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Biofortification of plants and plant products emerges as a promising remedy to enhance micronutrient levels in food. Utilizing agronomic biofortification, conventional plant breeding, and genetic engineering yields raw materials with heightened micronutrient contents and improved bioavailability. A similar strategy extends to animal-derived foods by fortifying eggs, meat, and dairy products with micronutrients. Employing \u201cdual\u201d biofortification, utilizing previously enriched plant materials as a micronutrient source for livestock, proves an innovative solution. Amid biofortification research, conducting in vitro and in vivo experiments is essential to assess the bioactivity of micronutrients from enriched materials, emphasizing digestibility, bioavailability, and safety. Mineral deficiencies in human diets present a significant health challenge. Biofortification of plants and animal products emerges as a promising approach to alleviate micronutrient deficiencies, necessitating further research into the utilization of biofortified raw materials in the human diet, with a focus on bioavailability, digestibility, and safety.<\/jats:p>","DOI":"10.3390\/nu16101481","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T08:03:08Z","timestamp":1715673788000},"page":"1481","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Biofortification of Plant- and Animal-Based Foods in Limiting the Problem of Microelement Deficiencies\u2014A Narrative Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1897-5166","authenticated-orcid":false,"given":"Wojciech","family":"Bia\u0142ow\u0105s","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza","family":"Blicharska","sequence":"additional","affiliation":[{"name":"Department of Pathobiochemistry and Interdyscyplinary Applications of Ion Chromatography, Faculty of Biomedicine, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-8439","authenticated-orcid":false,"given":"Kamil","family":"Drabik","sequence":"additional","affiliation":[{"name":"Institute of Biological Basis of Animal Production, University of Life Sciences in Lublin, 20-950 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nature01014","article-title":"Agricultural Sustainability and Intensive Production Practices","volume":"418","author":"Tilman","year":"2002","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1098\/rstb.2010.0134","article-title":"Livestock Production: Recent Trends, Future Prospects","volume":"365","author":"Thornton","year":"2010","journal-title":"Philos. Trans. R. Soc. Lond. B. Biol. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Hasanaliyeva, G., Sufar, E.K., Wang, J., Rempelos, L., Volakakis, N., Iversen, P.O., and Leifert, C. (2023). Effects of Agricultural Intensification on Mediterranean Diets: A Narrative Review. Foods, 12.","DOI":"10.3390\/foods12203779"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s43016-021-00322-9","article-title":"A Meta-Analysis of Projected Global Food Demand and Population at Risk of Hunger for the Period 2010\u20132050","volume":"2","author":"Morley","year":"2021","journal-title":"Nat. Food"},{"key":"ref_5","unstructured":"Alexandratos, N., and Bruinsma, J. (2012). World Agriculture towards 2030\/2050: The 2012 Revision, FAO. ESA Working Papers."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"589835","DOI":"10.3389\/fpls.2020.589835","article-title":"Simultaneous Biofortification of Rice With Zinc, Iodine, Iron and Selenium Through Foliar Treatment of a Micronutrient Cocktail in Five Countries","volume":"11","author":"Rashid","year":"2020","journal-title":"Front. Plant Sci."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Consentino, B.B., Ciriello, M., Sabatino, L., Vultaggio, L., Baldassano, S., Vasto, S., Rouphael, Y., La Bella, S., and De Pascale, S. (2023). Current Acquaintance on Agronomic Biofortification to Modulate the Yield and Functional Value of Vegetable Crops: A Review. Horticulturae, 9.","DOI":"10.3390\/horticulturae9020219"},{"key":"ref_8","first-page":"19","article-title":"Malnutrition in Obesity: Is It Possible?","volume":"15","author":"Antosik","year":"2021","journal-title":"Obes. Facts"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11695-015-1773-9","article-title":"Micronutrient Deficiencies in Morbidly Obese Women Prior to Bariatric Surgery","volume":"26","author":"Rojas","year":"2016","journal-title":"Obes. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Knazicka, Z., Bihari, M., Janco, I., Harangozo, L., Arvay, J., Kovacik, A., Massanyi, P., Galik, B., Saraiva, J.M.A., and Habanova, M. (2024). Blood Concentration of Macro- and Microelements in Women Who Are Overweight\/Obesity and Their Associations with Serum Biochemistry. Life, 14.","DOI":"10.3390\/life14040465"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e13129","DOI":"10.1111\/obr.13129","article-title":"Obesity in Young Children and Its Relationship with Diagnosis of Asthma, Vitamin D Deficiency, Iron Deficiency, Specific Allergies and Flat-Footedness: A Systematic Review and Meta-Analysis","volume":"22","author":"Malden","year":"2021","journal-title":"Obes. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Calcaterra, V., Verduci, E., Milanta, C., Agostinelli, M., Todisco, C.F., Bona, F., Dolor, J., La Mendola, A., Tosi, M., and Zuccotti, G. (2023). Micronutrient Deficiency in Children and Adolescents with Obesity\u2014A Narrative Review. Children, 10.","DOI":"10.3390\/children10040695"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1753-4887.2009.00228.x","article-title":"Impact of Micronutrient Deficiencies on Obesity","volume":"67","author":"Long","year":"2009","journal-title":"Nutr. