{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:09:22Z","timestamp":1781176162574,"version":"3.54.1"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The high prevalence of constipation after fracture surgery brings intolerable discomfort to patients on the one hand, and affects post-surgery nutrient absorption on the other hand, resulting in poor prognosis. Given the acknowledged probiotic properties of Lactobacillus rhamnosus, 100 fracture patients with post-surgery constipation were centrally enrolled and administered orally with L. rhamnosus JYLR-127 to assess the efficacy of probiotic-adjuvant therapy in alleviating post-fracture constipation symptoms. The results showed that L. rhamnosus JYLR-127 improved fecal properties, promoted gastrointestinal recovery, and relieved constipation symptoms, which were mainly achieved by elevating Firmicutes (p &lt; 0.01) and descending Bacteroidetes (p &lt; 0.001), hence remodeling the disrupted intestinal microecology. In addition, blood routine presented a decrease in C-reactive protein levels (p &lt; 0.05) and an increase in platelet counts (p &lt; 0.05) after probiotic supplementation, prompting the feasibility of L. rhamnosus JYLR-127 in anti-inflammation, anti-infection and hemorrhagic tendency prevention after fracture surgery. Our study to apply probiotics in ameliorating constipation after fracture surgery is expected to bless the bothered patients, and provide broader application scenarios for L. rhamnosus preparations.<\/jats:p>","DOI":"10.3390\/nu16101505","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T04:26:29Z","timestamp":1715919989000},"page":"1505","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Improvement of Post-Surgery Constipation in Patients with Fractures by Lactobacillus rhamnosus JYLR-127: A Single-Blind Randomized Controlled Trial"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2091-104X","authenticated-orcid":false,"given":"Yiyang","family":"Han","sequence":"first","affiliation":[{"name":"Department of Orthopedics, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang 330031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Leshan People\u2019s Hospital, Leshan 614003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang 330031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Chen","sequence":"additional","affiliation":[{"name":"Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang 330031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang 330031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang 330031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Leshan People\u2019s Hospital, Leshan 614003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Leshan People\u2019s Hospital, Leshan 614003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang 330031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang 330031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0506-8536","authenticated-orcid":false,"given":"Tingtao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Institute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang 330031, China"},{"name":"School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang 330031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1210\/endrev\/bnac008","article-title":"Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence","volume":"43","author":"Saul","year":"2022","journal-title":"Endocr. 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