{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:35:20Z","timestamp":1790883320396,"version":"4.1.0"},"reference-count":76,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Agriculture, Food and Rural Affairs and partly the Korea Food Research Institute","award":["G0220300-01"],"award-info":[{"award-number":["G0220300-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Heat-treated Lactiplantibacillus plantarum nF1 (HT-nF1) increases immune cell activation and the production of various immunomodulators (e.g., interleukin (IL)-12) as well as immunoglobulin (Ig) G, which plays an important role in humoral immunity, and IgA, which activates mucosal immunity. To determine the effect of HT-nF1 intake on improving immune function, a randomized, double-blind, placebo-controlled study was conducted on 100 subjects with normal white blood cell counts. The HT-nF1 group was administered capsules containing 5 \u00d7 1011 cells of HT-nF1 once a day for 8 weeks. After 8 weeks of HT-nF1 intake, significant changes in IL-12 were observed in the HT-nF1 group (p = 0.045). In particular, the change in natural killer (NK) cell activity significantly increased in subjects with low secretory (s) IgA (\u226449.61 \u03bcg\/mL) and low NK activity (E:T = 10:1) (\u22643.59%). These results suggest that HT-nF1 has no safety issues and improves the innate immune function by regulating T helper (Th)1-related immune factors. Therefore, we confirmed that HT-nF1 not only has a positive effect on regulating the body\u2019s immunity, but it is also a safe material for the human body, which confirms its potential as a functional health food ingredient.<\/jats:p>","DOI":"10.3390\/nu16091339","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T10:33:36Z","timestamp":1714386816000},"page":"1339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Heat-Treated Lactiplantibacillus plantarum nF1 on the Immune System Including Natural Killer Cell Activity: A Randomized, Placebo-Controlled, Double-Blind Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-1100","authenticated-orcid":false,"given":"Geun-Hye","family":"Hong","sequence":"first","affiliation":[{"name":"IMMUNOBIOTECH Corp., Seoul 06628, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-6108","authenticated-orcid":false,"given":"So-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"IMMUNOBIOTECH Corp., Seoul 06628, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Global Medical Research Center, Seoul 03737, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jangmi","family":"Suk","sequence":"additional","affiliation":[{"name":"Global Medical Research Center, Seoul 03737, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaemin","family":"Baeg","sequence":"additional","affiliation":[{"name":"Global Medical Research Center, Seoul 03737, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4316-2726","authenticated-orcid":false,"given":"Ji Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nano Bio Engineering, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"IMMUNOBIOTECH Corp., Seoul 06628, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Gee","family":"Kim","sequence":"additional","affiliation":[{"name":"IMMUNOBIOTECH Corp., Seoul 06628, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2674-0715","authenticated-orcid":false,"given":"Kun-Young","family":"Park","sequence":"additional","affiliation":[{"name":"IMMUNOBIOTECH Corp., Seoul 06628, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"ref_1","first-page":"298","article-title":"Inflammatory cytokines in nonpathological States","volume":"15","author":"Cannon","year":"2000","journal-title":"News Physiol. 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