{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:01:24Z","timestamp":1787029284060,"version":"build-2736575974"},"reference-count":114,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medicinal Gardens S.L. with funds from the Center for Industrial Technological Development (CDTI), \u201cCervera\u201d Transfer R&amp;D Projects","award":["IDI-20210622"],"award-info":[{"award-number":["IDI-20210622"]}]},{"name":"Science and Education Ministry, Spain","award":["IDI-20210622"],"award-info":[{"award-number":["IDI-20210622"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Taste disorders (TDs) are common among systemically treated cancer patients and negatively impact their nutritional status and quality of life. The novel food approved by the European Commission (EFSA), dried miracle berries (DMB), contains the natural taste-modifying protein miraculin. DMB, also available as a supplement, has emerged as a possible alternative treatment for TDs. The present study aimed to evaluate the efficacy and safety of habitual DMB consumption in malnourished cancer patients undergoing active treatment. An exploratory clinical trial was carried out in which 31 cancer patients were randomized into three arms [standard dose of DMB (150 mg DMB\/tablet), high dose of DMB (300 mg DMB\/tablet) or placebo (300 mg freeze-dried strawberry)] for three months. Patients consumed a DMB tablet or placebo daily before each main meal (breakfast, lunch, and dinner). Throughout the five main visits, electrochemical taste perception, nutritional status, dietary intake, quality of life and the fatty acid profile of erythrocytes were evaluated. Patients consuming a standard dose of DMB exhibited improved taste acuity over time (% change right\/left side: \u221252.8 \u00b1 38.5\/\u221258.7 \u00b1 69.2%) and salty taste perception (2.29 \u00b1 1.25 vs. high dose: 2.17 \u00b1 1.84 vs. placebo: 1.57 \u00b1 1.51 points, p &lt; 0.05). They also had higher energy intake (p = 0.075) and covered better energy expenditure (107 \u00b1 19%). The quality of life evaluated by symptom scales improved in patients receiving the standard dose of DMB (constipation, p = 0.048). The levels of arachidonic (13.1 \u00b1 1.8; 14.0 \u00b1 2.8, 12.0 \u00b1 2.0%; p = 0.004) and docosahexaenoic (4.4 \u00b1 1.7; 4.1 \u00b1 1.0; 3.9 \u00b1 1.6%; p = 0.014) acids in erythrocytes increased over time after DMB intake. The standard dose of DMB increased fat-free mass vs. placebo (47.4 \u00b1 9.3 vs. 44.1 \u00b1 4.7 kg, p = 0.007). Importantly, habitual patients with DMB did not experience any adverse events, and metabolic parameters remained stable and within normal ranges. In conclusion, habitual consumption of a standard 150 mg dose of DMB improves electrochemical food perception, nutritional status (energy intake, fat quantity and quality, fat-free mass), and quality of life in malnourished cancer patients receiving antineoplastic treatment. Additionally, DMB consumption appears to be safe, with no changes in major biochemical parameters associated with health status. Clinical trial registered (NCT05486260).<\/jats:p>","DOI":"10.3390\/nu16121905","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T08:48:31Z","timestamp":1718614111000},"page":"1905","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and Safety of Habitual Consumption of a Food Supplement Containing Miraculin in Malnourished Cancer Patients: The CLINMIR Pilot Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9310-1545","authenticated-orcid":false,"given":"Bricia","family":"L\u00f3pez-Plaza","sequence":"first","affiliation":[{"name":"Food, Nutrition and Health Platform, Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain"},{"name":"Medicine Department, Faculty of Medicine, Complutense University of Madrid, Plaza de Ram\u00f3n y Cajal, s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8476-9970","authenticated-orcid":false,"given":"Ana Isabel","family":"\u00c1lvarez-Mercado","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Granada, 18071 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Centre of Biomedical Research, University of Granada, Avda. del Conocimiento s\/n, Armilla, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Arcos-Castellanos","sequence":"additional","affiliation":[{"name":"Food, Nutrition and Health Platform, Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5171-9408","authenticated-orcid":false,"given":"Julio","family":"Plaza-Diaz","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain"},{"name":"Department of Biochemistry and Molecular Biology II, University of Granada, 18071 