{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:04:06Z","timestamp":1781003046875,"version":"3.54.1"},"reference-count":22,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Agency","award":["ANR-17-EURE-0028"],"award-info":[{"award-number":["ANR-17-EURE-0028"]}]},{"name":"National Research Agency","award":["PHRCN 2007, 2011 AOM11197"],"award-info":[{"award-number":["PHRCN 2007, 2011 AOM11197"]}]},{"name":"French Ministry of Health","award":["ANR-17-EURE-0028"],"award-info":[{"award-number":["ANR-17-EURE-0028"]}]},{"name":"French Ministry of Health","award":["PHRCN 2007, 2011 AOM11197"],"award-info":[{"award-number":["PHRCN 2007, 2011 AOM11197"]}]},{"name":"CNAM, Fondation de France, Fondation MGEN, EHESP, APHP, and CIFRE","award":["ANR-17-EURE-0028"],"award-info":[{"award-number":["ANR-17-EURE-0028"]}]},{"name":"CNAM, Fondation de France, Fondation MGEN, EHESP, APHP, and CIFRE","award":["PHRCN 2007, 2011 AOM11197"],"award-info":[{"award-number":["PHRCN 2007, 2011 AOM11197"]}]},{"name":"Eiffel PhD Fellowship","award":["ANR-17-EURE-0028"],"award-info":[{"award-number":["ANR-17-EURE-0028"]}]},{"name":"Eiffel PhD Fellowship","award":["PHRCN 2007, 2011 AOM11197"],"award-info":[{"award-number":["PHRCN 2007, 2011 AOM11197"]}]},{"name":"French National Institute of Health and Medical Research","award":["ANR-17-EURE-0028"],"award-info":[{"award-number":["ANR-17-EURE-0028"]}]},{"name":"French National Institute of Health and Medical Research","award":["PHRCN 2007, 2011 AOM11197"],"award-info":[{"award-number":["PHRCN 2007, 2011 AOM11197"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: According to the Cognitive\u2013Interpersonal model of anorexia nervosa (AN), the combined influence of cognitive and socio-emotional difficulties would constitute vulnerability and maintaining factors. Poor cognitive flexibility is one of the endophenotypic candidates (i.e., a trait marker) of the disorder, but few studies have examined its association with illness symptom variations, notably weight status. The study aimed to evaluate the relationships between cognitive flexibility performances and nutritional status indices (BMI; body composition) at different times of the disorder. Methods: Cross-sectional and longitudinal associations between cognitive flexibility (TAP 2.1) and nutritional status indices, along with anxious and depressive (HAD) and eating disorder (EDE-Q) symptomatology were investigated using univariate and multivariate analyses in a cohort of AN inpatients evaluated at hospital admission (N = 167) and discharge (N = 94). Results: We found no or negligible associations between nutritional status and HAD or EDE-Q scores or cognitive flexibility performances, either cross-sectionally or longitudinally. Cognitive performances did not significantly differ between the AN subtypes. Conclusions: In agreement with the Cognitive\u2013Interpersonal model of AN, cognitive flexibility is independent of nutritional status, as well as the AN subtype. It is also independent of the levels of anxious, depressive, or ED symptomatology. A new therapeutic approach targeting cognitive flexibility and intolerance to change could benefit severely emaciated people with AN, regardless of disease subtype and level of dysphoria.<\/jats:p>","DOI":"10.3390\/nu16131982","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T08:50:08Z","timestamp":1718959808000},"page":"1982","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["No Evidence for Cross-Sectional or Longitudinal Associations between Cognitive Flexibility Performances and Nutritional Status in a Cohort of Inpatients with Anorexia Nervosa"],"prefix":"10.3390","volume":"16","author":[{"given":"Lutzi","family":"Casta\u00f1o","sequence":"first","affiliation":[{"name":"Univ. Bordeaux, INCIA CNRS UMR 5287, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1298-7418","authenticated-orcid":false,"given":"Melina","family":"Fatseas","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INCIA CNRS UMR 5287, 33000 Bordeaux, France"},{"name":"Department of Addictology, H\u00f4pital Haut-L\u00e9v\u00eaque, CHU Bordeaux, 33600 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maylis","family":"Cuzacq","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INCIA CNRS UMR 5287, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-1798","authenticated-orcid":false,"given":"Lama","family":"Mattar","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Chouran Beirut, Beyrouth 1102 2801, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7233-6991","authenticated-orcid":false,"given":"Nathalie","family":"Godart","sequence":"additional","affiliation":[{"name":"Fondation Sant\u00e9 des Etudiants de France, 75014 Paris, France"},{"name":"CESP, Univ. Paris-Sud, UVSQ, INSERM U 1178, Universit\u00e9 Paris-Saclay, 94805 Villejuif, France"},{"name":"UFR Simone Veil-Sant\u00e9, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, 78180 Montigny-le-Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-2362","authenticated-orcid":false,"given":"Sylvie","family":"Berthoz","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INCIA CNRS UMR 5287, 33000 Bordeaux, France"},{"name":"Department of Psychiatry, Institut Mutualiste Montsouris, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.chc.2008.07.013","article-title":"Outcome of eating disorders","volume":"18","author":"Steinhausen","year":"2009","journal-title":"Child Adolesc. Psychiatr. Clin. N. 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Assoc."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/13\/1982\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:02:29Z","timestamp":1760108549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/13\/1982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,21]]},"references-count":22,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["nu16131982"],"URL":"https:\/\/doi.org\/10.3390\/nu16131982","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,21]]}}}