{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:19:23Z","timestamp":1784204363098,"version":"3.55.0"},"reference-count":42,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ICTQ","award":["#2024\/0001"],"award-info":[{"award-number":["#2024\/0001"]}]},{"name":"ICTQ","award":["#2012\/15165-2"],"award-info":[{"award-number":["#2012\/15165-2"]}]},{"name":"Sao Paulo Research Foundation (FAPESP)","award":["#2024\/0001"],"award-info":[{"award-number":["#2024\/0001"]}]},{"name":"Sao Paulo Research Foundation (FAPESP)","award":["#2012\/15165-2"],"award-info":[{"award-number":["#2012\/15165-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: Justicia pectoralis Jacq. is traditionally applied in folk medicine in Brazil and in several Latin American countries. The leaves are used in tea form, especially in the treatment of respiratory disorders, acting as an expectorant. It also has activity in gastrointestinal disorders, and it is anti-inflammatory, antioxidant, sedative, and estrogenic, among others. Aims: To investigate the gastroprotective activity of the methanol extract of the leaves of Justicia pectoralis Jacq. (MEJP) in different experimental models of gastric ulcers. Materials and methods: The adult leaves of Justicia pectoralis Jacq. were collected and cultivated in beds, with an approximate spacing of 40 \u00d7 40 cm, organic fertilization, irrigation with potable water and without shelter from light. The MEJP was prepared from the dried and pulverized leaves and concentrated under reduced pressure in a rotary evaporator. For the experimental model of gastric ulcer, Swiss male albino mice were used. The inputs used in the experiment were MEJP at three different concentrations (250, 500 and 1000 mg\/kg p.o.), cimetidine (50 mg\/kg p.o.), indomethacin (50 mg\/kg s.c.) and vehicle (10 mL\/kg p.o.). Results: MEJP (250, 500 and 1000 mg\/kg p.o.) demonstrated gastroprotective activity, with levels of protection of 45.65%, 44.80% and 40.22%, respectively, compared to the control (vehicle). Compared with cimetidine (48.29%), MEJP showed similar gastroprotective activity. Conclusions: This study demonstrated the gastroprotective activity of MEJP and contributes to validate the traditional use the species for gastric disorders and provides a pharmacological basis for its clinical potential.<\/jats:p>","DOI":"10.3390\/nu16101430","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T10:31:16Z","timestamp":1715250676000},"page":"1430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Gastroprotective Activity of the Methanolic Extract of Justicia pectoralis Jacq. (Acanthaceae)"],"prefix":"10.3390","volume":"16","author":[{"given":"Ismael Aureliano","family":"Rosa J\u00fanior","sequence":"first","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Pharmacology and Therapeutics, Evangelical University of Goi\u00e1s\u2014Unievang\u00e9lica, University Avenue Km 3,5, An\u00e1polis 75083-515, GO, Brazil"},{"name":"Instituto de Ci\u00eancia, Tecnologia e Qualidade\u2014ICTQ, An\u00e1polis 75023-085, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionys de Souza","family":"Almeida","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences, Department of Pharmacology, Federal University of Goi\u00e1s, Campus Samambaia, Campus Street, Goi\u00e2nia 74001-97, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamilton Barbosa","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Pharmacology and Therapeutics, Evangelical University of Goi\u00e1s\u2014Unievang\u00e9lica, University Avenue Km 3,5, An\u00e1polis 75083-515, GO, Brazil"},{"name":"Campus Central, State University of Goi\u00e1s, An\u00e1polis 75132-400, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josana de Castro","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Pharmacology and Therapeutics, Evangelical University of Goi\u00e1s\u2014Unievang\u00e9lica, University Avenue Km 3,5, An\u00e1polis 75083-515, GO, Brazil"},{"name":"Campus Central, State University of Goi\u00e1s, An\u00e1polis 75132-400, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucimar Pinheiro","family":"Rosseto","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Pharmacology and Therapeutics, Evangelical University of Goi\u00e1s\u2014Unievang\u00e9lica, University Avenue Km 3,5, An\u00e1polis 75083-515, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerith Mayra","family":"Hungria Pinto","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Pharmacology and Therapeutics, Evangelical University of Goi\u00e1s\u2014Unievang\u00e9lica, University Avenue Km 3,5, An\u00e1polis 75083-515, GO, Brazil"},{"name":"Campus Central, State University of Goi\u00e1s, An\u00e1polis 75132-400, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2858-7539","authenticated-orcid":false,"given":"Lucas Danilo","family":"Dias","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Pharmacology and Therapeutics, Evangelical University of Goi\u00e1s\u2014Unievang\u00e9lica, University Avenue Km 3,5, An\u00e1polis 75083-515, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7440-7581","authenticated-orcid":false,"given":"James Oluwagbamigbe","family":"Fajemiroye","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Pharmacology and Therapeutics, Evangelical University of Goi\u00e1s\u2014Unievang\u00e9lica, University Avenue Km 3,5, An\u00e1polis 75083-515, GO, Brazil"},{"name":"Institute of Biological Sciences, Department of Pharmacology, Federal University of Goi\u00e1s, Campus Samambaia, Campus Street, Goi\u00e2nia 74001-97, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1996-0901","authenticated-orcid":false,"given":"Elson Alves","family":"Costa","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences, Department of Pharmacology, Federal University of Goi\u00e1s, Campus Samambaia, Campus Street, Goi\u00e2nia 74001-97, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-1143","authenticated-orcid":false,"given":"Rodolfo P.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Pharmacology and Therapeutics, Evangelical University of Goi\u00e1s\u2014Unievang\u00e9lica, University Avenue Km 3,5, An\u00e1polis 75083-515, GO, Brazil"},{"name":"Postgraduate Program in Human Movement and Rehabilitation, Evangelical University of Goi\u00e1s\u2014Unievang\u00e9lica, University Avenue Km 3,5, An\u00e1polis 75083-515, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis Rodrigues","family":"Martins","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Pharmacology and Therapeutics, Evangelical University of Goi\u00e1s\u2014Unievang\u00e9lica, University Avenue Km 3,5, An\u00e1polis 75083-515, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.jep.2014.08.006","article-title":"Mechanisms involved in the gastroprotective activity of Celtis iguanaea (Jacq.) 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