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Fan, Y., Zhang, C., and Bu, J. (2017). Relationship between Selected Serum Metallic Elements and Obesity in Children and Adolescent in the U.S. Nutrients, 9.","DOI":"10.3390\/nu9020104"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.17796\/1053-4625-45.4.8","article-title":"Association of Salivary Zinc Levels to Dental Caries and Body Mass Index. A Comparative Study","volume":"45","author":"Sharma","year":"2021","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1515\/jpem-2019-0086","article-title":"Association between Inflammation, Oxidative Stress, Vitamin D, Copper and Zinc with Pre-Obesity and Obesity in School Children from the City of Podgorica, Montenegro","volume":"32","author":"Jaksic","year":"2019","journal-title":"J. Pediat. Endocrinol. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s40011-012-0029-x","article-title":"Micro Mineral Nutrient Deficiencies in Humans, Animals and Plants and Their Amelioration","volume":"82","author":"Prasad","year":"2012","journal-title":"Proc. Natl. Acad. Sci. India Sect. B Biol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0140-6736(07)61690-0","article-title":"Maternal and Child Undernutrition: Global and Regional Exposures and Health Consequences","volume":"371","author":"Black","year":"2008","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jinorgbio.2019.03.013","article-title":"The Essential Metals for Humans: A Brief Overview","volume":"195","author":"Zoroddu","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_20","first-page":"1","article-title":"Health Benefits of Micronutrients (Vitamins and Minerals) and Their Associated Deficiency Diseases: A Systematic Review","volume":"3","author":"Godswill","year":"2020","journal-title":"Int. J. Food Sci."},{"key":"ref_21","first-page":"E93","article-title":"Main Nutritional Deficiencies","volume":"63","author":"Kiani","year":"2022","journal-title":"J. Prev. Med. Hyg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.21273\/HORTSCI.44.1.15","article-title":"Declining Fruit and Vegetable Nutrient Composition: What Is the Evidence?","volume":"44","author":"Davis","year":"2009","journal-title":"HortScience"},{"key":"ref_23","first-page":"2397847317696366","article-title":"Bioavailability of Micronutrients Obtained from Supplements and Food: A Survey and Case Study of the Polyphenols","volume":"1","author":"Pressman","year":"2017","journal-title":"Toxicol. Res. Appl."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1017\/S0029665112003011","article-title":"Food Synergy: The Key to a Healthy Diet","volume":"72","author":"Jacobs","year":"2013","journal-title":"Proc. Nutr. Soc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrendo.2016.37","article-title":"Micronutrient Deficiencies in Pregnancy Worldwide: Health Effects and Prevention","volume":"12","author":"Gernand","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jtemb.2014.04.006","article-title":"Global Perspectives on Trace Element Requirements","volume":"31","author":"Sanjeevi","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Farias, P.M., Marcelino, G., Santana, L.F., de Almeida, E.B., Guimar\u00e3es, R.d.C.A., Pott, A., Hiane, P.A., and Freitas, K.d.C. (2020). Minerals in Pregnancy and Their Impact on Child Growth and Development. Molecules, 25.","DOI":"10.3390\/molecules25235630"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Oh, C., Keats, E.C., and Bhutta, Z.A. (2020). Vitamin and Mineral Supplementation During Pregnancy on Maternal, Birth, Child Health and Development Outcomes in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis. Nutrients, 12.","DOI":"10.3390\/nu12020491"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1017\/S0029665121001944","article-title":"Iron, Iodine and Vitamin D Deficiencies during Pregnancy: Epidemiology, Risk Factors and Developmental Impacts","volume":"80","author":"Kiely","year":"2021","journal-title":"Proc. Nutr. Soc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000345165","article-title":"Global Burden of Maternal and Child Undernutrition and Micronutrient Deficiencies","volume":"61","author":"Ahmed","year":"2013","journal-title":"Ann. Nutr. Metab."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bird, J.K., Murphy, R.A., Ciappio, E.D., and McBurney, M.I. (2017). Risk of Deficiency in Multiple Concurrent Micronutrients in Children and Adults in the United States. Nutrients, 9.","DOI":"10.3390\/nu9070655"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4103\/ijmr.IJMR_1768_18","article-title":"Micronutrient Status of Indian Population","volume":"148","author":"Gonmei","year":"2018","journal-title":"Indian J. Med. Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Wang, H., Wang, D., Ouyang, Y., Huang, F., Ding, G., and Zhang, B. (2017). Do Chinese Children Get Enough Micronutrients?. Nutrients, 9.","DOI":"10.20944\/preprints201704.0049.v1"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"100453","DOI":"10.1016\/j.gfs.2020.100453","article-title":"Measuring Malnutrition in All Its Forms: An Update of the Net State of Nutrition Index to Track the Global Burden of Malnutrition at Country Level","volume":"26","author":"Luo","year":"2020","journal-title":"Glob. Food Secur."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Beal, T., Massiot, E., Arsenault, J.E., Smith, M.R., and Hijmans, R.J. (2017). Global Trends in Dietary Micronutrient Supplies and Estimated Prevalence of Inadequate Intakes. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0175554"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Pickering, G., Mazur, A., Trousselard, M., Bienkowski, P., Yaltsewa, N., Amessou, M., Noah, L., and Pouteau, E. (2020). Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients, 12.","DOI":"10.3390\/nu12123672"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Yiannikourides, A., and Latunde-Dada, G.O. (2019). A Short Review of Iron Metabolism and Pathophysiology of Iron Disorders. Medicines, 6.","DOI":"10.3390\/medicines6030085"},{"key":"ref_38","first-page":"164","article-title":"Review on Iron and Its Importance for Human Health","volume":"19","author":"Abbaspour","year":"2014","journal-title":"J. Res. Med. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/ijpvm.IJPVM_48_19","article-title":"Trace Elements in Human Nutrition (II)\u2014An Update","volume":"11","author":"Mehri","year":"2020","journal-title":"Int. J. Prev. Med."},{"key":"ref_40","unstructured":"WHO (1996). Trace Elements in Human Nutrition and Health. Trace Elements in Human Nutrition and Health, World Health Organization."},{"key":"ref_41","unstructured":"Agnew, U.M., and Slesinger, T.L. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.envint.2017.12.035","article-title":"Selenium Distribution in the Chinese Environment and Its Relationship with Human Health: A Review","volume":"112","author":"Dinh","year":"2018","journal-title":"Environ. Int."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Hadrup, N., and Ravn-Haren, G. (2020). Acute Human Toxicity and Mortality after Selenium Ingestion: A Review. J. Trace Elem. Med. Biol., 58.","DOI":"10.1016\/j.jtemb.2019.126435"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1039\/C3MT00185G","article-title":"Selenium Biochemistry and Its Role for Human Health","volume":"6","author":"Roman","year":"2014","journal-title":"Metallomics"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(00)02490-9","article-title":"The Importance of Selenium to Human Health","volume":"356","author":"Rayman","year":"2000","journal-title":"Lancet"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/eurheartj\/ehs224","article-title":"Iron Deficiency and Heart Failure: Diagnostic Dilemmas and Therapeutic Perspectives","volume":"34","author":"Jankowska","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_47","first-page":"2087","article-title":"Iron Deficiency and Cognitive Functions","volume":"10","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1542\/peds.112.4.846","article-title":"Behavioral and Developmental Effects of Preventing Iron-Deficiency Anemia in Healthy Full-Term Infants","volume":"112","author":"Lozoff","year":"2003","journal-title":"Pediatrics"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0140-6736(96)02341-0","article-title":"Randomised Study of Cognitive Effects of Iron Supplementation in Non-Anaemic Iron-Deficient Adolescent Girls","volume":"348","author":"Bruner","year":"1996","journal-title":"Lancet"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jnutbio.2014.07.003","article-title":"Iron and Mechanisms of Emotional Behavior","volume":"25","author":"Kim","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_51","first-page":"119","article-title":"Chronic Anemia and Thyroid Function","volume":"88","author":"Ashraf","year":"2017","journal-title":"Acta Biomed."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/aps.2018.25","article-title":"Zinc Deficiency and Cellular Oxidative Stress: Prognostic Implications in Cardiovascular Diseases","volume":"39","author":"Choi","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3390\/ijerph7041342","article-title":"The Essential Toxin: Impact of Zinc on Human Health","volume":"7","author":"Plum","year":"2010","journal-title":"Int. J. Environ. Res. Public Health."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/eurheartj\/ehx050","article-title":"Subclinical Thyroid Dysfunction and Cardiovascular Diseases: 2016 Update","volume":"39","author":"Floriani","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.semcdb.2011.07.009","article-title":"The Role of Iodine in Human Growth and Development","volume":"22","author":"Zimmermann","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/2156587211414424","article-title":"Iodine: Health Implications of Deficiency","volume":"16","author":"Meletis","year":"2011","journal-title":"J. Evid. Based Complement. Altern. Med."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Buturi, C.V., Mauro, R.P., Fogliano, V., Leonardi, C., and Giuffrida, F. (2021). Mineral Biofortification of Vegetables as a Tool to Improve Human Diet. Foods, 10.","DOI":"10.3390\/foods10020223"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.crfs.2021.09.003","article-title":"Vitamin B12 Biofortification of Soymilk through Optimized Fermentation with Extracellular B12 Producing Lactobacillus Isolates of Human Fecal Origin","volume":"4","author":"Kumari","year":"2021","journal-title":"Curr. Res. Food Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.3402\/fnr.v56i0.5459","article-title":"Vitamin Food Fortification Today","volume":"56","year":"2012","journal-title":"Food Nutr. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"668819","DOI":"10.3389\/fpls.2021.668819","article-title":"Vitamin B12 (Cobalamin) and Micronutrient Fortification in Food Crops Using Nanoparticle Technology","volume":"12","author":"Oh","year":"2021","journal-title":"Front. Plant Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tifs.2021.01.023","article-title":"Meeting Human Dietary Vitamin Requirements in the Staple Rice via Strategies of Biofortification and Post-Harvest Fortification","volume":"109","author":"Tiozon","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41477-022-01154-6","article-title":"Biofortified Tomatoes Provide a New Route to Vitamin D Sufficiency","volume":"8","author":"Li","year":"2022","journal-title":"Nat. Plants"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.tifs.2022.01.006","article-title":"Futuristic Food Fortification with a Balanced Ratio of Dietary \u03c9-3\/\u03c9-6 Omega Fatty Acids for the Prevention of Lifestyle Diseases","volume":"120","author":"Patel","year":"2022","journal-title":"Trends Food Sci. Technol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2174\/1573401313666170728151350","article-title":"Food Fortification with Omega-3 Fatty Acids; Microencapsulation as an Addition Method","volume":"14","author":"Feizollahi","year":"2018","journal-title":"Curr. Nutr. Food Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"301899","DOI":"10.3389\/fnut.2018.00012","article-title":"Biofortified Crops Generated by Breeding, Agronomy, and Transgenic Approaches Are Improving Lives of Millions of People around the World","volume":"5","author":"Garg","year":"2018","journal-title":"Front. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Nieder, R., Benbi, D.K., and Reichl, F.X. (2018). Soil Components and Human Health, Springer Netherlands.","DOI":"10.1007\/978-94-024-1222-2"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1007\/s42729-022-00946-1","article-title":"Iron Biofortification of Wheat Grains by Foliar Application of Nano Zero-Valent Iron (nZVI) and Other Iron Sources with Urea","volume":"22","author":"Taskin","year":"2022","journal-title":"J. Soil Sci. Plant Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Buturi, C.V., Coelho, S.R.M., Cannata, C., Basile, F., Giuffrida, F., Leonardi, C., and Mauro, R.P. (2022). Iron Biofortification of Greenhouse Cherry Tomatoes Grown in a Soilless System. Horticulturae, 8.","DOI":"10.3390\/horticulturae8100858"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"103016","DOI":"10.1016\/j.algal.2023.103016","article-title":"Iron (Fe) Biofortification of Arthrospira Platensis: Effects on Growth, Biochemical Composition and in Vitro Iron Bioaccessibility","volume":"70","author":"Kougia","year":"2023","journal-title":"Algal Res."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Wei, Y., Shohag, M.J.I., and Yang, X. (2012). Biofortification and Bioavailability of Rice Grain Zinc as Affected by Different Forms of Foliar Zinc Fertilization. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045428"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.chemosphere.2019.03.168","article-title":"Comparison Study of Zinc Nanoparticles and Zinc Sulphate on Wheat Growth: From Toxicity and Zinc Biofortification","volume":"227","author":"Du","year":"2019","journal-title":"Chemosphere"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"D\u00e1vila Rangel, I.E., Trejo T\u00e9llez, L.I., Ortega Ortiz, H., Ju\u00e1rez Maldonado, A., Gonz\u00e1lez Morales, S., Companioni Gonz\u00e1lez, B., Cabrera De la Fuente, M., and Benavides Mendoza, A. (2020). Comparison of Iodide, Iodate, and Iodine-Chitosan Complexes for the Biofortification of Lettuce. Appl. Sci., 10.","DOI":"10.3390\/app10072378"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0160-4120(02)00129-0","article-title":"Iodine Uptake by Spinach (Spinacia oleracea L.) Plants Grown in Solution Culture: Effects of Iodine Species and Solution Concentrations","volume":"29","author":"Zhu","year":"2003","journal-title":"Environ. Int."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Krzemi\u0144ska, J., Smole\u0144, S., Kowalska, I., Pitala, J., Sularz, O., and Koronowicz, A. (2023). Effect of Biofortification with Iodine by 8-Hydroxy-7-Iodo-5-Quinolinesulfonic Acid and 5-Chloro-7-Iodo-8-Quinolinol on the Chemical Composition and Antioxidant Properties of Potato Tubers (Solanum tuberosum L.) in a Pot Experiment. Appl. Sci., 13.","DOI":"10.3390\/app13084659"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.copbio.2016.10.004","article-title":"Iodine Biofortification of Crops: Agronomic Biofortification, Metabolic Engineering and Iodine Bioavailability","volume":"44","author":"Gonzali","year":"2017","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1017\/S0014479718000157","article-title":"Selenium Biofortification Of Rice Through Foliar Application With Selenite And Selenate","volume":"55","author":"Lidon","year":"2019","journal-title":"Exp. Agric."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3389\/fpls.2018.00597","article-title":"Absorption and Bio-Transformation of Selenium Nanoparticles by Wheat Seedlings (Triticum aestivum L.)","volume":"9","author":"Hu","year":"2018","journal-title":"Front. Plant Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.scienta.2013.11.011","article-title":"Assessment of Biofortification with Iodine and Selenium of Lettuce Cultivated in the NFT Hydroponic System","volume":"166","author":"Kowalska","year":"2014","journal-title":"Sci. Hortic."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1288773","DOI":"10.3389\/fpls.2023.1288773","article-title":"Evaluation of the Chemical Composition and Nutritional Value of Lettuce (Lactuca sativa L.) Biofortified in Hydroponics with Iodine in the Form of Iodoquinolines","volume":"14","author":"Kowalska","year":"2023","journal-title":"Front. Plant Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1080\/01904167.2021.1927083","article-title":"Effects of Iron Fortification on Growth and Nutrient Amounts of Spinach (Spinacia oleracea L.)","volume":"44","year":"2021","journal-title":"J. Plant Nutr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.1002\/jsfa.12622","article-title":"Biofortification of Baby Leafy Vegetables Using Nutrient Solution Containing Selenium","volume":"103","author":"Francini","year":"2023","journal-title":"J. Sci. Food Agric."