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Medicine","award":["2021YFC2701900"],"award-info":[{"award-number":["2021YFC2701900"]}]},{"name":"Research Fund of Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine","award":["2021YFC2701903"],"award-info":[{"award-number":["2021YFC2701903"]}]},{"name":"Research Fund of Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine","award":["22ZR1457000"],"award-info":[{"award-number":["22ZR1457000"]}]},{"name":"Research Fund of Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine","award":["RCJD2021S03"],"award-info":[{"award-number":["RCJD2021S03"]}]},{"name":"Research Fund of Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine","award":["TRYJ2022LC05"],"award-info":[{"award-number":["TRYJ2022LC05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diabetes, especially type 2 diabetes (T2D), poses an unprecedented challenge to global public health. Hydration status also plays a fundamental role in human health, especially in people with T2D, which is often overlooked. This study aimed to explore the longitudinal associations between hydration status and the risk of T2D among the Chinese population. This study used data from the large community-based Kailuan cohort, which included adults who attended physical examinations from 2006 to 2007 and were followed until 2020. A total of 71,526 participants who eventually met the standards were divided into five hydration-status groups based on their levels of urine specific gravity (USG). Multivariable and time-dependent Cox proportional hazards models were employed to evaluate the associations of baseline and time-dependent hydration status with T2D incidence. Restricted cubic splines (RCS) analysis was used to examine the dose\u2013response relationship between hydration status and the risk of T2D. Over a median 12.22-year follow-up time, 11,804 of the participants developed T2D. Compared with the optimal hydration-status group, participants with dehydration and severe dehydration had a significantly increased risk of diabetes, with adjusted hazard ratios (95% CI) of 1.30 (1.04\u20131.63) and 1.38 (1.10\u20131.74). Time-dependent analyses further confirmed the adverse effects of impending dehydration, dehydration, and severe dehydration on T2D incidence by 16%, 26%, and 33% compared with the reference group. Inadequate hydration is significantly associated with increased risks of T2D among Chinese adults. Our findings provided new epidemiological evidence and highlighted the potential role of adequate hydration status in the early prevention of T2D development.<\/jats:p>","DOI":"10.3390\/nu16111643","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T09:33:31Z","timestamp":1716802411000},"page":"1643","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between Urine Specific Gravity as a Measure of Hydration Status and Risk of Type 2 Diabetes: The Kailuan Prospective Cohort Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3713-3590","authenticated-orcid":false,"given":"Yinqiao","family":"Dong","sequence":"first","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"},{"name":"Public Health Department, Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200335, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuohua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan 063000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohui","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Practice, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200335, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200335, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Huang","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200335, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-6022","authenticated-orcid":false,"given":"Shouling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan 063000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-7906","authenticated-orcid":false,"given":"Yong","family":"Cai","sequence":"additional","affiliation":[{"name":"Public Health Department, Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200335, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s00125-022-05713-6","article-title":"Low- and middle-income countries demonstrate rapid growth of type 2 diabetes: An analysis based on Global Burden of Disease 1990\u20132019 data","volume":"65","author":"Liu","year":"2022","journal-title":"Diabetologia"},{"key":"ref_2","unstructured":"Collaborators GBDD (2023). Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021. Lancet, 402, 203\u2013234."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1001\/jama.2021.22208","article-title":"Prevalence and Treatment of Diabetes in China, 2013\u20132018","volume":"326","author":"Wang","year":"2021","journal-title":"JAMA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12933-018-0728-6","article-title":"Prevalence of cardiovascular disease in type 2 diabetes: A systematic literature review of scientific evidence from across the world in 2007\u20132017","volume":"17","author":"Einarson","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.metabol.2018.10.013","article-title":"Burden of cancer attributable to obesity, type 2 diabetes and associated risk factors","volume":"92","year":"2019","journal-title":"Metabolism"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1056\/NEJMc1515130","article-title":"Excess Mortality among Persons with Type 2 Diabetes","volume":"374","author":"Zhang","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"102156","DOI":"10.1016\/j.dsx.2021.05.029","article-title":"Water intake and risk of type 2 diabetes: A systematic review and meta-analysis of observational studies","volume":"15","author":"Janbozorgi","year":"2021","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3945\/ajcn.111.032698","article-title":"Plain-water intake and risk of type 2 diabetes in young and middle-aged women","volume":"95","author":"Pan","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"l2368","DOI":"10.1136\/bmj.l2368","article-title":"Role