{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:05:20Z","timestamp":1789077920486,"version":"build-2803163510"},"reference-count":180,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["HD-81206"],"award-info":[{"award-number":["HD-81206"]}]},{"name":"National Institute of Health","award":["NS123883"],"award-info":[{"award-number":["NS123883"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Glucose is the primary energy source for most mammalian cells and its transport is affected by a family of facilitative glucose transporters (GLUTs) encoded by the SLC2 gene. GLUT1 and GLUT3, highly expressed isoforms in the blood\u2013brain barrier and neuronal membranes, respectively, are associated with multiple neurodevelopmental disorders including epilepsy, dyslexia, ADHD, and autism spectrum disorder (ASD). Dietary therapies, such as the ketogenic diet, are widely accepted treatments for patients with the GLUT1 deficiency syndrome, while ameliorating certain symptoms associated with GLUT3 deficiency in animal models. A ketogenic diet, high-fat diet, and calorie\/energy restriction during prenatal and postnatal stages can also alter the placental and brain GLUTs expression with long-term consequences on neurobehavior. This review focuses primarily on the role of diet\/energy perturbations upon GLUT isoform-mediated emergence of neurodevelopmental and neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/nu16142363","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T12:20:38Z","timestamp":1721650838000},"page":"2363","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Neurodevelopment Is Dependent on Maternal Diet: Placenta and Brain Glucose Transporters GLUT1 and GLUT3"],"prefix":"10.3390","volume":"16","author":[{"given":"Tomoko","family":"Daida","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Developmental Biology and Neonatal Research Center, at the UCLA Children\u2019s Discovery and Innovation Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7569-5121","authenticated-orcid":false,"given":"Bo-Chul","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Developmental Biology and Neonatal Research Center, at the UCLA Children\u2019s Discovery and Innovation Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cepeda","sequence":"additional","affiliation":[{"name":"Intellectual and Developmental Disabilities Research Center and Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherin U.","family":"Devaskar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Developmental Biology and Neonatal Research Center, at the UCLA Children\u2019s Discovery and Innovation Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1159\/000017333","article-title":"Glucose transporter expression in brain: Relationship to cerebral glucose utilization","volume":"20","author":"Vannucci","year":"1998","journal-title":"Dev. Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/(SICI)1097-4547(19970901)49:5<617::AID-JNR12>3.0.CO;2-S","article-title":"Ultrastructural localization of GLUT 1 and GLUT 3 glucose transporters in rat brain","volume":"49","author":"Leino","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1042\/bj3010379","article-title":"The GLUT3 glucose transporter is the predominant isoform in primary cultured neurons: Assessment by biosynthetic and photoaffinity labelling","volume":"301","author":"Maher","year":"1994","journal-title":"Biochem. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"E242","DOI":"10.1152\/ajpendo.90388.2008","article-title":"The facilitative glucose transporter GLUT3: 20 years of distinction","volume":"295","author":"Simpson","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0021-9258(18)48518-3","article-title":"Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization","volume":"267","author":"Nagamatsu","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/mp.2010.29","article-title":"Genome-wide copy number variation analysis in attention-deficit\/hyperactivity disorder: Association with neuropeptide Y gene dosage in an extended pedigree","volume":"16","author":"Lesch","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"154869","DOI":"10.1016\/j.metabol.2021.154869","article-title":"Glucose transporter 3 in neuronal glucose metabolism: Health and diseases","volume":"123","author":"Peng","year":"2021","journal-title":"Metabolism"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/mp.2009.102","article-title":"First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children","volume":"16","author":"Roeske","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainres.2012.11.050","article-title":"Early life nutrient restriction impairs blood-brain metabolic profile and neurobehavior predisposing to Alzheimer\u2019s disease with aging","volume":"1495","author":"Tomi","year":"2013","journal-title":"Brain Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/mp.2009.51","article-title":"Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders","volume":"15","author":"Zhao","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wu, A., Lee, D., and Xiong, W.C. (2023). Lactate Metabolism, Signaling, and Function in Brain Development, Synaptic Plasticity, Angiogenesis, and Neurodegenerative Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713398"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1038\/sj.jcbfm.9600521","article-title":"Supply and demand in cerebral energy metabolism: The role of nutrient transporters","volume":"27","author":"Simpson","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41582-022-00651-8","article-title":"The metabolic basis of epilepsy","volume":"18","author":"Rho","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1242\/dev.115.1.305","article-title":"Developmental expression and cellular localization of glucose transporter molecules during mouse preimplantation