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"716437","DOI":"10.3389\/fpls.2021.716437","article-title":"Biofortification of Sodium Selenate Improves Dietary Mineral Contents and Antioxidant Capacity of Culinary Herb Microgreens","volume":"12","author":"Newman","year":"2021","journal-title":"Front. Plant Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"138180","DOI":"10.1016\/j.foodchem.2023.138180","article-title":"Simultaneous Biofortification of Vitamin C and Mineral Nutrients in Arugula Microgreens","volume":"440","author":"Kathi","year":"2024","journal-title":"Food Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"112522","DOI":"10.1016\/j.scienta.2023.112522","article-title":"Biofortification of Kale Microgreens with Selenate-Selenium Using Two Delivery Methods: Selenium-Rich Soilless Medium and Foliar Application","volume":"323","author":"Tavan","year":"2024","journal-title":"Sci. Hortic."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.micres.2017.06.001","article-title":"Zinc Solubilizing Bacillus Spp. Potential Candidates for Biofortification in Maize","volume":"202","author":"Mumtaz","year":"2017","journal-title":"Microbiol. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jcs.2007.06.005","article-title":"Enhancing the Mineral and Vitamin Content of Wheat and Maize through Plant Breeding","volume":"46","author":"Meng","year":"2007","journal-title":"J. Cereal Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/nyas.13314","article-title":"Availability, Production, and Consumption of Crops Biofortified by Plant Breeding: Current Evidence and Future Potential","volume":"1390","author":"Saltzman","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.17485\/ijst\/2014\/v7i9.15","article-title":"Genotypic Variation for Micronutrient Content in Traditional and Improved Rice Lines and Its Role in Biofortification Programme","volume":"7","author":"Nachimuthu","year":"2014","journal-title":"Indian J. Sci. Technol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"13526","DOI":"10.1038\/s41598-018-31951-z","article-title":"Genetic Dissection of Grain Zinc Concentration in Spring Wheat for Mainstreaming Biofortification in CIMMYT Wheat Breeding","volume":"8","author":"Velu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/ppl.12151","article-title":"Genotypic Variation in the Ability of Landraces and Commercial Cereal Varieties to Avoid Manganese Deficiency in Soils with Limited Manganese Availability: Is There a Role for Root-Exuded Phytases?","volume":"151","author":"George","year":"2014","journal-title":"Physiol. Plant."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"103492","DOI":"10.1016\/j.apsoil.2019.103492","article-title":"Impact of Genetically Modified Crops on Rhizosphere Microorganisms and Processes: A Review Focusing on Bt Cotton","volume":"148","author":"Mandal","year":"2020","journal-title":"Appl. Soil Ecol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.3390\/v7082819","article-title":"Public Acceptance of Plant Biotechnology and GM Crops","volume":"7","author":"Lucht","year":"2015","journal-title":"Viruses"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40066-017-0135-3","article-title":"An Overview of Agriculture, Nutrition and Fortification, Supplementation and Biofortification: Golden Rice as an Example for Enhancing Micronutrient Intake","volume":"6","author":"Dubock","year":"2017","journal-title":"Agric. Food Secur."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.nbt.2010.05.010","article-title":"Golden Rice and \u2018Golden\u2019 Crops for Human Nutrition","volume":"27","author":"Beyer","year":"2010","journal-title":"New Biotech."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.3945\/ajcn.2008.27119","article-title":"Golden Rice Is an Effective Source of Vitamin A23","volume":"89","author":"Tang","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/7029","article-title":"Iron Fortification of Rice Seed by the Soybean Ferritin Gene","volume":"17","author":"Goto","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3389\/fpls.2018.00326","article-title":"Prospecting for Microelement Function and Biosafety Assessment of Transgenic Cereal Plants","volume":"9","author":"Yu","year":"2018","journal-title":"Front. Plant Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1023\/A:1026534009483","article-title":"Constitutive Expression of Soybean Ferritin cDNA Intransgenic Wheat and Rice Results in Increased Iron Levels in Vegetative Tissues but Not in Seeds","volume":"9","author":"Drakakaki","year":"2000","journal-title":"Transgenic Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1023\/B:TRAG.0000017158.96765.67","article-title":"Production of Two Highly Active Bacterial Phytases with Broad pH Optima in Germinated Transgenic Rice Seeds","volume":"13","author":"Hong","year":"2004","journal-title":"Transgenic Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.envpol.2006.01.008","article-title":"Overexpressing Both ATP Sulfurylase and Selenocysteine Methyltransferase Enhances Selenium Phytoremediation Traits in Indian Mustard","volume":"144","author":"LeDuc","year":"2006","journal-title":"Environ. Pollut."