{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:25:12Z","timestamp":1791581112938,"version":"4.3.4"},"reference-count":142,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key R&amp;D Program of China","award":["2022YFF1100104"],"award-info":[{"award-number":["2022YFF1100104"]}]},{"name":"National Key R&amp;D Program of China","award":["2022YFD1300501"],"award-info":[{"award-number":["2022YFD1300501"]}]},{"name":"National Key R&amp;D Program of China","award":["2022YFF1100102"],"award-info":[{"award-number":["2022YFF1100102"]}]},{"name":"National Key R&amp;D Program of China","award":["00109016"],"award-info":[{"award-number":["00109016"]}]},{"name":"China Agricultural University","award":["2022YFF1100104"],"award-info":[{"award-number":["2022YFF1100104"]}]},{"name":"China Agricultural University","award":["2022YFD1300501"],"award-info":[{"award-number":["2022YFD1300501"]}]},{"name":"China Agricultural University","award":["2022YFF1100102"],"award-info":[{"award-number":["2022YFF1100102"]}]},{"name":"China Agricultural University","award":["00109016"],"award-info":[{"award-number":["00109016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D, a crucial fat-soluble vitamin, is primarily synthesized in the skin upon exposure to ultraviolet radiation and is widely recognized as a bone-associated hormone. However, recent scientific advancements have unveiled its intricate association with gut health. The intestinal barrier serves as a vital component, safeguarding the intestinal milieu and maintaining overall homeostasis. Deficiencies in vitamin D have been implicated in altering the gut microbiome composition, compromising the integrity of the intestinal mucosal barrier, and predisposing individuals to various intestinal pathologies. Vitamin D exerts its regulatory function by binding to vitamin D receptors (VDR) present in immune cells, thereby modulating the production of pro-inflammatory cytokines and influencing the intestinal barrier function. Notably, numerous studies have reported lower serum vitamin D levels among patients suffering from intestinal diseases, including inflammatory bowel disease, irritable bowel syndrome, and celiac disease, highlighting the growing significance of vitamin D in gut health maintenance. This comprehensive review delves into the latest advancements in understanding the mechanistic role of vitamin D in modulating the gut microbiome and intestinal barrier function, emphasizing its pivotal role in immune regulation. Furthermore, we consolidate and present relevant findings pertaining to the therapeutic potential of vitamin D in the management of intestinal diseases.<\/jats:p>","DOI":"10.3390\/nu16142352","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T12:20:38Z","timestamp":1721650838000},"page":"2352","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Contemporary Perspectives on the Role of Vitamin D in Enhancing Gut Health and Its Implications for Preventing and Managing Intestinal Diseases"],"prefix":"10.3390","volume":"16","author":[{"given":"Jiaxin","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Mei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Hao","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5791-4629","authenticated-orcid":false,"given":"Yajun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Peking University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4108-9561","authenticated-orcid":false,"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4471-0154","authenticated-orcid":false,"given":"Zhaolai","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlong","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China"},{"name":"Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-0729","authenticated-orcid":false,"given":"Yun","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4161\/derm.24494","article-title":"Sunlight and Vitamin D: A global perspective for health","volume":"5","author":"Wacker","year":"2013","journal-title":"Dermato-Endocrinology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-3-031-11836-4_9","article-title":"Vitamin D and Gut Health","volume":"1390","author":"Fleet","year":"2022","journal-title":"Adv. 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