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Classically, ovarian cancer therapy has included conventional chemotherapy, and other therapeutic approaches are now being used to treat these patients, but the outcomes of the disease are still poor. Therefore, new strategies are needed to improve life expectancy and life quality of ovarian cancer patients. Considering that, we investigated the effect of the nutritional supplement Ocoxin Oral Solution (OOS) in ovarian cancer models. OOS contains several nutritional supplements, some of them with demonstrated antitumoral action. In vitro studies showed that OOS inhibited the proliferation of several ovarian cancer cell lines, especially of those representative of the endometrioid subtype, in a time- and dose-dependent manner. A fast cell death induction after OOS treatment was observed, and when the molecular mechanisms leading to this effect were investigated, an activation of the DNA damage checkpoint was detected, as shown by activation (phosphorylation) of CHK1 and CHK2 kinases that was followed by the phosphorylation of the target protein histone H2AX. When tested in animal models of ovarian cancer, OOS reduced tumor growth without any observed secondary effects. Moreover, such reduction in tumor proliferation was caused by the induction of DNA damage as corroborated by the in vivo phosphorylation of CHK2 and Histone H2AX. Finally, OOS potentiated the action of carboplatin or olaparib, the standard of care treatments used in ovarian clinics, opening the possibility of including OOS in combination with those standard of care agents in patients with ovarian cancer.<\/jats:p>","DOI":"10.3390\/nu16152416","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T11:43:44Z","timestamp":1721907824000},"page":"2416","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ocoxin Oral Solution Triggers DNA Damage and Cell Death in Ovarian Cancer"],"prefix":"10.3390","volume":"16","author":[{"given":"Sheila","family":"Almaraz-Postigo","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red C\u00e1ncer (CIBERONC), Campus Miguel de Unamuno, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Sanz","sequence":"additional","affiliation":[{"name":"Catalysis S.L., 28016 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-8971","authenticated-orcid":false,"given":"Atanasio","family":"Pandiella","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red C\u00e1ncer (CIBERONC), Campus Miguel de Unamuno, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6240-6327","authenticated-orcid":false,"given":"Elena","family":"D\u00edaz-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red C\u00e1ncer (CIBERONC), Campus Miguel de Unamuno, 37007 Salamanca, Spain"},{"name":"Department of Biochemistry, Universidad de Salamanca, 37008 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"ref_1","first-page":"723","article-title":"Update on the role of surgery in the management of advanced epithelial ovarian cancer","volume":"18","author":"Straubhar","year":"2020","journal-title":"Clin. 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