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1104\/pp.103.026989","article-title":"Overexpression of Selenocysteine Methyltransferase in Arabidopsis and Indian Mustard Increases Selenium Tolerance and Accumulation","volume":"135","author":"LeDuc","year":"2004","journal-title":"Plant Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Wo\u017aniak, D., Cichy, W., Dobrzy\u0144ska, M., Przys\u0142awski, J., and Drzyma\u0142a-Czy\u017c, S. (2022). Reasonableness of Enriching Cow\u2019s Milk with Vitamins and Minerals. Foods, 11.","DOI":"10.3390\/foods11081079"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.22271\/chemi.2020.v8.i3n.9339","article-title":"Physicochemical and Sensory Characteristics of Symbiotic Fruit Flavoured Yoghurt Fortified with Calcium and Vitamin D","volume":"8","author":"Manoharan","year":"2020","journal-title":"Int. J. Chem. Stud."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tifs.2020.05.018","article-title":"Naturally Enhanced Eggs as a Source of Vitamin D: A Review","volume":"102","author":"Barnkob","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cofs.2020.04.010","article-title":"Microencapsulation of Healthier Oils: An Efficient Strategy to Improve the Lipid Profile of Meat Products","volume":"40","author":"Heck","year":"2021","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_106","first-page":"329","article-title":"Quality Characteristics of Functional Chicken Meat Sausages Enriched With Omega-3-Fatty Acids","volume":"41","author":"Reddy","year":"2022","journal-title":"Asian J. Dairy Food Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"127612","DOI":"10.1016\/j.foodchem.2020.127612","article-title":"Fatty Acids Profile, Cholesterol Level and Quality of Table Eggs from Hens Fed with the Addition of Linseed and Soybean Oil","volume":"334","author":"Batkowska","year":"2021","journal-title":"Food Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"101379","DOI":"10.1016\/j.psj.2021.101379","article-title":"Fatty Acid Profile of Eggs Produced by Laying Hens Fed Diets Containing Different Shares of Fish Oil","volume":"100","author":"Kralik","year":"2021","journal-title":"Poult. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Long, S., Liu, S., Wu, D., Mahfuz, S., and Piao, X. (2020). Effects of Dietary Fatty Acids from Different Sources on Growth Performance, Meat Quality, Muscle Fatty Acid Deposition, and Antioxidant Capacity in Broilers. Animals, 10.","DOI":"10.3390\/ani10030508"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/nbu.12509","article-title":"Egg Enrichment with Vitamin D: The Sunshine Eggs Projects","volume":"46","author":"Clark","year":"2021","journal-title":"Nutr. Bull."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"130636","DOI":"10.1016\/j.foodchem.2021.130636","article-title":"Effect of Advanced Chelate Compounds-Based Mineral Supplement in Laying Hen Diet on the Performance, Egg Quality, Yolk Mineral Content, Fatty Acid Composition, and Oxidative Status","volume":"366","author":"Ghasemi","year":"2022","journal-title":"Food Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"109","DOI":"10.5194\/aab-61-109-2018","article-title":"Quality and Mineral Composition of Eggs from Hens Supplemented with Copper-Lysine Chelate","volume":"61","author":"Brodacki","year":"2018","journal-title":"Arch. Anim. Breed."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1007\/s12011-020-02284-8","article-title":"Effects of Replacing Inorganic with Organic Iron on Performance, Egg Quality, Serum and Egg Yolk Lipids, Antioxidant Status, and Iron Accumulation in Eggs of Laying Hens","volume":"199","author":"Sarlak","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/jpn.12871","article-title":"Effects of Zinc Oxide Nanoparticles on the Egg Quality, Immune Response, Zinc Retention, and Blood Parameters of Laying Hens in the Late Phase of Production","volume":"102","author":"Abedini","year":"2018","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12011-017-1180-2","article-title":"Effects of Zinc Oxide Nanoparticles on Performance, Egg Quality, Tissue Zinc Content, Bone Parameters, and Antioxidative Status in Laying Hens","volume":"184","author":"Abedini","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1439-0396.2010.01065.x","article-title":"Effect of Macroalgae Enriched with Microelements on Egg Quality Parameters and Mineral Content of Eggs, Eggshell, Blood, Feathers and Droppings","volume":"95","author":"Michalak","year":"2011","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/jpn.13027","article-title":"Biofortification of Hens\u2019 Eggs with Microelements by Innovative Bio-Based Dietary Supplement","volume":"103","author":"Witkowska","year":"2019","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10653-007-9086-0","article-title":"Improving Human Micronutrient Nutrition through Biofortification in the Soil\u2013Plant System: China as a Case Study","volume":"29","author":"Yang","year":"2007","journal-title":"Environ. Geochem. Health"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Koronowicz, A.A., Kope\u0107, A., Master, A., Smole\u0144, S., Pi\u0105tkowska, E., Bie\u017canowska-Kope\u0107, R., Ledwo\u017cyw-Smole\u0144, I., Skoczylas, \u0141., Rakoczy, R., and Leszczy\u0144ska, T. (2016). Transcriptome Profiling of Caco-2 Cancer Cell Line Following Treatment with Extracts from Iodine-Biofortified Lettuce (Lactuca sativa L.). PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0147336"},{"key":"ref_120","first-page":"33","article-title":"Selenium Biofortification Treatment Of Cauliflower Enhances Their Content In Chemopreventive Compounds And In Vitro Antitumoral Activity","volume":"XXI","author":"Utoiu","year":"2017","journal-title":"Sci. Bull. Ser. F Biotechnol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Tavares Antunes, P., Vaz-Tostes, M.d.G., Tom\u00e1z Sant\u2019Ana, C., Ara\u00fajo de Faria, R., Lopes Toledo, R.C., and Brunoro Costa, N.M. (2019). Bioavailability of Iron and the Influence of Vitamin a in Biofortified Foods. Agronomy, 9.","DOI":"10.3390\/agronomy9120777"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1475-2891-10-113","article-title":"Biofortified Red Mottled Beans (Phaseolus vulgaris L.) in a Maize and Bean Diet Provide More Bioavailable Iron than Standard Red Mottled Beans: Studies in Poultry (Gallus gallus) and an in Vitro Digestion\/Caco-2 Model","volume":"10","author":"Tako","year":"2011","journal-title":"Nutr. J."