Granada, Spain"},{"name":"Children\u2019s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4452-0855","authenticated-orcid":false,"given":"Francisco Javier","family":"Ruiz-Ojeda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Centre of Biomedical Research, University of Granada, Avda. del Conocimiento s\/n, Armilla, 18016 Granada, Spain"},{"name":"Department of Biochemistry and Molecular Biology II, University of Granada, 18071 Granada, Spain"},{"name":"CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5836-5008","authenticated-orcid":false,"given":"Marco","family":"Brandimonte-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Centre of Biomedical Research, University of Granada, Avda. del Conocimiento s\/n, Armilla, 18016 Granada, Spain"},{"name":"Department of Biochemistry and Molecular Biology II, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4867-1420","authenticated-orcid":false,"given":"Jaime","family":"Feli\u00fa-Batlle","sequence":"additional","affiliation":[{"name":"Oncology Department, Hospital La Paz Institute for Health Research\u2014IdiPAZ, Hospital Universitario La Paz, 28029 Madrid, Spain"},{"name":"CIBERONC (CIBER Cancer), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Medicine Department, Faculty of Medicine, Autonomous University of Madrid, Arzobispo Morcillo 4, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-0183","authenticated-orcid":false,"given":"Thomas","family":"Hummel","sequence":"additional","affiliation":[{"name":"Smell & Taste Clinic, Department of Otorhinolaryngology, Technische Universit\u00e4t Dresden, Fetscherstra\u00dfe 74, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7663-0939","authenticated-orcid":false,"given":"\u00c1ngel","family":"Gil","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Centre of Biomedical Research, University of Granada, Avda. del Conocimiento s\/n, Armilla, 18016 Granada, Spain"},{"name":"Department of Biochemistry and Molecular Biology II, University of Granada, 18071 Granada, Spain"},{"name":"CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samara","family":"Palma-Milla","sequence":"additional","affiliation":[{"name":"Food, Nutrition and Health Platform, Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain"},{"name":"Medicine Department, Faculty of Medicine, Autonomous University of Madrid, Arzobispo Morcillo 4, 28029 Madrid, Spain"},{"name":"Nutrition Department, Hospital University La Paz, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3109\/0284186X.2011.633554","article-title":"Taste Alterations in Breast and Gynaecological Cancer Patients Receiving Chemotherapy: Prevalence, Course of Severity, and Quality of Life Correlates","volume":"51","author":"Gamper","year":"2012","journal-title":"Acta Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1634\/theoncologist.2009-0333","article-title":"Taste Alterations in Cancer Patients Receiving Chemotherapy: A Neglected Side Effect?","volume":"15","author":"Zabernigg","year":"2010","journal-title":"Oncologist"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00520-007-0319-7","article-title":"Self-Reported Taste and Smell Changes during Cancer Chemotherapy","volume":"16","author":"Bernhardson","year":"2008","journal-title":"Support. Care Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jpainsymman.2006.12.010","article-title":"Chemosensory Changes Experienced by Patients Undergoing Cancer Chemotherapy: A Qualitative Interview Study","volume":"34","author":"Bernhardson","year":"2007","journal-title":"J. Pain Symptom Manag."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1001\/archneur.60.5.667","article-title":"Neurological Aspects of Taste Disorders","volume":"60","author":"Heckmann","year":"2003","journal-title":"Arch. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.oraloncology.2009.11.008","article-title":"Taste Disorders in Cancer Patients: Pathogenesis, and Approach to Assessment and Management","volume":"46","author":"Epstein","year":"2010","journal-title":"Oral Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1007\/s00520-018-4200-7","article-title":"Chemosensory Changes and Quality of Life in Patients Undergoing Hematopoietic Stem Cell Transplantation","volume":"26","author":"Abasaeed","year":"2018","journal-title":"Support. Care Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1200\/JCO.2008.18.2717","article-title":"Phase II Trial of Sorafenib in Metastatic Thyroid Cancer","volume":"27","author":"Kloos","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1158\/1078-0432.CCR-06-2889","article-title":"Phase I Trial of Sorafenib in Combination with Gefitinib in Patients with Refractory or Recurrent Non\u2013Small Cell Lung Cancer","volume":"13","author":"Adjei","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Buttiron Webber, T., Briata, I.M., DeCensi, A., Cevasco, I., and Paleari, L. (2023). Taste and Smell Disorders in Cancer Treatment: Results from an Integrative Rapid Systematic Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032538"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.foodqual.2017.09.003","article-title":"Altered Food Preferences and Chemosensory Perception during Chemotherapy in Breast Cancer Patients: A Longitudinal Comparison with Healthy Controls","volume":"63","author":"Winkels","year":"2018","journal-title":"Food Qual. Prefer."