":"1985","journal-title":"Atherosclerosis"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1042\/cs0610317","article-title":"Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men","volume":"61","author":"Sanders","year":"1981","journal-title":"Clin. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12944-016-0199-2","article-title":"Consumption of echium oil increases EPA and DPA in blood fractions more efficiently compared to linseed oil in humans","volume":"15","author":"Kuhnt","year":"2016","journal-title":"Lipids Health Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/ajcn\/88.3.801","article-title":"Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: A multiple-dosing trial comparing 2 sources of n-3 fatty acid","volume":"88","author":"Murphy","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.atherosclerosis.2004.12.029","article-title":"Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype","volume":"181","author":"Wilkinson","year":"2005","journal-title":"Atherosclerosis"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/ajcn\/86.1.74","article-title":"Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women","volume":"86","author":"Sun","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1476-511X-4-30","article-title":"Assessment of erythrocyte phospholipid fatty acid composition as a biomarker for dietary MUFA, PUFA or saturated fatty acid intake in a controlled cross-over intervention trial","volume":"4","author":"Poppitt","year":"2005","journal-title":"Lipids Health Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/ajcn\/59.2.364","article-title":"Fatty acid composition of serum cholesterol esters, and erythrocyte and platelet membranes as indicators of long-term adherence to fat-modified diets","volume":"59","author":"Sarkkinen","year":"1994","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/0026-0495(95)90006-3","article-title":"Comparison between fat intake assessed by a 3-day food record and phospholipid fatty acid composition of red blood cells: Results from the Monitoring of Cardiovascular Disease-Lille Study","volume":"44","author":"Romon","year":"1995","journal-title":"Metabolism"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/ajcn\/86.4.929","article-title":"Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart disease","volume":"86","author":"Sun","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1017\/S1368980008004503","article-title":"Evaluation of relative intake of fatty acids according to the Northern Sweden FFQ with fatty acid levels in erythrocyte membranes as biomarkers","volume":"12","author":"Wennberg","year":"2009","journal-title":"Public Health Nutr."},{"key":"ref_107","first-page":"46","article-title":"Fatty acids as biomarkers of total dairy and dairy fat intakes: A systematic review and meta-analysis","volume":"77","author":"Pranger","year":"2019","journal-title":"Nutr. Rev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/MOL.0000000000000381","article-title":"Milk fat biomarkers and cardiometabolic disease","volume":"28","author":"Marklund","year":"2017","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S2213-8587(14)70146-9","article-title":"Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: The EPIC-InterAct case-cohort study","volume":"2","author":"Forouhi","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3945\/ajcn.117.152702","article-title":"Odd-chain fatty acids as a biomarker for dietary fiber intake: A novel pathway for endogenous production from propionate","volume":"105","author":"Weitkunat","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1079\/BJN20041290","article-title":"The relation between alcohol intake and physical activity and the fatty acids 14:0, 15:0 and 17:0 in serum phospholipids and adipose tissue used as markers for dairy fat intake","volume":"93","author":"Rosell","year":"2005","journal-title":"Br. J. Nutr."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12986-019-0407-y","article-title":"Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients","volume":"16","author":"Pertiwi","year":"2019","journal-title":"Nutr. Metab."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1079\/BJN2003901","article-title":"Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of 13Calpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men","volume":"90","author":"Burdge","year":"2003","journal-title":"Br. J. Nutr."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1051\/rnd:2005047","article-title":"Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults","volume":"45","author":"Burdge","year":"2005","journal-title":"Reprod. Nutr. Dev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.plipres.2008.03.003","article-title":"Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake","volume":"47","author":"Hodson","year":"2008","journal-title":"Prog. Lipid Res."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/9\/1261\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:33:18Z","timestamp":1760106798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/9\/1261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,24]]},"references-count":115,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["nu16091261"],"URL":"https:\/\/doi.org\/10.3390\/nu16091261","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,24]]}}}