{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:34:51Z","timestamp":1788827691078,"version":"build-2803163510"},"reference-count":87,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Economic Development Board of Singapore","award":["COY-15-IDS-LL\/160011"],"award-info":[{"award-number":["COY-15-IDS-LL\/160011"]}]},{"name":"Abbott Nutrition Research and Development","award":["COY-15-IDS-LL\/160011"],"award-info":[{"award-number":["COY-15-IDS-LL\/160011"]}]},{"name":"Changi General Hospital","award":["COY-15-IDS-LL\/160011"],"award-info":[{"award-number":["COY-15-IDS-LL\/160011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Malnutrition may result in abnormal biochemical and hematological indices. This planned prespecified analysis investigated the effects of a specialized oral nutritional supplement (ONS) on biochemical and hematological indices in community-dwelling older adults at risk of malnutrition. In the Strengthening Health in ELDerly through nutrition (SHIELD) study, 811 older adults aged 65 years and above took part in this randomized, double-blind, placebo-controlled, multi-center study. Participants were randomly allocated to either a complete and balanced specialized ONS (each serving provides 262 kcal, 10.5 g protein, 7.75 \u00b5g vitamin D3, and 0.74 g calcium \u03b2-hydroxy-\u03b2-methylbutyrate) and dietary counselling (intervention group) or a placebo and dietary counselling (placebo group). Both groups consumed study products twice a day for 180 days. Data were collected at baseline, day 90, and day 180. Blood analysis results at follow-up visits were analyzed using repeated measures analysis of covariance with adjustments for confounders. Overall, when compared with the placebo group, the intervention group showed significantly greater urea (6.0 mmol\/L vs. 5.4 mmol\/L, p &lt; 0.001), urea to creatinine ratio (4.39 vs. 4.26, p &lt; 0.001), prealbumin (24.9 mg\/dL vs. 24.0 mg\/dL, p &lt; 0.001), vitamin B12 (480.0 pmol\/L vs. 420.1 pmol\/L, p &lt; 0.001), and globulin levels (26.8 g\/L vs. 26.5 g\/L, p = 0.032). The intervention group also had a significantly higher absolute reticulocyte count (62.0 \u00d7 103\/\u00b5L vs. 58.2 \u00d7 103\/\u00b5L, overall p &lt; 0.001) and mean platelet volume (10.0 fL vs. 9.9 fL, overall p = 0.003). Furthermore, significant improvements were seen in total protein at day 90 (71.7 g\/L vs. 71.1 g\/L, p = 0.017) and in absolute monocyte count at day 90 (0.50 \u00d7 103\/\u00b5L vs. 0.47 \u00d7 103\/\u00b5L, p = 0.009) in the intervention group. In conclusion, daily consumption of a specialized ONS for six months led to significant improvements in biochemical and hematological indices in community-dwelling older adults at risk of malnutrition.<\/jats:p>","DOI":"10.3390\/nu16152495","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T10:34:43Z","timestamp":1722422083000},"page":"2495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Oral Nutritional Supplement with \u03b2-Hydroxy-\u03b2-methylbutyrate (HMB) on Biochemical and Hematological Indices in Community-Dwelling Older Adults at Risk of Malnutrition: Findings from the SHIELD Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5064-5283","authenticated-orcid":false,"given":"Siew Ling","family":"Tey","sequence":"first","affiliation":[{"name":"Abbott Nutrition Research and Development, Singapore 138668, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieu Thi Thu","family":"Huynh","sequence":"additional","affiliation":[{"name":"Abbott Nutrition Research and Development, Singapore 138668, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4595-4428","authenticated-orcid":false,"given":"Sing Teang","family":"Kong","sequence":"additional","affiliation":[{"name":"Abbott Nutrition Research and Development, Singapore 138668, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery","family":"Oliver","sequence":"additional","affiliation":[{"name":"Abbott Nutrition Research and Development, Columbus, OH 43219, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-7040","authenticated-orcid":false,"given":"Geraldine","family":"Baggs","sequence":"additional","affiliation":[{"name":"Abbott Nutrition Research and Development, Columbus, OH 43219, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen Ling","family":"Low","sequence":"additional","affiliation":[{"name":"Abbott Nutrition Research and Development, Singapore 138668, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon How","family":"How","sequence":"additional","affiliation":[{"name":"Care and Health Integration, Changi General Hospital, Singapore 529889, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalin","family":"Cheong","sequence":"additional","affiliation":[{"name":"Department of Dietetic & Food Services, Changi General Hospital, Singapore 529889, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Leng","family":"Chow","sequence":"additional","affiliation":[{"name":"Health Services Research, Changi General Hospital, Singapore 529889, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngiap Chuan","family":"Tan","sequence":"additional","affiliation":[{"name":"SingHealth Polyclinics, Singapore 150167, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7814-8836","authenticated-orcid":false,"given":"Tar Choon","family":"Aw","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Changi General Hospital, Singapore 529889, Singapore"},{"name":"Duke-NUS Graduate School of Medicine, 8 College Road, Singapore 169857, Singapore"},{"name":"Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore 117597, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2810-1332","authenticated-orcid":false,"given":"Samuel Teong Huang","family":"Chew","sequence":"additional","affiliation":[{"name":"Duke-NUS Graduate School of Medicine, 8 College Road, Singapore 169857, Singapore"},{"name":"Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore 117597, Singapore"},{"name":"Department of Geriatric Medicine, Changi General Hospital, Singapore 529889, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"ref_1","unstructured":"(2024, May 15). 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