},{"key":"ref_12","first-page":"D748","article-title":"Tasty Food for Cancer Patients: The Impact of Smell and Taste Alterations on Eating Behaviour","volume":"160","author":"Postma","year":"2017","journal-title":"Ned. Tijdschr. Voor Geneeskd."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.2147\/CMAR.S188903","article-title":"Impact of Taste and Smell Training on Taste Disorders during Chemotherapy\u2014TASTE Trial","volume":"11","author":"Koch","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00520-010-0902-1","article-title":"A Systematic Review of Dysgeusia Induced by Cancer Therapies","volume":"18","author":"Hovan","year":"2010","journal-title":"Support. Care Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nutos.2023.06.004","article-title":"The Impact of Treatment-Induced Dysgeusia on the Nutritional Status of Cancer Patients","volume":"50","author":"Ghias","year":"2023","journal-title":"Clin. Nutr. Open Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0140-6736(00)02836-1","article-title":"Within Reach of an End to Unnecessary Bitterness?","volume":"356","author":"Brand","year":"2000","journal-title":"Lancet"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.2174\/1381612822666160216150812","article-title":"Smell and Taste Disorders Resulting from Cancer and Chemotherapy","volume":"22","author":"Cohen","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jpainsymman.2019.07.016","article-title":"Co-Occurring Gastrointestinal Symptoms Are Associated With Taste Changes in Oncology Patients Receiving Chemotherapy","volume":"58","author":"Nolden","year":"2019","journal-title":"J. Pain Symptom Manag."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1080\/01635581.2021.1957485","article-title":"The Relationship between Malnutrition and Subjective Taste Change Experienced by Patients with Cancer Receiving Outpatient Chemotherapy Treatment","volume":"74","author":"Taylan","year":"2022","journal-title":"Nutr. Cancer"},{"key":"ref_20","first-page":"427","article-title":"Smell and Taste Disorders: A Primary Care Approach","volume":"61","author":"Bromley","year":"2000","journal-title":"Am. Farm. Physician"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12937-015-0113-1","article-title":"Factors Associated with Malnutrition in Hospitalized Cancer Patients: A Croos-Sectional Study","volume":"14","author":"Souza","year":"2015","journal-title":"Nutr. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.clnu.2023.01.012","article-title":"Relationship between Global Leadership Initiative on Malnutrition (GLIM) Defined Malnutrition and Survival, Length of Stay and Post-Operative Complications in People with Cancer: A Systematic Review","volume":"42","author":"Brown","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.clnu.2023.02.019","article-title":"Impact of Malnutrition as Defined by the GLIM Criteria on Treatment Outcomes in Patients with Cancer: A Systematic Review and Meta-Analysis","volume":"42","author":"Matsui","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.clnu.2022.07.007","article-title":"Association of Global Leadership Initiative on Malnutrition with Survival Outcomes in Patients with Cancer: A Systematic Review and Meta-Analysis","volume":"41","author":"Xu","year":"2022","journal-title":"Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00520-004-0589-2","article-title":"Decreased Taste Sensitivity in Cancer Patients under Chemotherapy","volume":"12","author":"Berteretche","year":"2004","journal-title":"Support. Care Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00520-023-08156-w","article-title":"The Relationship between Loneliness, Psychological Resilience, Quality of Life and Taste Change in Cancer Patients Receiving Chemotherapy","volume":"31","author":"Ejder","year":"2023","journal-title":"Support. Care Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s005200100279","article-title":"Taste and Smell Dysfunction in Patients Receiving Chemotherapy: A Review of Current Knowledge","volume":"9","author":"Comeau","year":"2001","journal-title":"Support. Care Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1007\/s00520-022-06936-4","article-title":"Multicenter, Prospective, Observational Study of Chemotherapy-Induced Dysgeusia in Gastrointestinal Cancer","volume":"30","author":"Ito","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.21873\/anticanres.12995","article-title":"Improvement of Dysgeusia by Polaprezinc, a Zinc-L-Carnosine, in Outpatients Receiving Cancer Chemotherapy","volume":"38","author":"Fujii","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1634\/theoncologist.2007-0217","article-title":"Prevention of Docetaxel- or Paclitaxel-Associated Taste Alterations in Cancer Patients with Oral Glutamine: A Randomized, Placebo-Controlled, Double-Blind Study","volume":"13","author":"Strasser","year":"2008","journal-title":"Oncologist"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1017\/cjn.2020.115","article-title":"Successful Management of Glioblastoma Chemotherapy-Associated Dysgeusia with Gabapentin","volume":"47","author":"Turcotte","year":"2020","journal-title":"Can. J. Neurol. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00520-020-05609-4","article-title":"Taste and Smell Disturbances in Cancer Patients: A Scoping Review of Available Treatments","volume":"29","author":"Sevryugin","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1126\/science.161.3847.1241","article-title":"Taste-Modifying Protein from Miracle Fruit","volume":"161","author":"Kurihara","year":"1968","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.semcdb.2013.02.008","article-title":"Molecular Mechanisms of the Action of Miraculin, a Taste-Modifying Protein","volume":"24","author":"Misaka","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.appet.2016.09.014","article-title":"Miracle Fruit: An Alternative Sugar Substitute in Sour Beverages","volume":"107","author":"Rodrigues","year":"2016","journal-title":"Appetite"},{"key":"ref_36","first-page":"479","article-title":"Chemotherapy-Induced Taste Alteration","volume":"27","author":"Penna","year":"2023","journal-title":"Clin. J. Oncol. Nurs."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e19523","DOI":"10.1200\/jco.2010.28.15_suppl.e19523","article-title":"Treatment of Taste Alterations in Chemotherapy Patients Using the \u201cMiracle Fruit\u201d: Preliminary Analysis of a Pilot Study","volume":"28","author":"Soares","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"E173","DOI":"10.1188\/12.CJON.E173-E177","article-title":"Pilot Study of \u201cMiracle Fruit\u201d to Improve Food Palatability for Patients Receiving Chemotherapy","volume":"16","author":"Wilken","year":"2012","journal-title":"Clin. J. Oncol. Nurs."},{"key":"ref_39","first-page":"e06600","article-title":"Safety of Dried Fruits of Synsepalum Dulcificum as a Novel Food Pursuant to Regulation (EU) 2015\/2283","volume":"19","author":"Turck","year":"2021","journal-title":"EFSA J. Eur. Food Saf. Auth."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Plaza, B., Gil, \u00c1., Men\u00e9ndez-Rey, A., Bensadon-Naeder, L., Hummel, T., Feli\u00fa-Batlle, J., and Palma-Milla, S. (2023). Effect of Regular Consumption of a Miraculin-Based Food Supplement on Taste Perception and Nutritional Status in Malnourished Cancer Patients: A Triple-Blind, Randomized, Placebo-Controlled Clinical Trial-CLINMIR Pilot Protocol. Nutrients, 15.","DOI":"10.20944\/preprints202310.0649.v1"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnu.2018.08.002","article-title":"GLIM Criteria for the Diagnosis of Malnutrition\u2014A Consensus Report from the Global Clinical Nutrition Community","volume":"38","author":"Cederholm","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/chemse\/bjx054","article-title":"Differences in the Density of Fungiform Papillae and Composition of Saliva in Patients With Taste Disorders Compared to Healthy Controls","volume":"42","author":"Feron","year":"2017","journal-title":"Chem Senses"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/pon.555","article-title":"The EORTC QLQ-C30 (Version 3.0) Quality of Life Questionnaire: Validation Study for Spain with Head and Neck Cancer Patients","volume":"11","author":"Arraras","year":"2002","journal-title":"Psychooncology"},{"key":"ref_44","unstructured":"National Cancer Institute (2017). Common Terminology Criteria for Adverse Events (CTCAE) Common Terminology Criteria for Adverse Events (CTCAE) v5.0, U.S. Department of Health and Human Services, National Institutes of Health."