{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:32:30Z","timestamp":1784237550789,"version":"3.55.0"},"reference-count":74,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007686","name":"Instituto Nacional de Perinatolog\u00eda","doi-asserted-by":"crossref","award":["2017-2-101"],"award-info":[{"award-number":["2017-2-101"]}],"id":[{"id":"10.13039\/501100007686","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007686","name":"Instituto Nacional de Perinatolog\u00eda","doi-asserted-by":"crossref","award":["212250-494811"],"award-info":[{"award-number":["212250-494811"]}],"id":[{"id":"10.13039\/501100007686","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003141","name":"CONAHCyT","doi-asserted-by":"crossref","award":["A3-S-40575"],"award-info":[{"award-number":["A3-S-40575"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003141","name":"CONAHCyT","doi-asserted-by":"crossref","award":["CVU 288316"],"award-info":[{"award-number":["CVU 288316"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Pre-pregnancy body mass index (pBMI) is a predictor of gestational weight gain (GWG). However, other factors, such as adipokines and inflammation markers, may also be associated with GWG. The aim of the study was to determine the association of leptin, adiponectin, irisin, and C-reactive protein, with GWG in adolescents. A longitudinal study was conducted from 2018 to 2023 in adolescents with a clinically healthy pregnancy. The assessments included sociodemographic and clinical data, pBMI, percent of body fat, serum concentrations of leptin, adiponectin, irisin, and high-sensitivity C-reactive protein (hsCRP), and total GWG adequacy. Cox regression models were performed, the outcome variables were inadequate and excessive GWG. In 198 participants, being overweight\/obesity was marginally associated with a protective effect against inadequate GWG (HR = 0.44, 95%CI = 0.18\u20131.06), regardless of maternal characteristics and adipokines. Leptin (HR = 1.014, 95%CI = 1.008\u20131.021), and body fat percent (HR = 1.11, 95%CI = 1.05\u20131.17) were associated with a higher risk of excessive GWG, independent of other maternal variables such as pBMI, while adiponectin was associated with a lower risk. These findings suggest that, in Mexican adolescents, adipose tissue and its adipokines during pregnancy may play a more significant role in the final GWG than body weight.<\/jats:p>","DOI":"10.3390\/nu16132147","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T11:46:05Z","timestamp":1720179965000},"page":"2147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Total Gestational Weight Gain Is Explained by Leptin and Body Fat, Regardless of Pre-Pregnancy Body Mass Index and Other Adipokines, in Mexican Adolescents"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5741-0241","authenticated-orcid":false,"given":"Gabriela","family":"Chico-Barba","sequence":"first","affiliation":[{"name":"Programa de Maestr\u00eda y Doctorado en Ciencias M\u00e9dicas, Odontol\u00f3gicas y de la Salud, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"},{"name":"Coordinaci\u00f3n de Nutrici\u00f3n y Bioprogramaci\u00f3n, Instituto Nacional de Perinatolog\u00eda, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-1363","authenticated-orcid":false,"given":"Reyna","family":"S\u00e1mano","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n de Nutrici\u00f3n y Bioprogramaci\u00f3n, Instituto Nacional de Perinatolog\u00eda, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-9878","authenticated-orcid":false,"given":"Hugo","family":"Mart\u00ednez-Rojano","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Morales-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n de Nutrici\u00f3n y Bioprogramaci\u00f3n, Instituto Nacional de Perinatolog\u00eda, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9960-6579","authenticated-orcid":false,"given":"Edgar","family":"Barrientos-Galeana","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n de Nutrici\u00f3n y Bioprogramaci\u00f3n, Instituto Nacional de Perinatolog\u00eda, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Luna-Hidalgo","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n de Nutrici\u00f3n y Bioprogramaci\u00f3n, Instituto Nacional de Perinatolog\u00eda, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-6899","authenticated-orcid":false,"given":"Martha","family":"Kaufer-Horwitz","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3814-7449","authenticated-orcid":false,"given":"Gregorio","family":"Obrador","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad Panamericana, Mexico City 03920, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Villa-Romero","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Investigaci\u00f3n, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"ref_1","unstructured":"(2024, May 15). 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