development","volume":"115","author":"Aghayan","year":"1992","journal-title":"Development"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"E1241","DOI":"10.1152\/ajpendo.00344.2006","article-title":"Glucose transporter isoform-3 mutations cause early pregnancy loss and fetal growth restriction","volume":"292","author":"Ganguly","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"15613","DOI":"10.1073\/pnas.2536196100","article-title":"Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy","volume":"100","author":"Heilig","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1248\/bpb.29.1587","article-title":"Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice","volume":"29","author":"Ohtsuki","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Adastra, K.L., Frolova, A.I., Chi, M.M., Cusumano, D., Bade, M., Carayannopoulos, M.O., and Moley, K.H. (2012). Slc2a8 deficiency in mice results in reproductive and growth impairments. Biol. Reprod., 87.","DOI":"10.1095\/biolreprod.111.097675"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1242\/dev.116.3.555","article-title":"Differential screening of a PCR-generated mouse embryo cDNA library: Glucose transporters are differentially expressed in early postimplantation mouse embryos","volume":"116","author":"Smith","year":"1992","journal-title":"Development"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1530\/ror.0.0030077","article-title":"Glucose transporters in preimplantation development","volume":"3","author":"Pantaleon","year":"1998","journal-title":"Rev. Reprod."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/bbrc.1995.1475","article-title":"Abundant expression of GLUT1 and GLUT3 in rat embryo during the early organogenesis period","volume":"209","author":"Matsumoto","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_22","first-page":"R892","article-title":"Developmental regulation of genes mediating murine brain glucose uptake","volume":"276","author":"Khan","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.placenta.2011.09.014","article-title":"Glucose transporter 3 (GLUT3) protein expression in human placenta across gestation","volume":"32","author":"Brown","year":"2011","journal-title":"Placenta"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.1210\/endo.140.9.6993","article-title":"Maternal epidermal growth factor deficiency causes fetal hypoglycemia and intrauterine growth retardation in mice: Possible involvement of placental glucose transporter GLUT3 expression","volume":"140","author":"Kamei","year":"1999","journal-title":"Endocrinology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1210\/endo.138.9.5369","article-title":"Glucose transporter GLUT3 in the rat placental barrier: A possible machinery for the transplacental transfer of glucose","volume":"138","author":"Shin","year":"1997","journal-title":"Endocrinology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/mgme.2001.3212","article-title":"Sequence and functional analysis of GLUT10: A glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1","volume":"74","author":"Dawson","year":"2001","journal-title":"Mol. Genet. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Janzen, C., Lei, M.Y.Y., Jeong, I.S.D., Ganguly, A., Sullivan, P., Paharkova, V., Capodanno, G., Nakamura, H., Perry, A., and Shin, B.C. (2018). Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193583"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.placenta.2003.08.012","article-title":"Characterization of glucose transporter 8 (GLUT8) in the ovine placenta of normal and growth restricted fetuses","volume":"25","author":"Limesand","year":"2004","journal-title":"Placenta"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/physiol.00033.2015","article-title":"Intrauterine Growth Restriction: Hungry for an Answer","volume":"31","author":"Devaskar","year":"2016","journal-title":"Physiology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000322038","article-title":"Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood","volume":"93","author":"Sullivan","year":"2011","journal-title":"Neuroendocrinology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.mam.2012.07.001","article-title":"The SLC2 (GLUT) family of membrane transporters","volume":"34","author":"Mueckler","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/0148607104028005364","article-title":"The glucose transporter families SGLT and GLUT: Molecular basis of normal and aberrant function","volume":"28","author":"Scheepers","year":"2004","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1152\/physiol.00011.2007","article-title":"Facilitated hexose transporters: New perspectives on form and function","volume":"22","author":"Manolescu","year":"2007","journal-title":"Physiology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/09687680110090456","article-title":"The extended GLUT-family of sugar\/polyol transport facilitators: Nomenclature, sequence characteristics, and potential function of its novel members (review)","volume":"18","author":"Joost","year":"2001","journal-title":"Mol. Membr. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00424-020-02411-3","article-title":"Structure, function and regulation of mammalian glucose transporters of the SLC2 family","volume":"472","author":"Holman","year":"2020","journal-title":"Pflug. Arch."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7384","DOI":"10.1016\/S0021-9258(19)66976-0","article-title":"Reconstitution and purification of the D-glucose transporter from human erythrocytes","volume":"252","author":"Kasahara","year":"1977","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1152\/physrev.00022.2002","article-title":"Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells","volume":"83","author":"Mann","year":"2003","journal-title":"Physiol. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1126\/science.3839598","article-title":"Sequence and structure of a human glucose transporter","volume":"229","author":"Mueckler","year":"1985","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1073\/pnas.85.15.5434","article-title":"Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein","volume":"85","author":"Fukumoto","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"15245","DOI":"10.1016\/S0021-9258(19)37577-5","article-title":"Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues","volume":"263","author":"Kayano","year":"1988","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00424-020-02441-x","article-title":"Glucose transporters in brain in health and disease","volume":"472","author":"Koepsell","year":"2020","journal-title":"Pflug. Arch."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00109-019-01799-5","article-title":"The median eminence as the hypothalamic area involved in rapid transfer of glucose to the brain: Functional and cellular mechanisms","volume":"97","author":"Martinez","year":"2019","journal-title":"J. Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"E141","DOI":"10.1152\/ajpendo.00712.2009","article-title":"Glucose transporters in the 21st Century","volume":"298","author":"Thorens","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1016\/S0021-9258(19)85561-8","article-title":"Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane","volume":"255","author":"Cushman","year":"1980","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1073\/pnas.77.5.2542","article-title":"Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site","volume":"77","author":"Suzuki","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/09687680110072131","article-title":"GLUT4: A key player regulating glucose homeostasis? Insights from transgenic and knockout mice (review)","volume":"18","author":"Zierath","year":"2001","journal-title":"Mol. Membr. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1042\/bj3500771","article-title":"Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes","volume":"350","author":"Doege","year":"2000","journal-title":"Biochem. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1042\/bj3580517","article-title":"Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells","volume":"358","author":"Lisinski","year":"2001","journal-title":"Biochem. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1210\/endo.143.1.8587","article-title":"Immunolocalization of GLUTX1 in the testis and to specific brain areas and vasopressin-containing neurons","volume":"143","author":"Ibberson","year":"2002","journal-title":"Endocrinology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1006\/bbrc.2001.5866","article-title":"Mouse GLUT8: Genomic organization and regulation of expression in 3T3-L1 adipocytes by glucose","volume":"288","author":"Scheepers","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s10519-008-9208-1","article-title":"Deletion of glucose transporter GLUT8 in mice increases locomotor activity","volume":"38","author":"Schmidt","year":"2008","journal-title":"Behav. Genet."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"16229","DOI":"10.1074\/jbc.M312226200","article-title":"Identification and characterization of human glucose transporter-like protein-9 (GLUT9): Alternative splicing alters trafficking","volume":"279","author":"Augustin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/geno.2000.6457","article-title":"Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: A candidate gene for NIDDM susceptibility","volume":"72","author":"Lamson","year":"2001","journal-title":"Genomics"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.bbaexp.2005.06.012","article-title":"Functional characterization of the promoter of the human glucose transporter 10 gene","volume":"1730","author":"Segade","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"E733","DOI":"10.1152\/ajpendo.2002.282.3.E733","article-title":"Identification of a novel glucose transporter-like protein-GLUT-12","volume":"282","author":"Rogers","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1152\/physrev.00055.2009","article-title":"Biology of human sodium glucose transporters","volume":"91","author":"Wright","year":"2011","journal-title":"Physiol. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s13300-010-0006-4","article-title":"Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members","volume":"1","author":"Chen","year":"2010","journal-title":"Diabetes Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrendo.2011.243","article-title":"SGLT2 inhibition in diabetes mellitus: Rationale and clinical prospects","volume":"8","author":"Ferrannini","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"F10","DOI":"10.1152\/ajprenal.2001.280.1.F10","article-title":"Renal Na(+)-glucose cotransporters","volume":"280","author":"Wright","year":"2001","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"11753","DOI":"10.1073\/pnas.1733027100","article-title":"A glucose sensor hiding in a family of transporters","volume":"100","author":"Hirayama","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/21623945.2018.1516098","article-title":"SGLT6\u2014A pharmacological target for the treatment of obesity?","volume":"7","author":"Eckhardt","year":"2018","journal-title":"Adipocyte"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.abb.2008.11.008","article-title":"Human sodium\/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells","volume":"481","author":"Lin","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"14523","DOI":"10.1016\/S0021-9258(18)42067-4","article-title":"Fructose transporter in human spermatozoa and small intestine is GLUT5","volume":"267","author":"Burant","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"13276","DOI":"10.1016\/S0021-9258(19)38295-X","article-title":"Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6)","volume":"265","author":"Kayano","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"E238","DOI":"10.1152\/ajpendo.90394.2008","article-title":"GLUT7: A new intestinal facilitated hexose transporter","volume":"295","author":"Cheeseman","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1096-7192(02)00018-5","article-title":"Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues","volume":"76","author":"Wu","year":"2002","journal-title":"Mol. Genet. Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1042\/bj3590443","article-title":"Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle","volume":"359","author":"Doege","year":"2001","journal-title":"Biochem. J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1093\/emboj\/20.16.4467","article-title":"Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain","volume":"20","author":"Uldry","year":"2001","journal-title":"EMBO J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"E836","DOI":"10.1152\/ajpendo.00496.2009","article-title":"Will the original glucose transporter isoform please stand up!","volume":"297","author":"Carruthers","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.yfrne.2009.10.006","article-title":"Sweet talk in the brain: Glucosensing, neural networks, and hypoglycemic counterregulation","volume":"31","author":"Watts","year":"2010","journal-title":"Front. Neuroendocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1210\/endo.132.6.8504756","article-title":"Tissue distribution of the human GLUT3 glucose transporter","volume":"132","author":"Haber","year":"1993","journal-title":"Endocrinology"},{"key":"ref_72","first-page":"R1488","article-title":"GLUT3 glucose transporter isoform in rat testis: Localization, effect of diabetes mellitus, and comparison to human testis","volume":"267","author":"Burant","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/0002-9378(94)90154-6","article-title":"Expression of genes involved in placental glucose uptake and transport in the nonobese diabetic mouse pregnancy","volume":"171","author":"Devaskar","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1172\/JCI116305","article-title":"Placental glucose transporter gene expression and metabolism in the rat","volume":"91","author":"Zhou","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1210\/endo.131.3.1505464","article-title":"Cellular localization and characterization of Glut 3 glucose transporter isoform in human brain","volume":"131","author":"Mantych","year":"1992","journal-title":"Endocrinology"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1002\/jnr.22487","article-title":"Hypoxic-ischemic brain injury exacerbates neuronal apoptosis and precipitates spontaneous seizures in glucose transporter isoform 3 heterozygous null mice","volume":"88","author":"Fung","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0306-4522(01)00619-4","article-title":"Immunohistochemical localization and quantification of glucose transporters in the mouse brain","volume":"111","author":"Choeiri","year":"2002","journal-title":"Neuroscience"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0169-328X(02)00487-4","article-title":"Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain","volume":"107","author":"Sankar","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"113603","DOI":"10.1016\/j.expneurol.2021.113603","article-title":"Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders","volume":"338","author":"Shin","year":"2021","journal-title":"Exp. Neurol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"9579","DOI":"10.1523\/JNEUROSCI.0503-18.2018","article-title":"Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes","volume":"38","author":"Shin","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ymgme.2014.01.013","article-title":"GLUT3 gene expression is critical for embryonic growth, brain development and survival","volume":"111","author":"Carayannopoulos","year":"2014","journal-title":"Mol. Genet. Metab."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/bs.apcsb.2019.12.003","article-title":"Expression of placental glucose transporter proteins in pregnancies complicated by fetal growth disorders","volume":"123","author":"Stanirowski","year":"2021","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1203\/00006450-199905010-00019","article-title":"Effect of primary congenital hypothyroidism upon expression of genes mediating murine brain glucose uptake","volume":"45","author":"Khan","year":"1999","journal-title":"Pediatr. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"26768","DOI":"10.1074\/jbc.M402735200","article-title":"Trans-activators regulating neuronal glucose transporter isoform-3 gene expression in mammalian neurons","volume":"279","author":"Rajakumar","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"27474","DOI":"10.1074\/jbc.273.42.27474","article-title":"Sp1 and Sp3 regulate transcriptional activity of the facilitative glucose transporter isoform-3 gene in mammalian neuroblasts and trophoblasts","volume":"273","author":"Rajakumar","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_86","first-page":"255","article-title":"Post-transcription modulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors","volume":"59","author":"Boado","year":"2000","journal-title":"J. Neural Transm. Suppl."