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"790250","DOI":"10.3389\/fnut.2022.790250","article-title":"Docosahexaenoic and Eicosapentaenoic Intervention Modifies Plasma and Erythrocyte Omega-3 Fatty Acid Profiles But Not the Clinical Course of Children With Autism Spectrum Disorder: A Randomized Control Trial","volume":"9","author":"Mesa","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0022-2275(20)38553-9","article-title":"Specific Methylation of Plasma Nonesterified Fatty Acids in a One-Step Reaction","volume":"29","author":"Lepage","year":"1988","journal-title":"J. Lipid Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jpainsymman.2006.07.017","article-title":"Chemosensory Dysfunction Is a Primary Factor in the Evolution of Declining Nutritional Status and Quality of Life in Patients with Advanced Cancer","volume":"33","author":"Hutton","year":"2007","journal-title":"J. Pain Symptom Manag."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/082585970602200208","article-title":"Taste and Smell Abnormalities as an Independent Cause of Failure of Food Intake in Patients with Advanced Cancer--an Argument for the Application of Sensory Science","volume":"22","author":"Brisbois","year":"2006","journal-title":"J. Palliat. Care"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s00520-023-08013-w","article-title":"Taste-Taste Associations in Chemotherapy-Induced Subjective Taste Alterations: Findings from a Questionnaire Survey in an Outpatient Clinic","volume":"31","author":"Obayashi","year":"2023","journal-title":"Support. Care Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1007\/s00520-022-07091-6","article-title":"Taste Alterations during Neo\/Adjuvant Chemotherapy and Subsequent Follow-up in Breast Cancer Patients: A Prospective Single-Center Clinical Study","volume":"30","author":"Pedersini","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"E47","DOI":"10.1188\/09.ONF.E47-E56","article-title":"Self-Care Strategies to Cope with Taste Changes after Chemotherapy","volume":"36","author":"Rehwaldt","year":"2009","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_52","first-page":"1049","article-title":"[Incidence of Dysgeusia Associated with Chemotherapy for Cancer]","volume":"40","author":"Ishikawa","year":"2013","journal-title":"Gan Kagaku Ryoho"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/SPC.0000000000000669","article-title":"Loss of Appetite in Patients with Cancer: An Update on Characterization, Mechanisms, and Palliative Therapeutics","volume":"17","author":"Haemmerle","year":"2023","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1007\/s00520-017-3668-x","article-title":"Differences in Dietary Intake during Chemotherapy in Breast Cancer Patients Compared to Women without Cancer","volume":"25","author":"Boesveldt","year":"2017","journal-title":"Support. Care Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/j.gastro.2021.08.041","article-title":"High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites","volume":"162","author":"Yang","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.7150\/thno.56157","article-title":"High Fat Diet, Gut Microbiome and Gastrointestinal Cancer","volume":"11","author":"Tong","year":"2021","journal-title":"Theranostics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.7150\/ijbs.86717","article-title":"High-Fat Diet Promotes Colitis-Associated Tumorigenesis by Altering Gut Microbial Butyrate Metabolism","volume":"19","author":"Shao","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1158\/1078-0432.CCR-18-0106","article-title":"High-Fat Diet-Induced Inflammation Accelerates Prostate Cancer Growth via IL6 Signaling","volume":"24","author":"Hayashi","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1002\/2211-5463.12751","article-title":"Effects of High-Fat Diet-Induced Adipokines and Cytokines on Colorectal Cancer Development","volume":"9","author":"Zhang","year":"2019","journal-title":"FEBS Open Bio"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.abb.2016.09.015","article-title":"High-Fat Diet Feeding Promotes Stemness and Precancerous Changes in Murine Gastric Mucosa Mediated by Leptin Receptor Signaling Pathway","volume":"610","author":"Arita","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/01635581.2019.1637910","article-title":"Dietary Fat Intake and the Risk of Skin Cancer: A Systematic Review and Meta-Analysis of Observational Studies","volume":"72","author":"Ruan","year":"2020","journal-title":"Nutr. Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.clnu.2020.07.007","article-title":"Association between Dietary Fat Intake and Mortality from All-Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Meta-Analysis of Prospective Cohort Studies","volume":"40","author":"Kim","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1056\/NEJM199602083340603","article-title":"Cohort Studies of Fat Intake and the Risk of Breast Cancer--a Pooled Analysis","volume":"334","author":"Hunter","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.clnu.2009.07.001","article-title":"Resting Energy Expenditure and Body Composition in Patients with Newly Detected Cancer","volume":"29","author":"Cao","year":"2010","journal-title":"Clin. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1080\/10408398.2012.724481","article-title":"Dietary Fat and Breast Cancer Mortality: A Systematic Review and Meta-Analysis","volume":"57","author":"Brennan","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Bojkov\u00e1, B., Winklewski, P.J., and Wszedybyl-Winklewska, M. (2020). Dietary Fat and Cancer-Which Is Good, Which Is Bad, and the Body of Evidence. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21114114"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s00394-018-1682-5","article-title":"Saturated, Mono- and Polyunsaturated Fatty Acid Intake and Cancer Risk: Results from the French Prospective Cohort NutriNet-Sant\u00e9","volume":"58","author":"Sellem","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/CIRCRESAHA.118.313996","article-title":"Associations of Monounsaturated Fatty Acids From Plant and Animal Sources With Total and Cause-Specific Mortality in Two US Prospective Cohort Studies","volume":"124","author":"Zong","year":"2019","journal-title":"Circ. Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Gunstone, F.D. (1996). Fatty Acids\u2014Nomenclature, Structure, Isolation and Structure Deter-Mination, Biosynthesis and Chemical Synthesis.Tle. Fatty Acid and Lipid Chemistry, Springer.","DOI":"10.1007\/978-1-4615-4131-8_1"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1476-511X-10-127","article-title":"Olive Oil Intake Is Inversely Related to Cancer Prevalence: A Systematic Review and a Meta-Analysis of 13,800 Patients and 23,340 Controls in 19 Observational Studies","volume":"10","author":"Psaltopoulou","year":"2011","journal-title":"Lipids Health Dis."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Yao, X., and Tian, Z. (2015). Saturated, Monounsaturated and Polyunsaturated Fatty Acids Intake and Risk of Pancreatic Cancer: Evidence from Observational Studies. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0130870"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"36081","DOI":"10.18632\/oncotarget.5555","article-title":"Dietary Fatty Acids Intake and Endometrial Cancer Risk: A Dose-Response Meta-Analysis of Epidemiological Studies","volume":"6","author":"Wu","year":"2015","journal-title":"Oncotarget"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ypmed.2004.02.030","article-title":"The Omega-3 Index: A New Risk Factor for Death from Coronary Heart Disease?","volume":"39","author":"Harris","year":"2004","journal-title":"Prev. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41387-020-00140-1","article-title":"Erythrocyte \u03c9-3 Polyunsaturated Fatty Acids Are Inversely Associated with the Risk of Oral Cancer: A Case-Control Study","volume":"10","author":"Chen","year":"2020","journal-title":"Nutr. Diabetes"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/s41416-020-0761-6","article-title":"Omega-3, Omega-6 and Total Dietary Polyunsaturated Fat on Cancer Incidence: Systematic Review and Meta-Analysis of Randomised Trials","volume":"122","author":"Hanson","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41416-019-0650-z","article-title":"Reprogramming of Fatty Acid Metabolism in Cancer","volume":"122","author":"Koundouros","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Am\u00e9zaga, J., Arranz, S., Urruticoechea, A., Ugartemendia, G., Larraioz, A., Louka, M., Uriarte, M., Ferreri, C., and Tueros, I. (2018). Altered Red Blood Cell Membrane Fatty Acid Profile in Cancer Patients. Nutrients, 10.","DOI":"10.3390\/nu10121853"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jgo.2020.06.020","article-title":"Nutritional Status and Interventions for Patients with Cancer\u2014A Systematic Review","volume":"12","author":"Hamaker","year":"2021","journal-title":"J. Geriatr. Oncol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mam.2018.04.001","article-title":"Omega-3 Fatty Acids, Membrane Remodeling and Cancer Prevention","volume":"64","author":"Fuentes","year":"2018","journal-title":"Mol. Aspects Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10555-023-10091-5","article-title":"Resolution Medicine in Cancer, Infection, Pain and Inflammation: Are We on Track to Address the next Pandemic?","volume":"42","author":"Serhan","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"101165","DOI":"10.1016\/j.plipres.2022.101165","article-title":"Polyunsaturated Fatty Acids and Fatty Acid-Derived Lipid Mediators: Recent Advances in the Understanding of Their Biosynthesis, Structures, and Functions","volume":"86","author":"Dyall","year":"2022","journal-title":"Prog. Lipid Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.smim.2015.03.004","article-title":"The Resolution Code of Acute Inflammation: Novel pro-Resolving Lipid Mediators in Resolution","volume":"27","author":"Serhan","year":"2015","journal-title":"Semin. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Freitas, R.D.S., and Campos, M.M. (2019). Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications. Nutrients, 11.","DOI":"10.3390\/nu11050945"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/cdd.2017.177","article-title":"Resolution of Inflammation and Sepsis Survival Are Improved by Dietary \u03a9-3 Fatty Acids","volume":"25","author":"Schlegel","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Saini, R.K., Prasad, P., Sreedhar, R.V., Naidu, K.A., Shang, X., and Keum, Y.S. (2021). Omega-3 Polyunsaturated Fatty Acids (PUFAs): Emerging Plant and Microbial Sources, Oxidative Stability, Bioavailability, and Health Benefits-A Review. Antioxidants, 10.","DOI":"10.3390\/antiox10101627"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"655393","DOI":"10.3389\/fphys.2021.655393","article-title":"How Do Red Blood Cells Die?","volume":"12","author":"Thiagarajan","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00508-005-0455-3","article-title":"Effects of a High-Fat Diet on Body Composition in Cancer Patients Receiving Chemotherapy: A Randomized Controlled Study","volume":"117","author":"Breitkreutz","year":"2005","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.clnu.2004.09.012","article-title":"Bioelectrical Impedance Analysis-Part II: Utilization in Clinical Practice","volume":"23","author":"Kyle","year":"2004","journal-title":"Clin. Nutr."},{"key":"ref_89","first-page":"229","article-title":"Excessive Caloric Expenditure as a Cause of Malnutrition in Patients with Cancer","volume":"150","author":"Bozzetti","year":"1980","journal-title":"Surg. Gynecol. Obstet."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Lim, H.S., Lee, B., Cho, I., and Cho, G.S. (2020). Nutritional and Clinical Factors Affecting Weight and Fat-Free Mass Loss after Gastrectomy in Patients with Gastric Cancer. Nutrients, 12.","DOI":"10.3390\/nu12071905"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.biocel.2013.06.016","article-title":"Clinical Outcomes Related to Muscle Mass in Humans with Cancer and Catabolic Illnesses","volume":"45","author":"Baracos","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer Cachexia in the Age of Obesity: Skeletal Muscle Depletion Is a Powerful Prognostic Factor, Independent of Body Mass Index","volume":"31","author":"Martin","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.critrevonc.2018.05.006","article-title":"Cancer Cachexia: Diagnosis, Assessment, and Treatment","volume":"127","author":"Sadeghi","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Lewandowska, A., Rudzki, G., Lewandowski, T., Pr\u00f3chnicki, M., Rudzki, S., Laskowska, B., and Brudniak, J. (2020). Quality of Life of Cancer Patients Treated with Chemotherapy. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17196938"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Pola\u0144ski, J., Chabowski, M., \u015awi\u0105toniowska-Lonc, N., Dudek, K., Jankowska-Pola\u0144ska, B., Zabierowski, J., and Mazur, G. (2021). Relationship between Nutritional Status and Clinical Outcome in Patients Treated for Lung Cancer. Nutrients, 13.","DOI":"10.3390\/nu13103332"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"110769","DOI":"10.1016\/j.nut.2020.110769","article-title":"Malnutrition Is Associated with Poor Health-Related Quality of Life in Surgical Patients with Gastrointestinal Cancer","volume":"75\u201376","author":"Maia","year":"2020","journal-title":"Nutrition"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s11764-020-00869-9","article-title":"Quality of Life in \u201cChronic\u201d Cancer Survivors: A Meta-Analysis","volume":"14","author":"Firkins","year":"2020","journal-title":"J. Cancer Surviv."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and Classification of Cancer Cachexia: An International Consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e20180287","DOI":"10.1590\/0034-7167-2018-0287","article-title":"Prevalence of Symptoms and Quality of Life of Cancer Patients","volume":"73","author":"Salvetti","year":"2020","journal-title":"Rev. Bras. Enferm."