{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:39:40Z","timestamp":1787063980178,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>With the emergence of the COVID-19 pandemic, the absence of established evidence-based treatment protocols led healthcare professionals and the public to explore experimental treatments, including high doses of vitamin D supplements. This study aimed to assess changes in serum 25-hydroxyvitamin D levels during the pandemic, employing a retrospective cohort analysis of data from Charleston Area Medical Center (CAMC). The study analyzed serum 25-hydroxyvitamin D levels in a cohort of 35,556 patients treated at CAMC in 2019, a representative pre-pandemic period, to 2021, a representative pandemic period. Our findings revealed a significant increase in mean serum 25-hydroxyvitamin D levels as compared with 2019 (37 \u00b1 21 vs. 31 \u00b1 15 ng\/mL, p \u2264 0.001). Additionally, in 2021, there were significantly more patients exhibiting serum levels in the highest quintiles, specifically &gt;100 ng\/mL (1.6% vs. 0.2%), 75\u2013100 ng\/mL (4.6% vs. 1.2%), and 50\u201375 ng\/mL (16.0% vs. 8.4%), p \u2264 0.001. This upsurge suggests increased intake of vitamin D supplements, potentially fueled by widespread discussions that were taking place largely on the internet regarding the efficacy of vitamin D against COVID-19. Our findings underscore the critical need for evidence-based public health messaging, especially during health crises, to prevent unnecessary health risks and ensure patient safety.<\/jats:p>","DOI":"10.3390\/nu16152449","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T07:54:03Z","timestamp":1722239643000},"page":"2449","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rise in Serum 25-Hydroxyvitamin D Levels during the COVID-19 Pandemic"],"prefix":"10.3390","volume":"16","author":[{"given":"Witt","family":"Durden","sequence":"first","affiliation":[{"name":"Charleston Area Medical Center, Institute for Academic Medicine, 3200 MacCorkle Ave SE, Charleston, WV 25304, USA"},{"name":"Department of Internal Medicine, West Virginia University-Charleston Division, Charleston, WV 25304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shady","family":"Ezaldin","sequence":"additional","affiliation":[{"name":"Charleston Area Medical Center, Institute for Academic Medicine, 3200 MacCorkle Ave SE, Charleston, WV 25304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Amos","sequence":"additional","affiliation":[{"name":"Charleston Area Medical Center, Institute for Academic Medicine, 3200 MacCorkle Ave SE, Charleston, WV 25304, USA"},{"name":"Department of Internal Medicine, West Virginia University-Charleston Division, Charleston, WV 25304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Kemper","sequence":"additional","affiliation":[{"name":"Charleston Area Medical Center, Institute for Academic Medicine, 3200 MacCorkle Ave SE, Charleston, WV 25304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Campbell","sequence":"additional","affiliation":[{"name":"Charleston Area Medical Center, Institute for Academic Medicine, 3200 MacCorkle Ave SE, Charleston, WV 25304, USA"},{"name":"Department of Internal Medicine, West Virginia University-Charleston Division, Charleston, WV 25304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1177\/02601060221090293","article-title":"Vitamin D in the news: A call for clear public health messaging during COVID-19","volume":"28","author":"Heer","year":"2022","journal-title":"Nutr. 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