{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:32:27Z","timestamp":1790872347135,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Psoriasis predisposes to cardiovascular dysfunction. We investigated whether glycocalyx dietary supplement (GDS), which contains glycosaminoglycans and fucoidan, improves endothelial glycocalyx and arterial stiffness in psoriatic patients. Fifty participants with psoriasis under biological agents were randomly assigned to GDS (n = 25) or placebo (n = 25) for 4 months. We measured at baseline and at follow-up: (a) perfused boundary region (PBR) of the sublingual microvessels (range 4 to 25 \u03bcm), a marker of endothelium glycocalyx integrity; (b) carotid\u2013femoral pulse wave velocity (PWV-Complior SP-ALAM) and augmentation index (AIx), markers of arterial stiffness and (c) psoriasis area and severity index (PASI) score. Both groups displayed a similar decrease in PASI at four months (p &lt; 0.05), and no significant differences were found between groups (p &gt; 0.05). Compared to the placebo, participants in the GDS showed a greater percentage reduction in PBR4\u201325 \u03bcm (\u22129.95% vs. \u22120.87%), PBR 4\u20139 \u03bcm (\u22126.50% vs. \u22120.82%), PBR10\u201319 \u03bcm (\u22125.12% vs. \u22121.60%), PBR 20\u201325 \u03bcm (\u221214.9% vs. \u22120.31%), PWV (\u221215.27% vs. \u22124.04%) and AIx (\u221235.57% vs. \u221221.85%) (p &lt; 0.05). In the GDS group, the percentage reduction in PBR 4\u201325 \u03bcm was associated with the corresponding decrease in PWV (r = 0.411, p = 0.015) and A\u0399x (r = 0.481, p = 0.010) at follow-up. Four-month treatment with GDS improves glycocalyx integrity and arterial stiffness in patients with psoriasis. Clinical trial Identifier: NCT05184699.<\/jats:p>","DOI":"10.3390\/nu16152572","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T18:21:40Z","timestamp":1722882100000},"page":"2572","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of 4-Month Treatment with Glycocalyx Dietary Supplement on Endothelial Glycocalyx Integrity and Vascular Function in Patients with Psoriasis"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-7886","authenticated-orcid":false,"given":"Ignatios","family":"Ikonomidis","sequence":"first","affiliation":[{"name":"2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1025-9917","authenticated-orcid":false,"given":"Eleni","family":"Katsanaki","sequence":"additional","affiliation":[{"name":"2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3916-5350","authenticated-orcid":false,"given":"John","family":"Thymis","sequence":"additional","affiliation":[{"name":"2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-3446","authenticated-orcid":false,"given":"George","family":"Pavlidis","sequence":"additional","affiliation":[{"name":"2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Lampadaki","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology, Attikon University Hospital, Medical School, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1631-5210","authenticated-orcid":false,"given":"Konstantinos","family":"Katogiannis","sequence":"additional","affiliation":[{"name":"2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8838-5309","authenticated-orcid":false,"given":"Aristeidis","family":"Vaiopoulos","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology, Attikon University Hospital, Medical School, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Lazarou","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology, Attikon University Hospital, Medical School, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1732-2255","authenticated-orcid":false,"given":"Gavriella","family":"Kostelli","sequence":"additional","affiliation":[{"name":"2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Michalopoulou","sequence":"additional","affiliation":[{"name":"2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6480-3878","authenticated-orcid":false,"given":"Sotirios","family":"Pililis","sequence":"additional","affiliation":[{"name":"Research Unit and Diabetes Center, 2nd Department of Internal Medicine, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Vlachomitros","sequence":"additional","affiliation":[{"name":"2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6272-4459","authenticated-orcid":false,"given":"Konstantinos","family":"Theodoropoulos","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology, Attikon University Hospital, Medical School, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Vink","sequence":"additional","affiliation":[{"name":"GlycoCalyx Research Institute, Alpine, UT 84004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Long","sequence":"additional","affiliation":[{"name":"GlycoCalyx Research Institute, Alpine, UT 84004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Papadavid","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology, Attikon University Hospital, Medical School, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaia","family":"Lambadiari","sequence":"additional","affiliation":[{"name":"Research Unit and Diabetes Center, 2nd Department of Internal Medicine, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cjca.2019.06.021","article-title":"Effects of interleukin 17A inhibition on myocardial deformation and vascular function in psoriasis","volume":"36","author":"Makavos","year":"2020","journal-title":"Can. 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