{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:22:01Z","timestamp":1783783321642,"version":"3.55.0"},"reference-count":60,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention","award":["202327"],"award-info":[{"award-number":["202327"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Previous studies show that B vitamins and homocysteine (Hcy) may be associated with mental disorders, but the accurate causal relationship remains unclear. This study aimed to elucidate the potential causal relationship of serum B vitamins and Hcy levels with five common mental disorders through a two-sample Mendelian randomization (MR) study. In this MR analysis, 50 single-nucleotide polymorphisms (SNPs)\u201413 related to folate, 17 to vitamin B6, 8 to vitamin B12 and 12 to Hcy\u2014were obtained from a large-scale Genome-Wide Association Studies (GWAS) database and employed as instrumental variables (IVs). The MR analyses were conducted using the inverse variance weighted (IVW), weighted median (WM), MR-Egger methods and sensitivity analyses were further performed to test the robustness. This MR study found a suggestive causal relationships between serum vitamin B12 levels and the risk of anxiety disorders (odds ratio (OR): 1.34, 95% confidence interval (CI): 1.01\u20131.78, p = 0.046) and bipolar affective disorders (OR: 1.85, 95% CI: 1.16\u20132.96, p = 0.010). However, folate, vitamin B6 and Hcy levels may not be causally associated with the risk of mental disorders. In conclusion, this study reveals that elevated serum vitamin B12 levels might suggestively increase the risk of anxiety and bipolar affective disorders, even though horizontal pleiotropy cannot be completely eliminated. The potential implications of our results warrant validation in larger GWAS based on diverse populations.<\/jats:p>","DOI":"10.3390\/nu16131986","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T12:27:33Z","timestamp":1718972853000},"page":"1986","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploring the Association between Serum B Vitamins, Homocysteine and Mental Disorders: Insights from Mendelian Randomization"],"prefix":"10.3390","volume":"16","author":[{"given":"Yiming","family":"Hu","sequence":"first","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yu","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China"},{"name":"School of Public Health, Inner Mongolia Medical University, Hohhot 010107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China"},{"name":"School of Public Health, China Medical University, Shenyang 110122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Wu","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China"},{"name":"School of Public Health, Inner Mongolia Medical University, Hohhot 010107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Yang","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxin","family":"Chen","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China"},{"name":"School of Public Health, Baotou Medical College, Baotou 014010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/pcn.12797","article-title":"Comparison of cognitive performance in bipolar disorder, major depressive disorder, unaffected first-degree relatives, and healthy controls","volume":"73","author":"Bo","year":"2019","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1017\/S0033291721001185","article-title":"What is a mental disorder? An exemplar-focused approach","volume":"51","author":"Stein","year":"2021","journal-title":"Psychol. Med."},{"key":"ref_3","unstructured":"World Health Organization (2024, April 26). Mental Disorders. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/mental-disorders."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/wps.20493","article-title":"Psychotherapies for depression in low- and middle-income countries: A meta-analysis","volume":"17","author":"Cuijpers","year":"2018","journal-title":"World Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"GBD 2019 Mental Disorders Collaborators (2022). Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry, 9, 137\u2013150.","DOI":"10.1016\/S2215-0366(21)00395-3"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.mcna.2017.04.004","article-title":"Complementary Therapies for Mental Health Disorders","volume":"101","author":"Asher","year":"2017","journal-title":"Med. Clin. N. Am."},{"key":"ref_7","first-page":"39","article-title":"Folate, vitamin B12 and vitamin B6 and one carbon metabolism","volume":"6","author":"Selhub","year":"2002","journal-title":"J. Nutr. Health Aging"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1176\/appi.ajp.157.5.715","article-title":"Vitamin B(12) deficiency and depression in physically disabled older women: Epidemiologic evidence from the Women\u2019s Health and Aging Study","volume":"157","author":"Penninx","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/archpsyc.65.11.1286","article-title":"Homocysteine and depression in later life","volume":"65","author":"Almeida","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1471-4159.2001.00384.x","article-title":"Homocysteine potentiates beta-amyloid neurotoxicity: Role of oxidative stress","volume":"78","author":"Ho","year":"2001","journal-title":"J. Neurochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1474-4422(06)70598-1","article-title":"Vitamin B12, folic acid, and the nervous system","volume":"5","author":"Reynolds","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/156652409787847146","article-title":"Folic acid, neurodegenerative