{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:33:42Z","timestamp":1789050822816,"version":"build-2803163510"},"reference-count":107,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Methylsulfinyl hexyl isothiocyanate (6-MSITC) isolated from Eutrema japonicum is a promising candidate for the treatment of breast cancer, colorectal and stomach cancer, metabolic syndrome, heart diseases, diabetes, and obesity due to its anti-inflammatory and antioxidant properties. Also, its neuroprotective properties, improving cognitive function and protecting dopaminergic neurons, make it an excellent candidate for treating neurodegenerative diseases like dementia, Alzheimer\u2019s, and Parkinson\u2019s disease. 6-MSITC acts on many signaling pathways, such as PPAR, AMPK, PI3K\/AKT\/mTOR, Nrf2\/Keap1-ARE, ERK1\/2-ELK1\/CHOP\/DR5, and MAPK. However, despite the very promising results of in vitro and in vivo animal studies and a few human studies, the molecule has not yet been thoroughly tested in the human population. Nonetheless, wasabi should be classified as a \u201csuperfood\u201d for the primary and secondary prevention of human diseases. This article reviews the current state-of-the-art research on 6-MSITC and its potential clinical uses, discussing in detail the signaling pathways activated by the molecule and their interactions.<\/jats:p>","DOI":"10.3390\/nu16152509","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T08:14:46Z","timestamp":1722500086000},"page":"2509","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Methylsulfinyl Hexyl Isothiocyanate (6-MSITC) from Wasabi Is a Promising Candidate for the Treatment of Cancer, Alzheimer\u2019s Disease, and Obesity"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8347-0512","authenticated-orcid":false,"given":"Joanna","family":"Bartkowiak-Wieczorek","sequence":"first","affiliation":[{"name":"Physiology Department, Poznan University of Medical Sciences, 6, \u015awi\u0119cickiego Street, 60-781 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-5938","authenticated-orcid":false,"given":"Micha\u0142","family":"Malesza","sequence":"additional","affiliation":[{"name":"Physiology Department, Poznan University of Medical Sciences, 6, \u015awi\u0119cickiego Street, 60-781 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6740-8818","authenticated-orcid":false,"given":"Ida","family":"Malesza","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3230-8662","authenticated-orcid":false,"given":"Tomasz","family":"Hadada","sequence":"additional","affiliation":[{"name":"Physiology Department, Poznan University of Medical Sciences, 6, \u015awi\u0119cickiego Street, 60-781 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1415-6252","authenticated-orcid":false,"given":"Jakub","family":"Winkler-Galicki","sequence":"additional","affiliation":[{"name":"Physiology Department, Poznan University of Medical Sciences, 6, \u015awi\u0119cickiego Street, 60-781 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2815-0372","authenticated-orcid":false,"given":"Teresa","family":"Grzelak","sequence":"additional","affiliation":[{"name":"Physiology Department, Poznan University of Medical Sciences, 6, \u015awi\u0119cickiego Street, 60-781 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0081-6558","authenticated-orcid":false,"given":"Edyta","family":"M\u0105dry","sequence":"additional","affiliation":[{"name":"Physiology Department, Poznan University of Medical Sciences, 6, \u015awi\u0119cickiego Street, 60-781 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10522-023-10050-1","article-title":"Aging, oxidative stress and degenerative diseases: Mechanisms, complications and emerging therapeutic strategies","volume":"24","author":"Chaudhary","year":"2023","journal-title":"Biogerontology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Malesza, I.J., Malesza, M., Walkowiak, J., Mussin, N., Walkowiak, D., Aringazina, R., Bartkowiak-Wieczorek, J., and M\u0105dry, E. 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