},{"key":"ref_100","unstructured":"Juh\u00e9-Beaulaton, D. (2014). Le Fruit Miracle (Synsepalum Dulcificum): Des Voyageurs Sur La Cote Ouest Africaine Auxlaboratoires Pharmaceutiques, ATM Collections de Mus\u00e9ums sources d\u2019histoi."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.appet.2010.10.005","article-title":"Miracle Fruit Improves Sweetness of a Low-Calorie Dessert without Promoting Subsequent Energy Compensation","volume":"56","author":"Wong","year":"2011","journal-title":"Appetite"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1745-459X.2010.00321.x","article-title":"Mixing taste illusions: The effect of miraculin on binary and trinary mixtures","volume":"26","author":"Capitanio","year":"2011","journal-title":"J. Sens. Stud."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/1082013212443060","article-title":"Differential Sweetness of Commercial Sour Liquids Elicited by Miracle Fruit in Healthy Young Adults","volume":"19","author":"Igarashi","year":"2013","journal-title":"Food Sci. Technol. Int."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/chemse\/bjy032","article-title":"Flavor Alterations Associated with Miracle Fruit and Gymnema Sylvestre","volume":"43","author":"Hudson","year":"2018","journal-title":"Chem. Senses"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.lwt.2018.09.054","article-title":"Effect of Different Quantities of Miracle Fruit on Sour and Bitter Beverages","volume":"99","author":"Andrade","year":"2019","journal-title":"LWT"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"110762","DOI":"10.1016\/j.fct.2019.110762","article-title":"Safety Assessment of Miraculin Using in Silico and in Vitro Digestibility Analyses","volume":"133","author":"Tafazoli","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/1750-3841.14988","article-title":"Effects of Different Miracle Fruit Products on the Sensory Characteristics of Different Types of Sour Foods by Descriptive Analysis","volume":"85","author":"Choi","year":"2020","journal-title":"J. Food Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1007\/s00018-006-6077-8","article-title":"Natural Sweet Macromolecules: How Sweet Proteins Work","volume":"63","author":"Temussi","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/10408399209527598","article-title":"Characteristics of Antisweet Substances, Sweet Proteins, and Sweetness-Inducing Proteins","volume":"32","author":"Kurihara","year":"1992","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Huang, W., Chung, H.Y., Xuan, W., Wang, G., and Li, Y. (2020). The Cholesterol-Lowering Activity of Miracle Fruit (Synsepalum Dulcificum). J. Food Biochem., 44.","DOI":"10.1111\/jfbc.13185"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.joim.2020.09.001","article-title":"Antihyperglycemic and Hepatoprotective Properties of Miracle Fruit (Synsepalum dulcificum) Compared to Aspartame in Alloxan-Induced Diabetic Mice","volume":"18","author":"Haddad","year":"2020","journal-title":"J. Integr. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"112124","DOI":"10.1016\/j.jep.2019.112124","article-title":"Antidiabetic Property of Miracle Fruit Plant (Synsepalum dulcificum Shumach. & Thonn. Daniell) Leaf Extracts in Fructose-Fed Streptozotocin-Injected Rats via Anti-Inflammatory Activity and Inhibition of Carbohydrate Metabolizing Enzymes","volume":"244","author":"Obafemi","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/ptr.1919","article-title":"Improvement of Insulin Resistance by Miracle Fruit (Synsepalum Dulcificum) in Fructose-Rich Chow-Fed Rats","volume":"20","author":"Chen","year":"2006","journal-title":"Phyther. Res."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Shi, Y.C., Lin, K.S., Jhai, Y.F., Lee, B.H., Han, Y., Cui, Z., Hsu, W.H., and Wu, S.C. (2016). Miracle Fruit (Synsepalum Dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent. Molecules, 21.","DOI":"10.3390\/molecules21020140"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/12\/1905\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:59:56Z","timestamp":1760108396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/12\/1905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,17]]},"references-count":114,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["nu16121905"],"URL":"https:\/\/doi.org\/10.3390\/nu16121905","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.05.15.24307453","asserted-by":"object"}]},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,17]]}}}