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"E254","DOI":"10.1152\/ajpendo.00214.2012","article-title":"Temporal and spatial distribution of murine placental and brain GLUT3-luciferase transgene as a readout of in vivo transcription","volume":"304","author":"Thamotharan","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Plassmeyer, S.P., Florian, C.P., Kasper, M.J., Chase, R., Mueller, S., Liu, Y., White, K.M., Jungers, C.F., Djuranovic, S.P., and Djuranovic, S. (2023). A Massively Parallel Screen of 5\u2032UTR Mutations Identifies Variants Impacting Translation and Protein Production in Neurodevelopmental Disorder Genes. medRxiv.","DOI":"10.1101\/2023.11.02.23297961"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0165-3806(98)00021-2","article-title":"Alterations in GLUT1 and GLUT3 glucose transporter gene expression following unilateral hypoxia-ischemia in the immature rat brain","volume":"107","author":"Vannucci","year":"1998","journal-title":"Brain Res. Dev. Brain Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/00005072-199607000-00008","article-title":"Chronic seizures increase glucose transporter abundance in rat brain","volume":"55","author":"Gronlund","year":"1996","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.nbd.2011.05.007","article-title":"Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat","volume":"43","author":"Leroy","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s40478-014-0178-7","article-title":"Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington\u2019s disease mice","volume":"2","author":"McClory","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Iuliano, M., Seeley, C., Sapp, E., Jones, E.L., Martin, C., Li, X., DiFiglia, M., and Kegel-Gleason, K.B. (2021). Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175\/Q7 Huntington\u2019s Disease Mouse Striatum. Front. Synaptic Neurosci., 13.","DOI":"10.3389\/fnsyn.2021.618391"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1038\/ncomms3917","article-title":"A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington\u2019s disease in mice","volume":"4","author":"Acuna","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_95","first-page":"215","article-title":"Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington\u2019s disease","volume":"47","author":"Ciarmiello","year":"2006","journal-title":"J. Nucl. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1046\/j.1471-4159.1994.63041392.x","article-title":"Glucose transporter isoform expression in Huntington\u2019s disease brain","volume":"63","author":"Gamberino","year":"1994","journal-title":"J. Neurochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.bbrc.2012.04.070","article-title":"Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington\u2019s disease mice","volume":"421","author":"Li","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1093\/hmg\/ddu022","article-title":"Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington\u2019s disease","volume":"23","author":"Vittori","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/ana.410350507","article-title":"Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer\u2019s disease","volume":"35","author":"Simpson","year":"1994","journal-title":"Ann. Neurol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.febslet.2007.12.035","article-title":"Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease","volume":"582","author":"Liu","year":"2008","journal-title":"FEBS Lett."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jalz.2017.09.011","article-title":"Evidence for brain glucose dysregulation in Alzheimer\u2019s disease","volume":"14","author":"An","year":"2018","journal-title":"Alzheimers Dement."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"dev200397","DOI":"10.1242\/dev.200397","article-title":"The brain on time: Links between development and neurodegeneration","volume":"150","author":"Shabani","year":"2023","journal-title":"Development"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1002\/jnr.24503","article-title":"Developmental origins of cortical hyperexcitability in Huntington\u2019s disease: Review and new observations","volume":"97","author":"Cepeda","year":"2019","journal-title":"J. Neurosci. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.neurol.2024.04.001","article-title":"A developmental component to Huntington\u2019s disease","volume":"180","author":"Ratie","year":"2024","journal-title":"Rev. Neurol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/jnc.14036","article-title":"Is sporadic Alzheimer\u2019s disease a developmental disorder?","volume":"143","author":"Arendt","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/jcpp.12702","article-title":"SLC2A3 single-nucleotide polymorphism and duplication influence cognitive processing and population-specific risk for attention-deficit\/hyperactivity disorder","volume":"58","author":"Merker","year":"2017","journal-title":"J. Child Psychol. Psychiatry"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.neuroimage.2015.06.024","article-title":"Genetic dyslexia risk variant is related to neural connectivity patterns underlying phonological awareness in children","volume":"118","author":"Skeide","year":"2015","journal-title":"Neuroimage"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"E1084","DOI":"10.1152\/ajpendo.90491.2008","article-title":"Neuronal functions, feeding behavior, and energy balance in Slc2a3+\/\u2212 mice","volume":"295","author":"Schmidt","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.brainres.2011.02.014","article-title":"Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake","volume":"1384","author":"Stuart","year":"2011","journal-title":"Brain Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1056\/NEJMoa0706786","article-title":"Association between obesity during pregnancy and increased use of health care","volume":"358","author":"Chu","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"103972","DOI":"10.1016\/j.midw.2024.103972","article-title":"Prepregnancy dieting and obstetrical and neonatal outcomes: Findings from a national surveillance project in the United States","volume":"132","author":"Yu","year":"2024","journal-title":"Midwifery"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1096\/fj.09-144014","article-title":"Enduring consequences of maternal obesity for brain inflammation and behavior of offspring","volume":"24","author":"Bilbo","year":"2010","journal-title":"FASEB J."