{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:25:24Z","timestamp":1793172324396,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:00:00Z","timestamp":1720828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korean National IT Industry Promotion Agency","award":["G1701-23-1222"],"award-info":[{"award-number":["G1701-23-1222"]}],"id":[{"id":"https:\/\/ror.org\/026v53e29","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>While many studies have explored dietary substitutes and mobile apps separately, a combined approach to metabolic dysfunction-associated steatotic liver disease (MASLD) has not been investigated. This study evaluated short-term mobile interventions coupled with partial meal replacement in patients with MASLD. Sixty adults with MASLD and a body mass index \u226525 kg\/m2 from a health examination center were randomized into an intervention group using a mobile app with partial meal replacements or a control group receiving standard educational materials. Liver enzyme levels, lipid profiles, and anthropometric measurements were assessed at baseline and after 4 weeks. Twenty-five participants in the intervention group and 24 in the control group completed the trial. Significant reductions were observed in the intervention group for alanine aminotransferase (\u221228.32 versus [vs.] \u221210.67, p = 0.006) and gamma-glutamyl transferase (\u221227.76 vs. 2.79, p = 0.014). No significant changes in aspartate aminotransferase, body weight, or waist circumference were noted in the intervention group. Four weeks of mobile lifestyle intervention incorporating partial meal replacements improved liver enzyme profiles in patients with MASLD. This strategy demonstrated the potential for mitigating elevated liver enzyme levels without altering body weight or waist circumference. Comprehensive and longer-term research is needed to substantiate and elaborate these preliminary outcomes.<\/jats:p>","DOI":"10.3390\/nu16142254","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T08:35:17Z","timestamp":1721032517000},"page":"2254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Effect of Mobile Lifestyle Intervention Combined with High-Protein Meal Replacement on Liver Function in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: A Pilot Randomized Controlled Trial"],"prefix":"10.3390","volume":"16","author":[{"given":"Eunbyul","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Seoul National University Bundang Hospital, Seongnam-si 13620, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Health Promotion Center, Seoul Bumin Hospital, Seoul 07590, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soonkyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Health Promotion Center, Seoul Bumin Hospital, Seoul 07590, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6018-3337","authenticated-orcid":false,"given":"Ju Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Bionutrion Corp., Seoul 06097, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1916-7014","authenticated-orcid":false,"given":"Hwa Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Go","sequence":"additional","affiliation":[{"name":"Bionutrion Corp., Seoul 06097, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Bionutrion Corp., Seoul 06097, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haesol","family":"Lee","sequence":"additional","affiliation":[{"name":"Bionutrion Corp., Seoul 06097, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siye","family":"Gil","sequence":"additional","affiliation":[{"name":"Bionutrion Corp., Seoul 06097, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Kwon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Bionutrion Corp., Seoul 06097, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5357-7241","authenticated-orcid":false,"given":"Keonho","family":"Chu","sequence":"additional","affiliation":[{"name":"Bionutrion Corp., Seoul 06097, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3350\/cmh.2021.0178","article-title":"KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease","volume":"27","author":"Kang","year":"2021","journal-title":"Clin. 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