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"19792","DOI":"10.1038\/srep19792","article-title":"Biofortified Indica Rice Attains Iron and Zinc Nutrition Dietary Targets in the Field","volume":"6","author":"Trijatmiko","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/jsfa.7226","article-title":"Evaluation of Iron and Zinc Bioavailability of Beans Targeted for Biofortification Using in Vitro and in Vivo Models and Their Effect on the Nutritional Status of Preschool Children","volume":"96","author":"Verediano","year":"2016","journal-title":"J. Sci. Food Agric."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.3945\/jn.115.224741","article-title":"Consuming Iron Biofortified Beans Increases Iron Status in Rwandan Women after 128 Days in a Randomized Controlled Feeding Trial123","volume":"146","author":"Haas","year":"2016","journal-title":"J. Nutr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1021\/jf202338t","article-title":"Biofortification of Rice with Zinc: Assessment of the Relative Bioavailability of Zinc in a Caco-2 Cell Model and Suckling Rat Pups","volume":"60","author":"Jou","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.3945\/jn.113.176677","article-title":"Biofortification of Pearl Millet with Iron and Zinc in a Randomized Controlled Trial Increases Absorption of These Minerals above Physiologic Requirements in Young Children","volume":"143","author":"Kodkany","year":"2013","journal-title":"J. Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1111\/1750-3841.14785","article-title":"Bioavailability Assessment of Copper, Iron, Manganese, Molybdenum, Selenium, and Zinc from Selenium-Enriched Lettuce","volume":"84","author":"Cadore","year":"2019","journal-title":"J. Food Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"103817","DOI":"10.1016\/j.jff.2020.103817","article-title":"In Vitro Selenium Bioaccessibility Combined with in Vivo Bioavailability and Bioactivity in Se-Enriched Microalga (Chlorella sorokiniana) to Be Used as Functional Food","volume":"66","author":"Borrego","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.foodres.2018.10.049","article-title":"Assessing Bioaccessibility of Se and I in Dual Biofortified Radish Seedlings Using Simulated in Vitro Digestion","volume":"119","author":"Hu","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"104253","DOI":"10.1016\/j.jfca.2021.104253","article-title":"In Vitro Bioaccessibility and Bioavailability of Selenium in Agronomic Biofortified Wheat","volume":"105","author":"Delaqua","year":"2022","journal-title":"J. Food Compos. Anal."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1021\/acs.jafc.9b05912","article-title":"Fate and Bioaccessibility of Iodine in Food Prepared from Agronomically Biofortified Wheat and Rice and Impact of Cofertilization with Zinc and Selenium","volume":"68","author":"Cakmak","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s13197-017-2946-4","article-title":"The Bioaccessibility of Iodine in the Biofortified Vegetables throughout Cooking and Simulated Digestion","volume":"55","author":"Li","year":"2018","journal-title":"J. Food Sci. Technol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"E694","DOI":"10.1210\/jc.2012-3509","article-title":"Iodine Fortification of Vegetables Improves Human Iodine Nutrition: In Vivo Evidence for a New Model of Iodine Prophylaxis","volume":"98","author":"Tonacchera","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Pi\u0105tkowska, E., Kope\u0107, A., Bie\u017canowska-Kope\u0107, R., Pysz, M., Kapusta-Duch, J., Koronowicz, A.A., Smole\u0144, S., Skoczylas, \u0141., Ledwo\u017cyw-Smole\u0144, I., and Rakoczy, R. (2016). The Impact of Carrot Enriched in Iodine through Soil Fertilization on Iodine Concentration and Selected Biochemical Parameters in Wistar Rats. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0152680"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12011-016-0717-0","article-title":"The Iodine Content in Urine, Faeces and Selected Organs of Rats Fed Lettuce Biofortified with Iodine Through Foliar Application","volume":"174","author":"Rakoczy","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"111387","DOI":"10.1016\/j.fct.2020.111387","article-title":"Growth Performance, Bioavailability of Toxic and Essential Elements and Nutrients, and Biofortification of Iodine of Rainbow Trout (Onchorynchus mykiss) Fed Blends with Sugar Kelp (Saccharina latissima)","volume":"141","author":"Granby","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jff.2015.02.027","article-title":"Effect of Lettuce Biofortified with Iodine by Soil Fertilization on Iodine Concentration in Various Tissues and Selected Biochemical Parameters in Serum of Wistar Rats","volume":"14","author":"Pysz","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1080\/10408398.2017.1306484","article-title":"Advantages and Limitations of in Vitro and in Vivo Methods of Iron and Zinc Bioavailability Evaluation in the Assessment of Biofortification Program Effectiveness","volume":"58","author":"Dias","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1093\/jn\/135.12.2823","article-title":"Iron-Biofortified Rice Improves the Iron Stores of Nonanemic Filipino Women12","volume":"135","author":"Haas","year":"2005","journal-title":"J. Nutr."