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e290","DOI":"10.1542\/peds.2004-1808","article-title":"Metabolic syndrome in childhood: Association with birth weight, maternal obesity, and gestational diabetes mellitus","volume":"115","author":"Boney","year":"2005","journal-title":"Pediatrics"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11892-011-0248-1","article-title":"Metabolic programming, epigenetics, and gestational diabetes mellitus","volume":"12","author":"Pinney","year":"2012","journal-title":"Curr. Diabetes Rep."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Urbonaite, G., Knyzeliene, A., Bunn, F.S., Smalskys, A., and Neniskyte, U. (2022). The impact of maternal high-fat diet on offspring neurodevelopment. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.909762"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.siny.2009.09.002","article-title":"Obesity and gestational diabetes","volume":"15","author":"Sathyapalan","year":"2010","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1210\/endrev\/bnac003","article-title":"A Clinical Update on Gestational Diabetes Mellitus","volume":"43","author":"Sweeting","year":"2022","journal-title":"Endocr. Rev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1210\/en.2009-1019","article-title":"Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet","volume":"151","author":"Grayson","year":"2010","journal-title":"Endocrinology"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"E792","DOI":"10.1152\/ajpendo.00078.2006","article-title":"Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood","volume":"291","author":"Srinivasan","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jnutbio.2018.09.001","article-title":"High-fat diet affects pregestational adiposity and glucose tolerance perturbing gestational placental macronutrient transporters culminating in an obese offspring in wild-type and glucose transporter isoform 3 heterozygous null mice","volume":"62","author":"Ganguly","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1096\/fj.08-116889","article-title":"High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57\/BL6 mice","volume":"23","author":"Jones","year":"2009","journal-title":"FASEB J."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/oby.21165","article-title":"Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth","volume":"23","author":"Rosario","year":"2015","journal-title":"Obesity"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1210\/en.2016-1259","article-title":"Maternal Calorie Restriction Causing Uteroplacental Insufficiency Differentially Affects Mammalian Placental Glucose and Leucine Transport Molecular Mechanisms","volume":"157","author":"Ganguly","year":"2016","journal-title":"Endocrinology"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Chizhikov, D., Buddington, R.K., and Iskusnykh, I.Y. (2020). Effects of Phosphatidylserine Source of Docosahexaenoic Acid on Cerebellar Development in Preterm Pigs. Brain Sci., 10.","DOI":"10.3390\/brainsci10080475"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3945\/ajcn.112.040766","article-title":"Long-term effects of LCPUFA supplementation on childhood cognitive outcomes","volume":"98","author":"Colombo","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1753-4887.1986.tb07660.x","article-title":"n-3 fatty acids in the brain and retina: Evidence for their essentiality","volume":"44","author":"Neuringer","year":"1986","journal-title":"Nutr. Rev."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"S168","DOI":"10.1016\/S0022-3476(05)81252-1","article-title":"Visual and brain function measurements in studies of n-3 fatty acid requirements of infants","volume":"120","author":"Uauy","year":"1992","journal-title":"J. Pediatr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.nutres.2019.08.004","article-title":"Early life high-fat diet exposure maintains glucose tolerance and insulin sensitivity with a fatty liver and small brain size in the adult offspring","volume":"69","author":"Shin","year":"2019","journal-title":"Nutr. Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s11011-013-9437-8","article-title":"Maternal obesity induced by a high fat diet causes altered cellular development in fetal brains suggestive of a predisposition of offspring to neurological disorders in later life","volume":"28","author":"Stachowiak","year":"2013","journal-title":"Metab. Brain Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/WCO.0000000000000432","article-title":"New insights into the mechanisms of the ketogenic diet","volume":"30","author":"Boison","year":"2017","journal-title":"Curr. Opin. Neurol."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Dynka, D., Kowalcze, K., and Paziewska, A. (2022). The Role of Ketogenic Diet in the Treatment of Neurological Diseases. Nutrients, 14.","DOI":"10.3390\/nu14235003"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1528-1167.2008.01821.x","article-title":"History of the ketogenic diet","volume":"49","author":"Wheless","year":"2008","journal-title":"Epilepsia"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/epi4.12414","article-title":"Glut1 Deficiency Syndrome (Glut1DS): State of the art in 2020 and recommendations of the international Glut1DS study group","volume":"5","author":"Klepper","year":"2020","journal-title":"Epilepsia Open"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/ng0298-188","article-title":"GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier","volume":"18","author":"Seidner","year":"1998","journal-title":"Nat. Genet."