{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:19:31Z","timestamp":1787505571546,"version":"build-2736575974"},"reference-count":227,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"HA","award":["NCI R01CA258519"],"award-info":[{"award-number":["NCI R01CA258519"]}]},{"name":"HA","award":["G12MD007597"],"award-info":[{"award-number":["G12MD007597"]}]},{"name":"National Institute on Minority Health and Health Disparities of the National Institutes of Health","award":["NCI R01CA258519"],"award-info":[{"award-number":["NCI R01CA258519"]}]},{"name":"National Institute on Minority Health and Health Disparities of the National Institutes of Health","award":["G12MD007597"],"award-info":[{"award-number":["G12MD007597"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Inflammatory bowel disease (IBD) is a chronic inflammatory illness of the gastrointestinal tract (GI), characterized by recurrent episodes of inflammation and tissue destruction. It affects an increasing number of individuals worldwide who suffer from Crohn\u2019s disease (CD) or ulcerative colitis (UC). Despite substantial advances in understanding the underlying causes of IBD, the available treatments remain restricted and are sometimes accompanied by severe consequences. Consequently, there is an urgent need to study alternate therapeutic options. This review assesses the present drugs, identifies their limitations, and proposes the use of saffron, a natural plant with great therapeutic potential based on preclinical and clinical investigations. Saffron has gained attention for its potential therapeutic benefits in treating various ailments due to its established bioactive compounds possessing antioxidant and anti-inflammatory properties. This review covers how saffron impacts the levels of calprotectin, an inflammatory marker, for various inflammatory responses in multiple diseases including IBD. Data from clinical trials were assessed to determine the efficacy and safety of using saffron to counter inflammation in multiple diseases. Studies have shown that saffron may protect against inflammatory bowel disease (IBD) through several mechanisms by inhibiting pro-inflammatory cytokines (TNF-\u03b1, IL-1\u03b2, and IL-6), reducing oxidative stress through antioxidant effects, enhancing mucosal barrier function by upregulating tight junction proteins, and modulating the gut microbiota composition to promote beneficial bacteria while suppressing pathogenic ones; these combined actions contribute to its therapeutic potential in managing and alleviating the symptoms of IBD. This will enable future research endeavors and expedite the translation of saffron-based interventions into clinical practice as a valuable adjunctive therapy or a potential alternative to conventional treatments, thereby enhancing the quality of life for individuals suffering from inflammatory diseases including IBD.<\/jats:p>","DOI":"10.3390\/nu16142353","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T12:20:38Z","timestamp":1721650838000},"page":"2353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Saffron as a Promising Therapy for Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9342-6243","authenticated-orcid":false,"given":"Mudasir","family":"Rashid","sequence":"first","affiliation":[{"name":"Department of Medicine and Cancer Center, Howard University College of Medicine, Washington, DC 20059, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumaisa","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Center, Howard University College of Medicine, Washington, DC 20059, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabtain","family":"Saroya","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Center, Howard University College of Medicine, Washington, DC 20059, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinalini","family":"Deverapalli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Center, Howard University College of Medicine, Washington, DC 20059, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Brim","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Center, Howard University College of Medicine, Washington, DC 20059, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4048-4666","authenticated-orcid":false,"given":"Hassan","family":"Ashktorab","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Center, Howard University College of Medicine, Washington, DC 20059, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.crohns.2013.09.009","article-title":"A tale of two diseases: The history of inflammatory bowel disease","volume":"8","author":"Mulder","year":"2014","journal-title":"J. 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