{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:07:57Z","timestamp":1791284877826,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology and Metabolic and Mini-Invasive Surgery Foundation (Taipei, Taiwan)","award":["109-2221-E-002-174"],"award-info":[{"award-number":["109-2221-E-002-174"]}]},{"name":"Ministry of Science and Technology and Metabolic and Mini-Invasive Surgery Foundation (Taipei, Taiwan)","award":["110-2221-E-002-014-MY3"],"award-info":[{"award-number":["110-2221-E-002-014-MY3"]}]},{"name":"Ministry of Science and Technology and Metabolic and Mini-Invasive Surgery Foundation (Taipei, Taiwan)","award":["113-2221-E-002-047-MY3"],"award-info":[{"award-number":["113-2221-E-002-047-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Sarcopenia, characterized by degenerative skeletal muscle loss, is increasingly linked to poor surgical outcomes. Glutamine, an immune-modulating formula, may stimulate muscle protein synthesis and inhibit degradation. We used the psoas major muscle area (PMMA) at the third lumbar vertebra, normalized for height (PMMA index), as a skeletal muscle indicator. This study investigates whether perioperative glutamine supplementation mitigates psoas muscle atrophy. Methods: We enrolled gastric adenocarcinoma (GA) patients undergoing gastrectomy. Computed tomography assessed the psoas muscle short axis. Muscle atrophy was estimated by changes between preoperative and three-month post-gastrectomy scans. Perioperative glutamine supplementation (PGS) comprised five-day parenteral plus one-month oral use. Propensity score matching minimized potential bias. A linear regression model predicted the association. Results: Of 516 patients analyzed (2016\u20132019), 100 (19.4%) received PGS. After propensity score matching, each group contained 97 cases. The PGS group showed a significantly higher median PMMA index change than the non-PGS group (0.3 vs. \u22120.3 cm2\/m2, p = 0.004). Multivariate analysis revealed that PGS was significantly associated with increased PMMA index (coefficient = 0.60; 95% CI: 0.19\u20131.01; p = 0.005). Conclusions: PGS may help restore psoas muscle atrophy in GA patients undergoing gastrectomy. The underlying mechanisms likely relate to glutamine\u2019s role in protein metabolism and immune function. Further studies are needed to elucidate these mechanisms fully.<\/jats:p>","DOI":"10.3390\/nu16142301","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T15:15:19Z","timestamp":1721229319000},"page":"2301","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Perioperative Glutamine Supplementation May Restore Atrophy of Psoas Muscles in Gastric Adenocarcinoma Patients Undergoing Gastrectomy"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1821-239X","authenticated-orcid":false,"given":"Jin-Ming","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei 100, Taiwan"},{"name":"Department of Surgery, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu County 300, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9877-0630","authenticated-orcid":false,"given":"Hsing-Hua","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-6289","authenticated-orcid":false,"given":"Shang-Ming","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Surgery, National Taiwan University Hospital Jin-Shan Branch, New Taipei City 208, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kao-Lang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, National Taiwan University Cancer Center, Taipei 106, Taiwan"},{"name":"Department of Medical Imaging, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7313-7057","authenticated-orcid":false,"given":"Ming-Tsan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"ref_1","unstructured":"WHO (2023, June 21). 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