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"8736","DOI":"10.1038\/s41598-019-45147-6","article-title":"The ketogenic diet in children 3 years of age or younger: A 10-year single-center experience","volume":"9","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/epi.16543","article-title":"Use of ketogenic diet therapy in infants with epilepsy: A systematic review and meta-analysis","volume":"61","author":"Lyons","year":"2020","journal-title":"Epilepsia"},{"key":"ref_137","first-page":"CD001903","article-title":"Ketogenic diets for drug-resistant epilepsy","volume":"6","author":"Bresnahan","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.nut.2014.01.005","article-title":"Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: A case series","volume":"30","author":"Bertoli","year":"2014","journal-title":"Nutrition"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/j.0013-9580.2004.10004.x","article-title":"Early- and late-onset complications of the ketogenic diet for intractable epilepsy","volume":"45","author":"Kang","year":"2004","journal-title":"Epilepsia"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/ejcn.2013.116","article-title":"Beyond weight loss: A review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets","volume":"67","author":"Paoli","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/08830738030180020501","article-title":"Application of a ketogenic diet in children with autistic behavior: Pilot study","volume":"18","author":"Evangeliou","year":"2003","journal-title":"J. Child. Neurol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"305.e1","DOI":"10.1016\/j.ajog.2014.05.013","article-title":"Genetic variations in the GLUT3 gene associated with myelomeningocele","volume":"211","author":"Connealy","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1210\/en.2002-0057","article-title":"A ketogenic diet increases brain insulin-like growth factor receptor and glucose transporter gene expression","volume":"144","author":"Cheng","year":"2003","journal-title":"Endocrinology"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1210\/en.2016-1816","article-title":"Sex-Specific Life Course Changes in the Neuro-Metabolic Phenotype of Glut3 Null Heterozygous Mice: Ketogenic Diet Ameliorates Electroencephalographic Seizures and Improves Sociability","volume":"158","author":"Dai","year":"2017","journal-title":"Endocrinology"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000242635","article-title":"Lipid metabolism in pregnancy","volume":"51","author":"Herrera","year":"1987","journal-title":"Biol. Neonate"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Sussman, D., Ellegood, J., and Henkelman, M. (2013). A gestational ketogenic diet alters maternal metabolic status as well as offspring physiological growth and brain structure in the neonatal mouse. BMC Pregnancy Childbirth, 13.","DOI":"10.1186\/1471-2393-13-198"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"e00300","DOI":"10.1002\/brb3.300","article-title":"Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring","volume":"5","author":"Sussman","year":"2015","journal-title":"Brain Behav."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/0885066604269663","article-title":"Current concepts in intrauterine growth restriction","volume":"19","author":"Brodsky","year":"2004","journal-title":"J. Intensive Care Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1515\/JPM.2008.050","article-title":"Intrauterine restriction (IUGR)","volume":"36","author":"Mandruzzato","year":"2008","journal-title":"J. Perinat. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/bmj.303.6804.671","article-title":"Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease","volume":"303","author":"Barker","year":"1991","journal-title":"BMJ"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/uog.9008","article-title":"Neurodevelopment following fetal growth restriction and its relationship with antepartum parameters of placental dysfunction","volume":"37","author":"Baschat","year":"2011","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/j.1471-0528.2008.01827.x","article-title":"Cerebral palsy and restricted growth status at birth: Population-based case-control study","volume":"115","author":"Jacobsson","year":"2008","journal-title":"BJOG"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(03)14466-2","article-title":"Cerebral palsy and intrauterine growth in single births: European collaborative study","volume":"362","author":"Jarvis","year":"2003","journal-title":"Lancet"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.bpobgyn.2009.06.003","article-title":"Risk factors for small for gestational age infants","volume":"23","author":"McCowan","year":"2009","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1113\/JP271402","article-title":"The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome","volume":"594","author":"Miller","year":"2016","journal-title":"J. Physiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1440-1754.1995.tb00847.x","article-title":"Growth, development and behaviour in adolescents born small-for-gestational-age","volume":"31","author":"Pryor","year":"1995","journal-title":"J. Paediatr. Child Health"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Vollmer, B., and Edmonds, C.J. (2019). School Age Neurological and Cognitive Outcomes of Fetal Growth Retardation or Small for Gestational Age Birth Weight. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00186"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3109\/14767058.2015.1015417","article-title":"Neurodevelopment in children with intrauterine growth restriction: Adverse effects and interventions","volume":"29","author":"Wang","year":"2016","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1080\/14767058.2016.1245285","article-title":"Genetic, metabolic and endocrine aspect of intrauterine growth restriction: An update","volume":"30","author":"Sharma","year":"2017","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1373\/clinchem.2005.060665","article-title":"High maternal blood S100B concentrations in pregnancies complicated by intrauterine growth restriction and intraventricular hemorrhage","volume":"52","author":"Gazzolo","year":"2006","journal-title":"Clin. Chem."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1203\/00006450-200202000-00015","article-title":"Circulating S100beta protein is increased in intrauterine growth-retarded fetuses","volume":"51","author":"Gazzolo","year":"2002","journal-title":"Pediatr. Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e747","DOI":"10.1542\/peds.2005-2875","article-title":"Urinary S100B protein concentrations are increased in intrauterine growth-retarded newborns","volume":"118","author":"Florio","year":"2006","journal-title":"Pediatrics"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"113537","DOI":"10.1016\/j.expneurol.2020.113537","article-title":"Intrauterine growth restriction compromises cerebellar development by affecting radial migration of granule cells via the JamC\/Pard3a molecular pathway","volume":"336","author":"Iskusnykh","year":"2021","journal-title":"Exp. Neurol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.placenta.2013.08.010","article-title":"Placental glucose transporter 3 (GLUT3) is up-regulated in human pregnancies complicated by late-onset intrauterine growth restriction","volume":"34","author":"Janzen","year":"2013","journal-title":"Placenta"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000291493","article-title":"Placental glucose transporters in fetal intrauterine growth retardation and macrosomia","volume":"44","author":"Kainulainen","year":"1997","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.placenta.2011.01.007","article-title":"Upregulation of growth signaling and nutrient transporters in cotyledons of early to mid-gestational nutrient restricted ewes","volume":"32","author":"Ma","year":"2011","journal-title":"Placenta"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"R2252","DOI":"10.1152\/ajpregu.2000.279.6.R2252","article-title":"Time-dependent physiological regulation of ovine placental GLUT-3 glucose transporter protein","volume":"279","author":"Das","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1113\/jphysiol.2009.181214","article-title":"Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice","volume":"588","author":"Coan","year":"2010","journal-title":"J. Physiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1210\/en.2011-1973","article-title":"Placental glucose and amino acid transport in calorie-restricted wild-type and Glut3 null heterozygous mice","volume":"153","author":"Ganguly","year":"2012","journal-title":"Endocrinology"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1677\/joe.0.1740037","article-title":"Maternal undernutrition during late gestation-induced intrauterine growth restriction in the rat is associated with impaired placental GLUT3 expression, but does not correlate with endogenous corticosterone levels","volume":"174","author":"Lesage","year":"2002","journal-title":"J. Endocrinol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.705336","article-title":"Prenatal exposure to prednisone in humans and animals retards intrauterine growth","volume":"202","author":"Reinisch","year":"1978","journal-title":"Science"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Motta, K., Gomes, P.R.L., Sulis, P.M., Bordin, S., and Rafacho, A. (2018). Dexamethasone Administration During Late Gestation Has No Major Impact on Lipid Metabolism, but Reduces Newborn Survival Rate in Wistar Rats. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.00783"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S2352-4642(19)30292-5","article-title":"Maternal intramuscular dexamethasone versus betamethasone before preterm birth (ASTEROID): A multicentre, double-blind, randomised controlled trial","volume":"3","author":"Crowther","year":"2019","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.rbmo.2021.10.016","article-title":"Progesterone partially recovers placental glucose transporters in dexamethasone-induced intrauterine growth restriction","volume":"44","author":"Alawadhi","year":"2022","journal-title":"Reprod. Biomed. Online"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0006-8993(99)01145-2","article-title":"Intra-uterine growth restriction differentially regulates perinatal brain and skeletal muscle glucose transporters","volume":"823","author":"Sadiq","year":"1999","journal-title":"Brain Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000514709","article-title":"Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures","volume":"43","author":"Ye","year":"2021","journal-title":"Dev. Neurosci."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/jnr.24568","article-title":"Murine maternal dietary restriction affects neural Humanin expression and cellular profile","volume":"98","author":"Baldauf","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1210\/en.2012-1640","article-title":"Glucose intolerance and lipid metabolic adaptations in response to intrauterine and postnatal calorie restriction in male adult rats","volume":"154","author":"Garg","year":"2013","journal-title":"Endocrinology"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"E583","DOI":"10.1152\/ajpendo.00513.2012","article-title":"Hypoxic adaptation engages the CBP\/CREST-induced coactivator complex of Creb-HIF-1alpha in transactivating murine neuroblastic glucose transporter","volume":"304","author":"Thamotharan","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ymgme.2019.05.013","article-title":"Circulating blood cellular glucose transporters\u2014Surrogate biomarkers for neonatal hypoxic-ischemic encephalopathy assessed by novel scoring systems","volume":"127","author":"Maggiotto","year":"2019","journal-title":"Mol. Genet. Metab."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/14\/2363\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:20:34Z","timestamp":1760109634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/14\/2363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,21]]},"references-count":180,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["nu16142363"],"URL":"https:\/\/doi.org\/10.3390\/nu16142363","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,21]]}}}