{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:11:27Z","timestamp":1791659487146,"version":"4.3.4"},"reference-count":218,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ariel University Research &amp; Development Department","award":["RA2000000457"],"award-info":[{"award-number":["RA2000000457"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>It is now established that patients with rheumatoid arthritis (RA) have an increased risk of developing cervical cancer (CC) or its precursor, cervical intraepithelial neoplasia (CIN). However, the underlying mechanisms of this association have not been elucidated. RA is characterized by unresolved chronic inflammation. It is suggested that human papillomavirus (HPV) infection in RA patients exacerbates inflammation, increasing the risk of CC. The tumor microenvironment in RA patients with CC is also marked by chronic inflammation, which aggravates the manifestations of both conditions. Gut and vaginal dysbiosis are also considered potential mechanisms that contribute to the chronic inflammation and aggravation of RA and CC manifestations. Numerous clinical and pre-clinical studies have demonstrated the beneficial effects of various nutritional approaches to attenuate chronic inflammation, including polyunsaturated fatty acids and their derivatives, specialized pro-resolving mediators (SPMs), probiotics, prebiotics, and certain diets. We believe that successful resolution of chronic inflammation and correction of dysbiosis, in combination with current anti-RA and anti-CC therapies, is a promising therapeutic approach for RA and CC. This approach could also reduce the risk of CC development in HPV-infected RA patients.<\/jats:p>","DOI":"10.3390\/nu16152569","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T11:28:54Z","timestamp":1722857334000},"page":"2569","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nature of the Association between Rheumatoid Arthritis and Cervical Cancer and Its Potential Therapeutic Implications"],"prefix":"10.3390","volume":"16","author":[{"given":"Kirill","family":"Gusakov","sequence":"first","affiliation":[{"name":"Department of Morphological Sciences, Adelson School of Medicine, Ariel University, Ariel 4077625, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kalinkovich","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv 6905126, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7244-0679","authenticated-orcid":false,"given":"Shai","family":"Ashkenazi","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences, Adelson School of Medicine, Ariel University, Ariel 4077625, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-7493","authenticated-orcid":false,"given":"Gregory","family":"Livshits","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences, Adelson School of Medicine, Ariel University, Ariel 4077625, Israel"},{"name":"Department of Anatomy and Anthropology, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv 6905126, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"ref_1","first-page":"100768","article-title":"Risk of Cancer for Patients with Rheumatoid Arthritis versus General Population: A National Claims Database Cohort Study","volume":"35","author":"Beydon","year":"2023","journal-title":"Lancet Reg. 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