{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:49:38Z","timestamp":1791668978399,"version":"4.3.4"},"reference-count":48,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences (NIGMS)","doi-asserted-by":"publisher","award":["1SC3GM132010"],"award-info":[{"award-number":["1SC3GM132010"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences (NIGMS)","doi-asserted-by":"publisher","award":["5R16GM149383"],"award-info":[{"award-number":["5R16GM149383"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences (NIGMS)","doi-asserted-by":"publisher","award":["ENHC-50-80"],"award-info":[{"award-number":["ENHC-50-80"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"City University of New York Professional Staff Congress","award":["1SC3GM132010"],"award-info":[{"award-number":["1SC3GM132010"]}]},{"name":"City University of New York Professional Staff Congress","award":["5R16GM149383"],"award-info":[{"award-number":["5R16GM149383"]}]},{"name":"City University of New York Professional Staff Congress","award":["ENHC-50-80"],"award-info":[{"award-number":["ENHC-50-80"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Prenatal alcohol exposure (AE) affects cognitive development. However, it is unclear whether prenatal AE influences the metabolic health of offspring and whether postnatal AE exacerbates metabolic deterioration resulting from prenatal AE. Choline is a semi-essential nutrient that has been demonstrated to mitigate the cognitive impairment of prenatal AE. This study investigated how maternal choline supplementation (CS) may modify the metabolic health of offspring with prenatal and postnatal AE (AE\/AE). C57BL\/6J female mice were fed either a Lieber\u2013DeCarli diet with 1.4% ethanol between embryonic day (E) 9.5 and E17.5 or a control diet. Choline was supplemented with 4 \u00d7 concentrations versus the control throughout pregnancy. At postnatal week 7, offspring mice were exposed to 1.4% ethanol for females and 3.9% ethanol for males for 4 weeks. AE\/AE increased hepatic triglyceride accumulation in male offspring only, which was normalized by prenatal CS. Prenatal CS also improved glucose tolerance compared to AE\/AE animals. AE\/AE suppressed hepatic gene expression of peroxisome proliferator activated receptor alpha (Ppara) and low-density lipoprotein receptor (Ldlr), which regulate fatty acid catabolism and cholesterol reuptake, respectively, in male offspring. However, these changes were not rectified by prenatal CS. In conclusion, AE\/AE led to an increased risk of steatosis and was partially prevented by prenatal CS in male mice.<\/jats:p>","DOI":"10.3390\/nu16091264","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T10:18:36Z","timestamp":1713953916000},"page":"1264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prenatal Choline Supplementation Improves Glucose Tolerance and Reduces Liver Fat Accumulation in Mouse Offspring Exposed to Ethanol during the Prenatal and Postnatal Periods"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5189-058X","authenticated-orcid":false,"given":"Isma\u2019il","family":"Kadam","sequence":"first","affiliation":[{"name":"PhD Program in Biochemistry, Graduate Center of the City University of New York, New York, NY 10016, USA"},{"name":"Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Trasino","sequence":"additional","affiliation":[{"name":"Nutrition Program, School of Urban Public Health, Hunter College, City University of New York, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5612-1528","authenticated-orcid":false,"given":"Hunter","family":"Korsmo","sequence":"additional","affiliation":[{"name":"PhD Program in Biochemistry, Graduate Center of the City University of New York, New York, NY 10016, USA"},{"name":"Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Pinkas","sequence":"additional","affiliation":[{"name":"Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6090-371X","authenticated-orcid":false,"given":"Xinyin","family":"Jiang","sequence":"additional","affiliation":[{"name":"PhD Program in Biochemistry, Graduate Center of the City University of New York, New York, NY 10016, USA"},{"name":"Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.4088\/PCC.v09n0608","article-title":"Alcohol use during pregnancy: Prevalence and impact","volume":"9","author":"Bhuvaneswar","year":"2007","journal-title":"Prim. 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