{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:18:38Z","timestamp":1781893118399,"version":"3.54.5"},"reference-count":92,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Microscopic colitis (MC) is an emergent group of chronic inflammatory diseases of the colon, and celiac disease (CD) is a chronic gluten-induced immune-mediated enteropathy affecting the small bowel. We performed a narrative review to provide an overview regarding the relationship between both disorders, analyzing the most recent studies published at the epidemiological, clinical and pathophysiological levels. In fact, MC and CD are concomitantly prevalent in approximately 6% of the cases, mainly in the subset of refractory patients. Thus, physicians should screen refractory patients with CD against MC and vice versa. Both disorders share more than a simple epidemiological association, being multifactorial diseases involving innate and adaptive immune responses to known or unknown luminal factors based on a rather common genetic ground. Moreover, autoimmunity is a shared characteristic between the patients with MC and those with CD, with autoimmunity in the latter being quite well-established. Furthermore, CD and MC share some common clinical symptoms and risk factors and overlap with other gastrointestinal diseases, but some differences exist between both disorders. More studies are therefore needed to better understand the complex mechanisms involving the common pathogenetic ground contributing to the CD and MC epidemiological association.<\/jats:p>","DOI":"10.3390\/nu16142233","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T11:33:22Z","timestamp":1720697602000},"page":"2233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Microscopic Colitis and Celiac Disease: Sharing More than a Diagnostic Overlap"],"prefix":"10.3390","volume":"16","author":[{"given":"Ana Mar\u00eda","family":"Gonz\u00e1lez-Castro","sequence":"first","affiliation":[{"name":"Translational Mucosal Immunology Laboratory, Vall d\u2019Hebron Institut de Recerca, 08035 Barcelona, Spain"},{"name":"Neuro-Immuno-Gastroenterology Laboratory, Vall d\u2019Hebron Institut de Recerca, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Fern\u00e1ndez-Ba\u00f1ares","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University Hospital M\u00fatua Terrassa, 08221 Terrassa, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd, Instituto Carlos III), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-8868","authenticated-orcid":false,"given":"Yamile","family":"Zabana","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University Hospital M\u00fatua Terrassa, 08221 Terrassa, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd, Instituto Carlos III), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Farago-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Translational Mucosal Immunology Laboratory, Vall d\u2019Hebron Institut de Recerca, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0036-1044","authenticated-orcid":false,"given":"Jonathan","family":"Ortega-Barrionuevo","sequence":"additional","affiliation":[{"name":"Translational Mucosal Immunology Laboratory, Vall d\u2019Hebron Institut de Recerca, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elba","family":"Exp\u00f3sito","sequence":"additional","affiliation":[{"name":"Translational Mucosal Immunology Laboratory, Vall d\u2019Hebron Institut de Recerca, 08035 Barcelona, Spain"},{"name":"Neuro-Immuno-Gastroenterology Laboratory, Vall d\u2019Hebron Institut de Recerca, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danila","family":"Guagnozzi","sequence":"additional","affiliation":[{"name":"Translational Mucosal Immunology Laboratory, Vall d\u2019Hebron Institut de Recerca, 08035 Barcelona, Spain"},{"name":"Neuro-Immuno-Gastroenterology Laboratory, Vall d\u2019Hebron Institut de Recerca, 08035 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd, Instituto Carlos III), 28029 Madrid, Spain"},{"name":"Gastroenterology Department, University Hospital Vall d\u2019Hebron, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/2050640620951905","article-title":"European guidelines on microscopic colitis: United European Gastroenterology (UEG) and European Microscopic Colitis Group (EMCG) statements and recommendations","volume":"9","author":"Miehlke","year":"2021","journal-title":"United Eur. 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