{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:44:05Z","timestamp":1790163845450,"version":"4.1.0"},"reference-count":85,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902599"],"award-info":[{"award-number":["81902599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Yz2023313"],"award-info":[{"award-number":["Yz2023313"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation and Entrepreneurship training program for college students at Yangtze University","award":["81902599"],"award-info":[{"award-number":["81902599"]}]},{"name":"Innovation and Entrepreneurship training program for college students at Yangtze University","award":["Yz2023313"],"award-info":[{"award-number":["Yz2023313"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Folate is a water-soluble B vitamin involved in the synthesis of purines and pyrimidines and is one of the essential vitamins for human growth and reproduction. Folate deficiency due to low dietary intake, poor absorption of folate, and alterations in folate metabolism due to genetic defects or drug interactions significantly increases the risk of diseases such as neural tube defects, cardiovascular disease, cancer, and cognitive dysfunction. Recent studies have shown that folate deficiency can cause hyperhomocysteinemia, which increases the risk of hypertension and cardiovascular disease, and that high homocysteine levels are an independent risk factor for liver fibrosis and cirrhosis. In addition, folate deficiency results in increased secretion of pro-inflammatory factors and impaired lipid metabolism in the liver, leading to lipid accumulation in hepatocytes and fibrosis. There is substantial evidence that folate deficiency contributes to the development and progression of a variety of liver diseases, including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic liver disease (ALD), viral hepatitis, hepatic fibrosis, and liver cancer. Here we review key studies on the role of folate in the pathophysiology of liver diseases, summarize the current status of studies on folate in the treatment of liver diseases, and speculate that folate may be a potential therapeutic target for liver diseases.<\/jats:p>","DOI":"10.3390\/nu16121872","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T08:02:26Z","timestamp":1718352146000},"page":"1872","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Role of Folate in Liver Diseases"],"prefix":"10.3390","volume":"16","author":[{"given":"Minlan","family":"Yang","sequence":"first","affiliation":[{"name":"School of Medicine, Yangtze University, Jingzhou 434020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingye","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Yangtze University, Jingzhou 434020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Yangtze University, Jingzhou 434020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Mei","sequence":"additional","affiliation":[{"name":"School of Medicine, Yangtze University, Jingzhou 434020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Medicine, Yangtze University, Jingzhou 434020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"ref_1","first-page":"117","article-title":"Treatment of \u201cpernicious anaemia of pregnancy\u201d and \u201ctropical anaemia\u201d with special reference to yeast extract as a curative agent 1931","volume":"26","author":"Wills","year":"2013","journal-title":"Natl. 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