{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:15:48Z","timestamp":1779887748023,"version":"3.53.1"},"reference-count":37,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","award":["Me977\/20"],"award-info":[{"award-number":["Me977\/20"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","award":["PRONEM 0797-4.05\/14"],"award-info":[{"award-number":["PRONEM 0797-4.05\/14"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","award":["311386\/2019-9"],"award-info":[{"award-number":["311386\/2019-9"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","award":["Me977\/20"],"award-info":[{"award-number":["Me977\/20"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","award":["PRONEM 0797-4.05\/14"],"award-info":[{"award-number":["PRONEM 0797-4.05\/14"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","award":["311386\/2019-9"],"award-info":[{"award-number":["311386\/2019-9"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["Me977\/20"],"award-info":[{"award-number":["Me977\/20"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["PRONEM 0797-4.05\/14"],"award-info":[{"award-number":["PRONEM 0797-4.05\/14"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["311386\/2019-9"],"award-info":[{"award-number":["311386\/2019-9"]}]},{"name":"2021 EFSD Boehringer Ingelheim European Research Programme on \u201cMulti-System Challenges in Diabetes\u201d","award":["Me977\/20"],"award-info":[{"award-number":["Me977\/20"]}]},{"name":"2021 EFSD Boehringer Ingelheim European Research Programme on \u201cMulti-System Challenges in Diabetes\u201d","award":["PRONEM 0797-4.05\/14"],"award-info":[{"award-number":["PRONEM 0797-4.05\/14"]}]},{"name":"2021 EFSD Boehringer Ingelheim European Research Programme on \u201cMulti-System Challenges in Diabetes\u201d","award":["311386\/2019-9"],"award-info":[{"award-number":["311386\/2019-9"]}]},{"name":"INSERM institutional","award":["Me977\/20"],"award-info":[{"award-number":["Me977\/20"]}]},{"name":"INSERM institutional","award":["PRONEM 0797-4.05\/14"],"award-info":[{"award-number":["PRONEM 0797-4.05\/14"]}]},{"name":"INSERM institutional","award":["311386\/2019-9"],"award-info":[{"award-number":["311386\/2019-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(1) Background: Dysregulated serum amino acids (AA) are known to be associated with obesity and risk of Type 2 Diabetes (T2D) in adults, and recent studies support the same notion in the pubertal age. It is, however, unknown whether childhood overweight may already display alterations of circulating AA. (2) Methods: We used liquid chromatography coupled to tandem mass spectrometry (LC-MS\/MS)\u2014targeted metabolomics to determine plasma concentrations of AA and AA-related molecules in 36 children aged 7\u201312 years with normal weight or overweight. Clinical and anthropometric parameters were measured. (3) Results: Overweight in children is associated with an altered AA profile, with increased branched-chain amino acids (BCAA) and decreased glycine levels, with no clinically manifested metabolic conditions. Moreover, z-BMI was positively and negatively correlated with BCAA and glycine levels, respectively, even after adjustment for age and gender. We also found a correlation between the AA profile and clinical parameters such as lipids profile and glycemia. (4) Conclusions: A pattern of low glycine, and increased BCAA is correlated to z-BMI, total cholesterol, and triglycerides in overweight but otherwise healthy children. Our data suggest that, in childhood overweight, AA disturbances may precede other clinical parameters, thus providing an early indicator for the later development of metabolic disease.<\/jats:p>","DOI":"10.3390\/nu16121843","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T04:30:12Z","timestamp":1718253012000},"page":"1843","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between Childhood Overweight and Altered Concentrations of Circulating Amino Acids"],"prefix":"10.3390","volume":"16","author":[{"given":"J\u00e9ssica de Oliveira","family":"Campos","sequence":"first","affiliation":[{"name":"Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Academic Center of Vit\u00f3ria, Universidade Federal de Pernambuco, UFPE, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"},{"name":"Laboratory of Physical Evaluation and Signal Processing, Academic Center of Vit\u00f3ria, Universidade Federal de Pernambuco, UFPE, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"},{"name":"INSERM Unit 1060, CarMeN Laboratory, Lyon Civil Hospitals, Claude Bernard Lyon1 University, 69310 Pierre B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tafnes La\u00eds Pereira Santos de Almeida","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Academic Center of Vit\u00f3ria, Universidade Federal de Pernambuco, UFPE, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"},{"name":"Laboratory of Physical Evaluation and Signal Processing, Academic Center of Vit\u00f3ria, Universidade Federal de Pernambuco, UFPE, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriane","family":"Vitalis","sequence":"additional","affiliation":[{"name":"INSERM Unit 1060, CarMeN Laboratory, Lyon Civil Hospitals, Claude Bernard Lyon1 University, 69310 Pierre B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Gonzaga","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Academic Center of Vit\u00f3ria, Universidade Federal de Pernambuco, UFPE, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"},{"name":"Laboratory of Physical Evaluation and Signal Processing, Academic Center of Vit\u00f3ria, Universidade Federal de Pernambuco, UFPE, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella da Costa Ribeiro","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Evaluation and Signal Processing, Academic Center of Vit\u00f3ria, Universidade Federal de Pernambuco, UFPE, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Carvalho Jurema","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Evaluation and Signal Processing, Academic Center of Vit\u00f3ria, Universidade Federal de Pernambuco, UFPE, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Chikh","sequence":"additional","affiliation":[{"name":"INSERM Unit 1060, CarMeN Laboratory, Lyon Civil Hospitals, Claude Bernard Lyon1 University, 69310 Pierre B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol Gois","family":"Leandro","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Academic Center of Vit\u00f3ria, Universidade Federal de Pernambuco, UFPE, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"},{"name":"Laboratory of Physical Evaluation and Signal Processing, Academic Center of Vit\u00f3ria, Universidade Federal de Pernambuco, UFPE, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Henrique da","family":"Costa-Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Academic Center of Vit\u00f3ria, Universidade Federal de Pernambuco, UFPE, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"},{"name":"Laboratory of Physical Evaluation and Signal Processing, Academic Center of Vit\u00f3ria, Universidade Federal de Pernambuco, UFPE, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6539-5435","authenticated-orcid":false,"given":"Luciano","family":"Pirola","sequence":"additional","affiliation":[{"name":"INSERM Unit 1060, CarMeN Laboratory, Lyon Civil Hospitals, 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