{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:31:12Z","timestamp":1774366272536,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PrecisionBiotics Group Ltd."},{"name":"Axon Pharma"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Irritable bowel syndrome (IBS) and vitamin D deficiency are common among children in Latin America. Previous studies show that Bifidobacterium longum35624TM improves IBS symptoms in adults. This real-world, single-arm, open-label study conducted in Chile investigated the effects of B. longum 35624 (1 \u00d7 109 colony-forming units, 12 weeks) on gastrointestinal symptoms (adapted IBS severity scoring system [IBS-SSS]; adapted Questionnaire on Pediatric Gastrointestinal Symptoms [QPGS], and Bristol Stool Form Scale) in 64 children and adolescents (8\u201318 years) and explored the relationship with baseline vitamin D status. Improvements in all IBS-SSS domains and composite score were observed at week 6 and 12 (p &lt; 0.0007 versus baseline), with 98.3% of participants experiencing numerical improvements in \u22653 domains. Clinically meaningful improvement was seen in 96.6% of participants. The distribution of IBS-SSS severity categories shifted from moderate\/severe at baseline to mild\/remission (p &lt; 0.0001). Improvements were not maintained during the two-week washout. Low baseline serum vitamin D levels did not correlate to IBS severity or probiotic response. QPGS significantly decreased from baseline to week 6 (p = 0.0005) and 12 (p = 0.02). B. longum 35624 may improve IBS symptoms in children and adolescents, even those with vitamin D deficiency. A confirmatory randomized controlled trial and further exploration of probiotic response and vitamin D status are needed.<\/jats:p>","DOI":"10.3390\/nu16121967","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T05:27:19Z","timestamp":1718861239000},"page":"1967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Bifidobacterium longum 35624 in Children and Adolescents with Irritable Bowel Syndrome"],"prefix":"10.3390","volume":"16","author":[{"given":"Sylvia","family":"Cruchet Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Instituto de Nutrici\u00f3n y Tecnolog\u00eda de los Alimentos \u201cDr. Fernando Monckeberg\u201d, \u00c1rea Nutrici\u00f3n Humana, Universidad de Chile, El L\u00edbano 5524, Macul, Santiago 7830490, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-7065","authenticated-orcid":false,"given":"Sandra","family":"Verbeke Palma","sequence":"additional","affiliation":[{"name":"Escuela de Tecnolog\u00eda M\u00e9dica, Facultad de Salud, Universidad Santo Tom\u00e1s, Campus Santiago, Chile. Av. Ej\u00e9rcito 146, Santiago 8370003, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Lera Marqu\u00e9s","sequence":"additional","affiliation":[{"name":"Faculty of Graduate Business and Education Programs, Keiser University eCampus, 1900 West Commercial Boulevard. Ste 100, Ft. Lauderdale, FL 33309, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Espinosa Pizarro","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad de los Andes, Monse\u00f1or \u00c1lvaro del Portillo 12455, Las Condes, Santiago 7620001, Chile"},{"name":"Hospital Militar de Santiago, Av. Fernando Castillo Velasco 9100, La Reina, Santiago 7880047, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Malig Mechasqui","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Red Salud Vitacura de Santiago, Tabancura 1141, Vitacura, Santiago 7650018, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katy","family":"Sorensen","sequence":"additional","affiliation":[{"name":"Medical Affairs, Novozymes A\/S, Krogsh\u00f8jvej 36, 2880 Bagsvaerd, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","article-title":"Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1053\/j.gastro.2016.02.015","article-title":"Functional Disorders: Children and Adolescents","volume":"150","author":"Hyams","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Vernon-Roberts, A., Alexander, I., and Day, A.S. 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