{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:43:23Z","timestamp":1790034203153,"version":"4.0.1"},"reference-count":61,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Several dietary approaches have been used to induce remission in patients with eosinophilic esophagitis (EoE), yielding varied results. Methods: We searched the MEDLINE, EMBASE, and Scopus databases up to May 2024 to identify studies including dietary interventions for EoE used as monotherapy. Summary estimates with 95% CIs for achieving &lt;15 eosinophils\/HPF were calculated for each approach. Fixed or random effects models were used depending on heterogeneity (I2); publication bias risks were assessed using funnel plot analyses. Subgroup analyses results were compared using meta-regression. Results: Forty-three studies with 2825 patients were included in quantitative summaries. The overall rate of histologic remission was 60.6% (95% CI, 54.6\u201366.5%). Effectiveness rates were 94.5% (95% CI, 92.3\u201396.4%) for elemental diets, 63.9% (95% CI, 58.5\u201369.2%) for six-food elimination diets, 54.7% (95% CI, 45.7\u201363.6%) for four-food elimination diets, 44.3% (95% CI, 36.1\u201352.8%) for two-food elimination diets, 46.4% (95% CI, 40\u201352.9%) for one-food elimination diets, and 39.5% (95% CI, 30.3\u201349.2%) for allergy testing-directed food elimination diets. Overall, superior efficacy was noted in children than in adults and in retrospective compared to prospective studies. Conclusion: Diet therapy remains an effective therapeutic asset for pediatric and adult patients with EoE, with increasing efficacy noted as the levels of dietary restriction increase.<\/jats:p>","DOI":"10.3390\/nu16142231","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T11:33:22Z","timestamp":1720697602000},"page":"2231","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Efficacy of Dietary Therapy for Eosinophilic Esophagitis in Children and Adults: An Updated Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1006-0958","authenticated-orcid":false,"given":"\u00c1ngel","family":"Arias","sequence":"first","affiliation":[{"name":"Research Unit Complejo Hospitalario La Mancha Centro, 13600 Alc\u00e1zar de San Juan, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), 28006 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Princesa, 20006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7954-5753","authenticated-orcid":false,"given":"Antonio","family":"Tejera-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Research Unit Complejo Hospitalario La Mancha Centro, 13600 Alc\u00e1zar de San Juan, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0522-4129","authenticated-orcid":false,"given":"Luc\u00eda","family":"Guti\u00e9rrez-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Research Unit Complejo Hospitalario La Mancha Centro, 13600 Alc\u00e1zar de San Juan, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain"},{"name":"Fundaci\u00f3n del Hospital Nacional de Parapl\u00e9jicos para la Investigaci\u00f3n y la Integraci\u00f3n, 45007 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Molina-Infante","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), 28006 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Princesa, 20006 Madrid, Spain"},{"name":"Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, 10003 Caceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-1072","authenticated-orcid":false,"given":"Alfredo J.","family":"Lucendo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), 28006 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Princesa, 20006 Madrid, Spain"},{"name":"Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, 13700 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/2050640616689525","article-title":"Guidelines on Eosinophilic Esophagitis: Evidence-Based Statements and Recommendations for Diagnosis and Management in Children and Adults","volume":"5","author":"Lucendo","year":"2017","journal-title":"United Eur. 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