{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:50:56Z","timestamp":1790812256109,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Elevated maternal triglycerides (TGs) have been associated with excessive fetal growth. However, the role of maternal lipid profile is less studied in gestational diabetes mellitus (GDM). We aimed to study the association between maternal lipid profile in the third trimester and the risk for large-for-gestational-age (LGA) newborns in women with GDM. We performed an observational and retrospective study of pregnant women with GDM who underwent a lipid profile measurement during the third trimester. We applied a logistic regression model to assess predictors of LGA. A total of 100 singleton pregnant women with GDM and third-trimester lipid profile evaluation were included. In the multivariate analysis, pre-pregnancy BMI (OR 1.19 (95% CI 1.03\u20131.38), p = 0.022) and hypertriglyceridemia (OR 7.60 (1.70\u201334.10), p = 0.008) were independently associated with LGA. Third-trimester hypertriglyceridemia was found to be a predictor of LGA among women with GDM, independently of glycemic control, BMI, and pregnancy weight gain. Further investigation is needed to confirm the role of TGs in excessive fetal growth in GDM pregnancies.<\/jats:p>","DOI":"10.3390\/nu16111577","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T09:04:25Z","timestamp":1716455065000},"page":"1577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Maternal Hypertriglyceridemia in Gestational Diabetes: A New Risk Factor?"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9510-419X","authenticated-orcid":false,"given":"Francisca","family":"Marques Puga","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo, Unidade Local de Sa\u00fade de Santo Ant\u00f3nio, 4050-366 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-6888","authenticated-orcid":false,"given":"Diana","family":"Borges Duarte","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Unidade Local de Sa\u00fade de Braga, 4710-243 Braga, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-7414","authenticated-orcid":false,"given":"V\u00e2nia","family":"Benido Silva","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Unidade Local de Sa\u00fade do T\u00e2mega e Sousa, 4560-136 Penafiel, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8073-9734","authenticated-orcid":false,"given":"Maria Teresa","family":"Pereira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo, Unidade Local de Sa\u00fade de Santo Ant\u00f3nio, 4050-366 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-7115","authenticated-orcid":false,"given":"Susana","family":"Garrido","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo, Unidade Local de Sa\u00fade de Santo Ant\u00f3nio, 4050-366 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1218-3743","authenticated-orcid":false,"given":"Joana","family":"Vilaverde","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo, Unidade Local de Sa\u00fade de Santo Ant\u00f3nio, 4050-366 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sales Moreira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Obstetr\u00edcia e Medicina Materno-Fetal, Unidade Local de Sa\u00fade de Santo Ant\u00f3nio, 4050-366 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6250-0092","authenticated-orcid":false,"given":"Fernando","family":"Pichel","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Nutri\u00e7\u00e3o, Unidade Local de Sa\u00fade de Santo Ant\u00f3nio, 4050-366 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-1775","authenticated-orcid":false,"given":"Clara","family":"Pinto","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Obstetr\u00edcia e Medicina Materno-Fetal, Unidade Local de Sa\u00fade de Santo Ant\u00f3nio, 4050-366 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9883-3809","authenticated-orcid":false,"given":"Jorge","family":"Dores","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo, Unidade Local de Sa\u00fade de Santo Ant\u00f3nio, 4050-366 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.ajog.2004.11.039","article-title":"Gestational diabetes: The consequences of not treating","volume":"192","author":"Langer","year":"2005","journal-title":"Am. 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