{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:21:55Z","timestamp":1790824915608,"version":"4.1.0"},"reference-count":0,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study aimed to investigate the ability of highly trained athletes to consistently perform at their highest level during a simulated three-day 400 m race and to examine the impact of an alkaline diet associated with chronic consumption of bicarbonate-rich water or placebo on their blood metabolic responses before and after the three races. Twenty-two highly trained athletes, divided into two groups\u2014one with an alkalizing diet and placebo water (PLA) and the other with an alkalizing diet and bicarbonate-rich water (BIC)\u2014performed a 400 m race for three consecutive days. Performance metrics, urine and blood samples assessing acid-base balance, and indirect markers of neuro-muscular fatigue were measured before and after each 400 m race. The evolution of the Potential Renal Acid Load (PRAL) index and urinary pH highlights the combination of an alkalizing diet and bicarbonate-rich hydration, modifying the acid-base state (p &lt; 0.05). Athletes in the PLA group replicated the same level of performance during three consecutive daily races without an increase in fatigue-associated markers. Athletes experienced similar levels of metabolic perturbations during the three 400 m races, with improved lactate clearance 20 min after the third race compared to the first two (p &lt; 0.05). This optimization of the buffering capacity through ecological alkaline nutrition and hydration allowed athletes in the BIC group to improve their performance during the third 400 m race (p &lt; 0.01). This study highlights athletes\u2019 ability to replicate high-level performances over three consecutive days with the same extreme level of metabolic disturbances, and an alkaline diet combined with bicarbonate-rich water consumption appears to enhance performance in a 400 m race.<\/jats:p>","DOI":"10.3390\/nu16131987","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T12:27:33Z","timestamp":1718972853000},"page":"1987","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Exploring the Influence of Acid-Base Status on Athletic Performance during Simulated Three-Day 400 m Race"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7828-5363","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Chiron","sequence":"first","affiliation":[{"name":"Exercise Biology for Performance and Health Laboratory (LBEPS), Univ Evry, IRBA, University Paris Saclay, 91025 Evry, France"},{"name":"French Athletics Federation (FFA), 33 Avenue Pierre de Coubertin, 75640 Paris CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9gane","family":"Erblang","sequence":"additional","affiliation":[{"name":"Exercise Biology for Performance and Health Laboratory (LBEPS), Univ Evry, IRBA, University Paris Saclay, 91025 Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bora","family":"Gul\u00f6ren","sequence":"additional","affiliation":[{"name":"Exercise Biology for Performance and Health Laboratory (LBEPS), Univ Evry, IRBA, University Paris Saclay, 91025 Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Bredariol","sequence":"additional","affiliation":[{"name":"Exercise Biology for Performance and Health Laboratory (LBEPS), Univ Evry, IRBA, University Paris Saclay, 91025 Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imad","family":"Hamri","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research and Epidemiology of Sport (IRMES), Institut National du Sport de l\u2019Expertise et de la Performance (INSEP), 11, Avenue du Tremblay, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1168-480X","authenticated-orcid":false,"given":"Damien","family":"Leger","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, VIFASOM (Vigilance, Fatigue, Sleep and Public Health), ERC 7330, APHP, H\u00f4tel-Dieu, Centre du Sommeil et de la Vigilance, 1 Place Parvis Notre Dame, 75004 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Hanon","sequence":"additional","affiliation":[{"name":"French Athletics Federation (FFA), 33 Avenue Pierre de Coubertin, 75640 Paris CEDEX, France"},{"name":"French National Institute for Sport, Expertise and Performance (INSEP), Research Department, Laboratory Sport, Expertise and Performance, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Tiollier","sequence":"additional","affiliation":[{"name":"French National Institute for Sport, Expertise and Performance (INSEP), Research Department, Laboratory Sport, Expertise and Performance, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Thomas","sequence":"additional","affiliation":[{"name":"Exercise Biology for Performance and Health Laboratory (LBEPS), Univ Evry, IRBA, University Paris Saclay, 91025 Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,21]]},"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/13\/1987\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:02:38Z","timestamp":1760108558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/13\/1987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,21]]},"references-count":0,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["nu16131987"],"URL":"https:\/\/doi.org\/10.3390\/nu16131987","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,21]]}}}