of diet in type 2 diabetes incidence: Umbrella review of meta-analyses of prospective observational studies","volume":"366","author":"Neuenschwander","year":"2019","journal-title":"BMJ"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Johnson, E.C., and Adams, W.M. (2020). Water Intake, Body Water Regulation and Health. Nutrients, 12.","DOI":"10.3390\/nu12030702"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/ejcn.2009.111","article-title":"Water as an essential nutrient: The physiological basis of hydration","volume":"64","author":"Jequier","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41581-024-00817-1","article-title":"Long-term health outcomes associated with hydration status","volume":"20","author":"Dmitrieva","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Dmitrieva, N.I., Gagarin, A., Liu, D., Wu, C.O., and Boehm, M. (2023). Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality. eBioMedicine, 87.","DOI":"10.1016\/j.ebiom.2022.104404"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Stookey, J.D., Kavouras, S., Suh, H., and Lang, F. (2020). Underhydration Is Associated with Obesity, Chronic Diseases, and Death within 3 to 6 Years in the U.S. Population Aged 51\u201370 Years. Nutrients, 12.","DOI":"10.3390\/nu12040905"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Amaerjiang, N., Li, M., Xiao, H., Zunong, J., Li, Z., Huang, D., Vermund, S.H., Perez-Escamilla, R., Jiang, X., and Hu, Y. (2022). Dehydration Status Aggravates Early Renal Impairment in Children: A Longitudinal Study. Nutrients, 14.","DOI":"10.3390\/nu14020335"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Nishi, S.K., Babio, N., Paz-Graniel, I., Serra-Majem, L., Vioque, J., Fito, M., Corella, D., Pinto, X., Bueno-Cavanillas, A., and Tur, J.A. (2023). Water intake, hydration status and 2-year changes in cognitive performance: A prospective cohort study. BMC Med., 21.","DOI":"10.1186\/s12916-023-02771-4"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1093\/eurheartj\/ehac138","article-title":"Middle age serum sodium levels in the upper part of normal range and risk of heart failure","volume":"43","author":"Dmitrieva","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.numecd.2023.01.007","article-title":"Association of serum osmolality with all-cause and cardiovascular mortality in US adults: A prospective cohort study","volume":"33","author":"Wang","year":"2023","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00394-015-0944-8","article-title":"Water intake: Validity of population assessment and recommendations","volume":"54","author":"Gandy","year":"2015","journal-title":"Eur. J. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ekingen, T., Sob, C., Hartmann, C., Ruhli, F.J., Matthes, K.L., Staub, K., and Bender, N. (2022). Associations between hydration status, body composition, sociodemographic and lifestyle factors in the general population: A cross-sectional study. BMC Public Health, 22.","DOI":"10.1186\/s12889-022-13280-z"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.nutres.2017.05.004","article-title":"Reduced water intake deteriorates glucose regulation in patients with type 2 diabetes","volume":"43","author":"Johnson","year":"2017","journal-title":"Nutr. Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Johnson, R.J., Garcia-Arroyo, F.E., Gonzaga-Sanchez, G., Velez-Orozco, K.A., Alvarez-Alvarez, Y.Q., Aparicio-Trejo, O.E., Tapia, E., Osorio-Alonso, H., Andres-Hernando, A., and Nakagawa, T. (2022). Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases. Nutrients, 14.","DOI":"10.3390\/nu14102070"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1161\/CIRCULATIONAHA.109.909663","article-title":"Plasma copeptin and the risk of diabetes mellitus","volume":"121","author":"Enhorning","year":"2010","journal-title":"Circulation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/ijo.2012.88","article-title":"Copeptin, a marker of vasopressin, in abdominal obesity, diabetes and microalbuminuria: The prospective Malmo Diet and Cancer Study cardiovascular cohort","volume":"37","author":"Enhorning","year":"2013","journal-title":"Int. J. Obes."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1210\/JC.2015-2362","article-title":"Copeptin, Insulin Resistance, and Risk of Incident Diabetes in Older Men","volume":"100","author":"Wannamethee","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1007\/s00125-019-4917-y","article-title":"Correction to: Sex differences in the association between plasma copeptin and incident type 2 diabetes: The Prevention of Renal and Vascular Endstage Disease (PREVEND) study","volume":"62","author":"Abbasi","year":"2019","journal-title":"Diabetologia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1017\/S0007114514003213","article-title":"Assessment of hydration status in a large population","volume":"113","author":"Baron","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1053\/j.ajkd.2021.03.021","article-title":"Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study","volume":"79","author":"Cohen","year":"2022","journal-title":"Am. J. Kidney Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/ki.2008.328","article-title":"Survival analysis: Time-dependent effects and time-varying risk factors","volume":"74","author":"Dekker","year":"2008","journal-title":"Kidney Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.2337\/dc20-2375","article-title":"Associations of Type 2 Diabetes Onset Age with Cardiovascular Disease and Mortality: The Kailuan Study","volume":"44","author":"Zhao","year":"2021","journal-title":"Diabetes Care"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/ajcn\/nqaa331","article-title":"A prospective study of waist circumference trajectories and incident cardiovascular disease in China: The Kailuan Cohort Study","volume":"113","author":"Wang","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Feng, Y., Fang, G., Li, M., Cui, S., Geng, X., Qu, C., and Zhao, J. (2022). Hydration monitoring and rehydration guidance system for athletes based on urine color\u2019s L*a*b* parameters. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.1043028"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00394-023-03254-1","article-title":"Validity of combined hydration self-assessment measurements to estimate a low vs. high urine concentration in a small sample of (tactical) athletes","volume":"63","author":"Wardenaar","year":"2024","journal-title":"Eur. J. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1007\/s00394-021-02575-3","article-title":"Associations between urinary hydration markers and metabolic dysfunction: A cross-sectional analysis of NHANES data, 2008\u20132010","volume":"60","author":"Vanhaecke","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1984.e9","DOI":"10.1016\/j.jamda.2022.08.015","article-title":"Point-of-Care Saliva Osmolarity Testing for the Screening of Hydration in Older Adults with Hypertension","volume":"23","author":"Atjo","year":"2022","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.2337\/dci15-0012","article-title":"Update on Prevention of Cardiovascular Disease in Adults with Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement from the American Heart Association and the American Diabetes Association","volume":"38","author":"Fox","year":"2015","journal-title":"Diabetes Care"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1161\/STROKEAHA.113.678839","article-title":"Ideal cardiovascular health metrics and the risks of ischemic and intracerebral hemorrhagic stroke","volume":"44","author":"Zhang","year":"2013","journal-title":"Stroke"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1161\/STROKEAHA.117.020277","article-title":"Longitudinal Change of Perceived Salt Intake and Stroke Risk in a Chinese Population","volume":"49","author":"Li","year":"2018","journal-title":"Stroke"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1161\/CIRCOUTCOMES.111.963694","article-title":"Prevalence of ideal cardiovascular health and its relationship with the 4-year cardiovascular events in a northern Chinese industrial city","volume":"5","author":"Wu","year":"2012","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101365","DOI":"10.1016\/j.diabet.2022.101365","article-title":"Triglyceride-glucose index associates with incident heart failure: A cohort study","volume":"48","author":"Xu","year":"2022","journal-title":"Diabetes Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12933-022-01701-7","article-title":"Association of cumulative monocyte to high-density lipoprotein ratio with the risk of type 2 diabetes: A prospective cohort study","volume":"21","author":"Wu","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/HYPERTENSIONAHA.122.19256","article-title":"Hypertension, Arterial Stiffness, and Diabetes: A Prospective Cohort Study","volume":"79","author":"Tian","year":"2022","journal-title":"Hypertension"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e49291","DOI":"10.2196\/49291","article-title":"L-Shaped Association of Serum Chloride Level with All-Cause and Cause-Specific Mortality in American Adults: Population-Based Prospective Cohort Study","volume":"9","author":"Hou","year":"2023","journal-title":"JMIR Public Health Surveill."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e015776","DOI":"10.1161\/JAHA.120.015776","article-title":"Relationship Between Time-Dependent Proteinuria and Risk of Stroke in Population with Different Glucose Tolerance Status","volume":"9","author":"Wang","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3945\/ajcn.2010.29490","article-title":"Biological variation and diagnostic accuracy of dehydration assessment markers","volume":"92","author":"Cheuvront","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.2337\/dc11-0652","article-title":"Low water intake and risk for new-onset hyperglycemia","volume":"34","author":"Roussel","year":"2011","journal-title":"Diabetes Care"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.nutres.2015.06.015","article-title":"Higher plain water intake is associated with lower type 2 diabetes risk: A cross-sectional study in humans","volume":"35","author":"Carroll","year":"2015","journal-title":"Nutr. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e140848","DOI":"10.1172\/jci.insight.140848","article-title":"Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor","volume":"6","author":"Jensen","year":"2021","journal-title":"JCI Insight"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1210\/jc.2016-1113","article-title":"Plasma Copeptin, AVP Gene Variants, and Incidence of Type 2 Diabetes in a Cohort from the Community","volume":"101","author":"Roussel","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1210\/jc.2018-02195","article-title":"Water Supplementation Reduces Copeptin and Plasma Glucose in Adults with High Copeptin: The H2O Metabolism Pilot Study","volume":"104","author":"Enhorning","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1007\/s00394-017-1471-6","article-title":"Effect of increased water intake on plasma copeptin in healthy adults","volume":"57","author":"Lemetais","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.physbeh.2017.03.003","article-title":"Disturbances of thirst and fluid balance associated with aging","volume":"178","author":"Begg","year":"2017","journal-title":"Physiol. Behav."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.mad.2013.11.009","article-title":"Water-loss dehydration and aging","volume":"136\u2013137","author":"Hooper","year":"2014","journal-title":"Mech. Ageing Dev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12986-020-00531-2","article-title":"The comparison of water intake patterns and hydration biomarkers among young adults with different hydration statuses in Hebei, China","volume":"18","author":"Zhang","year":"2021","journal-title":"Nutr. 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