{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:44:43Z","timestamp":1790196283616,"version":"4.1.0"},"reference-count":300,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:00:00Z","timestamp":1720828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Associazione Italiana per la Ricerca sul Cancro","award":["#22098"],"award-info":[{"award-number":["#22098"]}]},{"name":"Associazione Italiana per la Ricerca sul Cancro","award":["5 \u00d7 1000 2014"],"award-info":[{"award-number":["5 \u00d7 1000 2014"]}]},{"name":"Associazione Italiana per la Ricerca sul Cancro","award":["BC161452P1"],"award-info":[{"award-number":["BC161452P1"]}]},{"name":"Ospedale Policlinico San Martino IRCCS","award":["#22098"],"award-info":[{"award-number":["#22098"]}]},{"name":"Ospedale Policlinico San Martino IRCCS","award":["5 \u00d7 1000 2014"],"award-info":[{"award-number":["5 \u00d7 1000 2014"]}]},{"name":"Ospedale Policlinico San Martino IRCCS","award":["BC161452P1"],"award-info":[{"award-number":["BC161452P1"]}]},{"name":"Breast Cancer Research Program","award":["#22098"],"award-info":[{"award-number":["#22098"]}]},{"name":"Breast Cancer Research Program","award":["5 \u00d7 1000 2014"],"award-info":[{"award-number":["5 \u00d7 1000 2014"]}]},{"name":"Breast Cancer Research Program","award":["BC161452P1"],"award-info":[{"award-number":["BC161452P1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>There is currently a growing interest in diets and physical activity patterns that may be beneficial in preventing and treating breast cancer (BC). Mounting evidence indicates that indeed, the so-called Mediterranean diet (MedDiet) and regular physical activity likely both help reduce the risk of developing BC. For those who have already received a BC diagnosis, these interventions may decrease the risk of tumor recurrence after treatment and improve quality of life. Studies also show the potential of other dietary interventions, including fasting or modified fasting, calorie restriction, ketogenic diets, and vegan or plant-based diets, to enhance the efficacy of BC therapies. In this review article, we discuss the biological rationale for utilizing these dietary interventions and physical activity in BC prevention and treatment. We highlight published and ongoing clinical studies that have applied these lifestyle interventions to BC patients. This review offers valuable insights into the potential application of these dietary interventions and physical activity as complimentary therapies in BC management.<\/jats:p>","DOI":"10.3390\/nu16142262","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T08:35:17Z","timestamp":1721032517000},"page":"2262","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Advances in Diet and Physical Activity in Breast Cancer Prevention and Treatment"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-5496","authenticated-orcid":false,"given":"Amr","family":"Khalifa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1595-2173","authenticated-orcid":false,"given":"Ana","family":"Guijarro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Nencioni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, Italy"},{"name":"IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Keys, A. 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