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Science and Technology Innovation Project","award":["2022A149"],"award-info":[{"award-number":["2022A149"]}]},{"name":"Guangzhou Medical University Students\u2019 Science and Technology Innovation Project","award":["2022ekky005"],"award-info":[{"award-number":["2022ekky005"]}]},{"name":"Guangzhou Medical University Students\u2019 Science and Technology Innovation Project","award":["02-408-2203-2079"],"award-info":[{"award-number":["02-408-2203-2079"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Nutrients"],"abstract":"<jats:p>Adenovirus (HAdV) can cause severe respiratory infections in children and immunocompromised patients. There is a lack of specific therapeutic drugs for HAdV infection, and the study of anti-adenoviral drugs has far-reaching clinical implications. Elemental selenium can play a specific role as an antioxidant in the human immune cycle by non-specifically binding to the amino acid methionine in body proteins. Methods: The antiviral mechanism of selenomethionine was explored by measuring cell membrane status, intracellular DNA status, cytokine secretion, mitochondrial membrane potential, and ROS production. Conclusions: Selenomethionine improved the regulation of ROS-mediated apoptosis by modulating the expression of Jak1\/2, STAT3, and BCL-XL, which led to the inhibition of apoptosis. It is anticipated that selenomethionine will offer a new anti-adenoviral therapeutic alternative.<\/jats:p>","DOI":"10.3390\/nu16121966","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T11:42:03Z","timestamp":1718883723000},"page":"1966","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway"],"prefix":"10.3390","volume":"16","author":[{"given":"Chuqing","family":"Li","sequence":"first","affiliation":[{"name":"Center Laboratory, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Center Laboratory, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Li","sequence":"additional","affiliation":[{"name":"Center Laboratory, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Lai","sequence":"additional","affiliation":[{"name":"Center Laboratory, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyao","family":"Su","sequence":"additional","affiliation":[{"name":"Center Laboratory, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center Laboratory, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buyun","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Fudan University, Shanghai 200437, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-8283","authenticated-orcid":false,"given":"Yinghua","family":"Li","sequence":"additional","affiliation":[{"name":"Center Laboratory, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center Laboratory, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/CMR.00116-13","article-title":"Adenovirus infections in immunocompetent and immunocompromised patients","volume":"27","author":"Lion","year":"2014","journal-title":"Clin. 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