and neuropsychiatric disease","volume":"9","author":"Kronenberg","year":"2009","journal-title":"Curr. Mol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.arr.2015.04.005","article-title":"Folates and aging: Role in mild cognitive impairment, dementia and depression","volume":"22","author":"Martel","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jpsychires.2017.07.019","article-title":"The association of folate and depression: A meta-analysis","volume":"95","author":"Bender","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4088\/JCP.8157su1c.03","article-title":"Folate in depression: Efficacy, safety, differences in formulations, and clinical issues","volume":"70","author":"Fava","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1475-2891-10-102","article-title":"Use of folic acid and vitamin supplementation among adults with depression and anxiety: A cross-sectional, population-based survey","volume":"10","author":"Zhao","year":"2011","journal-title":"Nutr. J."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hsieh, Y.-C., Chou, L.-S., Lin, C.-H., Wu, H.-C., Li, D.-J., and Tseng, P.-T. (2019). Serum folate levels in bipolar disorder: A systematic review and meta-analysis. BMC Psychiatry, 19.","DOI":"10.1186\/s12888-019-2269-2"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"10817","DOI":"10.1038\/s41598-018-29141-y","article-title":"Vitamin D, Folate and the Intracranial Volume in Schizophrenia and Bipolar Disorder and Healthy Controls","volume":"8","author":"Gurholt","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1440-1819.2005.01425.x","article-title":"Serum folate and homocysteine levels in patients with obsessive-compulsive disorder","volume":"59","author":"Atmaca","year":"2005","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_20","first-page":"1671","article-title":"Vitamin B12, folate, and homocysteine levels in patients with obsessive-compulsive disorder","volume":"10","author":"Bilici","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1007\/s00213-018-4926-4","article-title":"Folic acid\/methylfolate for the treatment of psychopathology in schizophrenia: A systematic review and meta-analysis","volume":"235","author":"Sakuma","year":"2018","journal-title":"Psychopharmacology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/ejcn.2015.202","article-title":"Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: The Quebec Longitudinal Study on Nutrition and Aging","volume":"70","author":"Gougeon","year":"2016","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e7156","DOI":"10.5867\/medwave.2018.01.7155","article-title":"Is augmentation with folate effective for major depressive disorder?","volume":"18","author":"Trincado","year":"2018","journal-title":"Medwave"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s40471-017-0128-6","article-title":"Recent Developments in Mendelian Randomization Studies","volume":"4","author":"Zheng","year":"2017","journal-title":"Curr. Epidemiol. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta-analysis and Mendelian randomization: A review","volume":"10","author":"Bowden","year":"2019","journal-title":"Res. Synth. Methods"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1681\/ASN.2016010098","article-title":"Mendelian Randomization as an Approach to Assess Causality Using Observational Data","volume":"27","author":"Sekula","year":"2016","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s00394-024-03329-7","article-title":"Inferring the genetic effects of serum homocysteine and vitamin B levels on autism spectral disorder through Mendelian randomization","volume":"63","author":"Jin","year":"2024","journal-title":"Eur. J. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1001\/jama.2021.18236","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement","volume":"326","author":"Skrivankova","year":"2021","journal-title":"JAMA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3945\/ajcn.112.044545","article-title":"Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease","volume":"98","author":"Pare","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int. J. Epidemiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10654-015-0011-z","article-title":"Using published data in Mendelian randomization: A blueprint for efficient identification of causal risk factors","volume":"30","author":"Burgess","year":"2015","journal-title":"Eur. J. Epidemiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet. Epidemiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: Effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet. Epidemiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0006-3223(98)00043-2","article-title":"Multiple correlations and bonferroni\u2019s correction","volume":"44","author":"Curtin","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Yuan, S., Mason, A.M., Carter, P., Burgess, S., and Larsson, S.C. (2021). Homocysteine, B vitamins, and cardiovascular disease: A Mendelian randomization study. BMC Med., 19.","DOI":"10.1186\/s12916-021-01977-8"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3390\/nu2030299","article-title":"Vitamin B12 in health and disease","volume":"2","author":"Samman","year":"2010","journal-title":"Nutrients"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Yoon, S.I., Moon, H.R., Lee, S.R., Zhang, J., Lee, S., and Cho, J.A. (2023). Nutrient Inadequacy in Korean Young Adults with Depression: A Case Control Study. Nutrients, 15.","DOI":"10.3390\/nu15092195"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/ipj.ipj_86_22","article-title":"Are vitamin D, B12, and folate deficiency associated with depressive disorder? A case-control study","volume":"32","author":"Yadav","year":"2023","journal-title":"Ind. Psychiatry J."