{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:18:59Z","timestamp":1792603139867,"version":"4.5.0"},"reference-count":96,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ANID-FONDECYT-Iniciaci\u00f3n","award":["11230112"],"award-info":[{"award-number":["11230112"]}]},{"name":"ANID-FONDECYT-Iniciaci\u00f3n","award":["3201028"],"award-info":[{"award-number":["3201028"]}]},{"name":"Concurso de Investigaci\u00f3n con Colaboraci\u00f3n Internacional de la Universidad Finis Terrae (LS)","award":["11230112"],"award-info":[{"award-number":["11230112"]}]},{"name":"Concurso de Investigaci\u00f3n con Colaboraci\u00f3n Internacional de la Universidad Finis Terrae (LS)","award":["3201028"],"award-info":[{"award-number":["3201028"]}]},{"name":"ANID-FONDECYT-Postdoctorado","award":["11230112"],"award-info":[{"award-number":["11230112"]}]},{"name":"ANID-FONDECYT-Postdoctorado","award":["3201028"],"award-info":[{"award-number":["3201028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Gastric cancer is an aggressive and multifactorial disease. Helicobacter pylori (H. pylori) is identified as a significant etiological factor in gastric cancer. Although only a fraction of patients infected with H. pylori progresses to gastric cancer, bacterial infection is critical in the pathology and development of this malignancy. The pathogenic mechanisms of this bacterium involve the disruption of the gastric epithelial barrier and the induction of chronic inflammation, oxidative stress, angiogenesis and metastasis. Adherence molecules, virulence (CagA and VacA) and colonization (urease) factors are important in its pathogenicity. On the other hand, resveratrol is a natural polyphenol with anti-inflammatory and antioxidant properties. Resveratrol also inhibits cancer cell proliferation and angiogenesis, suggesting a role as a potential therapeutic agent against cancer. This review explores resveratrol as an alternative cancer treatment, particularly against H. pylori-induced gastric cancer, due to its ability to mitigate the pathogenic effects induced by bacterial infection. Resveratrol has shown efficacy in reducing the proliferation of gastric cancer cells in vitro and in vivo. Moreover, the synergistic effects of resveratrol with chemotherapy and radiotherapy underline its therapeutic potential. However, further research is needed to fully describe its efficacy and safety in treating gastric cancer.<\/jats:p>","DOI":"10.3390\/nu16132141","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T03:48:56Z","timestamp":1720151336000},"page":"2141","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antitumor Effects of Resveratrol Opposing Mechanisms of Helicobacter pylori in Gastric Cancer"],"prefix":"10.3390","volume":"16","author":[{"given":"Daniela","family":"Trautmann","sequence":"first","affiliation":[{"name":"Nutrition and Dietetic School, Universidad Finis Terrae, Santiago 7501015, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Suazo","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetic School, Universidad Finis Terrae, Santiago 7501015, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-6438","authenticated-orcid":false,"given":"Keila","family":"Torres","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetic School, Universidad Finis Terrae, Santiago 7501015, Chile"},{"name":"Department of Hematology and Oncology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8331150, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-3519","authenticated-orcid":false,"given":"Layla","family":"Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetic School, Universidad Finis Terrae, Santiago 7501015, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Machlowska, J., Baj, J., Sitarz, M., Maciejewski, R., and Sitarz, R. 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