{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:57:09Z","timestamp":1787921829082,"version":"build-2784847793"},"reference-count":55,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"German Federal Ministry of Education and Research (Bundesministerium f\u00fcr Bildung und Forschung, BMBF)","doi-asserted-by":"publisher","award":["01EA1707"],"award-info":[{"award-number":["01EA1707"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Synbiotics modulate the gut microbiome and contribute to the prevention of liver diseases such as metabolic-dysfunction-associated fatty liver disease (MAFLD). This study aimed to evaluate the effect of a randomized, placebo-controlled, double-blinded seven-week intervention trial on the liver metabolism in 117 metabolically healthy male participants. Anthropometric data, blood parameters, and stool samples were analyzed using linear mixed models. After seven weeks of intervention, there was a significant reduction in alanine aminotransferase (ALT) in the synbiotic group compared to the placebo group (\u221214.92%, CI: \u221226.60\u2013\u22123.23%, p = 0.013). A stratified analysis according to body fat percentage revealed a significant decrease in ALT (\u221220.70%, CI: \u221240.88\u2013\u22120.53%, p = 0.045) in participants with an elevated body fat percentage. Further, a significant change in microbiome composition (1.16, CI: 0.06\u20132.25, p = 0.039) in this group was found, while the microbial composition remained stable upon intervention in the group with physiological body fat. The 7-week synbiotic intervention reduced ALT levels, especially in participants with an elevated body fat percentage, possibly due to modulation of the gut microbiome. Synbiotic intake may be helpful in delaying the progression of MAFLD and could be used in addition to the recommended lifestyle modification therapy.<\/jats:p>","DOI":"10.3390\/nu16091300","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T08:18:27Z","timestamp":1714119507000},"page":"1300","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of Synbiotic Intake on Liver Metabolism in Metabolically Healthy Participants and Its Potential Preventive Effect on Metabolic-Dysfunction-Associated Fatty Liver Disease (MAFLD): A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-5674","authenticated-orcid":false,"given":"Aakash","family":"Mantri","sequence":"first","affiliation":[{"name":"Institute of Nutrition and Food Science, Nutrition and Microbiota, University of Bonn, 53115 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Center (CRNL), Centre National de la Recherche Scientifique (CNRS), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Universit\u00e9 Claude Bernard Lyon 1, 69500 Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilke","family":"Plassmann","sequence":"additional","affiliation":[{"name":"Institut Europ\u00e9en d\u2019Administration des Affaires (INSEAD), 77300 Fontainebleau, France"},{"name":"Control-Interoception-Attention Team, Paris Brain Institute (ICM), 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Simon","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Science, Nutrition and Microbiota, University of Bonn, 53115 Bonn, 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