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Vahid, F., Rahmani, W., Davoodi, S.H., and Bohn, T. (2023). Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study. Nutrients, 15.","DOI":"10.3390\/nu15234981"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/camh.12387","article-title":"The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents","volume":"25","author":"Esnafoglu","year":"2020","journal-title":"Child Adolesc. Ment. Health"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.pnpbp.2005.06.021","article-title":"Homocysteine and folate metabolism in depression","volume":"29","author":"Bottiglieri","year":"2005","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1176\/ajp.2007.164.6.861","article-title":"The homocysteine hypothesis of depression","volume":"164","author":"Folstein","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/fcp.12145","article-title":"Homocysteine excess: Delineating the possible mechanism of neurotoxicity and depression","volume":"29","author":"Bhatia","year":"2015","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/bs.vh.2022.01.001","article-title":"Neuropsychiatric manifestations in vitamin B12 deficiency","volume":"119","author":"Sahu","year":"2022","journal-title":"Vitam. Horm."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2147\/NDT.S399378","article-title":"Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-\u03b1 and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms","volume":"19","author":"Tan","year":"2023","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1017\/S1368980008002413","article-title":"Intake of B vitamins in childhood and adult life in relation to psychological distress among women in a British birth cohort","volume":"12","author":"Mishra","year":"2009","journal-title":"Public Health Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1017\/S1368980020002943","article-title":"Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: A cross-sectional study","volume":"24","author":"Mozaffari","year":"2021","journal-title":"Public Health Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Marazziti, D., Mangiapane, P., Carbone, M.G., Morana, F., Arone, A., Massa, L., Palermo, S., Violi, M., Bertini, G., and Massoni, L. (2023). Decreased Levels of Vitamin D in Bipolar Patients. Life, 13.","DOI":"10.3390\/life13040883"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12603-013-0378-z","article-title":"Older adult psychiatric inpatients with non-cognitive disorders should be screened for vitamin B12 deficiency","volume":"18","author":"Lachner","year":"2014","journal-title":"J. Nutr. Health Aging"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/qjmed\/hct051","article-title":"The pathophysiology of elevated vitamin B12 in clinical practice","volume":"106","author":"Serraj","year":"2013","journal-title":"QJM Mon. J. Assoc. Physicians"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"145","DOI":"10.7861\/clinmedicine.15-2-145","article-title":"Vitamin B12 deficiency\u2014A 21st century perspective","volume":"15","author":"Shipton","year":"2015","journal-title":"Clin. Med."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Arendt, J.F.B., and Nexo, E. (2012). Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045979"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/ppe.12414","article-title":"Maternal Multivitamin Intake, Plasma Folate and Vitamin B(12) Levels and Autism Spectrum Disorder Risk in Offspring","volume":"32","author":"Raghavan","year":"2018","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8114","DOI":"10.1096\/fj.201900855RRR","article-title":"Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia: A comparison among participants between 2 and 53 years","volume":"34","author":"Hope","year":"2020","journal-title":"FASEB J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4137\/NMI.S17245","article-title":"Relationship between Urinary Concentrations of Nine Water-soluble Vitamins and their Vitamin Intakes in Japanese Adult Males","volume":"7","author":"Shibata","year":"2014","journal-title":"Nutr. Metab. Insights"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1017\/S0007114513000974","article-title":"Unravelling the basis of variability in cobalamin levels in the general population","volume":"110","author":"Andrew","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ajhg.2009.02.011","article-title":"Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations","volume":"84","author":"Tanaka","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Grarup, N., Sulem, P., Sandholt, C.H., Thorleifsson, G., Ahluwalia, T.S., Steinthorsdottir, V., Bjarnason, H., Gudbjartsson, D.F., Magnusson, O.T., and Spars\u00f8, T. (2013). Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets. PLoS Genet., 9.","DOI":"10.1371\/journal.pgen.1003530"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/13\/1986\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:02:38Z","timestamp":1760108558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/13\/1986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,21]]},"references-count":60,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["nu16131986"],"URL":"https:\/\/doi.org\/10.3390\/nu16131986","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,21]]}}}