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.3945\/jn.114.208009","article-title":"A Randomized Trial of Iron-Biofortified Pearl Millet in School Children in India","volume":"145","author":"Finkelstein","year":"2015","journal-title":"J. Nutr."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4103\/ijmr.IJMR_1893_18","article-title":"Nutritional Security through Crop Biofortification in India: Status & Future Prospects","volume":"148","author":"Yadava","year":"2018","journal-title":"Indian J. Med. Res."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Sheoran, S., Kumar, S., Ramtekey, V., Kar, P., Meena, R.S., and Jangir, C.K. (2022). Current Status and Potential of Biofortification to Enhance Crop Nutritional Quality: An Overview. Sustainability, 14.","DOI":"10.3390\/su14063301"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s42729-020-00346-3","article-title":"Effects of Foliar Fertilization: A Review of Current Status and Future Perspectives","volume":"21","author":"Niu","year":"2021","journal-title":"J. Soil Sci. Plant Nutr."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"106936","DOI":"10.1016\/j.envint.2021.106936","article-title":"Global Water Shortage and Potable Water Safety; Today\u2019s Concern and Tomorrow\u2019s Crisis","volume":"158","author":"Salehi","year":"2022","journal-title":"Environ. Int."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/fsn3.301","article-title":"Effect of Processing Methods on Nutritional, Sensory, and Physicochemical Characteristics of Biofortified Bean Flour","volume":"4","author":"Nkundabombi","year":"2016","journal-title":"Food Sci. Nutr."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1021\/acs.jafc.7b01176","article-title":"Biofortification with Iron and Zinc Improves Nutritional and Nutraceutical Properties of Common Wheat Flour and Bread","volume":"65","author":"Ciccolini","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"407","DOI":"10.12944\/CRNFSJ.10.2.2","article-title":"A Review of Food-Based Intervention Strategies for Improving Micronutrient Status and Health During Childhood","volume":"10","author":"Chiplonkar","year":"2022","journal-title":"Curr. Res. Nutr. Food Sci."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Islam, M.H., Jubayer, A., Nowar, A., Nayan, M.M., and Islam, S. (2023). Dietary Diversity and Micronutrients Adequacy among the Women of Reproductive Age at St. Martin\u2019s Island in Bangladesh. BMC Nutr., 9.","DOI":"10.1186\/s40795-023-00715-y"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1093\/jn\/nxab273","article-title":"Disparities in Risks of Inadequate and Excessive Intake of Micronutrients during Pregnancy","volume":"151","author":"Sauder","year":"2021","journal-title":"J. Nutr."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"von Braun, J., Afsana, K., Fresco, L.O., and Hassan, M.H.A. (2023). Science and Innovations for Food Systems Transformation, Springer International Publishing.","DOI":"10.1007\/978-3-031-15703-5"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0140-6736(18)31788-4","article-title":"Food in the Anthropocene: The EAT\u2013Lancet Commission on Healthy Diets from Sustainable Food Systems","volume":"393","author":"Willett","year":"2019","journal-title":"Lancet"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"100689","DOI":"10.1016\/j.gfs.2023.100689","article-title":"What Is Wrong with Biofortification","volume":"37","author":"Cherfas","year":"2023","journal-title":"Glob. Food Secur."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s11062-020-09854-5","article-title":"Roles of Metal Microelements in Neurodegenerative Diseases","volume":"52","author":"Leal","year":"2020","journal-title":"Neurophysiology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1024\/0300-9831\/a000226","article-title":"The Biochemical Role of Macro and Micro-Minerals in the Management of Diabetes Mellitus and Its Associated Complications: A Review","volume":"85","year":"2015","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10653-015-9758-0","article-title":"Analysis of the Relationship between the Blood Concentration of Several Metals, Macro- and Micronutrients and Endocrine Disorders Associated with Male Aging","volume":"38","author":"Rotter","year":"2016","journal-title":"Environ. Geochem. Health"},{"key":"ref_157","unstructured":"Mohn, E.S., and Johnson, E.J. (2015). Nanotechnology and Functional Foods, John Wiley & Sons, Ltd."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jtemb.2019.02.009","article-title":"Assessing the Dietary Intake of Calcium, Magnesium, Iron, Zinc and Copper in Institutionalised Children and Adolescents from Guatemala. Contribution of Nutritional Supplements","volume":"53","author":"Muros","year":"2019","journal-title":"J. Trace Elem. Med. Biol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/10\/1481\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:42:12Z","timestamp":1760107332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/10\/1481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,14]]},"references-count":158,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["nu16101481"],"URL":"https:\/\/doi.org\/10.3390\/nu16101481","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,14]]}}}